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Open Access 01.12.2020 | Research article

Epidemiology of genital infections caused by Mycoplasma hominis, M. genitalium and Ureaplasma urealyticum in Iran; a systematic review and meta-analysis study (2000–2019)

verfasst von: Khadijeh Moridi, Mohammad Hemmaty, Amir Azimian, Mohammad Hosein Fallah, Hamid Khaneghahi Abyaneh, Kiarash Ghazvini

Erschienen in: BMC Public Health | Ausgabe 1/2020

Abstract

Background

Although many species of mycoplasmas regard as normal flora, but some species causes serious genital disease. In Iran several epidemiological studies have documented the prevalence of Mycoplasma hominis, M. genitalium and Ureaplasma urealyticum in genital disorders. This meta-analysis is going to represent the prevalence of M. hominis, M. genitalium and U. urealyticum among Iranian couples and the correlation between mycoplasmas infection and infertility.

Methods

We search online databases from January 2000 to June 2019. We used following MeSH keywords (Prevalence, M. hominis, M. genitalium, U. urealyticum, male, female, fertility, Infertility, genitourinary tract infection and Iran) with all possible combinations with “OR” and “AND”. Finally, forty-four articles from 2670 were chosen for data extraction and analysis by software using STATA version 14.0.

Results

This meta-analysis revealed that the prevalence of U. urealyticum was 17.53% in Iran and the prevalence of M. genitalium and M. hominis were 11.33 and 9.68% respectively. The rate of M. genitalium, M. hominis and U. urealyticum infection in women with symptoms of genitourinary tract infection was higher than men with genitourinary tract infection (6.46% vs 5.4, 7.67% vs 5.88 and 21.04% vs 12.13%, respectively). As expected, the prevalence of M. genitalium, U. urealyticum and M. hominis among infertile women (12.73, 19.58 and 10.81%) were higher than fertile women (3%, 10. 85% and 4. 35%). Similarly, the prevalence of M. hominis and U. urealyticum among infertile men (14 and 21.18%) were higher than fertile men (4 and 3%). Based on this analysis, the rate of U. urealyticum was higher than M. genitalium and M. hominis among infertile men and women compared to the fertile group. The prevalence rate of M. genitalium, M. hominis and U. urealyticum in central provinces is higher than other parts of Iran.

Conclusions

This meta-analysis reemphasizes a significant relationship between the infertility rate and U. urealyticum, M. genitalium and M. hominis infections. Our finding help to plan the prevalence map of M. hominis, M. genitalium and U. urealyticum in Iran but further studies are needed to suggest routine screening of the pathogens.

Publisher’s Note

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Mycoplasma

Ureaplasma

PCR

polymerase chain reaction

Background

Mycoplasma and Ureaplasma geniuses are the smallest self-replicating organism that belong to the Mollicutes class [1‐4]. They live as external parasites of the human, animal, bird, insect and plant cells. Some species have a free-living existence in soil and water [5]. Since Dienes and Edsall isolated first mycoplasma from human in a Bartholin’s gland abscess in 1937, seventeen species of human mycoplasmas species have been identified [6, 7]. As a new derivative genus Ureaplasma is divided in to 14 known serotypes and two biovars: U. parvum and U. urealyticum. U. urealyticum can be transmitted in different ways, including directly by sexual transmission, vertically from mother to offspring, or through transplanted tissues [8‐13]. Generally, genital mycoplasmas such as M. hominis, M. genitalium and U. urealyticum are important emerging sexually transmitted bacterial pathogens capable to cause asymptomatic, long-term and chronic infection in genitourinary tract which is considered to be a threat to community health [14, 15]. In a clinical study, about 40% of infants born from infected mothers with genital Mycoplasma infection had symptomatic infection such as neonatal conjunctivitis and meningitis by an ascending route or by crossing the placenta from the mother’s blood via delivery through a colonized birth canal [16].

Despite the worldwide incidence of genital mycoplasmas infections, there are no accurate reports of prevalence, common types, common routes of transmission and antibiotic resistance patterns of M. genitalium, M. hominis and U. urealyticum in Iran [17]. There are some studies about the presence of genital mycoplasmas among men, women, pregnant, newborns, infertile and etc in Iran. In this systematic review and meta-analysis, we are going to present an illustration of prevalence of M. hominis, M. genitalium, and U. urealyticum in Iran and the correlation between mycoplasmas infection and infertility in Iranian couples.

Methods

Search strategy

We search online databases including Pubmed, Scopus, Science Direct, IranMedex, SID (Scientific Information Database), and Google Scholar for the papers that were performed in Iran from January 2000 to June 2019. We used following MeSH keywords (Prevalence, M. hominis, M. genitalium, U. urealyticum, male, female, fertility, Infertility, genitourinary tract infection and Iran) with all possible combinations with “OR” and “AND”. Then the titles of the articles were entered into Mendeley software to find similar articles. Difinition of terms were considered as WHO recommended. One of the limitations of this study is the lack of data in some part of Iran. Since different researchers worked on different samples and conditions, the data was categorized in six groups: 1. Fertile men 2. Infertile men 3. Men with urinary tract infection or prostatitis 4. Fertile women 5. Infertile women 6. Women with urogenital infection or abortion or pregnant.

Inclusion and exclusion criteria

Inclusion criteria of this study consisted of a reference to the prevalence of M. genitalium, M. hominis, and U. urealyticum in Iranian men and women by culture and PCR. Exclusion criteria were irrelevance or limited information, countries other than Iran, review articles, methods other than culture and PCR. At the end, 44 articles, which met our inclusion criteria, were conducted for meta- analysis.

Data extraction

The data were extraction by a pre-prepared checklist from all included articles. The checklist included the author’s name, year of the study, the location, sample volume, type of specimen and the prevalence of M. genitalium, M. hominis, and U. urealyticum. The studies on each Mycoplasma species were further categorized into subgroups, considering (1) study population according to gender (men and women) fertile, infertile and urogenital tract infection; (2) Analytical method (including PCR, and culture); (3) geographical region of sampling (including Eastern provinces: Kerman, North Khorasan, Razavi Khorasan, South Khorasan, Sistan and Baluchestan, and Yazd Provinces; Middle provinces (Northern, Central & Southern): Alborz, Golestan, Mazandaran, Qazvin, Qom, Semnan, Tehran, Bushehr, Chaharmahal and Bakhtiari, Fars, Hormozgan, Isfahan, Kohgiluyeh and Boyer-Ahmad Provinces; Western provinces: Ardabil, East Azerbaijan, Gilan, Kordestan, West Azerbaijan, Zanjan, Hamadan, Ilam, Kermanshah, Khuzestan, Lorestan and Markazi Provinces).

Analytic approach

The ratio of positive samples to total samples was defined as prevalence. Meta-analysis was conducted by STATA version 14 for prevalence of each bacterium on available data. Chi-squared (Q) and I-squared tests were used to assess heterogeneity among the studies. Since the heterogeneity was statistically significant (p-value of Q test < 0.1 and I² index > 75%), a random-effects model was used; The outcome was estimated as prevalence and 95% confidence intervals (CI).

Results

Description of included and excluded studies

Initially 11,345 articles were identified through database searching. About 2670 articles were remained after discarding duplicate papers based on title and abstract. From 2670 articles, we excluded further 1606 papers based on exclusion criteria (489 papers on M. genitalium, 595 papers on M. hominis, and 522 papers on U. urealyticum were excluded). Forty-four original articles (full texts) related to prevalence of M. genitalium, M. hominis, and U. urealyticum in Iranian men and women in our literature review remained for reviewing and assessing for eligibility criteria. The final 44 articles were included: M. genitalium [17], M. hominis [18], U. urealyticum [19] with some of them contains two [15] or three [2] of these bacteria (Fig. 1). Table 1 provides an overview of the eligible studies.

Table 1

Prior studies concerning prevalence of Mycoplasma hominis, Mycoplasma genitalium and Ureaplasma urealyticum in Iran

no:	Location	Year	Author	Number & kind of sample	Method	Prevalence (%)	Comment	Ref
1	Tehran	2001	Badami	n = 375 cervical swab	Culture	Fertile women: MH = 18(7.2) & UU = 48(19.2) Infertile women: MH = 32(25.6) & UU = 41(32.8)	Fertile women = 250 Infertile women = 125	[20]
2	Tehran	2003	Salari	n = 125 swab urethral	PCR	MG = 9(7.2) UU = 24(19.2) MH = 3(2.4)	Men with NGU	[21]
3	Tehran	2005	AleYasin	n = 312 cervical swab	Culture PCR	Culture: MH = 20(6.4) PCR:MH = 50(16) Culture &PCR = 16(5)	Infertile women	[22]
4	Tehran	2005	Najar Peerayeh	n = 312 cervical swab	Culture PCR	Culture: UU = 18(5.7) PCR: UU = 32(10.25)	Infertile women	[23]
5	Tehran	2006	Najar Peerayeh	n = 377 cervical swab	PCR	MH = 31(8.2) UU = 60(15.9) MH & UU = 25(6.6)	Infertile women	[18]
6	Tehran	2007	Golshani	n = 200 semen samples	Multiplex PCR	MH = 22(11) UU = 6(3) MH&UU = 2(1)	Infertile men	[24]
7	Tehran	2007	Zeighami	n = 200 semen samples	PCR	Fertile men: UU = 3(3) Infertile men: UU = 12(12)	Fertile men = 100 Infertile men = 100	[19]
8	Tehran	2007	soleimani rahbar	n = 100 semen samples	PCR	MH = 3(3) UU = 17(17)	Infertile men	[25]
9	Tehran	2007	Najar Peerayeh	n = 377 cervical swab	PCR	UU = 85(22.5)	Infertile women	[26]
10	Tehran	2008	NajarPeerayeh	n = 312 cervical swab	Culture PCR	Culture: MH = 12(4) & UU = 39(12) PCR: MH = 28(9) & UU = 54(17)	Infertile women	[27]
11	Tehran	2008	Ghazisaidi	n = 75 urethral secretion samples after prostatic massage & First void urine	PCR	urethral secretion: MH = 11(15) & UU = 19(25) First void urine: MH = 9 (12)& UU = 17(23)	Men suffering from nongonococcal urethritis and non-specific urethritis	[28]
12	Tehran	2008	Najar Peerayeh	n = 246 semen samples	PCR	Fertile men: UU = 3(3) Infertile men: UU = 23(15.7)	Fertile men = 100 Infertile men = 146	[29]
13	Tehran	2009	Amirmozafari	n = 210 cervical swab	Culture PCR	Culture: UU = 69(32.8) PCR: UU = 67(31.9)	Women with urogenital infection	[30]
14	Tehran	2010	Ahmadi	n = 220 semen sample	PCR	MH = 34 (15) UU = 89(40) MH&UU = 25(11)	Infertile men	[31]
15	Tehran	2011	Mirnejad	n = 210 genital samples	PCR	UU = 89(42.4) MG = 7(3.3)	Women with urogenital infection	[32]
16	Sabzevar	2011	Haghighi Hasanabad	n = 196 urine	PCR	MG = 2(1)	Pregnant women	[33]
17	Ahwaz	2011	Moosavian	n = 265 urine = 110 cervical swab = 155	Culture Multiplex PCR	Culture: MH = 5 (1.8)& UU = 0 Multiplex PCR: MH = 11(4)&UU = 13(5)	Women with urogenital infection	[34]
18	Kerman	2013	Vosooghi	n = 58 semen sample	PCR	MH = 13(22)	Infertile men	[35]
19	Tehran	2013	irajian	n = 200 paraffin blocks	PCR	MG = 4(2)	Men with prostatitis	[36]
20	Ahvaz	2013	Maleki	n = 265 urine = 110 cervical swab = 155	Multiplex PCR	Urine: MH = 11(10) & UU = 13(12) cervical swab: MH = 7 (4)& UU = 15(10)	Women with urogenital infection	[37]
21	Tehran	2013	Yeganeh	n = 200 urine	PCR	MG = 14(7)	Men refer to urology clinic	[38]
22	Tehran	2013	Sadrpour	n = 120 semen samples	PCR	MG = 12(10)	Infertile men	[39]
23	Mazandaran	2013	mohseni	n = 44 genital samples	PCR	MG = 10(22.7)	Pregnant women	[40]
24	Tehran	2014	Seifoleslami	n = 350 cervical swab	PCR	Infertile women: MH = 8(5.3) & UU = 10(6.6) MH&UU = 4(2.6) Fertile women: MH = 3(1.5) & UU = 5(2.5) MH&UU = 1	Infertile women = 150 Fertile women = 200	[17]
25	Kurdistan	2014	Ahmadi	n = 218 cervical swab	PCR	Pregnant women: UU = 8(7.3) Spontaneous abortion: UU = 18(16.5)	Pregnant women = 109 Spontaneous abortion = 109	[41]
26	Sanandaj	2014	Mousavi	n = 104 cervical swab	Multiplex PCR	MH = 3(3) MG = 3(3) UU = 39(37) MH&UU = 1(1) MH&MG = 1(1) MG&UU = 1(1) MG&UU&MH = 1(1)	Infertile women	[42]
27	Kerman	2014	JamalizadehBahaabadi	n = 200 semen sample = 100 cervical swab = 100	PCR	Semen sample: MH = 15(7) cervical swab: MH = 18(18)	Infertile men & Infertile women	[43]
28	Kerman	2014	Mohseni Moghadam	n = 200 semen samples = 100 cervical swab = 100	PCR	Semen samples: MG = 13(13) cervical swab: MG = 10(10)	Infertile men Infertile women	[11]
29	Tehran	2014	Sobouti	n = 330 cervical swab their baby after delivery	Multiplex PCR	Pregnant women: MH = 25(15.1) & UU = 25(15.1) their baby after delivery: MH = 15(9) & UU = 18(10.9)	Pregnant women = 165 their baby after delivery = 165	[44]
30	Tehran	2015	Dadashi	n = 124 sample from ovarian cancer	PCR	MG = 9(7.2)	Ovarian Cancer = 62 Benign Ovarian Cancer =62	[45]
31	Tehran	2015	Eslami	n = 124 paraffin blocks	PCR	MG = 0 UU = 1(0.8)	From men who undergo prostatectomy	[46]
32	Tehran	2015	Safavifar	n = 45 semen samples	PCR	Infertile men: MG = 6(40) Fertile men: MG = 11(37)	Infertile men = 15 Fertile men = 30	[47]
33	Kerman	2015	EftekhariMoghadam	n = 50 urine	PCR	MH = 3(6)	UTI patients	[14]
34	Kashan	2015	Safari	n = 864 urine	PCR	MH = 1(0.1)	UTI patients	[48]
35	Sanandaj	2016	Ramazanzadeh	n = 218 genital swab	PCR	Normal pregnant: MG = 4(3.6) Spontaneous abortion: MG = 2(1.8)	Normal pregnant = 109 Spontaneous abortion = 109	[49]
36	Tehran	2016	Ahmadi	n = 330 semen samples	Real-time PCR	Infertile men = MH = 24(14) Fertile men: MH = 6(4)	Infertile men = 165 Fertile men = 165	[50]
37	Qazvin	2016	Bahrami	n = 232 cervical swab	culture	UU = 87(37.5)	married females(20–50 years)	[51]
38	Qom	2016	Asgari	n = 187 semen samples	PCR	MH = 71(39)	Infertile men	[52]
39	Tehran	2016	Irajian	n = 200 prostatitis tissues with paraffin	PCR	UU = 7(3.5)	men suffering from prostatitis	[53]
40	Tehran	2017	sameni	n = 65 cervical swab	PCR	MG = 11(16.9)	Infertile women	[54]
41	Tehran	2017	Javadinia	n = 194 urine	PCR	UU = 22(11.3) MG = 11(5.6) UU&MG = 5(2.6)	Pregnant women	[55]
42	Mashhad	2017	Makari golkhatmi	n = 200 vaginal swab	PCR-ELISA	Infertile women: MG = 21(21) Fertile women: MG = 3(3)	Infertile women = 100 Fertile women = 100	[56]
43	Hamedan	2018	Moradi	n = 234 cervical swab	Culture PCR	Culture: MH = 14(5.9) PCR: MH = 30(12.8)	married females(20–50 years)	[57]
44	Mashhad	2018	Moridi	n = 100 semen samples	Culture PCR	Culture: MH = 7(7) PCR: MH = 8(8) Culture: MG = 0(0) PCR: MG = 0(0)	Infertile men	^a

^aThe data is under publication

Prevalence of M. genitalium

The overall prevalence of M. genitalium was 16.60% (CI 95%; 12.01–21.18%) and 8.26%(CI 95%; 6.33–10.19%) in male and female respectively (Table 2).

Table 2

The prevalence of M. genitalium in Iran based of meta-analysis

Study Population	studies	sample	prevalence, 95% CI	Model
Men	8	1114	16.60, 12.01–21.18	Random
Fertile	1	30	37.00, 36.83–37.17	Random
Infertile	4	435	21.00, 13.18–28.82	Random
Symptomatic¹	4	649	5.40, 1.55–9.25	Random
Women	11	1455	8.26, 6.33–10.19	Random
Fertile	1	100	3.00, 2.97–3.03	Random
Infertile	4	369	12.73, 4.44–21.01	Random
Symptomatic²	7	986	6.46, 4.62–8.29	Random
Women and men	18	2569	11.33, 9.58–13.08	Random

1. Men with urinary tract infection or prostatitis; 2. Women with urogenital infection or abortion or pregnant

Prevalence of M. hominis

The overall prevalence of M. hominis was 10.73% (CI 95%; 6.77–14.69%) and 8.83% (CI 95%; 6.67–10.98%), among male and female respectively (Table 3).

Table 3

The prevalence of M. hominis in Iran based of meta-analysis

Study Population	studies	sample	prevalence, 95% CI	Model
Men	12	2344	10.73, 6.77–14.69	Random
Fertile	1	165	4.00, 3.97–4.03	Random
Infertile	7	1130	14.00, 7.45–20.55	Random
Symptomatic¹	4	1049	5.88, 2.18–9.57	Random
Women	12	3670	8.83, 6.67–10.98	Random
Fertile	2	450	4.35, −1.24 - 9.94	Random
Infertile	7	1480	10.81, 7.18–14.45	Random
Symptomatic²	3	1740	7.67, 4.34–10.99	Random
Women and men	22	6014	9.68, 7.75–11.61	Random

1. Men with urinary tract infection or prostatitis; 2. Women with urogenital infection or abortion or pregnant

Prevalence of U. urealyticum

The prevalence of U. urealyticum was 13.92% (CI 95%; 7.58–20.26%) and 19.43% (CI 95%; 11.56–27.30%), in male and female respectively (Table 4).

Table 4

The prevalence of U. urealyticum in Iran based of meta-analysis

Study Population	studies	sample	prevalence, 95% CI	Model
Men	8	1290	13.92, 7.58–20.26	Random
Fertile	2	200	3.00, 2.98–3.02	Random
Infertile	4	766	21.18, 8.61–33.74	Random
Symptomatic¹	4	324	12.13, 3.23–21.02	Random
Women	14	4441	19.43, 11.56–27.30	Random
Fertile	2	450	10.85, −5.52 - 27.22	Random
Infertile	7	1757	19.58, 13.59–25.57	Random
Symptomatic²	5	2234	21.04, 8.95–33.13	Random
Women and men	24	5731	17.53, 11.40–23.66	Random

1. Men with urinary tract infection or prostatitis; 2. Women with urogenital infection or abortion or pregnant

The prevalence rates of genital mycoplasma infection are due to U. urealyticum, M. genitalium and M. hominis respectively, in Iran. This study shows that the rate of U. urealyticum, M. genitalium and M. hominis infection in women with symptoms of genitourinary tract infection was higher than men with genitourinary tract infection. The result indicated that the prevalence of U. urealyticum, M. genitalium and M. hominis in infertile women were higher than fertile women. However, the prevalence of U. urealyticum and M. hominis in infertile men were higher than fertile men.

Geographical distribution of M. hominis, M. genitalium and U. urealyticum in Iran

In Eastern provinces of Iran, the prevalence of M. genitalium and M. hominis were 9.60 and 9.73% respectively based of meta-analysis (CI 95%). There is no documented study on U. urealyticum in Eastern provinces. In Middle provinces, the prevalence of M. genitalium, M. hominis and U. urealyticum were 13.39, 11.17 and 17.94% respectively. While in Western provinces of Iran, the prevalence of M. genitalium, M. hominis and U. urealyticum were 3.3, 5.65 and 14.98% respectively (Table 5).

Table 5

The prevalence and 95% CI of Mycoplasma hominis, Mycoplasma genitalium and Ureaplasma urealyticum in different regions of Iran based of meta-analysis

Study Location	M. genitalium		M. hominis		U. urealyticum
Study Location	provinces (studies)	prevalence, 95% CI	provinces (studies)	prevalence, 95% CI	provinces (studies)	prevalence, 95% CI
Eastern provinces¹	2 (4)	9.60, 4.01–15.19	2 (5)	9.73, 4.49–14.96	0	–
Middle provinces²	2 (12)	13.39, 11.14–15.64	2 (11)	11.17, 8.10–14.24	2 (17)	17.94, 11.08–24.80
Western provinces³	1 (2)	3.30, 2.71–3.89	3 (4)	5.65, 3.09–8.22	2 (4)	14.98, 6.83–23.12

(1) Eastern provinces: Kerman, North Khorasan, Razavi Khorasan, Sistan and Baluchestan, South Khorasan and Yazd Provinces; (2) Middle provinces: (Northern Central & southern): Alborz, Golestan, Mazandaran, Qazvin, Qom, Semnan, Tehran, Bushehr, Chaharmahal and Bakhtiari, Fars, Hormozgan, Isfahan, Kohgiluyeh and Boyer-Ahmad Provinces; (3) Western provinces: Ardabil, East Azerbaijan, Gilan, Kordestan, West Azerbaijan, Zanjan, Hamadan, Ilam, Kermanshah, Khuzestan, Lorestan and Markazi Provinces

Analytical method

The forty- four selected articles which met our inclusion criteria were analyzed according to the culture and PCR methods. The prevalence rate of M. hominis and M. genitalium base on PCR (10.13%&11.33%) was higher than culture method (8.27%& 0%), whereas that was contrary in U. urealyticum (Figs. 2, 3 and 4).

Discussion

The epidemiology and role of M. hominis, M. genitalium and U. urealyticum in infertility has been less discussed in Iran [14]. The different reports documented in other countries around the world. M. genitalium has been identified as a causative agent of 10–35% nongonococcal-nonchlamydia urethritis [58‐62]. According to the community-based prospective cohort study from Oakeshott (2010) M. genitalium is found in 0.7 to 3.3% of women in general populations, while the prevalence in high-risk groups such as sex workers and STD clinic attendees is 7–22% in London [5, 63]. However, M. hominis resides commensally on the mucosal surfaces of the cervix or vagina. It’s colonization values ranges between 20 and 30% around the world [48, 64]. M. hominis was detected in 21–53% of women without genitourinary tract infection and at a lower percentage in the urethra of male [1]. Several studies have proposed that M. hominis is potentially pathogenic and sometimes associated with a variety of disorders including bacterial vaginosis, pyelonephritis, pelvic inflammatory disease, chorioamnionitis, endometritis, preterm birth, low birth, spontaneous abortion, stillbirth, premature birth, postpartum fever, perinatal mortality and infertility overtime [65, 66]. The positive rates of M. hominis, M. genitalium and U. urealyticum are controversial and diverse in the world [67]. Recently, Ghadiri (2019) in Iran (Ahwaz) detected U. urealyticum (28%) and M. hominis (10%) in semen specimens of infertile men by PCR and isolated 22% of U. urealyticum and 2% of M. hominis in the same samples by culture. While, U. urealyticum and M. hominis were detected in 50% & 26% by PCR of endocervical swabs specimens of infertile women and 8% & 4% by culture [68]. Christian Leli (2018) was detected U. urealyticum in 4.7%, M. hominis in 3.4% and M.genitalium in 0% of 232 cervical swab specimens of infertile women by real-time PCR in Italy [69]. Xiaofei Zhu (2016) showed that the prevalence of U. urealyticum and M. hominis were 42.3 and 0.4% among 7374 infertile men by culture [70]. Mahlangu (2019) was determined M. genitalium in 8.9% of urine and 10.6% of endocervical swab specimens which collected from males and females with genital discharge syndrome [71].

Baumann (2017) performed a meta-analysis on prevalence of M. genitalium and found that: the prevalence among women is similar to men and was 1.4% in developed countries and 3.9% in developing countries among general population. He showed that the prevalence among pregnant women were 0.9%, and the prevalence among men who have sex with men in the community was 3.2%, and among female commercial sex workers was 15.9% in the world [72]. Huang performed meta-analysis study (2015) and investigated the association between U. urealyticum, and M. hominis positive rate (5.2% & 14.9%) and risk of male infertility. While the M. genitalium prevalence did not showed any correlation to male infertility [73]. Kasprzykowska (2018) indicated that the prevalence of Ureaplasma spp in women (14.4%) and men (3.9%) is higher than M. hominis in women (0.2%) and men (0.2%) with urogenital tract infection in Poland [74]. Cassell estimated that the U. urealyticum can be found in 40 to 80% of cervicovaginal samples from sexually mature women [74, 75]. Zinzendorf (2008) investigated M. hominis in 23.8% of infertile men in Africa [76]. Taken (2016) could determine M. hominis in 3% of infertile men in Turkey [77]. Abusarah (2013) detected U. urealyticum in 10.8% versus 5.7% and M. genitalium in 3.2% versus 1.4% among infertile and fertile men respectively in Jordan [78]. Jensen indicated M. genitalium in 17% of male patient with urogenital tract infection in Denmark [79]. Al- Sweih (2012) in Kuwait detected M. hominis in 17.1% & 32.4%, M. genitalium in 4.7% & 3.2% and U. urealyticum in 24.4% & 26.1%, among infertile and fertile men respectively [80]. Lee (2013) displayed U.urealyticum in 48% & 25%, M. hominis in 14% & 6.3% of infertile and fertile men, while, U. urealyticum in 40% & 22.9% and M. hominis in 8% & 4.2% of infertile and fertile women in Korea [81]. Andersen reported that the prevalence of infection due to M. genitalium in general population was 2.3% in women and 1.1% in men whereas that was about 19% in men with urethritis and 11% in women with cervicitis in Denmark [82]. Also Grześko indicated M. genitalium from 19.6% of specimens obtained from cervical canal of infertile women, whereas it was 4.4% in control group (women with proven fertility) in Poland [83].

The prevalence rates of Mycoplasma and Ureaplasma are not well established and varies from one study to another. The heterogeneity of prevalence of mycoplasma urinary tract infection in different reports can be probably caused by differences in the geographic areas, the sensitivity of the identification method, the condition of the group (fertile/infertile), other infection accompanied agents, the sample size, and the operator proficiency.

Based on present meta-analysis study the prevalence rates of genital Mycoplasma infection are due to U. urealyticum (17.53%), M. genitalium (11.33%) and M. hominis (9.68%) respectively in Iran which is parallel to Christian Leli (Italy) and Xiaofei (China) results. According to other researcher results, this study shows that the rate of M. genitalium, M. hominis and U. urealyticum infections in women with symptoms of genitourinary tract infection is higher than men with genitourinary tract infection (6.46% Vs 5.4, 7.67% Vs 5.88 and 21.04% Vs 12.13%, respectively). That is in line with kasprzykowska and Mahlangu results. Iranian researches indicated that the prevalence of M. genitalium, U. urealyticum and M. hominis among infertile women (12.73, 19.58 and 10.81%) are higher than fertile women (3%, 10. 85% and 4. 35%), which is similar to Lee (2013) report. However, the prevalence of M. hominis and U. urealyticum in infertile men (14 and 21.18%) is higher than fertile men (4 and 3%), which is like Lee (2013) result.

According to analysis result, the prevalence of M. genitalium, M. hominis and U. urealyticum in Middle provinces is higher than other provinces in Iran. This may be due to the presence of infertility centers and specialized STD clinics in the capital of the country; Tehran. There are some different diagnostic equipment and facilities to research and attract infertile couples for treatment all over Iran.

Conclusions

Based on our meta-analysis, the most common Mycoplasma in Iran, in descending order are: U. urealyticum, M. genitalium, and M. hominis. There is statistically significant relationship between couple infertility and U. urealyticum, M. genitalium and M. hominis infections. There is the higher rate of mycoplasmas infection in women than men and their correlated infertilities.

However, obstetricians should consider mycoplasmas infection as a major agent of infertility. Since mycoplasmas are resistant to common antibiotics and the high prevalence of some mycoplasmas like U. urealyticum, Iranian physicians should be careful in the treatment of genitourinary tract infections to the possible presence of mycoplasmas agent and the sensitive antibiotics.

Further epidemiological and phylogenetic studies in different provinces will be needed to clarify the exact prevalence and distribution pattern of U. urealyticum, M. genitalium and M. hominis in Iran, and proposed routine screening of the pathogens in patients with infertility.

Acknowledgements

We gratefully acknowledge the help provided by Branch Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Mashhad, Iran; and Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Not applicable.

Competing interests

No conflicts of interest are declared.

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Jironkin A, Brown RJ, Underwood A, Chalker VJ, Spiller OB. Genomic determination of minimum multi-locus sequence typing schemas to represent the genomic phylogeny of Mycoplasma hominis. BMC Genomics. 2016;17(1):16.

Bébéar CM, Pereyre S. Infections à « Mycoplasma hominis ». EMC - Mal Infect. 2004;1(1):1–6 Available from: http://linkinghub.elsevier.com/retrieve/pii/S1166859802000807.

Wolf M, Müller T, Dandekar T, Pollack JD. Phylogeny of Firmicutes with special reference to Mycoplasma (Mollicutes) as inferred from phosphoglycerate kinase amino acid sequence data. Int J Syst Evol Microbiol. 2004;54(3):871–5.PubMed

Weisburg WG, Tully JG, Rose DL, Petzel JP, Oyaizu H, Yang D, et al. A phylogenetic analysis of the mycoplasmas: basis for their classification. J Bacteriol. 1989;171(12):6455–67.PubMedPubMedCentral

Lokken E. Recent bacterial vaginosis is associated with the acquisition of Mycoplasma genitalium: University of Washington; ProQuest; 2015.

Zhang S, Tsai S, Wu TT, Li B, Shih JW-K, Lo S-C. Mycoplasma fermentans infection promotes immortalization of human peripheral blood mononuclear cells in culture. Blood. 2004;104(13):4252–9 Available from: http://www.ncbi.nlm.nih.gov/pubmed/15331449%5Cn, http://www.bloodjournal.org/cgi/doi/10.1182/blood-2004-04-1245.PubMed

Hayflick L, Chanock RM. Mycoplasma species of man. Bacteriol Rev. 1965;29(2):185–221.PubMedPubMedCentral

Sweeney EL, Dando SJ, Kallapur SG, Knox CL. The human Ureaplasma species as causative agents of chorioamnionitis. Clin Microbiol Rev. 2017;30(1):349–79.PubMed

Zarei O, Rezania S, Mousavi A. MINI-REVIEW Mycoplasma genitalium and Cancer : a brief review. Asian Pac J Cancer Prev. 2013;14:3425–8.PubMed

10.

Ahmadi MH, Mirsalehian A, Bahador A. Prevalence of Urogenital Mycoplasmas in iran and their effects on fertility potential. Syst Rev Meta-Anal. 2016;45(4):409–22.

11.

Moghadam NM, Kheirkhah B, Mirshekari TR, Harandi F, Tafsiri E. Isolation and molecular identification of Mycoplasma genitalium from the secretion of genital tract in infertile male and female. Iran J Reprod Med. 2014;12(9):601–8.

12.

Haghighi Hasanabad M, Mohammadzadeh M, Bahador A, Fazel N, Rakhshani H, Majnooni A. Prevalence of Chlamydia trachomatis and Mycoplasma genitalium in pregnant women of Sabzevar-Iran. Iran J Microbiol. 2011;3(3):123–8.PubMedPubMedCentral

13.

Jensen JS, Cusini M, Gomberg M, Moi H. Background review for the 2016 European guideline on Mycoplasma genitalium infections. J Eur Acad Dermatology Venereol. 2016;30(10):1686–93 Available from: http://doi.wiley.com/10.1111/jdv.13850.

14.

Moghaddam HE, Kheirkhah B, Amirheidari B. A comparison between the molecular identity of Mycoplasma hominis in urine samples of patients with urinary tract infections and similar strains available in GenBank. J Babol Univ Med Sci. 2015;17(10):67–73.

15.

Manhart LE, Holmes KK, Hughes JP, Houston LS, Totten PA. Mycoplasma genitalium among young adults in the United States: an emerging sexually transmitted infection. Am J Public Health. 2007;97(6):1118–25.PubMedPubMedCentral

16.

Stellrecht KA, Woron AM, Mishrik NG, Venezia RA. Comparison of multiplex PCR assay with culture for detection of genital Mycoplasmas. J Clin Microbiol. 2004;42(4):1528–33.PubMedPubMedCentral

17.

Seifoleslami M, Safari A, Khayyat KM. Prevalence of Ureaplasma urealyticum and Mycoplasma hominis in high vaginal swab samples of infertile females. Iran Red Crescent Med J. 2015;17(12):0–4 Available from: http://ircmj.neoscriber.org/en/articles/16257.html.

18.

Sh NP, Sattari M. Detection of Ureaplasma urealyticum and Mycoplasma hominis in endocervical specimens from infertile women by polymerase chain reaction. Middle East Fertil Soc J. 2006;11(2):104–8 Available from: http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L44788413%5Cn, http://www.bioline.org.br/pdf?mf06020%5Cn, http://bj7rx7bn7b.search.serialssolutions.com?sid=EMBASE&issn=11105690&id=doi:&atitle=Detection+of+Ureaplasma+urealyticum+and+My.

19.

Zeighami H, Sh NP, Safarlu M. Detection of Ureaplasma urealyticum in semen of infertile men by PCR. Pak J Biol Sci. 2007;10(21):3960–3.PubMed

20.

Badami N. Rate of Chlamydia trachomatis, Mycoplasma hominis and Ureaplasma urealyticum in infertile females and control group. Iran J Publ Heal. 2001;30(1–2):57–60.

21.

Salari MH. Prevalence of Ureaplasma urealyticum and Mycoplasma genitalium in men with non-gonococcal urethritis. East Mediterr Heal J. 2003;9(3):291–5.

22.

Ale YA. Comparison of PCR with culture for detection of Mycoplasma hominis in infertile women. Kowsar Med J. 2005;10(3):183–90.

23.

Peerayeh SN, Mirdamadi R. Comparison of culture with polymerase chain reaction for detection of Ureaplasma urealyticum in endocervical specimens. Med J Islam Repub Iran. 2005;19(2):175–9.

24.

Golshani M, Eslami G, Mohhammadzadeh Ghobadloo S, Fallah F, Goudarzi H, Soleimani Rahbar AA, et al. Detection of Chlamydia trachomatis, mycoplasma hominis and Ureaplasma urealyticum by multiplex PCR in semen sample of infertile men. Iran J Public Health. 2007;36(2):50–7.

25.

Soleimani Rahbar A, Golshani M, Fayyaz F, Rafiee Tabatabaei SMA. Detection of Mycoplasma DNA from the sperm specimens of infertile men by PCR. Iran J Med Microbiol. 2007;1(1):47–53.

26.

Najar Peerayeh S. Samimi R. Detection of Ureaplasma urealyticum in clinical samples from infertile women by polymerase chain reaction. Iran J Pharmacol Ther. 2007;6(1):23–6 Available from: http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L351727895%5Cn, http://ijpt.iums.ac.ir/index.php/ijpt/article/view/418/247%5Cn, http://bj7rx7bn7b.search.serialssolutions.com?sid=EMBASE&issn=17352657&id=doi:&atitle=Detection+of+Ureapla.

27.

Peerayeh SN, Samimi R. Comparison of culture with the polymerase chain reaction for detection of genital mycoplasma. Eur J Gen Med. 2008;5(2):107–11 Available from: http://www.ejgm.org/index.php/EJGM/article/view/52/21.

28.

Ghazisaidi K, Fateminasab F. Prostatic massage method versus first -void urine samples to isolate Mycoplasma hominis and Ureaplasma urealyticum from urinary tract infection. Spring Summer. 2008;2(1):69.

29.

Sh NP, Yazdi RS, Zeighami H. Association of Ureaplasma urealyticum infection with Varicocele-related infertility. J Infect Dev Ctries. 2008;2(2):116–9.

30.

Amirmozafari N, Mirnejad R, Kazemi B, Sariri E. Comparison of polymerase chain reaction and culture for detection of genital mycoplasma in clinical samples from patients with genital infections. Saudi Med J. 2009;30(11):1401–5.PubMed

31.

Ahmadi MH, Amirmozafari N, Kazemi B, Gilani MAS, Jazi FM. Use of PCR to detect Mycoplasma hominis and Ureaplasma urealyticum from semen samples of infertile men who referred to royan institute in 2009. Yakhteh Med J. 2010;12(3):371–80 Available from: http://www.scopus.com/inward/record.url?eid=2-s2.0-78650502633&partnerID=tZOtx3y1.

32.

Mirnejad R, Amirmozafari N, Kazemi B. Simultaneous and rapid differential diagnosis of Mycoplasma genitalium and Ureaplasma urealyticum based on a polymerase chain reaction-restriction fragment length polymorphism. Indian J Med Microbiol. 2011;29:33–6.PubMed

33.

Hasanabad MH, Mohammadzadeh M, Bahador A, Fazel N, Rakhshani H, Majnooni A. Prevalence of Chlamydia trachomatis and Mycoplasma genitalium in pregnant women of Sabzevar-Iran. Iran J Microbiol. 2011;3(3):123–8 Available from: http://journals.tums.ac.ir/upload_files/pdf/_/19951.pdf.

34.

Moosavian SM, Motamedi H, Maleki S, Shahbazian N. Comparison between prevalence of Mycoplasma Hominis and Ureaplasma urealyticum in women with urogenital infections by multiplex PCR and culture methods. Med J Tab Univ Med Sci. 2011;33(5):33.

35.

Vosooghi S, Karimi B, Kheirkhah B, Mirshekari T. Molecular detection of Mycoplasma hominis from genital secretions of infertile men referred to the Kerman infertility center. J Microb World. 2013;6(1):14–22.

36.

Irajian GR, Mirnejad R, Jalili Nidishan MR. Determing the prevalence rate of Mycoplasma genitalium in patients with prostatitis by PCR-RFLP technique. J Ardabil Univ Med Sci. 2013;13(1):86–92.

37.

Maleki S, Motamedi H, Moosavian SM, Shahbaziyan N. Frequency of Mycoplasma hominis and Ureaplasma urealyticum in females with urogenital infections and habitual abortion history in Ahvaz, Iran; using multiplex PCR. Jundishapur J Microbiol. 2013;6(6):e10088.

38.

Yeganeh O, Jeddi-Tehrani M, Yaghmaie F, Kamali K, Heidari-Vala H, Zeraati H, et al. A survey on the prevalence of Chlamydia trachomatis and Mycoplasma genitalium infections in symptomatic and asymptomatic men referring to urology clinic of labbafinejad hospital, Tehran, Iran. Iran Red Crescent Med J. 2013;15(4):340–4.PubMedPubMedCentral

39.

Sadrpour P, Bahador A, Abbas S, Bagheri R, Chamani-Tabriz L. Detection of Chlamydia trachomatis and Mycoplasma genitaliumin semen samples of infertile men using multiplex PC. Tehran Univ Med J. 2013;70(10):623–9.

40.

Mohseni R, Sadeghi F, Mirinargesi M. A study on the frequency of vaginal species of Mycoplasma genitalium, Gardnerella vaginalisand Neisseria gonorrhoeaeamong pregnant women by PCR technique. Int J Mol Clin Microbiol. 2013;1(3):231–6.

41.

Ahmadi A, Khodabandehloo M, Ramazanzadeh R, Farhadifar F, Nikkhoo B, Soofizade N, et al. Association between Ureaplasma urealyticum endocervical infection and spontaneous abortion. Iran J Microbiol. 2014;6(6):392–7.PubMedPubMedCentral

42.

Mousavi A, Farhadifar F, Mirnejad R, Ramazanzadeh R. Detection of genital mycoplasma infections among infertile females by multiplex PCR. Iran J Microbiol. 2014;6(6):398–403.PubMedPubMedCentral

43.

Jamalizadeh Bahaabadi S, Mohseni Moghadam N, Kheirkhah B, Farsinejad A, Habibzadeh V. Isolation and molecular identification of Mycoplasma hominis in infertile female and male reproductive system. Nephrourol Mon. 2014;6(6):e22390 Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4330675&tool=pmcentrez&rendertype=abstract.PubMedPubMedCentral

44.

Sobouti B, Fallah S, Mobayen M, Noorbakhsh S, Ghavami Y. Colonization of Mycoplasma hominis and Ureaplasma urealyticum in pregnant women and their transmission to offspring. Iran J Microbiol. 2014;6(4):219–24.PubMedPubMedCentral

45.

Dadashi M, Eslami G, Ghalavand Z, Goudarzi H, Fallah F, Owlia P. Prevalence of Chlamydia trachomatis and Mycoplasma genitalium in patients with Benign and malignant ovarian cancer by nested PCR method. Novel Biomed. 2016;4(1):18–23.

46.

Eslami G, Goudarzi H, Baseri N, Ghalavand Z, Taherpour A, Zhaam H. The prevalence of Ureaplasma urealyticum and Mycoplasma genitalium in patients with prostate cancer in Shohada Hospital in Tehran, Iran. Novel Biomed. 2015;3(2):73–8.

47.

Safavifar F, Bandehpour M, Hosseiny SJ, Khorramizadeh MR. Mycoplasma infection in Pyospermic infertile and healthy fertile men. Nov Biomed. 2015;3(1):25–9.

48.

Safari M, Bakhshi A, Erami M, Kheirkhah B, Pourbakhsh A, Pourbabei H. Sequences of Mycoplasma hominis in patients with urinary tract infection in a Hospital in Kashan, Iran. Res J Microbiol. 2015;10(6):260–9 Available from: http://www.scialert.net/abstract/?doi=jm.2015.260.269.

49.

Ramazanzadeh R, Khodabandehloo M, Farhadifar F, Rouhi S, Ahmadi A, Menbari S, et al. A case–control study on the relationship between Mycoplasma genitalium infection in women with Normal pregnancy and spontaneous abortion using polymerase chain reaction. Osong Public Heal Res Perspect. 2016;7(5):334–8 Available from: https://doi.org/10.1016/j.phrp.2016.07.001.

50.

Ahmadi MH, Mirsalehian A, Sadighi Gilani MA, Bahador A, Talebi M. Asymptomatic infection with Mycoplasma hominis negatively affects semen parameters and leads to male infertility as confirmed by improved semen parameters after antibiotic treatment. Urology. 2017;100:97–102 Available from: https://doi.org/10.1016/j.urology.2016.11.018.PubMed

51.

Bahrami H, Farivar TN, Aslanimehr M, Peymani A, Dabaghi T, Ghaleh T, et al. Prevalence of Ureaplasma urealyticum in Endocervical Specimens of Female Patients in Qazvin, Iran. BiotechHealth Sci. 2016;3(4):e39599.

52.

Asgari A, Nazari R, Mohammad S, Razavian H. Investigation of frequency of Mycoplasma hominis and biological parameters in semen sample of men referred to Qom Jahad Daneshgahi infertility treatment center in 2016. Qom Univ Med Sci J. 2018;12(4):81–8.

53.

Irajian G, Sharifi M, Mirkalantari S, Mirnejad R, Jalali Nadoushan MR. Molecular detection of Ureaplasma urealyticum from prostate tissues using PCR-RFLP, Tehran, Iran. Iran J Pathol. 2016;11(2):138–43.PubMedPubMedCentral

54.

Sameni F, Zadehmodarres S, Dabiri H. Prevalence of Chlamydia Trachomatis , Mycoplasma genitalium and Neisseria gonorrhea in infertile females referred to Mahdieh hospital in Tehran. Iran J Med Microbiol. 2017;11(5):90–7.

55.

Javadinia S, Movahedi Z, Shokrollahi MR, Naghdalipour M, Tabatabaee A, Asgarian R, et al. Prevalence of Mycoplasma genitalium and Ureaplasma urealyticum in pregnant women of Tehran by duplex PCR. Curr Pediatr Res. 2017;21(4):680–5.

56.

Golkhatmi Mokari A, Farsiani H, Goshayeshi L, Radmanesh H, Jamehdar AS. Development of PCR-ELISA for specific and sensitive detection of Mycoplasma genitalium. Clin Microbiol. 2017;6(1):1.

57.

Moradi F, Yousefi MR. Comparison of PCR and culture methods to determine the prevalence of Mycoplasma hominis in woman’s endocervical samples referred to Infertility Center of Hamadan Fatemieh Hospital in 2016. IJOGI. 2018;20(11):83–92.

58.

Cabral SLI. Genetic variation in Mycoplasma genitalium. In: Antigenic diversity and persistence of infection within a genomically challenged pathogen. ProQuest; 2008.

59.

Cazanave C, Charron A, Renaudin H, Bébéar C. Method comparison for molecular typing of French and Tunisian Mycoplasma genitalium-positive specimens. J Med Microbiol. 2012;61(4):500–6.PubMed

60.

Jensen JS, Cusini M, Gomberg M, Moi H. 2016 European guideline on Mycoplasma genitalium infections. J Eur Acad Dermatol Venereol. 2016;30(10):1650–6.PubMed

61.

Horner PJ, Blee K, Falk L, van der Meijden W, Moi H. European guideline on the management of non-gonococcal urethritis. Int J STD AIDS. 2016;27(11):928.PubMed

62.

Munoz JL, Goje OJ. Mycoplasma genitalium: an emerging sexually transmitted infection. Scientifica (Cairo). 2012;2016(December):942–55 Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019115353&doi=10.1155%2F2016%2F7537318&partnerID=40&md5=61dfd6c5e393f35d2bef0d22667a9056.

63.

Oakeshott P, Aghaizu A, Hay P, Reid F, Kerry S, Atherton H, et al. Is Mycoplasma genitalium in women the “new chlamydia?” a community-based prospective cohort study. Clin Infect Dis. 2010;51(10):1160–6.PubMed

64.

Lee MY, Kim MH, Lee WI, Kang SY, La JY. Prevalence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma urealyticum in pregnant women. Int J Infect Dis. 2010;57(14):e90–5 Available from: https://doi.org/10.1016/j.ijid.2009.03.020.

65.

Taylor-Robinson D. Infections due to species of Mycoplasma and Ureaplasma: an update. Clin Infect Dis. 1996;23(4):671–84.PubMed

66.

Embree JE, Embil JA. Mycoplasmas in diseases of humans. Can Med Assoc J. 1980;123(2):105–11 Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1704661/%0A, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1704661/pdf/canmedaj01462-0025.pdf.PubMedPubMedCentral

67.

Ghorbanalinezhad E, Amirmozafari N, Khavari-nejad R, Sepahi AA. International journal of molecular and clinical microbiology survey on the genital mycoplasmosis by multiplex PCR, vol. 2; 2014. p. 451–6.

68.

Ghadiri A, Ahmadi K, Rashno M, Moosavian M, Afzali M, Amirzadeh S. Investigating Chlamydia trachomatis and genital Mycoplasma prevalence and apoptosis markers in infertile and fertile couples. Jundishapur J Microbiol. 2019;12(1):1–7.

69.

Leli C, Mencacci A, Latino MA, Clerici P, Rassu M, Perito S, et al. Prevalence of cervical colonization by Ureaplasma parvum, Ureaplasma urealyticum, Mycoplasma hominis and Mycoplasma genitalium in childbearing age women by a commercially available multiplex real-time PCR: an Italian observational multicentre study. J Microbiol Immunol Infect. 2018;51(2):220–5 Available from: https://doi.org/10.1016/j.jmii.2017.05.004.PubMed

70.

Zhu X, Li M, Cao H, Yang X, Zhang C. Epidemiology of Ureaplasma urealyticum and Mycoplasma hominis in the semen of male outpatients with reproductive disorders. Exp Ther Med. 2016;12(2):1165–70.PubMedPubMedCentral

71.

Mahlangu MP, Müller EE, Venter JME, Maseko DV, Kularatne RS. The prevalence of Mycoplasma genitalium and association with human immunodeficiency virus infection in symptomatic patients, Johannesburg, South Africa, 2007–2014. Sex Transm Dis. 2019;46(6):395–9.PubMedPubMedCentral

72.

Baumann L, Cina M, Egli-Gany D, Goutaki M, Halbeisen FS, Lohrer GR, et al. Prevalence of Mycoplasma genitalium in different population groups: systematic review andmeta-analysis. Sex Transm Infect. 2018;94(4):255–62.PubMedPubMedCentral

73.

Huang C, Zhu HL, Xu KR, Wang SY, Fan LQ, Zhu WB. Mycoplasma and ureaplasma infection and male infertility: a systematic review and meta-analysis. Andrology. 2015;3(5):809–16.PubMed

74.

Kasprzykowska U, Sobieszczańska B, Duda-Madej A, Secewicz A, Nowicka J, Gościniak G. A twelve–year retrospective analysis of prevalence and antimicrobial susceptibility patterns of Ureaplasma spp. and Mycoplasma hominis in the province of lower Silesia in Poland. Eur J Obstet Gynecol Reprod Biol. 2018;220:44–9.PubMed

75.

Cassell GH, Waites KB, Watson HL, Crouse DT, Harasawa R. Ureaplasma urealyticum intrauterine infection: role in prematurity and disease in newborns. Clin Microbiol Rev. 1993;6(1):69–87.PubMedPubMedCentral

76.

Zinzendorf NY, Kouassi-Agbessi BT, Lathro JS, Don C, Kouadio L, Loukou YG. Ureaplasma urealyticum or Mycoplasma hominis infections and semen quality of infertile men in Abidjan. J Reprod Contracept. 2008;19(2):65–72.

77.

Taken K. Prevalence of Ureaplasma and Mycoplasma in infertile men in Van region and effects to semen parameters. J Clin Anal Med [Internet]. 2016;7(3):4–7 Available from: http://www.jcam.com.tr/files/KATD-2668.pdf.

78.

Abusarah EA, Awwad ZM, Charvalos E, Shehabi AA. Molecular detection of potential sexually transmitted pathogens in semen and urine specimens of infertile and fertile males. Diagn Microbiol Infect Dis. 2013;77(4):283–6 Available from: https://doi.org/10.1016/j.diagmicrobio.2013.05.018.PubMed

79.

Jensen JS, Hansen HT, Seruminstitut S. S D-C. isolation of Mycoplasma genitalium strains from the male urethra. Microbiology. 1996;34(2):286–91.

80.

Al-Sweih NA, Al-Fadli AH, Omu AE, Rotimi VO. Prevalence of Chlamydia trachomatis, Mycoplasma hominis, Mycoplasma genitalium, and Ureaplasma urealyticum infections and seminal quality in infertile and fertile men in Kuwait. J Androl. 2012;33:1323–9.PubMed

81.

Lee JS, Kim KT, Lee HS, Yang KM, Seo JT, Choe JH. Concordance of Ureaplasma urealyticum and Mycoplasma hominis in infertile couples: impact on semen parameters. Urology. 2013;81(6):1219–24 Available from: https://doi.org/10.1016/j.urology.2013.02.044.PubMed

82.

Andersen B, Sokolowski I, Østergaard L, Kjølseth Møller J, Olesen F, Jensen JS. Mycoplasma genitalium: prevalence and behavioural risk factors in the general population. Sex Transm Infect. 2007;83(3):237–41 Available from: http://sti.bmj.com/cgi/doi/10.1136/sti.2006.022970%0A, http://www.ncbi.nlm.nih.gov/pubmed/17090566%0A, http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC2659104.PubMed

83.

Grześko J, Elias M, Maczyńska B, Kasprzykowska U, Tłaczała M, Goluda M. Occurrence of Mycoplasma genitalium in fertile and infertile women. Fertil Steril. 2009;91(6):2376–80.PubMed

Titel: Epidemiology of genital infections caused by Mycoplasma hominis, M. genitalium and Ureaplasma urealyticum in Iran; a systematic review and meta-analysis study (2000–2019)
verfasst von: Khadijeh Moridi
Mohammad Hemmaty
Amir Azimian
Mohammad Hosein Fallah
Hamid Khaneghahi Abyaneh
Kiarash Ghazvini
Publikationsdatum: 01.12.2020
Verlag: BioMed Central
Erschienen in: BMC Public Health / Ausgabe 1/2020
Elektronische ISSN: 1471-2458
DOI: https://doi.org/10.1186/s12889-020-08962-5

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Epidemiology of genital infections caused by Mycoplasma hominis, M. genitalium and Ureaplasma urealyticum in Iran; a systematic review and meta-analysis study (2000–2019)

Abstract

Background

Methods

Results

Conclusions

Publisher’s Note

Background

Methods

Search strategy

Inclusion and exclusion criteria

Data extraction

Analytic approach

Results

Description of included and excluded studies

Prevalence of M. genitalium

Prevalence of M. hominis

Prevalence of U. urealyticum

Geographical distribution of M. hominis, M. genitalium and U. urealyticum in Iran

Analytical method

Discussion

Conclusions

Acknowledgements

Competing interests

Publisher’s Note

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Background

Methods

Results

Conclusions

Publisher’s Note

Background

Methods

Search strategy

Inclusion and exclusion criteria

Data extraction

Analytic approach

Results

Description of included and excluded studies

Prevalence of M. genitalium

Prevalence of M. hominis

Prevalence of U. urealyticum

Geographical distribution of M. hominis, M. genitalium and U. urealyticum in Iran

Analytical method

Discussion

Conclusions

Acknowledgements

Ethics approval and consent to participate

Consent for publication

Competing interests

Publisher’s Note

Weitere Artikel der Ausgabe 1/2020

Patterns of access to reproductive health services in Ghana and Nigeria: results of a cluster analysis

Dropout at Danish vocational schools: does the school’s health promotion capacity play a role? A survey- and register-based prospective study

Mental health literacy in a diverse sample of undergraduate students: demographic, psychological, and academic correlates

Assessment and prioritization of the WHO “best buys” and other recommended interventions for the prevention and control of non-communicable diseases in Iran

The development of a questionnaire to assess leisure time screen-based media use and its proximal correlates in children (SCREENS-Q)

Hygiene programming during outbreaks: a qualitative case study of the humanitarian response during the Ebola outbreak in Liberia