Correction to: Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress
verfasst von:
Dan Zhao, Xulin Xu, Linna Pan, Wei Zhu, Xiaopei Fu, Lianjun Guo, Qing Lu, Jian Wang
Following the publication of the original article [1], it was noted that the authors identified an error in Figs. 2 and 9.
1.
The representative western blot image for α7AchR protein expression in Fig. 2b was incorrect by mistake. The corrected version of Fig. 2 (JPG file) is given below.
2.
CRS21d image in Fig. 9a, CRS 21d + DMXBA image in Fig. 9b are incorrect. During the preparation of figures, we inadvertently provided an incorrect image, and are updated with correct images, Con group image in Fig. 9a was also updated for more accuracy. The corrected version of Fig. 9 is given below.
3.
We would like to add in the correction that "the authors clarify that this work was not financially supported by the NIH grants or by the Johns Hopkins University."
Fig. 2
Chronic restraint stress (CRS)-induced alterations in components of central cholinergic signaling in hippocampus. a Doubleimmunolabeling showed that α7nAChR colocalized primarily with NeuN+ neurons and to a lesser extent with GFAP + astrocytes and Iba-1+ microglia in the hippocampus; scale bar, 30 μm. b Representative immunoblots and relative levels of α7nAChR protein in hippocampus. Results are shown as fold change relative to GAPDH protein level. c Representative immunoblots and relative levels of choline acetyltransferase (ChAT) protein in hippocampus. Results are shown as fold change relative to GAPDH protein level. d Acetylcholinesterase (AChE) activity in hippocampus at different time points of CRS. e Representative immunoblots and relative levels of STAT3 protein in hippocampus. Results are shown as fold change relative to histone1 protein level. Con, control group. Data are expressed as mean ± SEM. n = 8 per group; *P < 0.05, **P < 0.01 vs. control group
Fig. 9
Chronic DMXBA treatment reverses chronic restraint stress (CRS)-induced reductions in T regulatory (Treg) cells in mouse periphery and hippocampus. a Representative flow cytometry profiles and statistics of Foxp3+-expressing cells among CD4+ CD25+ splenocytes on days 7, 14, and 21 of CRS. b Representative flow cytometry profiles and statistics of Treg cells among splenocytes from mice treated with vehicle or DMXBA. c Representative immunoblots and relative levels of Foxp3 protein in hippocampus. Results are shown as fold change relative to GAPDH protein level. Con, control group. All data are expressed as mean ± SEM. n = 8; *P < 0.05 vs. control group; #P < 0.05, ##P < 0.01 vs. CRS 21d + Veh group; ++P < 0.01 vs. CRS 21d + DMXBA group
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The corrections did not affect the overall conclusions and we hope to make the corrigendum as soon as possible. We apologize for this mistake due to our carelessness.
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Correction to: Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress
verfasst von
Dan Zhao Xulin Xu Linna Pan Wei Zhu Xiaopei Fu Lianjun Guo Qing Lu Jian Wang
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