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Erschienen in:

2020 | OriginalPaper | Buchkapitel

23. Dermatika

verfasst von : Dr. rer. nat. Judith Günther, Prof. Dr. rer. nat. Uwe Fricke

Erschienen in: Arzneiverordnungs-Report 2020

Verlag: Springer Berlin Heidelberg

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Zusammenfassung

Auf einen Blick

Verordnungsprofil Seit Jahren verändert sich das Verordnungsspektrum der zahlreichen dermatologischen Wirkstoffklassen nur marginal. Wie in den Vorjahren werden topische Corticosteroide am häufigsten verordnet. Auf sie entfällt fast jede zweite verordnete Dermatikatagesdosis. Antimykotika (12 %), Psoriasismittel (10 %), Aknemittel (6 %), Antiinfektiva (5 %), Warzenmittel, Wundbehandlungsmittel und Mittel bei aktinischen Keratosen (jeweils 4 %) sowie Rosazeamittel und Antipruriginosa (jeweils 3 %) werden deutlich seltener verordnet. Die verbleibenden Gruppen hatten 2019 zusammen nur noch einen Verordnungsanteil von weniger als 3 %.

Trend Die Verordnungen in den einzelnen Marktsegmenten werden weitgehend durch nationale und internationale Therapieempfehlungen gestützt. Die Gesamtverordnungsmenge bezogen auf DDD stieg 2019 im Vergleich zum Vorjahr lediglich um 2,3 %, mit deutlicheren Zuwächsen bei den Corticosteroidtopika und den Psoriasismitteln. Die Mehrverordnungen sind jedoch mit Kostensteigerungen von 13,5 % verbunden, die in erster Linie auf das Konto der hochwirksamen Biologika (Ustekinumab, Secukinumab, Guselkumab) zur Behandlung der Psoriasis gehen. Damit entfällt fast die Hälfte der gesamten dermatologischen Verordnungskosten (1.934 Mio. €) nur auf diese drei Präparate.

Alsterholm M, Flytström I, Bergbrant IM, Faergemann J (2010) Fusidic acid-resistant Staphylococcus aureus in impetigo contagiosa and secondarily infected atopic dermatitis. Acta Derm Venereol 90:52–57PubMed

Arzneimittelkommission der deutschen Ärzteschaft (2005) Myopathie nach Tacrolimus-Salbe (Protopic^®). Dtsch Arztebl 102:A3138

Arzneimittelkommission der deutschen Ärzteschaft (2006) Psychiatrische Reaktionen nach Terninafin (Lamisil^®). Dtsch Arztebl 103:A3432

Arzneimittelkommission der deutschen Ärzteschaft (2011) Multiple aktinische Keratosen (Carcinomata in situ der Haut) nach langjähriger topischer Anwendung von Tacrolimus (Protopic^®). Dtsch Arztebl 108:A545–A546

Arzneimittelkommission der deutschen Ärzteschaft (2013) Rhabdomyolyse nach Isotretinoin. Dtsch Arztebl 110:240

Arzneimittelkommission der deutschen Ärzteschaft (2019a) „Aus der UAW-Datenbank“: Rezidiv eines Morbus Crohn nach Behandlung einer atopischen Dermatitis mit Dupilumab. Dtsch Arztebl 116:A1919–A1920

Arzneimittelkommission der deutschen Ärzteschaft (2019b) Retinoide (Acitretin, Adapalen, Alitretinoin, Bexaroten, lsotretinoin, Tazaroten und Tretinoin) – Aktualisierungen zu Teratogenität und neuropsychiatrischen Erkrankungen. Drug Safety Mail 2019-50. www.akdae.de

Arzneimittelkommission der deutschen Ärzteschaft (2020) Brivudinhaltige Arzneimittel: Potenziell tödliche Toxizität von Fluoropyrimidinen bei der Anwendung kurz vor, gleichzeitig mit oder innerhalb von 4 Wochen nach Ende der Behandlung mit Brivudin. Drug Safety Mail 2020-31. www.akdae.de

Atwan A, Ingram JR, Abbott R, Kelson MJ, Pickles T, Bauer A, Piguet V (2016) Oral fumaric acid esters for psoriasis: abridged Cochrane systematic review including GRADE assessments. Br J Dermatol 175:873–881PubMedPubMedCentral

Balak DMW, Fallah Arani S, Hajdarbegovic E, Hagemans CAF, Bramer WM, Thio HB, Neumann HAM (2016) Efficacy, effectiveness and safety of fumaric acid esters in the treatment of psoriasis: a systematic review of randomized and observational studies. Br J Dermatol 175:250–226PubMed

Balak DMW, Hajdarbegovic E, Bramer WM, Neumann HAM, Thio HB (2017) Progressive mulrifocal leukencephalopathy associated wirh fumaric acid etsres treatment in psoriasis patients. J Eur Acad Dermatol Venereol 31:1475–1482PubMed

Barajas-Nava LA, López-Alcalde J, Roqué i Figuls M, Solà I, Bonfill Cosp X (2013) Antibiotic prophylaxis for preventing burn wound infection. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD008738.pub2 PubMedCrossRef

Bell-Syer SEM, Khan SM, Torgerson DJ (2012) Oral treatments for fungal infections of the skin of the foot. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD003584.pub2 PubMedPubMedCentralCrossRef

de Berker D, McGregor JM, Mohd Mustapa MF, Exton LS, Hughes BR (2017) British Association of Dermatologists’ guidelines for the care of patients with actinic keratosis 2017. Br J Dermatol 176:20–43PubMed

Blauvelt A, de Bruin-Weller M, Gooderham M, Cather JC, Weisman J, Pariser D, Simpson EL, Papp KA, Hong HC, Rubel D, Foley P, Prens E, Griffiths CEM, Etoh T, Pinto PH, Pujol RM, Szepietowski JC, Ettler K, Kemény L, Zhu X, Akinlade B, Hultsch T, Mastey V, Gadkari A, Eckert L, Amin N, Graham NMH, Pirozzi G, Stahl N, Yancopoulos GD, Shumel B (2017a) Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a 1-year, randomised, double-blinded, placebo-controlled, phase 3 trial. Lancet 389:2287–2303PubMed

Blauvelt A, Reich K, Tsai TF, Tyring S, Vanaclocha F, Kingo K, Ziv M, Pinter A, Vender R, Hugot S, You R, Mi-lutinovic M, Thaçi D (2017b) Secukinumab is superior to ustekinumab in clearing skin of subjects with moderate-to-severe plaque psoriasis up to 1 year: results from the CLEAR study. J Am Acad Dermatol 76:60–69.e9PubMed

Blauvelt A, Papp KA, Griffiths CE, Randazzo B, Wasfi Y, Shen YK, Li S, Kimball AB (2017c) Efficacy and safety of guselkumab, an anti-interleukin-23 monoclonal antibody, compared with adalimumab for the continuous treatment of patients with moderate to severe psoriasis: Results from the phase III, double-blinded, placebo- and active comparator-controlled VOYAGE 1 trial. J Am Acad Dermatol 76:405–417PubMed

Booij MT, van De Kerkhof PC (2011) Acitretin revisited in the era of biologics. J Dermatolog Treat 22:86–89PubMed

Brodt HR (2013) Stille – Antibiotikatherapie. Klinik und Praxis der antiinfektiösen Behandlung, 12. Aufl. Schattauer, Stuttgart

Bundesministerium für Gesundheit (2015) Bekanntmachung eines Beschlusses des Gemeinsamen Bundesausschusses über eine Änderung der Arzneimittel-Richtlinie (AM-RL) (Anlage XII – Beschlüsse über die Nutzenbewertung von Arzneimitteln mit neuen Wirkstoffen nach § 35a des Fünften Buches Sozialgesetzbuch (SGB V) – Secukinumab vom: 27. Nov. 2015. BAnz AT 29. Dez. 2015 B4)

Bundesministerium für Gesundheit (2017) Bekanntmachung eines Beschlusses des Gemeinsamen Bundesausschusses über eine Änderung der Arzneimittel-Richtlinie (AM-RL) (Anlage XII – Beschlüsse über die Nutzenbewertung von Arzneimitteln mit neuen Wirkstoffen nach § 35a des Fünften Buches Sozialgesetzbuch (SGB V) – Secukinumab (Neubewertung aufgrund neuer wissenschaftlicher Erkenntnisse) vom: 17. Aug. 2017. BAnz AT 12. Sept. 2017 B2)

Bundesministerium für Gesundheit (2018) Bekanntmachung eines Beschlusses des Gemeinsamen Bundesausschusses über eine Änderung der Arzneimittel-Richtlinie (AM-RL) (Anlage XII – Beschlüsse über die Nutzenbewertung von Arzneimitteln mit neuen Wirkstoffen nach § 35a des Fünften Buches Sozialgesetzbuch (SGB V) – Guselkumab vom: 17.05.2018. BAnz AT 04.07.2018 B2)

Calow T, Oberle K, Bruckner-Tuderman L, Jakob T, Schumann H (2009) Contact dermatitis due to use of Octenisept(R) in wound care. J Dtsch Dermatol Ges 7:759–765PubMed

Cardwell LA, Alinia H, Moradi Tuchayi S, Feldman SR (2016) New developments in the treatment of rosacea – role of once-daily ivermectin cream. Clin Cosmet Investig Dermatol 9:71–77PubMedPubMedCentral

Chen F, Xu H, Liu J, Cui Y, Luo X, Zhou Y, Chen Q, Jiang L (2017) Efficacy and safety of nucleoside antiviral drugs for treatment of recurrent herpes labialis: a systematic review and meta-analysis. J Oral Pathol Med 46:561–568PubMed

Chi CC, Wang SH, Delamere FM, Wojnarowska F, Peters MC, Kanjirath PP (2015) Interventions for prevention of herpes simplex labialis (cold sores on the lips). Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD010095.pub2 PubMedPubMedCentralCrossRef

Christiansen B (1988) Untersuchungen über die Wirksamkeit eines Hautdesinfektionsmittels mit kationenaktivem Zusatz. Zbl Bakt Hyg B 186:368–374

Christoffers WA, Coenraads PJ, Svensson Å, Diepgen TL, Dickinson-Blok JL, Xia J, Williams HC (2019) Interventions for hand eczema. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD004055.pub2 PubMedPubMedCentralCrossRef

Chroni E, Monastirli A, Tsambaos D (2010) Neuromuscular adverse effects associated with systemic retinoid dermatotherapy: monitoring and treatment algorithm for clinicians. Drug Saf 33:25–34PubMed

Clerens I, Goossens A (2017) Allergic contact dermatitis caused by panthenol: a rare but relevant sensitizer. Contact Derm 76:122–123PubMed

Conde JF, Yelverton CB, Balkrishnan R, Fleischer AB Jr, Feldman SR (2007) Managing rosacea: a review of the use of metronidazole alone and in combination with oral antibiotics. J Drugs Dermatol 6:495–498PubMed

Costa CS, Bagatin E, Martimbianco ALC, da Silva EMK, Lúcio MM, Magin P, Riera R (2018) Oral isotretinoin for acne. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD009435.pub2 PubMedPubMedCentralCrossRef

Crawford F, Hollis S (2007) Topical treatments for fungal infections of the skin and nails of the foot. Cochrane Database Syst Rev 2007(3):CD1434. https://doi.org/10.1002/14651858.CD001434.pub2 PubMedCentralCrossRef

Cunningham A, Griffiths P, Leone P, Mindel A, Patel R, Stanberry L, Whitley R (2012) Current management and recommendations for access to antiviral therapy of herpes labialis. J Clin Virol 53:6–11PubMed

Czaika VA, Zuberbier T (2015) Lokale Kombinationstherapie bei entzündlichen Dermatomykosen. Review zu den Therapieempfehlungen in nationalen und internationalen Leitlinien. Hautarzt 66:360–369PubMed

Dall’oglio F, D’Amico V, Nasca MR, Micali G (2012) Treatment of cutaneous warts: an evidence-based review. Am J Clin Dermatol 13:73–96PubMed

Darkes MJM, Scott LJ, Goa KL (2003) Terbinafine. A review of its use in onychomycosis in adults. Am J Clin Dermatol 4:39–65PubMed

Deutsche Dermatologische Gesellschaft (2013) Leitlinie zur Behandlung der Rosazea. AWMF-Leitlinien-Register Nr. 013/065, Entwicklungsstufe S1. Gültigkeit seit 28.02.2018 abgelaufen. http://www.awmf.org/uploads/tx_szleitlinien/013-065l_S1_Rosazea_2014-04.pdf

Deutsche Dermatologische Gesellschaft (2016) Leitlinie zur Diagnostik und Therapie der Ichthyosen (Aktualisierung). AWMF-Leitlinien-Register Nr. 013/043, Entwicklungsstufe S1. http://www.awmf.org/uploads/tx_szleitlinien/013-043l_S1_Ichtyosen_2017-05.pdf

Deutsche Dermatologische Gesellschaft (2017) S3-Leitlinie zur Therapie der Psoriasis vulgaris – Update 2017. AWMF-Leitlinien-Register Nr. 013/001 mit Appendix: „Topische Therapie, Phototherapie, Sonstige Therapien, Schnittstellendefinition“ Fortbestand der Empfehlungen vom Update 2011. https://www.awmf.org/leitlinien/detail/ll/013-001.html (In Überarbeitung, Gültig bis 31.12.2020)

Deutsche Dermatologische Gesellschaft et al (2015) Leitlinie Neurodermitis [atopisches Ekzem; atopische Dermatitis] Entwicklungsstufe: S2k [ICD 10: L20.8, L20.9, L28.0], AWMF-Registernummer: 013-027. Gültigkeit verlängert bis zum 30.03.2020. http://www.awmf.org/uploads/tx_szleitlinien/013-027l_S2k_Neurodermitis_2016-06-verlaengert.pdf

Diepgen TL, Andersen KE, Chosidow O, Coenraads PJ, Elsner P, English J, Fartasch M, Gimenez-Arnau A, Nixon R, Sasseville D, Agner T (2015) Guidelines for diagnosis, prevention and treatment of hand eczema. J Dtsch Dermatol Ges 13:e1–e22PubMed

Dissemond J, Gerber V, Kramer A, Riepe G, Strohal R, Vasel-Biergans A, Eberlein T (2009) Praxisorientierte Expertenempfehlung zur Behandlung kritisch kolonisierter und lokal infizierter Wunden mit Polihexanid. WundManagement 2009:62–68

Dissemond J, Augustin M, Eming SA, Goerge T, Horn T, Karrer S, Schumann H, Stücker M, Working Group for wound healing (AGW) of the German Society of Dermatology (DDG) (2014) Modern wound care – practical aspects of non-interventional topical treatment of patients with chronic wounds. J Dtsch Ges Dermatol. https://doi.org/10.1111/ddg.12351 CrossRef

Dissemond J, Assenheimer B, Bültemann A, Gerber V, Gretener S, Kohler-von Siebenthal E, Koller S, Kröger K, Kurz P, Läuchli S, Münter C, Panfil EM, Probst S, Protz K, Riepe G, Strohal R, Traber J, Partsch H (2016) Kompressionstherapie bei Patienten mit Ulcus cruris venosum. J Dtsch Dermatol Ges 14:1073–1089PubMed

Dittmann K, Schmidt T, Müller G, Cuny C, Holtfreter S, Troitzsch D, Pfaff P, Hübner NO (2019) Susceptibility of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) to chlorhexidine digluconate, octenidine dihydrochloride, polyhexanide, PVP-iodine and triclosan in comparison to hospital-acquired MRSA (HA-MRSA) and community-aquired MRSA (CA-MRSA): a standardized comparison. Antimicrob Resist Infect Control 8:122PubMedPubMedCentral

Dobie D, Gray J (2004) Fusidic acid resistance in Staphylococcus aureus. Arch Dis Child 89:74–77PubMedPubMedCentral

Dréno B, Bettoli V, Ochsendorf F, Layton AM, Perez M, Dakovic R, Gollnick H (2014) Efficacy and safety of clindamycin phosphate 1.2%/tretinoin 0.025% formulation for the treatment of acne vulgaris: pooled analysis of data from three randomised, double-blind, parallel-group, phase III studies. Eur J Dermatol 24:201–209PubMed

Drucker CR (2012) Update on topical antibiotics in dermatology. Dermatol Ther 25:6–11PubMed

Drucker AM, Adam GP, Rofeberg V, Gazula A, Smith B, Moustafa F, Weinstock MA, Trikalinos TA (2018) Treatments of primary basal cell carcinoma of the skin: a systematic review and network Meta-analysis. Ann Intern Med 169:456–466PubMed

Dumville JC, Keogh SJ, Liu Z, Stubbs N, Walker RM, Fortnam M (2015a) Alginate dressings for treating pressure ulcers. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD011277.pub2 PubMedPubMedCentralCrossRef

Dumville JC, Stubbs N, Keogh SJ, Walker RM, Liu Z (2015b) Hydrogel dressings for treating pressure ulcers. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD011226.pub2 PubMedPubMedCentralCrossRef

Dumville JC, Gray TA, Walter CJ, Sharp CA, Page T, Macefield R, Blencowe N, Milne TK, Reeves BC, Blazeby J (2016) Dressings for the prevention of surgical site infection. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD003091.pub4 PubMedPubMedCentralCrossRef

Ebbelaar CCF, Venema AW, Van Dijk MR (2018) Topical Ivermectin in the treatment of papulopustular rosacea: a systematic review of evidence and clinical guideline recommendations. Dermatol Ther (heidel) 8:379–387

Eberlein T, Assadian O (2010) Clinical use of polihexanide on acute and chronic wounds for antisepsis and decontamination. Skin Pharmacol Physiol 23(Suppl 1):45–51PubMed

Ebner F, Heller A, Rippke F, Tausch I (2002) Topical use of dexpanthenol in skin disorders. Am J Clin Dermatol 3:427–433PubMed

Eifler-Bollen R, Fluhr JW (2005) Antimikrobiell wirksame Magistralrezepturen. Stellenwert in der Praxis und kritische Anmerkungen. Hautarzt 56:752–758PubMed

El-Gohary M, van Zuuren EJ, Fedorowicz Z, Burgess H, Doney L, Stuart B, Moore M, Little P (2014) Topical antifungal treatments for tinea cruris and tinea corporis. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD009992.pub2 PubMedCrossRef

Erbagci Z (2004) Topical therapy for dermatophytoses. Should corticosteroids be included? Am J Clin Dermatol 5:375–384PubMed

European Medicines Agency (2009) Committee on herbal Medicinal Products (HMPC) Assessment report on Hamamelis virginiana L, Cortex; Hamamelis virginiana L, Folium, Hamamelis virginiana L. Folium et cortex aut ramunculus destillatum. http://www.ema.europa.eu/ema/

European Medicines Agency (EMA) (2015) Committee on herbal Medicinal Produkts (HMPC) Assessment report on Matricaria recutita L., flos and Matricaria recutita L., aetheroleum. http://www.ema.europa.eu/ema/

European Medicines Agency (2020) Risks of Picato for actinic keratosis outweigh benefits. https://www.ema.europa.eu/ (Erstellt: 30. Apr. 2020) (EMA/228384/2020)

Feng X, Xiong X, Ran Y (2017) Efficacy and tolerability of amorolfine 5% nail lacquer in combination with systemic antifungal agents for onychomycosis: a meta-analysis and systematic review. Dermatol Ther. https://doi.org/10.1111/dth.12457 PubMedCrossRef

Ference JD, Last AR (2009) Choosing topical corticosteroids. Am Fam Physician 79:135–140PubMed

Fjeld H, Lingaas E (2016) Polyhexanide – safety and efficacy as an antiseptic. Tidsskr Nor Laegeforen 136:707–711PubMed

Fluhr JW, Degitz K (2010) Antibiotika, Azelainsäure und Benzoylperoxid in der topische Aknetherapie. J Dtsch Dermatol Ges 8(Suppl 1):S24–S30PubMed

Fölster-Holst R, Latussek E (2007) Synthetic tannins in dermatology – a therapeutic option in a variety of pediatric dermatoses. Pediatr Dermatol 24:296–301PubMed

Food and Drug Administration (2014) FDA warns of rare but serious hypersensitivity reactions with certain over-the-counter topical acne products. http://www.fda.gov/downloads/Drugs/DrugSafety/UCM402663.pdf

Fowler J, Jarratt M, Moore A, Meadows K, Pollack A, Steinhoff M, Liu Y, Leoni M, Brimonidine Phase II Study Group (2012) Once-daily topical brimonidine tartrate gel 0·5% is a novel treatment for moderate to severe facial erythema of rosacea: results of two multicentre, randomized and vehicle-controlled studies. Br J Dermatol 166:633–641PubMedPubMedCentral

Francis NA, Ridd MJ, Thomas-Jones E, Butler CC, Hood K, Shepherd V, Marwick CA, Huang C, Longo M, Wootton M, Sullivan F, CREAM Trial Management Group (2017) Oral and topical antibiotics for clinically infected eczema in children: a pragmatic randomized controlled trial in ambulatory care. Ann Fam Med 15:124–130PubMedPubMedCentral

Franz T, Vögelin E (2012) Aseptic tissue necrosis and chronic inflammation after irrigation of penetrating hand wounds using Octenisept. J Hand Surg Eur 37:61–64

Gaspari A, Tyring SK, Rosen T (2009) Beyond a decade of 5% imiquimod topical therapy. J Drugs Dermatol 8:467–474

Gemeinsamer Bundesausschuss (2020) Richtlinie des Gemeinsamen Bundesausschusses über die Verordnung von Arzneimitteln in der vertragsärztlichen Versorgung (Arzneimittel-Richtlinie/AM-RL) in der Fassung vom 18. Dezember 2008/22.Januar 2009 veröffentlicht im Bundesanzeiger 2009 Nr. 49a. https://www.g-ba.de/downloads/62-492-2115/AM-RL_2020-02-20_iK-2020-04-10_AT-09-04-2020-B4.pdf (Erstellt: 20. Febr. 2020) (veröffentlicht im Bundesanzeiger (BAnz AT 09.04.2020 B4) in Kraft getreten am 10. April 2020))

Gieselbach RJ, Muller-Hansma AH, Wijburg MT, de Bruin-Weller MS, van Oosten BW, Nieuwkamp DJ, Coenjaerts FE, Wattjes MP, Murk JL (2017) Progressive multifocal leukencephalopathy in patients treated with fumaric acid esters: a review of 19 cases. J Neurol 264:1155–1164PubMed

Glenn CJ, Kobraei KB, Russo JJ (2011) New-onset psoriasis associated with adalimumab: a report of two cases. Dermatol Online J 17:15PubMed

Gloor M (1982) Pharmakologie dermatologischer Externa. Springer, Berlin Heidelberg New York

Gold LS, Papp K, Lynde C, Lain E, Gooderham M, Johnson S, Kerrouche N (2017) Treatment of rosacea with concomitant use of topical Ivermectin 1% cream and Brimonidine 0.33% gel: a randomized, vehicle-controlled study. J Drugs Dermatol 16:909–916PubMed

Gollnick HP, Draelos Z, Glenn MJ, Rosoph LA, Kaszuba A, Cornelison R, Gore B, Liu Y, Graeber M, Adapalene-BPO Study Group (2009) Adapalene-benzoyl peroxide, a unique fixed-dose combination topical gel for the treatment of acne vulgaris: a transatlantic, randomized, double-blind, controlled study in 1670 patients. Br J Dermatol 161:1180–1189PubMed

Goreshi R, Samrao A, Ehst BD (2012) A double-blind, randomized, bilateral comparison of skin irritancy following application of the combination acne products clindamycin/tretinoin and benzoyl peroxide/adapalene. J Drugs Dermatol 11:1422–1426PubMed

Griffiths CE, Barker JN (2007) Pathogenesis and clinical features of psoriasis. Lancet 370:263–271PubMed

Griffiths CE, Strober BE, van de Kerkhof P, Ho V, Fidelus-Gort R, Yeilding N, Guzzo C, Xia Y, Zhou B, Li S, Dooley LT, Goldstein NH, Menter A, ACCEPT Study Group (2010) Comparison of ustekinumab and etanercept for moderate-to-severe psoriasis. N Engl J Med 362:118–128PubMed

Grillo-Ardila CF, Angel-Müller E, Salazar-Díaz LC, Gaitán HG, Ruiz-Parra AI, Lethaby A (2014) Imiquimod for anogenital warts in non-immunocompromised adults. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD010389.pub2 PubMedCrossRef

Grover C, Khurana A (2012) An update on treatment of onychomycosis. Mycoses 55:541–551PubMed

Gupta AK, Joseph WS (2000) Ciclopirox 8% nail lacquer in the treatment of onychomycosis of the toenails in the United States. J Am Podiatr Med Assoc 9:495–501

Gupta AK, Cherman AM, Tyring SK (2005) Viral and nonviral uses of imiquimod: a review. J Cut Med Surg 8:338–352

Gupta AK, Paquet M, Villanueva E, Brintnell W (2012) Interventions for actinic keratoses. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD004415.pub2 PubMedPubMedCentralCrossRef

Hayden MK, Lolans K, Haffenreffer K, Avery TR, Kleinman K, Li H, Kaganov RE, Lankiewicz J, Moody J, Septimus E, Weinstein RA, Hickok J, Jernigan J, Perlin JB, Platt R, Huang SS (2016) Chlorhexidine and Mupirocin susceptibility of Methicillin-resistant staphylococcus aureus isolates in the REDUCE-MRSA trial. J Clin Microbiol 54:2735–2742PubMedPubMedCentral

Hendriks AG, Keijsers RR, de Jong EM, Seyger MM, van de Kerkhof PC (2013a) Combinations of classical time-honoured topicals in plaque psoriasis: a systematic review. J Eur Acad Dermatol Venereol 27:399–410PubMed

Hendriks AG, Keijsers RR, de Jong EM, Seyger MM, van de Kerkhof PC (2013b) Efficacy and safety of combinations of first-line topical treatments in chronic plaque psoriasis: a systematic literature review. J Eur Acad Dermatol Venereol 27:931–951PubMed

Heng YK, Tan KT, Sen P, Chow A, Leo YS, Lye DC, Chan RK (2013) Staphylococcus aureus and topical fusidic acid use: results of a clinical audit on antimicrobial resistance. Int J Dermatol 52:876–881PubMed

Hengge UR, Ruzicka T, Schartz RA, Cork MJ (2006) Adverse effects of topical glucocorticosteroids. J Am Acad Dermatol 54:1–15

Hoffmann R, Happle R (2000) Current understanding of androgenetic alopecia. Part II: clinical aspects and treatment. Eur J Dermatol 10:410–417PubMed

Hund M, Sinkgraven R, Rzany B (2004) Randomisierte, plazebokontrollierte klinische Doppelblindstudie zur Wirksamkeit und Verträglichkeit der oralen Therapie mit Methantheliniumbromid (Vagantin^®) bei fokaler Hyperhidrose. J Dtsch Dermatol Ges 2:343–349PubMed

Iorizzo M, Piraccini BM, Tosti A (2010) Today’s treatments options for onychomycosis. J Dtsch Dermatol Ges 8:875–879PubMed

Jacobi A, Mayer A, Augustin M (2015) Keratolytics and emollients and their role in the therapy of psoriasis: a systematic review. Dermatol Ther 5:1–18

Jansen MHE, Kessels JPHM, Nelemans PJ, Kouloubis N, Arits AHMM, van Pelt HPA, Quaedvlieg PJF, Essers BAB, Steijlen PM, Kelleners-Smeets NWJ, Mosterd K (2019) Randomized trial of four treatment approaches for actinic keratosis. N Engl J Med 380:935–946PubMed

Johnson MR, Hageboutros A, Wang K, High L, Smith JB, Diasio RB (1999) Life-threatening toxicity in a dihydropyrimidine dehydrogenase-deficient patient after treatment with topical 5-fluorouracil. Clin Cancer Res 5:2006–2011PubMed

van de Kerkhof PC, Kragballe K, Segaert S, Lebwohl M, International Psoriasis Council (2011) Factors impacting the combination of topical corticosteroid therapies for psoriasis: perspectives from the International Psoriasis Council. J Eur Acad Dermatol Venereol 25:1130–1139PubMed

Koburger T, Hübner NO, Braun M, Siebert J, Kramer A (2010) Standardized comparison of antiseptic efficacy of triclosan, PVP-iodine, octenidine dihydrochloride, polyhexanide and chlorhexidine digluconate. J Antimicrob Chemother 65:1712–1719PubMed

Koning S, van der Sande R, Verhagen AP, van Suijlekom-Smit LWA, Morris AD, Butler CC, Berger M, van der Wouden JC (2012) Interventions for impetigo. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD003261.pub3 PubMedPubMedCentralCrossRef

Konopka EA, Kimble EF, Zogans HC, Heyman H (1975) Antimicrobial effectiveness of Locacorten-Vioform cream in secondary infections of common dermatoses. Dermatologica 151:1–8PubMed

Koo JYM (2005) New developments in topical sequential therapy for psoriasis. Skin Therapy Lett 10:1–4PubMed

Kreijkamp-Kaspers S, Hawke K, Guo L, Kerin G, Bell-Syer SEM, Magin P, Bell-Syer SV, van Driel ML (2017) Oral antifungal medication for toenail onychomycosis. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD010031.pub2 PubMedPubMedCentralCrossRef

von Krogh G (1978) Topical treatment of penile condylomata acuminata with podophyllin, podophyllotoxin and colchicine. A comparative study. Acta Derm Venereol 58:163–168

Kujath P, Michelsen A (2008) Wunden – von der Physiologie zum Verband. Dtsch Arztebl 105:239–248

Küster W, Bohnsack K, Rippke F, Upmeyer HJ, Groll S, Traupe H (1998) Efficacy of urea therapy in children with ichthyosis. A multicenter randomized, placebo-controlled, double-blind, semilateral study. Dermatology 196:217–222PubMed

Kwok CS, Gibbs S, Bennett C, Holland R, Abbott R (2012) Topical treatments for cutaneous warts. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.cd001781.pub3 PubMedCrossRef

Lachapelle JM (2014) A comparison of the irritant and allergenic properties of antiseptics. Eur J Dermatol 24:3–9PubMed

Langley RG, Elewski BE, Lebwohl M, Reich K, Griffiths CE, Papp K, Puig L, Nakagawa H, Spelman L, Sigur-geirsson B, Rivas E, Tsai TF, Wasel N, Tyring S, Salko T, Hampele I, Notter M, Karpov A, Helou S, Papavassilis C, ERASURE Study Group, FIXTURE Study Group (2014) Secukinumab in plaque psoriasis-results of two phase 3 trials. N Engl J Med 371:326–338PubMed

Langley RG, Lebwohl M, Krueger GG, Szapary PO, Wasfi Y, Chan D, Hsu MC, You Y, Poulin Y, Korman N, Prinz JC, Reich K, PHOENIX 2 Investigators (2015) Long-term efficacy and safety of ustekinumab, with and without dosing adjustment, in patients with moderate-to-severe psoriasis: results from the PHOENIX 2 study through 5 years of follow-up. Br J Dermatol 172:1371–1383PubMed

Langley RG, Tsai TF, Flavin S, Song M, Randazzo B, Wasfi Y, Jiang J, Li S, Puig L (2018) Efficacy and safety of guselkumab in patients with psoriasis who have an inadequate response to ustekinumab: results of the randomized, double-blind, phase III NAVIGATE trial. Br J Dermatol 178:114–123PubMed

Langner A, Sheehan-Dare R, Layton A (2007) A randomized, single-blind comparison of topical clindamycin + benzoyl peroxide (Duac) and erythromycin + zinc acetate (Zineryt) in the treatment of mild to moderate facial acne vulgaris. J Eur Acad Dermatol Venereol 21:311–319PubMed

Lansdown AB, Mirastschijski U, Stubbs N, Scanlon E, Ågren MS (2007) Zinc in wound healing: theoretical, experimental, and clinical aspects. Wound Repair Regen 15:2–16PubMed

Layton AM, Schaller M, Homey B, Hofmann MA, Bewley AP, Lehmann P, Nohlgård C, Sarwer DB, Kerrouche N, Ma YM (2015) Brimonidine gel 0.33% rapidly improves patient-reported outcomes by controlling facial erythema of rosacea: a randomized, double-blind, vehicle-controlled study. J Eur Acad Dermatol Venereol 29:2405–2410PubMedPubMedCentral

Lipp HP (Hrsg) (2019) Arzneistoff-Profile, Basisinformation über arzneilich wirksame Wirkstoffe. Stammlieferung 1982 mit 1. bis 32. Erg.-Lieferung 2019. Govi (Imprint) in der Avoxa-Mediengruppe Deutscher Apotheker GmbH, Eschborn

Lohde H, Stahlmann R (Hrsg.) (2004): Nadifloxacin – irrationaler Einsatz eines Fluorchinolons zur lokalen Aknetherapie. Zeitschr Chemother 25: 27–29

Løkkevik E, Skovlund E, Reitan JB, Hannisdal E, Tanum G (1996) Skin treatment with Bepanthen cream versus no cream during radiotherapy. Acta Oncol 35:1021–1026PubMed

Lopaschuk CR (2013) New approach to managing genital warts. Can Fam Physician 59:731–736PubMedPubMedCentral

Luger TA, Loske KD, Elsner P, Kapp A, Kerscher M, Korting HC, Krutmann J, Niedner R, Röcken M, Ruzicka T, Schwarz T (2004) Topische Dermatotherapie mit Glukokortikoiden – Therapeutischer Index. J Deut Dermatol Gesell 2:629–634

McClellan KJ, Noble S (2000) Topical metronidazole. A review of its use in rosacea. Am J Clin Dermatol 1:191–199PubMed

McNeil JC, Hulten KG, Kaplan SL, Mason EO (2014) Decreased susceptibilities to Retapamulin, Mupirocin, and Chlorhexidine among Staphylococcus aureus isolates causing skin and soft tissue infections in otherwise healthy children. Antimicrob Agents Chemother 58:2878–2883PubMedPubMedCentral

Medicines and Healthcare Products Regulatory Agency (MRHA) (2016) Brimonidine gel (Mirvaso): risk of exacerbation of rosacea. https://www.gov.uk/drug-safety-update/brimonidine-gel-mirvaso-risk-of-exacerbation-of-rosacea (Erstellt: 8. Nov. 2016)

Menezes de Padua CA, Schnuch A, Nink K, Pfahlberg A, Uter W (2008) Allergic contact dermatitis to topical drugs – epidemiological risk assessment. Pharmacoepidemiol Drug Saf 17:813–821

Merk HF (2007) Topical diclofenac in the treatment of actinic keratoses. Int J Dermatol 46:12–18PubMed

Moore ZEH, Cowman S (2013) Wound cleansing for pressure ulcers. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD004983.pub3 PubMedPubMedCentralCrossRef

Mrowietz U, Szepietowski JC, Loewe R, van de Kerkhof P, Lamarca R, Ocker WG, Tebbs VM, Pau-Charles I (2017) Efficacy and safety of LAS41008 (dimethyl fumarate) in adults with moderate-to-severe chronic plaque psoriasis: a randomized, double-blind, Fumaderm(®) – and placebo-controlled trial (BRIDGE). Br J Dermatol 176:615–623PubMed

Müller G, Kramer A (2008) Biocompatibility index of antiseptic agents by parallel assessment of antimicrobial activity and cellular cytotoxicity. Antimicrob Chemother 61:1281–1287

Muller A, Talon D, Potier A, Belle E, Cappelier G, Bertrand X (2005) Use of intranasal mupirocin to prevent methicillin-resistant Staphylococcus aureus infection in intensive care units. Crit Care 9:R246–R250PubMedPubMedCentral

Müller C, Berensmeier A, Hamm H, Dirschka T, Reich K, Fischer T, Rzany B (2013) Efficacy and safety of methantheline bromide (Vagantin(®)) in axillary and palmar hyperhidrosis: results from a multicenter, randomized, placebo-controlled trial. J Eur Acad Dermatol Venereol 27:1278–1284PubMed

Nast A, Dréno B, Bettoli V, Bukvic Mokos Z, Degitz K, Dressler C, Finlay AY, Haedersdal M, Lambert J, Layton A, Lomholt HB, López-Estebaranz JL, Ochsendorf F, Oprica C, Rosumeck S, Simonart T, Werner RN, Gollnick H (2016) European evidence-based (S3) guideline for the treatment of acne – update 2016 – short version. J Eur Acad Dermatol Venereol 30:1261–1128PubMed

National Institute für Clinical Excellence NICE (2016) Chronic wounds: advanced wound dressings and chronic wounds: advanced wound dressings and antimicrobial dressingsantimicrobial dressings. Evidence summary. https://www.nice.org.uk/advice/esmpb2/resources/chronic-wounds-advanced-wound-dressings-and-antimicrobial-dressings-pdf-1502609570376901 (Erstellt: 30. März 2016)

Nieuwkamp DJ, Murk JL, van Oosten BW, Cremers CH, Killestein J, Viveen MC, Van Hecke W, Frijlink DW, Wattjes MP (2015) PML in a patient without severe lymphocytopenia receiving dimethyl fumarate. N Engl J Med 372:1474–1476PubMed

Nímia HH, Carvalho VF, Isaac C, Souza FÁ, Gemperli R, Paggiaro AO (2019) Comparative study of Silver Sulfadiazine with other materials for healing and infection prevention in burns: A systematic review and meta-analysis. Burns 45:282–292PubMed

O’Meara S, Cullum N, Nelson EA, Dumville JC (2012) Compression for venous leg ulcers. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD000265.pub3 PubMedPubMedCentralCrossRef

O’Meara S, Al-Kurdi D, Ologun Y, Ovington LG, Martyn-St JM, Richardson R (2014) Antibiotics and antiseptics for venous leg ulcers. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD003557.pub5 PubMedCrossRef

Papp K, Reich K, Leonardi CL, Kircik L, Chimenti S, Langley RG, Hu C, Stevens RM, Day RM, Gordon KB, Korman NJ, Griffiths CE (2015) Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: results of a phase III, randomized, controlled trial (efficacy and safety trial evaluating the effects of Apremilast in psoriasis [ESTEEM] 1). J Am Acad Dermatol 73:37–49PubMed

Patel R, Kennedy OJ, Clarke E, Geretti A, Nilsen A, Lautenschlager S, Green J, Donders G, van der Meijden W, Gomberg M, Moi H, Foley E (2017) 2017 European guidelines for the management of genital herpes. Int J STD Aids 28:1366–1379PubMed

Patry J, Blanchette V (2017) Enzymatic debridement with collagenase in wounds and ulcers: a systematic review and meta-analysis. Int Wound J 14:1055–1065PubMed

Paul C, Cather J, Gooderham M, Poulin Y, Mrowietz U, Ferrandiz C, Crowley J, Hu C, Stevens RM, Shah K, Day RM, Girolomoni G, Gottlieb AB (2015) Efficacy and safety of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with moderate-to-severe plaque psoriasis over 52 weeks: a phase III, randomized controlled trial (ES-TEEM 2). Br J Dermatol 173:1387–1399PubMed

Pippi B, Reginatto P, Machado GDRM, Bergamo VZ, Lana DFD, Teixeira ML, Franco LL, Alves RJ, Andrade SF, Fuentefria AM (2017) Evaluation of 8-hydroxyquinoline derivatives as hits for antifungal drug design. Med Mycol 55:763–773PubMed

Post B, Jänner M (1971) Zur Indikation der Gerbstofftherapie in der Dermatologie. Klinische Erfahrungen mit Tannosynt. Ther Ggw 110:1477–1494PubMed

Rahimi H, Mara T, Costella J, Speechley M, Bohay R (2012) Effectiveness of antiviral agents for the prevention of recurrent herpes labialis: a systematic review and meta-analysis. Oral Surg Oral Med Oral Pathol Oral Radiol 113:618–627PubMed

Ramos-e-Silva M, Lima CM, Schechtman R, Trope MB, Carneiro S (2012) Systemic mycoses in immunodepressed patients (AIDS). Clin Dermatol 30:616–627PubMed

Rashaan ZM, Krijnen P, Klamer RR, Schipper IB, Dekkers OM, Breederveld RS (2014) Nonsilver treatment vs. silver sulfadiazine in treatment of partial-thickness burn wounds in children: a systematic review and meta-analysis. Wound Repair Regen 22:473–482PubMed

Rathi SK, D’Souza P (2012) Rational and ethical use of topical corticosteroids based on safety and efficacy. Indian J Dermatol 57:251–259PubMedPubMedCentral

Reich K, Gooderham M, Green L, Bewley A, Zhang Z, Khanskaya I, Day RM, Goncalves J, Shah K, Piguet V, Soung J (2017a) The efficacy and safety of apremilast, etanercept and placebo in patients with moderate-to-severe plaque psoriasis: 52-week results from a phase IIIb, randomized, placebo-controlled trial (LIBERATE). J Eur Acad Dermatol Venereol 31:507–517PubMed

Reich K, Armstrong AW, Foley P, Song M, Wasfi Y, Randazzo B, Li S, Shen YK, Gordon KB (2017b) Efficacy and safety of guselkumab, an anti-interleukin-23 monoclonal antibody, compared with adalimumab for the treatment of patients with moderate to severe psoriasis with randomized withdrawal and retreatment: Results from the phase III, double-blind, placebo- and active comparator-controlled VOYAGE 2 trial. J Am Acad Dermatol 76:418–431PubMed

Ring J, Fröhlich HH (1985) Wirkstoffe in der dermatologischen Therapie, 2. Aufl. Springer, Berlin Heidelberg

Rotta I, Sanchez A, Gonçalves PR, Otuki MF, Correr CJ (2012) Efficacy and safety of topical antifungals in the treatment of dermatomycosis: a systematic review. Br J Dermatol 166:927–933PubMed

Ruzicka T (2006) Methylprednisolone aceponate in eczema and other inflammatory skin disorders – a clinical update. Int J Clin Pract 60:85–92PubMed

Saco M, Howe N, Nathoo R, Cherpelis B (2016) Comparing the efficacies of alginate, foam, hydrocolloid, hydrofiber, and hydrogel dressings in the management of diabetic foot ulcers and venous leg ulcers: a systematic review and meta-analysis examining how to dress for success. Dermatol Online J 22:13030/qt7ph5v17z

Samrao A, Cockerell CJ (2013) Pharmacotherapeutic management of actinic keratosis: focus on newer topical agents. Am J Clin Dermatol 14:273–237PubMed

Sapijaszko MJA (2005) Imiquimod 5% cream (Aldara^®) in the treatment of basal cell carcinoma. Skin Ther Lett 10:2–5

Saraswat A (2014) Ethical use of topical corticosteroids. Indian J Dermatol 59:469–472PubMedPubMedCentral

Sawyer LM, Cornic L, Levin LÅ, Gibbons C, Møller AH, Jemec GB (2019) Long-term efficacy of novel therapies in moderate-to-severe plaque psoriasis: a systematic review and network meta-analysis of PASI response. J Eur Acad Dermatol Venereol 33:355–366PubMed

Sbidian E, Chaimani A, Afach S, Doney L, Dressler C, Hua C, Mazaud C, Phan C, Hughes C, Riddle D, Naldi L, Garcia-Doval I, Le Cleach L (2020) Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD011535.pub3 PubMedCrossRef

Schäfer-Korting M, Schmid MH, Korting HC (1996) Topical glucocorticoids with improved risk-benefit ratio. Drug Saf 14:375–385PubMed

Schaller M, Friedrich M, Papini M, Pujol RM, Veraldi S (2016) Topical antifungal-corticosteroid combination therapy for the treatment of superficial mycoses: conclusions of an expert panel meeting. Mycoses 59:365–373PubMed

Schöfer H, Simonsen L (2010) Fusidic acid in dermatology: an updated review. Eur J Dermatol 20:6–15PubMed

Shmidt E, Wetter DA, Ferguson SB, Pittelkow MR (2011) Psoriasis and palmoplantar pustulosis associated with tumor necrosis factor-α inhibitors: The Mayo Clinic experience, 1998 to 2010. J Am Acad Dermatol 67:e179–e185PubMed

Singal A, Khanna D (2011) Onychomycosis: diagnosis and management. Indian J Dermatol Venereol Leprol 77:659–672PubMed

Singh S, Fatima Z, Hameed S (2015) Predisposing factors endorsing Candida infections. Infez Med 23:211–223PubMed

Solares CA, Batra PS, Hall GS, Citardi MJ (2006) Treatment of chronic rhinosinusitis exacerbations due to methicillin-resistant Staphylococcus aureus with mupirocin irrigations. Am J Otolaryngol 27:161–165PubMed

Stein Gold L, Kircik L, Fowler J, Jackson JM, Tan J, Draelos Z, Fleischer A, Appell M, Steinhoff M, Lynde C, Sugarman J, Liu H, Jacovella J, Ivermectin Phase 3 Study Group (2014) Long-term safety of ivermectin 1% cream vs azelaic acid 15% gel in treating inflammatory lesions of rosacea: results of two 40-week controlled, investigator-blinded trials. J Drugs Dermatol 13:1380–1386PubMed

Sticherling M, Mrowietz U, Augustin M, Thaçi D, Melzer N, Hentschke C, Kneidl J, Sieder C, Reich K (2017) Secukinumab is superior to fumaric acid esters in treating subjects with moderate to severe plaque psoriasis who are Naïve to systemic treatments: results from the randomized controlled PRIME trial. Br J Dermatol Br J Dermatol 177:1024–1032PubMed

Stockfleth E, Beti H, Orasan R, Grigorian F, Mescheder A, Tawfik H, Thielert C (2008) Topical Polyphenon E in the treatment of external genital and perianal warts: a randomized controlled trial. Br J Dermatol 158:1329–1338PubMed

Stockfleth E, Kerl H, Zwingers T, Willers C (2011) Low-dose 5-fluorouracil in combination with salicylic acid as a new lesion-directed option to treat topically actinic keratoses: histological and clinical study results. Br J Dermatol 165:1101–1108PubMed

Stockfleth E, Sibbring GC, Alarcon I (2016) New topical treatment options for actinic keratosis: a systematic review. Acta Derm Venereol 96:17–22PubMed

Strober B, Gottlieb AB, Sherif B, Mollon P, Gilloteau I, McLeod L, Fox T, Mordin M, Gnanasakthy A, Papavassilis C, Lebwohl MG (2017) Secukinumab sustains early patient-reported outcome benefits through 1 year: Results from 2 phase III randomized placebo-controlled clinical trials comparing secukinumab with etanercept. J Am Acad Dermatol 76:655–661PubMed

Subissi A, Monti D, Togni G, Mailland F (2010) Ciclopirox: recent nonclinical and clinical data relevant to its use as a topical antimycotic agent. Drugs 70:2133–2152PubMed

Swanson N, Abramovits W, Berman B, Kulp J, Rigel DS, Levy S (2010) Imiquimod 2.5% and 3.75% for the treatment of actinic keratoses: results of two placebo-controlled studies of daily application to the face and balding scalp for two 2-week cycles. J Am Acad Dermatol 62:582–590PubMed

Taieb A, Ortonne JP, Ruzicka T, Roszkiewicz J, Berth-Jones J, Peirone MH, Jacovella J, Ivermectin Phase III study group (2015) Superiority of ivermectin 1% cream over metronidazole 0·75% cream in treating inflammatory lesions of rosacea: a randomized, investigator-blinded trial. Br J Dermatol 172:1103–1110PubMed

Tatti S, Swinehart JM, Thielert C, Tawfik H, Mescheder A, Beutner KR (2008) Sinecatechins, a defined green tea extract, in the treatment of external anogenital warts: a randomized controlled trial. Obstet Gynecol 111:1371–1379PubMed

Thaçi D, Schöfer H (2005) Topische Antibiotika zur Therapie von Hautinfektionen. Hautarzt 56:381–396PubMed

Thaçi D, Blauvelt A, Reich K, Tsai TF, Vanaclocha F, Kingo K, Ziv M, Pinter A, Hugot S, You R, Milutinovic M (2015) Secukinumab is superior to ustekinumab in clearing skin of subjects with moderate to severe plaque psoriasis: CLEAR, a randomized controlled trial. J Am Acad Dermatol 73:400–409PubMed

Thaçi D, Pinter A, Sebastian M, Termeer C, Sticherling M, Gerdes S, Wegner S, Krampe S, Bartz H, Rausch C, Mensch A, Eyerich K (2019) Guselkumab is superior to fumaric acid esters in patients with moderate-to-severe plaque psoriasis who are naive to systemic treatment: results from a randomized, active-comparator-controlled phase IIIb trial (POLARIS). Br J Dermatol. https://doi.org/10.1111/bjd.18696 PubMedPubMedCentralCrossRef

Thiboutot DM, Weiss J, Bucko A, Eichenfield L, Jones T, Clark S, Liu Y, Graeber M, Kang S, Adapalene-BPO Study Group (2007) Adapalene-benzoyl peroxide, a fixed-dose combination for the treatment of acne vulgaris: results of a multicenter, randomized double-blind, controlled study. J Am Acad Dermatol 57:791–799PubMed

Thielitz A, Abdel-Naser MB, Fluhr JW, Zouboulis CC, Gollnick H (2010) Topische Retinoide bei Akne – eine evidenzbasierte Übersicht. J Dtsch Dermatol Ges 8(Suppl 1):S15–S23PubMed

Thurgar E, Barton S, Karner C, Edwards SJ (2016) Clinical effectiveness and cost-effectiveness of interventions for the treatment of anogenital warts: systematic review and economic evaluation. Health Technol Assess 20(v–vi):1–486PubMedCentral

Udompataikul M, Limpa-o-vart D (2012) Comparative trial of 5% dexpanthenol in water-in-oil formulation with 1% hydrocortisone ointment in the treatment of childhood atopic dermatitis: a pilot study. J Drugs Dermatol 11:366–374PubMed

Valente Duarte de Sousa IC (2014) Novel pharmacological approaches for the treatment of acne vulgaris. Expert Opin Investig Drugs 23:1389–1410PubMed

Wananukul S, Limpongsanuruk W, Singalavanija S, Wisuthsarewong W (2006) Comparison of dexpanthenol and zinc oxide ointment with ointment base in the treatment of irritant diaper dermatitis from diarrhea: a multicenter study. J Med Assoc Thai 89:1654–1658PubMed

Weidinger S, Novak N (2016) Atopic dermatitis. Lancet 387:1109–1122PubMed

Werner RN, Westfechtel L, Dressler C, Nast A (2017) Self-administered interventions for anogenital warts in immunocompetent patients: a systematic review and meta-analysis. Sex Transm Infect 93:155–161PubMed

Wheat CM, Bickley RJ, Hsueh YH, Cohen BA (2017) Current trends in the use of two combination antifungal/corticosteroid creams. J Pediatr 186:192–195PubMed

Williams H (2002) New treatments for topic dermatitis. Brit Med J 324:1533–1534PubMed

Williamson DA, Carter GP, Howden BP (2017) Current and emerging topical antibacterials and antiseptics: agents, action, and resistance patterns. Clin Microbiol Rev 30(3):827–860PubMedPubMedCentral

Willy C, Stichling M, Müller M, Gatzer R, Kramer A, Vogt D (2016) Akute Maßnahmen beim „limb salvage“ – Prozedere Teil 2. Debridement, Lavagetechniken und antiinfektiöse Strategien. Unfallchirurg 119:388–399PubMed

Wohlrab J (2016) Topika und deren Einsatz in der Dermatologie. J Dtsch Dermatol Ges 14:1061–1071PubMed

Wollenberg A, Barbarot S, Bieber T, Christen-Zaech S, Deleuran M, Fink-Wagner A, Gieler U, Girolomoni G, Lau S, Muraro A, Czarnecka-Operacz M, Schäfer T, Schmid-Grendelmeier P, Simon D, Szalai Z, Szepietowski JC, Taïeb A, Torrelo A, Werfel T, Ring J, European Dermatology Forum (EDF), European Academy of Dermatology and Venereology (EADV), European Academy of Allergy and Clinical Immunology (EAACI), European Task Force on Atopic Dermatitis (ETFAD), European Federation of Allergy and Airways Diseases Patients’ Associations (EFA), European Society for Dermatology and Psychiatry (ESDaP), European Society of Pediatric Dermatology (ESPD), Global Allergy and Asthma European Network (GA2LEN), European Union of Medical Specialists (UEMS) (2018) Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I. J Eur Acad Dermatol Venereol 32:657–682PubMed

Wong RK, Bensadoun RJ, Boers-Doets CB, Bryce J, Chan A, Epstein JB, Eaby-Sandy B, Lacouture ME (2013) Clinical practice guidelines for the prevention and treatment of acute and late radiation reactions from the MASCC Skin Toxicity Study Group. Support Care Cancer 21:2933–2948PubMed

Worret WI, Fluhr JW (2006) Acne therapy with topical benzoyl peroxide, antibiotics and azelaic acid. J Dtsch Dermatol Ges 4:293–300PubMed

Zaenglein AL, Pathy AL, Schlosser BJ, Alikhan A, Baldwin HE, Berson DS, Bowe WP, Graber EM, Harper JC, Kang S, Keri JE, Leyden JJ, Reynolds RV, Silverberg NB, Gold SLF, Tollefson MM, Weiss JS, Dolan NC, Sagan AA, Stern M, Boyer KM, Bhushan R (2016) Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol 74(3):945–973.e33PubMed

Zhu TH, Nakamura M, Abrouk M, Farahnik B, Koo J, Bhutani T (2016) Demyelinating disorders secondary to TNF-inhibitor therapy for the treatment of psoriasis: A review. J Dermatolog Treat 2:1–8

van Zuuren EJ, Fedorowicz Z, Arents BWM (2017) Emollients and moisturizers for eczema: abridged Cochrane systematic review including GRADE assessments. Br J Dermatol 177:1256–1271PubMed

van Zuuren EJ, Fedorowicz Z, Tan J, van der Linden MMD, Arents BWM, Carter B, Charland L (2019) Interventions for rosacea based on the phenotype approach: an updated systematic review including GRADE assessments. Br J Dermatol 181:65–79PubMedPubMedCentral

Titel: Dermatika
verfasst von: Dr. rer. nat. Judith Günther
Prof. Dr. rer. nat. Uwe Fricke
Verlag: Springer Berlin Heidelberg
Buch: Arzneiverordnungs-Report 2020
Print ISBN: 978-3-662-62167-7

Electronic ISBN: 978-3-662-62168-4

Copyright-Jahr: 2020
DOI: https://doi.org/10.1007/978-3-662-62168-4_23

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