The data in the sections under Abstract and Results has been updated.
Abstract
Results The need for re-intervention with medication or surgery due to surgical or clinical recurrence increased over time. The recurrence rates in patients after ileocecal resection were lower than the rates under biologic therapy. The odds ratio for clinical recurrence under biologics versus after surgical treatment was 2.50 (95% confidence interval [CI] 1.53–4.08, p-value < 0.001). The odds ratio for surgical recurrence under biologics versus after surgery was 3.60 (95% CI 1.06–12.3, p-value 0.041).
Results
Overall evaluation
After 60 months, the surgical recurrence rates were 0.11 (95% CI, 0.06–0.19) in the surgery group and 0.26 (95% CI, 0.23–0.30) in the biologics group. There were no studies from the combination therapy group for the probability of recurrence after 60 months. The results of the two types of therapy, surgery and biologics, were statistically significant (Fig. 6); more than twice as many surgical recurrences occurred in the biologics group after 60 months as in the surgical group.