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Erschienen in: Die Gynäkologie 4/2021

18.01.2021 | Leitthema

Der Einfluss von Umweltfaktoren und Lebensstil auf die männliche Fertilität

verfasst von: Frank-Michael Köhn, Prof. Dr. Hans-Christian Schuppe

Erschienen in: Die Gynäkologie | Ausgabe 4/2021

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Zusammenfassung

Bei der Erfassung kausaler Faktoren männlicher Fertilitätsstörungen spielen Lebensstil und Umweltfaktoren eine wichtige Rolle. Das Wissen um die Wechselwirkungen zwischen derartigen Einflüssen und reproduktiven Funktionen des Mannes eröffnet zudem die Möglichkeit eines präventiven Ansatzes in der Andrologie. Relevante exogene Noxen sind Genussgifte, Pharmaka einschließlich Lifestyle-Medikamenten, Berufsstoffe, Umweltchemikalien sowie physikalische Faktoren. Reproduktionstoxische Effekte können sich prätestikulär, testikulär oder posttestikulär entfalten und neben einer Beeinträchtigung der Spermatogenese oder Spermienfunktion auch Hormon- und Sexualstörungen verursachen. Aufgrund der komplexen Regulation des männlichen Reproduktionssystems sowie der begrenzten Übertragbarkeit tierexperimenteller Befunde und In-vitro-Daten auf die Situation beim Menschen liegen allerdings nur für wenige Noxen gesicherte Erkenntnisse vor. In der andrologischen Sprechstunde sollten bei Erhebung der Anamnese potenzielle Expositionsrisiken erfasst und die Patienten über eine gesicherte oder mögliche Relevanz für ihre Fertilität aufgeklärt werden.
Literatur
2.
Zurück zum Zitat Aitken RJ, Koopman P, Lewis SE (2004) Seeds of concern. Nature 432:48–52PubMed Aitken RJ, Koopman P, Lewis SE (2004) Seeds of concern. Nature 432:48–52PubMed
3.
Zurück zum Zitat Alvarez S (2015) Do some addictions interfere with fertility? Fertil Steril 103(1):22–26PubMed Alvarez S (2015) Do some addictions interfere with fertility? Fertil Steril 103(1):22–26PubMed
4.
Zurück zum Zitat Axelsson J, Rylander L, Rignell-Hydbom A, Silfver KA, Stenqvist A, Giwercman A (2013) The impact of paternal andmaternal smoking on semen quality of adolescent men. PLoS One 8:e66766PubMedPubMedCentral Axelsson J, Rylander L, Rignell-Hydbom A, Silfver KA, Stenqvist A, Giwercman A (2013) The impact of paternal andmaternal smoking on semen quality of adolescent men. PLoS One 8:e66766PubMedPubMedCentral
5.
Zurück zum Zitat Bahrke MS, Yesalis CE, Kopstein AN, Stephens JA (2000) Risk factors associated with anabolic-androgenic steroid use among adolescents. Sports Med 29:397–405PubMed Bahrke MS, Yesalis CE, Kopstein AN, Stephens JA (2000) Risk factors associated with anabolic-androgenic steroid use among adolescents. Sports Med 29:397–405PubMed
6.
Zurück zum Zitat Bonde JP (2006) Effects of lifestyle and toxicants. In: Schill W‑B, Comhaire F, Hargreave TB (Hrsg) Andrology for the clinician. Springer, Heidelberg, S 348–357 Bonde JP (2006) Effects of lifestyle and toxicants. In: Schill W‑B, Comhaire F, Hargreave TB (Hrsg) Andrology for the clinician. Springer, Heidelberg, S 348–357
7.
Zurück zum Zitat Bonde JP, Flachs EM, Rimborg S, Glazer CH, Giwercman A, Ramlau-Hansen CH, Hougaard KS, Høyer BB, Hærvig KK, Petersen SB, Rylander L, Specht IO, Toft G, Bräuner EV (2016) The epidemiologic evidence linking prenatal and postnatal exposure to endocrine disrupting chemicals with male reproductive disorders: a systematic review and meta-analysis. Hum Reprod Update 23(1):104–125PubMedPubMedCentral Bonde JP, Flachs EM, Rimborg S, Glazer CH, Giwercman A, Ramlau-Hansen CH, Hougaard KS, Høyer BB, Hærvig KK, Petersen SB, Rylander L, Specht IO, Toft G, Bräuner EV (2016) The epidemiologic evidence linking prenatal and postnatal exposure to endocrine disrupting chemicals with male reproductive disorders: a systematic review and meta-analysis. Hum Reprod Update 23(1):104–125PubMedPubMedCentral
8.
Zurück zum Zitat Boos C, Wulff P, Kujath P, Bruch H‑P (1998) Medikamentenmißbrauch beim Freizeitsportler im Fitneßbereich. Dtsch Ärztebl 95:A-953–957 Boos C, Wulff P, Kujath P, Bruch H‑P (1998) Medikamentenmißbrauch beim Freizeitsportler im Fitneßbereich. Dtsch Ärztebl 95:A-953–957
9.
Zurück zum Zitat Brenker C, Rehfeld A, Schiffer C, Kierzek M, Kaupp UB, Skakkebæk NE, Strünker T (2018) Synergistic activation of CatSper Ca2+ channels in human sperm by oviductal ligands and endocrine disrupting chemicals. Hum Reprod 33(10):1915–1923PubMed Brenker C, Rehfeld A, Schiffer C, Kierzek M, Kaupp UB, Skakkebæk NE, Strünker T (2018) Synergistic activation of CatSper Ca2+ channels in human sperm by oviductal ligands and endocrine disrupting chemicals. Hum Reprod 33(10):1915–1923PubMed
10.
Zurück zum Zitat Broe A, Pottegård A, Hallas J, Ahern TP, Fedder J, Damkier P (2018) Association between use of phthalate-containing medication and semen quality among men in couples referred for assisted reproduction. Hum Reprod 33(3):503–511PubMedPubMedCentral Broe A, Pottegård A, Hallas J, Ahern TP, Fedder J, Damkier P (2018) Association between use of phthalate-containing medication and semen quality among men in couples referred for assisted reproduction. Hum Reprod 33(3):503–511PubMedPubMedCentral
12.
Zurück zum Zitat Carlsen E, Giwercman A, Keiding N, Skakkebaek NE (1992) Evidence for decreasing quality of semen during past 50 years. BMJ 305:609–613PubMedPubMedCentral Carlsen E, Giwercman A, Keiding N, Skakkebaek NE (1992) Evidence for decreasing quality of semen during past 50 years. BMJ 305:609–613PubMedPubMedCentral
13.
Zurück zum Zitat Carroll K, Pottinger AM, Wynter S, DaCosta V (2020) Marijuana use and its influence on sperm morphology and motility: identified risk for fertility among Jamaican men. Andrology 8(1):136–142PubMed Carroll K, Pottinger AM, Wynter S, DaCosta V (2020) Marijuana use and its influence on sperm morphology and motility: identified risk for fertility among Jamaican men. Andrology 8(1):136–142PubMed
14.
Zurück zum Zitat Chastain LG, Sarkar DK (2017) Alcohol effects on the epigenome in the germline: role in the inheritance of alcohol-related pathology. Alcohol 60:53–66PubMedPubMedCentral Chastain LG, Sarkar DK (2017) Alcohol effects on the epigenome in the germline: role in the inheritance of alcohol-related pathology. Alcohol 60:53–66PubMedPubMedCentral
15.
Zurück zum Zitat Corona G, Sansone A, Pallotti F, Ferlin A, Pivonello R, Isidori AM, Maggi M, Jannini EA (2020) People smoke for nicotine, but lose sexual and reproductive health for tar: a narrative review on the effect of cigarette smoking on male sexuality and reproduction. J Endocrinol Invest 43(10):1391–1408PubMed Corona G, Sansone A, Pallotti F, Ferlin A, Pivonello R, Isidori AM, Maggi M, Jannini EA (2020) People smoke for nicotine, but lose sexual and reproductive health for tar: a narrative review on the effect of cigarette smoking on male sexuality and reproduction. J Endocrinol Invest 43(10):1391–1408PubMed
16.
Zurück zum Zitat Craig JR, Jenkins TG, Carrell DT, Hotaling JM (2017) Obesity, male infertility, and the sperm epigenome. Fertil Steril 107:848–859PubMed Craig JR, Jenkins TG, Carrell DT, Hotaling JM (2017) Obesity, male infertility, and the sperm epigenome. Fertil Steril 107:848–859PubMed
17.
Zurück zum Zitat Crujeiras AB, Casanueva FF (2015) Obesity and the reproductive system disorders: epigenetics as a potential bridge. Hum Reprod Update 21(2):249–261PubMed Crujeiras AB, Casanueva FF (2015) Obesity and the reproductive system disorders: epigenetics as a potential bridge. Hum Reprod Update 21(2):249–261PubMed
18.
Zurück zum Zitat Dai JB, Wang ZX, Qiao ZD (2015) The hazardous effects of tobacco smoking on male fertility. Asian J Androl 17:954–960PubMedPubMedCentral Dai JB, Wang ZX, Qiao ZD (2015) The hazardous effects of tobacco smoking on male fertility. Asian J Androl 17:954–960PubMedPubMedCentral
19.
Zurück zum Zitat Darbandi M, Darbandi S, Agarwal A, Henkel R, Sadeghi MR (2018) The effects of exposure to low frequency electromagnetic fields on male fertility. Altern Ther Health Med 24(4):24–29PubMed Darbandi M, Darbandi S, Agarwal A, Henkel R, Sadeghi MR (2018) The effects of exposure to low frequency electromagnetic fields on male fertility. Altern Ther Health Med 24(4):24–29PubMed
20.
Zurück zum Zitat De-Celis R, Feria-Velasco A, Gonzalez-Unzaga M, Torres-Calleja J, Pedron-Nuevo N (2000) Semen quality of workers occupationally exposed to hydrocarbons. Fertil Steril 73:221–228PubMed De-Celis R, Feria-Velasco A, Gonzalez-Unzaga M, Torres-Calleja J, Pedron-Nuevo N (2000) Semen quality of workers occupationally exposed to hydrocarbons. Fertil Steril 73:221–228PubMed
21.
Zurück zum Zitat Fariello RM, Pariz JR, Spaine DM, Cedenho AP, Bertolla RP, Fraietta R (2012) Association between obesity and alteration of sperm DNA integrity and mitochondrial activity. BJU Int 110:863–867 Fariello RM, Pariz JR, Spaine DM, Cedenho AP, Bertolla RP, Fraietta R (2012) Association between obesity and alteration of sperm DNA integrity and mitochondrial activity. BJU Int 110:863–867
22.
Zurück zum Zitat Fritsche E, Schuppe HC, Döhr O, Ruzicka T, Gleichmann E, Abel J (1998) Increased frequencies of cytochrome P4501A1 polymorphisms in infertile men. Andrologia 30:125–128PubMed Fritsche E, Schuppe HC, Döhr O, Ruzicka T, Gleichmann E, Abel J (1998) Increased frequencies of cytochrome P4501A1 polymorphisms in infertile men. Andrologia 30:125–128PubMed
23.
Zurück zum Zitat Fronczak CM, Kim ED, Barqawi AB (2012) The insults of illicit drug use on male fertility. J Androl 33(4):515–528PubMed Fronczak CM, Kim ED, Barqawi AB (2012) The insults of illicit drug use on male fertility. J Androl 33(4):515–528PubMed
24.
Zurück zum Zitat Garolla A, Torino M, Sartini B, Cosci I, Patassini C, Carraro U, Foresta C (2013) Seminal and molecular evidence that sauna exposure affects human spermatogenesis. Hum Reprod 28:877–885PubMed Garolla A, Torino M, Sartini B, Cosci I, Patassini C, Carraro U, Foresta C (2013) Seminal and molecular evidence that sauna exposure affects human spermatogenesis. Hum Reprod 28:877–885PubMed
25.
Zurück zum Zitat Gaskins AJ, Colaci DS, Mendiola J, Swan SH, Chavarro JE (2012) Dietary patterns and semen quality in young men. Hum Reprod 27(10):2899–2907PubMedPubMedCentral Gaskins AJ, Colaci DS, Mendiola J, Swan SH, Chavarro JE (2012) Dietary patterns and semen quality in young men. Hum Reprod 27(10):2899–2907PubMedPubMedCentral
26.
Zurück zum Zitat Gaskins AJ, Mendiola J, Afeiche M, Jørgensen N, Swan SH, Chavarro JE (2015) Physical activity and television watching in relation to semen quality in young men. Br J Sports Med 49:265–270PubMed Gaskins AJ, Mendiola J, Afeiche M, Jørgensen N, Swan SH, Chavarro JE (2015) Physical activity and television watching in relation to semen quality in young men. Br J Sports Med 49:265–270PubMed
27.
Zurück zum Zitat Gianfrilli D, Ferlin A, Isidori AM, Garolla A, Maggi M, Pivonello R, Santi D, Sansone A, Balercia G, Granata ARM, Sinisi A, Lanfranco F, Pasqualetti P, Foresta C, Lenzi A, ‘Amico-Andrologo’ Study Group (2019) Risk behaviours and alcohol in adolescence are negatively associated with testicular volume: results from the Amico-Andrologo survey. Andrology 7(6):769–777PubMed Gianfrilli D, Ferlin A, Isidori AM, Garolla A, Maggi M, Pivonello R, Santi D, Sansone A, Balercia G, Granata ARM, Sinisi A, Lanfranco F, Pasqualetti P, Foresta C, Lenzi A, ‘Amico-Andrologo’ Study Group (2019) Risk behaviours and alcohol in adolescence are negatively associated with testicular volume: results from the Amico-Andrologo survey. Andrology 7(6):769–777PubMed
28.
Zurück zum Zitat Gundersen TD, Jørgensen N, Andersson AM, Bang AK, Nordkap L, Skakkebæk NE, Priskorn L, Juul A, Jensen TK (2015) Association between use of marijuana and male reproductive hormones and semen quality: a study among 1,215 healthy young men. Am J Epidemiol 182:473–481PubMed Gundersen TD, Jørgensen N, Andersson AM, Bang AK, Nordkap L, Skakkebæk NE, Priskorn L, Juul A, Jensen TK (2015) Association between use of marijuana and male reproductive hormones and semen quality: a study among 1,215 healthy young men. Am J Epidemiol 182:473–481PubMed
29.
Zurück zum Zitat Håkonsen LB, Ernst A, Ramlau-Hansen CH (2014) Maternal cigarette smoking during pregnancy and reproductive health in children: a review of epidemiological studies. Asian J Androl 16:39–49PubMed Håkonsen LB, Ernst A, Ramlau-Hansen CH (2014) Maternal cigarette smoking during pregnancy and reproductive health in children: a review of epidemiological studies. Asian J Androl 16:39–49PubMed
30.
Zurück zum Zitat Haidl G, Allam J‑P, Schuppe H‑C, Köhn F‑M (2013) Nimmt die Fruchtbarkeit der Männer ab? Gynäkologe 46:18–21 Haidl G, Allam J‑P, Schuppe H‑C, Köhn F‑M (2013) Nimmt die Fruchtbarkeit der Männer ab? Gynäkologe 46:18–21
31.
Zurück zum Zitat Hales BF, Robaire B (2020) Effects of brominated and organophosphate ester flame retardants on male reproduction. Andrology 8(4):915–923PubMed Hales BF, Robaire B (2020) Effects of brominated and organophosphate ester flame retardants on male reproduction. Andrology 8(4):915–923PubMed
33.
Zurück zum Zitat Hassan MAM, Killick SR (2004) Negative lifestyle is associated with a significant reduction in fecundity. Fertil Steril 81:384–392PubMed Hassan MAM, Killick SR (2004) Negative lifestyle is associated with a significant reduction in fecundity. Fertil Steril 81:384–392PubMed
34.
Zurück zum Zitat Hipwell AE, Kahn LG, Factor-Litvak P, Porucznik CA, Siegel EL, Fichorova RN, Hamman RF, Klein-Fedyshin M, Harley KG, program collaborators for Environmental influences on Child Health Outcomes (2019) Exposure to non-persistent chemicals in consumer products and fecundability: a systematic review. Hum Reprod Update 25(1):51–71PubMed Hipwell AE, Kahn LG, Factor-Litvak P, Porucznik CA, Siegel EL, Fichorova RN, Hamman RF, Klein-Fedyshin M, Harley KG, program collaborators for Environmental influences on Child Health Outcomes (2019) Exposure to non-persistent chemicals in consumer products and fecundability: a systematic review. Hum Reprod Update 25(1):51–71PubMed
35.
Zurück zum Zitat Holmboe SA, Priskorn L, Jensen TK, Skakkebaek NE, Andersson AM, Jørgensen N (2020) Use of e‑cigarettes associated with lower sperm counts in a cross-sectional study of young men from the general population. Hum Reprod 35(7):1693–1701PubMed Holmboe SA, Priskorn L, Jensen TK, Skakkebaek NE, Andersson AM, Jørgensen N (2020) Use of e‑cigarettes associated with lower sperm counts in a cross-sectional study of young men from the general population. Hum Reprod 35(7):1693–1701PubMed
36.
Zurück zum Zitat Hoyes KP, Morris ID (1996) Environmental radiation and male reproduction. Int J Androl 19:199–204PubMed Hoyes KP, Morris ID (1996) Environmental radiation and male reproduction. Int J Androl 19:199–204PubMed
37.
Zurück zum Zitat Høyer S, Riis AH, Toft G, Wise LA, Hatch EE, Wesselink AK, Rothman KJ, Sørensen HT, Mikkelsen EM (2020) Male alcohol consumption and fecundability. Hum Reprod 35(4):816–825PubMed Høyer S, Riis AH, Toft G, Wise LA, Hatch EE, Wesselink AK, Rothman KJ, Sørensen HT, Mikkelsen EM (2020) Male alcohol consumption and fecundability. Hum Reprod 35(4):816–825PubMed
38.
Zurück zum Zitat Jensen T, Gottschau M, Broby Madsen J, Andersson AM, Harmer T, Skakkebæk N et al (2014) Habitual alcohol consumption associated with reduced semen quality and changes in reproductive hormones; a cross-sectional study among 1221 young Danish men. BMJ Open 4:e5462PubMedPubMedCentral Jensen T, Gottschau M, Broby Madsen J, Andersson AM, Harmer T, Skakkebæk N et al (2014) Habitual alcohol consumption associated with reduced semen quality and changes in reproductive hormones; a cross-sectional study among 1221 young Danish men. BMJ Open 4:e5462PubMedPubMedCentral
40.
Zurück zum Zitat Jung A, Schuppe HC (2007) Influence of genital heat stress on semen quality in humans. Andrologia 39:203–215PubMed Jung A, Schuppe HC (2007) Influence of genital heat stress on semen quality in humans. Andrologia 39:203–215PubMed
41.
Zurück zum Zitat Kahn LG, Philippat C, Nakayama SF, Slama R, Trasande L (2020) Endocrine-disrupting chemicals: implications for human health. Lancet Diabetes Endocrinol 8:703–718PubMedPubMedCentral Kahn LG, Philippat C, Nakayama SF, Slama R, Trasande L (2020) Endocrine-disrupting chemicals: implications for human health. Lancet Diabetes Endocrinol 8:703–718PubMedPubMedCentral
42.
Zurück zum Zitat Karayiannis D, Kontogianni MD, Mendorou C, Douka L, Mastrominas M, Yiannakouris N (2017) Association between adherence to the Mediterranean diet and semen quality parameters in male partners of couples attempting fertility. Hum Reprod 32(1):215–222PubMed Karayiannis D, Kontogianni MD, Mendorou C, Douka L, Mastrominas M, Yiannakouris N (2017) Association between adherence to the Mediterranean diet and semen quality parameters in male partners of couples attempting fertility. Hum Reprod 32(1):215–222PubMed
43.
Zurück zum Zitat Karmon AE, Toth TL, Chiu YH, Gaskins AJ, Tanrikut C, Wright DL, Hauser R, Chavarro JE, Earth Study Team (2017) Male caffeine and alcohol intake in relation to semen parameters and in vitro fertilization outcomes among fertility patients. Andrology 5(2):354–361PubMedPubMedCentral Karmon AE, Toth TL, Chiu YH, Gaskins AJ, Tanrikut C, Wright DL, Hauser R, Chavarro JE, Earth Study Team (2017) Male caffeine and alcohol intake in relation to semen parameters and in vitro fertilization outcomes among fertility patients. Andrology 5(2):354–361PubMedPubMedCentral
45.
Zurück zum Zitat Kiguradze T, Temps WH, Yarnold PR, Cashy J, Brannigan RE, Nardone B, Micali G, West DP, Belknap SM (2017) Persistent erectile dysfunction in men exposed to the 5α-reductase inhibitors, finasteride, or dutasteride. PeerJ 5:e3020PubMedPubMedCentral Kiguradze T, Temps WH, Yarnold PR, Cashy J, Brannigan RE, Nardone B, Micali G, West DP, Belknap SM (2017) Persistent erectile dysfunction in men exposed to the 5α-reductase inhibitors, finasteride, or dutasteride. PeerJ 5:e3020PubMedPubMedCentral
46.
Zurück zum Zitat Köhn F‑M, Schuppe H‑C (2016) Umweltfaktoren und männliche Fertilität. Urologe A 55:877–882PubMed Köhn F‑M, Schuppe H‑C (2016) Umweltfaktoren und männliche Fertilität. Urologe A 55:877–882PubMed
47.
Zurück zum Zitat La Vignera S, Condorelli RA, Balercia G, Vicari E, Calogero AE (2013) Does alcohol have any effect on male reproductive function? A review of literature. Asian J Androl 15:221–225PubMed La Vignera S, Condorelli RA, Balercia G, Vicari E, Calogero AE (2013) Does alcohol have any effect on male reproductive function? A review of literature. Asian J Androl 15:221–225PubMed
48.
Zurück zum Zitat Lerchl A (2013) Electromagnetic pollution: another risk factor for infertility, or a red herring? Asian J Androl 15:201–203PubMed Lerchl A (2013) Electromagnetic pollution: another risk factor for infertility, or a red herring? Asian J Androl 15:201–203PubMed
49.
Zurück zum Zitat Levine RJ, Brown MH, Bell M, Shue F, Greenberg GN, Bordson BL (1992) Air-conditioned environments do not prevent deterioration of human semen quality during the summer. Fertil Steril 57:1075–1083PubMed Levine RJ, Brown MH, Bell M, Shue F, Greenberg GN, Bordson BL (1992) Air-conditioned environments do not prevent deterioration of human semen quality during the summer. Fertil Steril 57:1075–1083PubMed
50.
Zurück zum Zitat Levine H, Jørgensen N, Martino-Andrade A, Mendiola J, Weksler-Derri D, Mindlis I, Pinotti R, Swan SH (2017) Temporal trends in sperm count: a systematic review and meta-regression analysis. Hum Reprod Update 23(6):646–659PubMedPubMedCentral Levine H, Jørgensen N, Martino-Andrade A, Mendiola J, Weksler-Derri D, Mindlis I, Pinotti R, Swan SH (2017) Temporal trends in sperm count: a systematic review and meta-regression analysis. Hum Reprod Update 23(6):646–659PubMedPubMedCentral
51.
Zurück zum Zitat Liu K, Li Y, Zhang G, Liu J, Cao J, Ao L, Zhang S (2014) Association between mobile phone use and semen quality: a systemic review and meta-analysis. Andrology 2:491–501PubMed Liu K, Li Y, Zhang G, Liu J, Cao J, Ao L, Zhang S (2014) Association between mobile phone use and semen quality: a systemic review and meta-analysis. Andrology 2:491–501PubMed
52.
Zurück zum Zitat Liu K, Hou G, Wang X, Chen H, Shi F, Liu C, Zhang X, Han F, Yang H, Zhou N, Ao L, Liu J, Cao J, Chen Q (2020) Adverse effects of circadian desynchrony on the male reproductive system: an epidemiological and experimental study. Hum Reprod 35(7):1515–1528PubMedPubMedCentral Liu K, Hou G, Wang X, Chen H, Shi F, Liu C, Zhang X, Han F, Yang H, Zhou N, Ao L, Liu J, Cao J, Chen Q (2020) Adverse effects of circadian desynchrony on the male reproductive system: an epidemiological and experimental study. Hum Reprod 35(7):1515–1528PubMedPubMedCentral
53.
Zurück zum Zitat Lötsch J, Schneider G, Reker D, Parnham MJ, Schneider P, Geisslinger G, Doehring A (2013) Common non-epigenetic drugs as epigenetic modulators. Trends Mol Med 19(12):742–753PubMed Lötsch J, Schneider G, Reker D, Parnham MJ, Schneider P, Geisslinger G, Doehring A (2013) Common non-epigenetic drugs as epigenetic modulators. Trends Mol Med 19(12):742–753PubMed
54.
Zurück zum Zitat MacLeod J, Wang Y (1979) Male fertility potential in terms of semen quality: a review of the past, a study of the present. Fertil Steril 31:103–116PubMed MacLeod J, Wang Y (1979) Male fertility potential in terms of semen quality: a review of the past, a study of the present. Fertil Steril 31:103–116PubMed
55.
Zurück zum Zitat McBride JA, Coward RM (2016) Recovery of spermatogenesis following testosterone replacement therapy or anabolic-androgenic steroid use. Asian J Androl 18(3):373–380PubMedPubMedCentral McBride JA, Coward RM (2016) Recovery of spermatogenesis following testosterone replacement therapy or anabolic-androgenic steroid use. Asian J Androl 18(3):373–380PubMedPubMedCentral
56.
Zurück zum Zitat Mínguez-Alarcón L, Chavarro JE, Mendiola J, Gaskins AJ, Torres-Cantero AM (2014) Physical activity is not related to semen quality in young healthy men. Fertil Steril 102:1103–1109PubMedPubMedCentral Mínguez-Alarcón L, Chavarro JE, Mendiola J, Gaskins AJ, Torres-Cantero AM (2014) Physical activity is not related to semen quality in young healthy men. Fertil Steril 102:1103–1109PubMedPubMedCentral
57.
Zurück zum Zitat Mínguez-Alarcón L, Gaskins AJ, Chiu YH, Messerlian C, Williams PL, Ford JB, Souter I, Hauser R, Chavarro JE (2018) Type of underwear worn and markers of testicular function among men attending a fertility center. Hum Reprod 33(9):1749–1756PubMedPubMedCentral Mínguez-Alarcón L, Gaskins AJ, Chiu YH, Messerlian C, Williams PL, Ford JB, Souter I, Hauser R, Chavarro JE (2018) Type of underwear worn and markers of testicular function among men attending a fertility center. Hum Reprod 33(9):1749–1756PubMedPubMedCentral
58.
Zurück zum Zitat Møllerløkken OJ, Moen BE (2008) Is fertility reduced among men exposed to radiofrequency fields in the Norwegian navy? Bioelectromagnetics 29:345–352PubMed Møllerløkken OJ, Moen BE (2008) Is fertility reduced among men exposed to radiofrequency fields in the Norwegian navy? Bioelectromagnetics 29:345–352PubMed
60.
Zurück zum Zitat Nassan FL, Arvizu M, Mínguez-Alarcón L, Williams PL, Attaman J, Petrozza J, Hauser R, Chavarro J, EARTH Study Team (2019) Marijuana smoking and markers of testicular function among men from a fertility centre. Hum Reprod 34(4):715–723PubMedPubMedCentral Nassan FL, Arvizu M, Mínguez-Alarcón L, Williams PL, Attaman J, Petrozza J, Hauser R, Chavarro J, EARTH Study Team (2019) Marijuana smoking and markers of testicular function among men from a fertility centre. Hum Reprod 34(4):715–723PubMedPubMedCentral
61.
Zurück zum Zitat Nazmara Z, Najafi M, Rezaei-Mojaz S, Movahedin M, Zandiyeh Z, Shirinbayan P, Roshanpajouh M, Asgari HR, Hosseini Jafari Lavasani L, Koruji M (2019) The effect of heroin addiction on human sperm parameters, histone-to-protamine transition, and serum sexual hormones levels. Urol J 16(3):289–294PubMed Nazmara Z, Najafi M, Rezaei-Mojaz S, Movahedin M, Zandiyeh Z, Shirinbayan P, Roshanpajouh M, Asgari HR, Hosseini Jafari Lavasani L, Koruji M (2019) The effect of heroin addiction on human sperm parameters, histone-to-protamine transition, and serum sexual hormones levels. Urol J 16(3):289–294PubMed
63.
Zurück zum Zitat Nelson CMK, Bunge RG (1974) Semen analysis: evidence for changing parameters of male fertility potential. Fertil Steril 25:503–507PubMed Nelson CMK, Bunge RG (1974) Semen analysis: evidence for changing parameters of male fertility potential. Fertil Steril 25:503–507PubMed
64.
Zurück zum Zitat Nieschlag E, Vorona E (2015) Mechanisms in endocrinology: medical consequences of doping with anabolic androgenic steroids: effects on reproductive functions. Eur J Endocrinol 173:R47–R58PubMed Nieschlag E, Vorona E (2015) Mechanisms in endocrinology: medical consequences of doping with anabolic androgenic steroids: effects on reproductive functions. Eur J Endocrinol 173:R47–R58PubMed
65.
Zurück zum Zitat Nordkap L, Jensen TK, Hansen ÅM, Lassen TH, Bang AK, Joensen UN, Blomberg Jensen M, Skakkebæk NE, Jørgensen N (2016) Psychological stress and testicular function: a cross-sectional study of 1,215 Danish men. Fertil Steril 105(1):174–187PubMed Nordkap L, Jensen TK, Hansen ÅM, Lassen TH, Bang AK, Joensen UN, Blomberg Jensen M, Skakkebæk NE, Jørgensen N (2016) Psychological stress and testicular function: a cross-sectional study of 1,215 Danish men. Fertil Steril 105(1):174–187PubMed
66.
Zurück zum Zitat Nordkap L, Priskorn L, Bräuner EV, Hansen MÅ, Kirstine Bang A, Holmboe SA, Winge SB, Egeberg Palme DL, Mørup N, Skakkebaek EN, Kold Jensen T, Jørgensen N (2020) Impact of psychological stress measured in three different scales on testis function: a cross-sectional study of 1362 young men. Andrology. https://doi.org/10.1111/andr.12835CrossRefPubMed Nordkap L, Priskorn L, Bräuner EV, Hansen MÅ, Kirstine Bang A, Holmboe SA, Winge SB, Egeberg Palme DL, Mørup N, Skakkebaek EN, Kold Jensen T, Jørgensen N (2020) Impact of psychological stress measured in three different scales on testis function: a cross-sectional study of 1362 young men. Andrology. https://​doi.​org/​10.​1111/​andr.​12835CrossRefPubMed
67.
Zurück zum Zitat Pacey AA, Povey AC, Clyma JA, McNamee R, Moore HD, Baillie H, Cherry NM (2014) Modifiable and non-modifiable risk factors for poor sperm morphology. Hum Reprod 29:1629–1636PubMed Pacey AA, Povey AC, Clyma JA, McNamee R, Moore HD, Baillie H, Cherry NM (2014) Modifiable and non-modifiable risk factors for poor sperm morphology. Hum Reprod 29:1629–1636PubMed
68.
Zurück zum Zitat Pflieger-Bruss S, Schuppe H‑C, Schill W‑B (2004) The male reproductive system and its susceptibility to endocrine disrupting chemicals. Andrologia 36:337–345PubMed Pflieger-Bruss S, Schuppe H‑C, Schill W‑B (2004) The male reproductive system and its susceptibility to endocrine disrupting chemicals. Andrologia 36:337–345PubMed
69.
Zurück zum Zitat Potashnik G, Porath A (1995) Dibromochloropropane (DBCP): a 17-year reassessment of testicular function and reproductive performance. J Occup Environ Med 37:1278–1291 Potashnik G, Porath A (1995) Dibromochloropropane (DBCP): a 17-year reassessment of testicular function and reproductive performance. J Occup Environ Med 37:1278–1291
70.
Zurück zum Zitat Rahban R, Priskorn L, Senn A, Stettler E, Galli F, Vargas J, Van den Bergh M, Fusconi A, Garlantezec R, Jensen TK, Multigner L, Skakkebaek NE, Germond M, Jørgensen N, Nef S, NICER Working Group (2019) Semen quality of young men in Switzerland: a nationwide cross-sectional population-based study. Andrology 7:818–826PubMedPubMedCentral Rahban R, Priskorn L, Senn A, Stettler E, Galli F, Vargas J, Van den Bergh M, Fusconi A, Garlantezec R, Jensen TK, Multigner L, Skakkebaek NE, Germond M, Jørgensen N, Nef S, NICER Working Group (2019) Semen quality of young men in Switzerland: a nationwide cross-sectional population-based study. Andrology 7:818–826PubMedPubMedCentral
72.
Zurück zum Zitat Rajanahally S, Raheem O, Rogers M, Brisbane W, Ostrowski K, Lendvay T, Walsh T (2019) The relationship between cannabis and male infertility, sexual health, and neoplasm: a systematic review. Andrology 7(2):139–147PubMed Rajanahally S, Raheem O, Rogers M, Brisbane W, Ostrowski K, Lendvay T, Walsh T (2019) The relationship between cannabis and male infertility, sexual health, and neoplasm: a systematic review. Andrology 7(2):139–147PubMed
74.
Zurück zum Zitat Ricci E, Al Beitawi S, Cipriani S, Candiani M, Chiaffarino F, Viganò P, Noli S, Parazzini F (2017) Semen quality and alcohol intake: a systematic review and meta-analysis. Reprod Biomed Online 34:38–47PubMed Ricci E, Al Beitawi S, Cipriani S, Candiani M, Chiaffarino F, Viganò P, Noli S, Parazzini F (2017) Semen quality and alcohol intake: a systematic review and meta-analysis. Reprod Biomed Online 34:38–47PubMed
75.
Zurück zum Zitat Ricci E, Viganò P, Cipriani S, Somigliana E, Chiaffarino F, Bulfoni A, Parazzini F (2017) Coffee and caffeine intake and male infertility: a systematic review. Nutr J 16:37PubMedPubMedCentral Ricci E, Viganò P, Cipriani S, Somigliana E, Chiaffarino F, Bulfoni A, Parazzini F (2017) Coffee and caffeine intake and male infertility: a systematic review. Nutr J 16:37PubMedPubMedCentral
76.
Zurück zum Zitat Rosety MÁ, Díaz AJ, Rosety JM, Pery MT, Brenes-Martín F, Bernardi M, García N, Rosety-Rodríguez M, Ordoñez FJ, Rosety I (2017) Exercise improved semen quality and reproductive hormone levels in sedentary obese adults. Nutr Hosp 34:603–607PubMed Rosety MÁ, Díaz AJ, Rosety JM, Pery MT, Brenes-Martín F, Bernardi M, García N, Rosety-Rodríguez M, Ordoñez FJ, Rosety I (2017) Exercise improved semen quality and reproductive hormone levels in sedentary obese adults. Nutr Hosp 34:603–607PubMed
77.
Zurück zum Zitat Rowley MJ, Leach DR, Warner GA, Heller CG (1974) Effect of graded doses of ionizing radiation on the human testis. Radiat Res 59:665–678PubMed Rowley MJ, Leach DR, Warner GA, Heller CG (1974) Effect of graded doses of ionizing radiation on the human testis. Radiat Res 59:665–678PubMed
78.
Zurück zum Zitat Salas-Huetos A, Bulló M, Salas-Salvadó J (2017) Dietary patterns, foods and nutrients in male fertility parameters and fecundability: a systematic review of observational studies. Hum Reprod Update 23:371–389PubMed Salas-Huetos A, Bulló M, Salas-Salvadó J (2017) Dietary patterns, foods and nutrients in male fertility parameters and fecundability: a systematic review of observational studies. Hum Reprod Update 23:371–389PubMed
79.
Zurück zum Zitat Samavat J, Cantini G, Lotti F, Di Franco A, Tamburrino L, Degl’Innocenti S, Maseroli E, Filimberti E, Facchiano E, Lucchese M, Muratori M, Forti G, Baldi E, Maggi M, Luconi M (2017) Massive weight loss obtained by bariatric surgery affects semen quality in morbid male obesity: a preliminary prospective double-armed study. OBES SURG. https://doi.org/10.1007/s11695-017-2802-7CrossRef Samavat J, Cantini G, Lotti F, Di Franco A, Tamburrino L, Degl’Innocenti S, Maseroli E, Filimberti E, Facchiano E, Lucchese M, Muratori M, Forti G, Baldi E, Maggi M, Luconi M (2017) Massive weight loss obtained by bariatric surgery affects semen quality in morbid male obesity: a preliminary prospective double-armed study. OBES SURG. https://​doi.​org/​10.​1007/​s11695-017-2802-7CrossRef
80.
Zurück zum Zitat Samplaski MK, Lo K, Grober E, Jarvi K (2013) Finasteride use in the male infertility population: effects on semen and hormone parameters. Fertil Steril 100(6):1542–1546PubMed Samplaski MK, Lo K, Grober E, Jarvi K (2013) Finasteride use in the male infertility population: effects on semen and hormone parameters. Fertil Steril 100(6):1542–1546PubMed
81.
Zurück zum Zitat Schagdarsurengin U, Steger K (2016) Epigenetics in male reproduction: effect of paternal diet on sperm quality and offspring health. Nat Rev Urol 13:584–595PubMed Schagdarsurengin U, Steger K (2016) Epigenetics in male reproduction: effect of paternal diet on sperm quality and offspring health. Nat Rev Urol 13:584–595PubMed
82.
Zurück zum Zitat Schuppe H‑C, Jung A, Köhn F‑M, Haidl G (2011) Wie Genußgifte die Fertilität beeinflussen können. MMW Fortschr Med 153(6):33–36PubMed Schuppe H‑C, Jung A, Köhn F‑M, Haidl G (2011) Wie Genußgifte die Fertilität beeinflussen können. MMW Fortschr Med 153(6):33–36PubMed
83.
Zurück zum Zitat Schuppe H‑C (2012) Missbrauch anabol-androgener Steroide. In: Harth W, Brähler E, Schuppe H‑C (Hrsg) Praxishandbuch Männergesundheit. Medizinisch Wissenschaftliche Verlagsgesellschaft, Berlin, S 224–230 Schuppe H‑C (2012) Missbrauch anabol-androgener Steroide. In: Harth W, Brähler E, Schuppe H‑C (Hrsg) Praxishandbuch Männergesundheit. Medizinisch Wissenschaftliche Verlagsgesellschaft, Berlin, S 224–230
84.
Zurück zum Zitat Schuppe H‑C, Köhn F‑M (2014) Fertilitätsstörungen des Mannes. In: Gnoth C, Mallmann P (Hrsg) Perikonzeptionelle Frauenheilkunde. Springer, Berlin, Heidelberg, S 251–280 Schuppe H‑C, Köhn F‑M (2014) Fertilitätsstörungen des Mannes. In: Gnoth C, Mallmann P (Hrsg) Perikonzeptionelle Frauenheilkunde. Springer, Berlin, Heidelberg, S 251–280
85.
Zurück zum Zitat Schuppe H‑C, Köhn F‑M (2018) Andrologie. In: Plewig G et al (Hrsg) Braun-Falco’s Dermatologie, Venerologie und Allergologie, 7. Aufl. Springer, Berlin, Heidelberg Schuppe H‑C, Köhn F‑M (2018) Andrologie. In: Plewig G et al (Hrsg) Braun-Falco’s Dermatologie, Venerologie und Allergologie, 7. Aufl. Springer, Berlin, Heidelberg
87.
Zurück zum Zitat Semet M, Paci M, Saïas-Magnan J, Metzler-Guillemain C, Boissier R, Lejeune H, Perrin J (2017) The impact of drugs on male fertility: a review. Andrology 5(4):640–663PubMed Semet M, Paci M, Saïas-Magnan J, Metzler-Guillemain C, Boissier R, Lejeune H, Perrin J (2017) The impact of drugs on male fertility: a review. Andrology 5(4):640–663PubMed
88.
Zurück zum Zitat Sengupta P, Borges E Jr, Dutta S, Krajewska-Kulak E (2018) Decline in sperm count in European men during the past 50 years. Hum Exp Toxicol 37:247–255PubMed Sengupta P, Borges E Jr, Dutta S, Krajewska-Kulak E (2018) Decline in sperm count in European men during the past 50 years. Hum Exp Toxicol 37:247–255PubMed
89.
Zurück zum Zitat Sermondade N, Faure C, Fezeu L, Shayeb AG, Bonde JP, Jensen TK, Van Wely M, Cao J, Martini AC, Eskandar M, Chavarro JE, Koloszar S, Twigt JM, Ramlau-Hansen CH, Borges E Jr, Lotti F, Steegers-Theunissen RP, Zorn B, Polotsky AJ, La Vignera S, Eskenazi B, Tremellen K, Magnusdottir EV, Fejes I, Hercberg S, Lévy R, Czernichow S (2013) BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Hum Reprod Update 19:221–231PubMed Sermondade N, Faure C, Fezeu L, Shayeb AG, Bonde JP, Jensen TK, Van Wely M, Cao J, Martini AC, Eskandar M, Chavarro JE, Koloszar S, Twigt JM, Ramlau-Hansen CH, Borges E Jr, Lotti F, Steegers-Theunissen RP, Zorn B, Polotsky AJ, La Vignera S, Eskenazi B, Tremellen K, Magnusdottir EV, Fejes I, Hercberg S, Lévy R, Czernichow S (2013) BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Hum Reprod Update 19:221–231PubMed
90.
Zurück zum Zitat Sharpe RM, Skakkebaek NE (1993) Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 341:1392–1395PubMed Sharpe RM, Skakkebaek NE (1993) Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 341:1392–1395PubMed
91.
Zurück zum Zitat Skakkebaek NE, Rajpert-De Meyts E, Buck Louis GM, Toppari J, Andersson AM, Eisenberg ML, Jensen TK, Jørgensen N, Swan SH, Sapra KJ, Ziebe S, Priskorn L, Juul A (2016) Male reproductive disorders and fertility trends: influences of environment and genetic susceptibility. Physiol Rev 96(1):55–97PubMed Skakkebaek NE, Rajpert-De Meyts E, Buck Louis GM, Toppari J, Andersson AM, Eisenberg ML, Jensen TK, Jørgensen N, Swan SH, Sapra KJ, Ziebe S, Priskorn L, Juul A (2016) Male reproductive disorders and fertility trends: influences of environment and genetic susceptibility. Physiol Rev 96(1):55–97PubMed
92.
Zurück zum Zitat Skarberg K, Nyberg F, Engstrom I (2009) Multisubstance use as a feature of addiction to anabolic-androgenic steroids. Eur Addict Res 15(2):99–106PubMed Skarberg K, Nyberg F, Engstrom I (2009) Multisubstance use as a feature of addiction to anabolic-androgenic steroids. Eur Addict Res 15(2):99–106PubMed
93.
Zurück zum Zitat Sun B, Messerlian C, Sun ZH, Duan P, Chen HG, Chen YJ, Wang P, Wang L, Meng TQ, Wang Q, Arvizu M, Chavarro JE, Wang YX, Xiong CL, Pan A (2019) Physical activity and sedentary time in relation to semen quality in healthy men screened as potential sperm donors. Hum Reprod 34(12):2330–2339PubMed Sun B, Messerlian C, Sun ZH, Duan P, Chen HG, Chen YJ, Wang P, Wang L, Meng TQ, Wang Q, Arvizu M, Chavarro JE, Wang YX, Xiong CL, Pan A (2019) Physical activity and sedentary time in relation to semen quality in healthy men screened as potential sperm donors. Hum Reprod 34(12):2330–2339PubMed
94.
Zurück zum Zitat Swan SH, Elkin EP, Fenster L (1997) Have sperm densities declined? A reanalysis of global trend data. Environ Health Perspect 105:1228–1232PubMedPubMedCentral Swan SH, Elkin EP, Fenster L (1997) Have sperm densities declined? A reanalysis of global trend data. Environ Health Perspect 105:1228–1232PubMedPubMedCentral
95.
Zurück zum Zitat Stokes VJ, Anderson RA, George JT (2015) How does obesity affect fertility in men—and what are the treatment options? Clin Endocrinol (Oxf) 82(5):633–638 Stokes VJ, Anderson RA, George JT (2015) How does obesity affect fertility in men—and what are the treatment options? Clin Endocrinol (Oxf) 82(5):633–638
96.
Zurück zum Zitat Striegel H, Simon P, Frisch S, Roecker K, Dietz K, Dickhuth HH, Ulrich R (2006) Anabolic ergogenic substance users in fitness-sports: a distinct group supported by the health care system. Drug Alcohol Depend 81:11–19PubMed Striegel H, Simon P, Frisch S, Roecker K, Dietz K, Dickhuth HH, Ulrich R (2006) Anabolic ergogenic substance users in fitness-sports: a distinct group supported by the health care system. Drug Alcohol Depend 81:11–19PubMed
97.
Zurück zum Zitat Suzuki Y, Yoshinga J, Mizumoto Y et al (2012) Foetal exposure to phthalate esters and anogenital distance in male newborns. Int J Androl 35:236–244PubMed Suzuki Y, Yoshinga J, Mizumoto Y et al (2012) Foetal exposure to phthalate esters and anogenital distance in male newborns. Int J Androl 35:236–244PubMed
98.
Zurück zum Zitat Tas S, Lauwerys R, Lison D (1996) Occupational hazards for the male reproductive system. Crit Rev Toxicol 26:261–307PubMed Tas S, Lauwerys R, Lison D (1996) Occupational hazards for the male reproductive system. Crit Rev Toxicol 26:261–307PubMed
99.
Zurück zum Zitat Tavares RS, Mansell S, Barratt CL, Wilson SM, Publicover SJ, Ramalho-Santos J (2013) p,p′-DDE activates CatSper and compromises human sperm function at environmentally relevant concentrations. Hum Reprod 28(12):3167–3177PubMedPubMedCentral Tavares RS, Mansell S, Barratt CL, Wilson SM, Publicover SJ, Ramalho-Santos J (2013) p,p′-DDE activates CatSper and compromises human sperm function at environmentally relevant concentrations. Hum Reprod 28(12):3167–3177PubMedPubMedCentral
100.
Zurück zum Zitat Thonneau P, Bujan L, Multigner L, Mieusset R (1998) Occupational heat exposure and male fertility: a review. Hum Reprod 13:2122–2125PubMed Thonneau P, Bujan L, Multigner L, Mieusset R (1998) Occupational heat exposure and male fertility: a review. Hum Reprod 13:2122–2125PubMed
102.
Zurück zum Zitat Traish AM (2020) Post-finasteride syndrome: a surmountable challenge for clinicians. Fertil Steril 113(1):21–50PubMed Traish AM (2020) Post-finasteride syndrome: a surmountable challenge for clinicians. Fertil Steril 113(1):21–50PubMed
104.
Zurück zum Zitat Veulemans H, Steeno O, Masschelein R, Groeseneken D (1993) Exposure to ethylene glycol ethers and spermatogenic disorders in man: a case-control study. Br J Ind Med 50:71–78PubMedPubMedCentral Veulemans H, Steeno O, Masschelein R, Groeseneken D (1993) Exposure to ethylene glycol ethers and spermatogenic disorders in man: a case-control study. Br J Ind Med 50:71–78PubMedPubMedCentral
105.
Zurück zum Zitat Vine MF, Margolin BH, Morrison HI, Hulka BS (1994) Cigarette smoking and sperm density: a meta-analysis. Fertil Steril 61:35–43PubMed Vine MF, Margolin BH, Morrison HI, Hulka BS (1994) Cigarette smoking and sperm density: a meta-analysis. Fertil Steril 61:35–43PubMed
106.
Zurück zum Zitat Wagner U, Schlebusch H, van der Ven H, van der Ven K, Diedrich K, Krebs D (1990) Accumulation of pollutants in the genital tract of sterility patients. J Clin Chem Clin Biochem 28:683–688PubMed Wagner U, Schlebusch H, van der Ven H, van der Ven K, Diedrich K, Krebs D (1990) Accumulation of pollutants in the genital tract of sterility patients. J Clin Chem Clin Biochem 28:683–688PubMed
108.
109.
Zurück zum Zitat Woodruff TJ, Carlson A, Schwartz JM, Giudice LC (2008) Proceedings of the summit on environmental challenges to reproductive health and fertility: executive summary. Fertil Steril 89(2):281–300PubMedPubMedCentral Woodruff TJ, Carlson A, Schwartz JM, Giudice LC (2008) Proceedings of the summit on environmental challenges to reproductive health and fertility: executive summary. Fertil Steril 89(2):281–300PubMedPubMedCentral
110.
Zurück zum Zitat World Health Organization (2012) WHO Laborhandbuch zur Untersuchung und Aufarbeitung des menschlichen Ejakulates, 5. Aufl. Springer, Berlin, Heidelberg, New York World Health Organization (2012) WHO Laborhandbuch zur Untersuchung und Aufarbeitung des menschlichen Ejakulates, 5. Aufl. Springer, Berlin, Heidelberg, New York
112.
Zurück zum Zitat Zilberlicht A, Wiener-Megnazi Z, Sheinfeld Y, Grach B, Lahav-Baratz S, Dirnfeld M (2015) Habits of cell phone usage and sperm quality—does it warrant attention? Reprod Biomed Online 31(3):421–426PubMed Zilberlicht A, Wiener-Megnazi Z, Sheinfeld Y, Grach B, Lahav-Baratz S, Dirnfeld M (2015) Habits of cell phone usage and sperm quality—does it warrant attention? Reprod Biomed Online 31(3):421–426PubMed
113.
Zurück zum Zitat Zitzmann M et al (2003) Male smokers have a decreased success rate for in vitro fertilization and intracytoplasmic sperm injection. Fertil Steril 79:1550–1554PubMed Zitzmann M et al (2003) Male smokers have a decreased success rate for in vitro fertilization and intracytoplasmic sperm injection. Fertil Steril 79:1550–1554PubMed
Metadaten
Titel
Der Einfluss von Umweltfaktoren und Lebensstil auf die männliche Fertilität
verfasst von
Frank-Michael Köhn
Prof. Dr. Hans-Christian Schuppe
Publikationsdatum
18.01.2021
Verlag
Springer Medizin
Erschienen in
Die Gynäkologie / Ausgabe 4/2021
Print ISSN: 2731-7102
Elektronische ISSN: 2731-7110
DOI
https://doi.org/10.1007/s00129-020-04742-9

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