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Clinical Oral Investigations

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03.01.2021 | Original Article

Effects of low and high molecular weight hyaluronic acid on the osteoarthritic temporomandibular joint in rabbit

verfasst von: Veronica Iturriaga, Bélgica Vásquez, Thomas Bornhardt, Mariano del Sol

Erschienen in: Clinical Oral Investigations | Ausgabe 7/2021

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Abstract

Objective

To compare the effect between intra-articular infiltration of low molecular weight (LMW-HA) and high molecular weight hyaluronic acid (HMW-HA) on the histopathological characteristics of the cartilage and disc of the temporomandibular joint (TMJ) osteoarthritis (OA) induced in rabbits.

Material and methods

An experimental study was conducted on 38 rabbit TMJs. The effect of different hyaluronic acids was compared at 30 and 135 days. Histopathological analysis was performed. Cartilage damage was assessed with the OARSI scale.

Results

The severity of the induced OA according to OARSI was 3.4 degrees in the mandibular condyle (MC) and 3.2 in the mandibular fossa (MF); the articular disc (AD) presented disorganization of the collagen fibers, with randomly arranged hypertrophic chondrocytes. At 30 days, untreated TMJs worsened. TMJ treated with LMW-HA reduced its severity to 1.5 degrees in MC and 1.6 in MF, the AD presented histological aspects within normal limits. TMJ treated with HMW-HA presented 2.4 degrees in MC and 2.2 in MF, the AD maintained characteristics similar to the group with OA. At 135 days, all groups worsened.

Conclusion

Exogenous HA is effective in the management of TMJ-OA induced in rabbits, showing cartilage and articular disc repair at 30 days. The LMW-HA group had better effects on joint tissue than HMW-HA 30 days after treatment. However, at 135 days, both groups presented regression of joint tissue repair.

Clinical relevance

HA is effective in the anti-arthritic treatment of TMJ-OA induced in rabbits; LMW-HA shows better results in cartilage and articular disc repair than HMW-HA.

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Titel: Effects of low and high molecular weight hyaluronic acid on the osteoarthritic temporomandibular joint in rabbit
verfasst von: Veronica Iturriaga
Bélgica Vásquez
Thomas Bornhardt
Mariano del Sol
Publikationsdatum: 03.01.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 7/2021
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-020-03763-x

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Effects of low and high molecular weight hyaluronic acid on the osteoarthritic temporomandibular joint in rabbit

Abstract

Objective

Material and methods

Results

Conclusion

Clinical relevance

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Abstract

Objective

Material and methods

Results

Conclusion

Clinical relevance

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