Background
Methods
Subjects
Procedures
Outcomes
Sample size and statistics
Results
Characteristic | Total No. (%) | Cohort 1 | Cohort 2 |
---|---|---|---|
Patient Characteristics | n = 30 | n = 20 | n = 10 |
Male | 19 (63.3%) | 14 (70.0%) | 5 (50.0%) |
Age in Years | |||
8–12 | 10 (33.3%) | 8 (40.0%) | 2 (20.0%) |
13–18 | 20 (66.7%) | 12 (60.0%) | 8 (80.0%) |
White | 17 (56.7%) | 9 (45.0%) | 8 (80.0%) |
Diagnosis | |||
Leukemia | 11 (36.7%) | 9 (45.0%) | 2 (20.0%) |
Lymphoma | 7 (23.3%) | 3 (15.0%) | 4 (40.0%) |
Solid tumor | 7 (23.3%) | 4 (20.0%) | 3 (30.0%) |
Brain tumor | 5 (16.7%) | 4 (20.0%) | 1 (10.0%) |
Metastatic Disease | 9 (30.0%) | 5 (25.0%) | 4 (40.0%) |
Relapse | 2 (6.7%) | 2 (10%) | 0 (0%) |
Treatments Received | |||
Chemotherapy | 29 (96.7%) | 19 (95.0%) | 10 (100.0%) |
Surgery | 1 (3.3%) | 0 (0.0%) | 1 (10.0%) |
Radiotherapy | 1 (3.3%) | 0 (0.0%) | 1 (10.0%) |
Stem cell transplantation | 2 (6.7%) | 2 (10%) | 0 (0%) |
Inpatient at Enrollment | 8 (26.7%) | 5 (25.0%) | 3 (30.0%) |
Date of Diagnosis | |||
< 6 months before enrollment | 20 (66.7%) | 10 (50%) | 10 (100%) |
6 to 12 months before enrollment | 5 (16.7%) | 5 (25%) | 0 (0%) |
> 12 months before enrollment | 5 (16.7%) | 5 (25.0%) | 0 (0%) |
English as First Language | 24 (80.0%) | 15 (75.0%) | 9 (90.0%) |
Other Languages Spoken | |||
French | 3 (10%) | 2 (10%) | 1 (10%) |
Tamil | 3 (10%) | 2 (10%) | 1 (10%) |
Other* | 8 (26.7%) | 7 (35%) | 1 (10%) |
Challenge | Intervention |
---|---|
Patient less invested in study than parent Patient unwilling to complete SSPedi on their own | Engage parent to enable pediatric patient self-reporting of symptoms by: • Present the option to have parent receive reminders in addition to the patient • Parent can sign-in to SPARK on behalf of the patient and hand the device to the patient to self-report symptoms using SSPedi |
Patient and parent forgetting SPARK username and password | Encourage patient and parent use the following to remember the SPARK username and password: • Take a picture of the reminder information sheet (includes their username and password) using their device (such as smart phone) • Write down their username and password in their device • Save their username and password on their device |
Patient and parent unaware of potential benefits of study | Highlight to patient and parent that the primary healthcare team will receive a SSPedi report by email if the patient reports at least one symptom that is “a lot” or “extremely” bothersome • Inform patient and parent at point of study introduction • Remind patient and parent at week 4 time point |
Patient and parent unclear on how to use the SPARK platform on their own device | Train patient and parent together to use SPARK on their own device • Have patient or parent navigate to the SPARK website on their own device • Suggest patient or parent bookmark SPARK website on their own device |
Baseline | Week 4 | Week 8 | |
---|---|---|---|
n = 30 | n = 29 | n = 28 | |
SSPedi Outcome Scores | |||
Median SSPedi score (IQR) | 10 (6 to 12) | 5 (3 to 12) | 6 (2 to 11) |
Median Minutes to Complete (IQR) | 1.6 (1.4 to 2.0) | 0.9 (0.8 to 1.7) | 1.0 (0.5 to 1.2) |
Number Severely Bothersome (%)* | |||
Any symptom | 14 (46.7%) | 7 (24.1%) | 4 (14.3%) |
Feeling disappointed or sad | 1 (3.3%) | 0 (0.0%) | 1 (3.6%) |
Feeling scared or worried | 1 (3.3%) | 1 (3.4%) | 0 (0.0%) |
Feeling cranky or angry | 0 (0.0%) | 1 (3.4%) | 0 (0.0%) |
Problems with thinking or remembering things | 1 (3.3%) | 0 (0.0%) | 0 (0.0%) |
Changes in how your body or face look | 2 (6.7%) | 0 (0.0%) | 1 (3.6%) |
Feeling tired | 5 (16.7%) | 4 (13.8%) | 0 (0.0%) |
Mouth sores | 3 (10%) | 1 (3.4%) | 0 (0.0%) |
Headache | 1 (3.3%) | 2 (6.9%) | 0 (0.0%) |
Hurt or pain (other than headache) | 1 (3.3%) | 0 (0.0%) | 0 (0.0%) |
Tingly or numb hands or feet | 1 (3.3%) | 1 (3.4%) | 1 (3.6%) |
Throwing up or feeling like you may throw up | 2 (6.7%) | 2 (6.9%) | 2 (7.1%) |
Feeling more or less hungry than you usually do | 5 (16.7%) | 1 (3.4%) | 1 (3.6%) |
Changes in taste | 1 (3.3%) | 0 (0.0%) | 0 (0.0%) |
Constipation (hard to poop) | 0 (0.0%) | 1 (3.4%) | 0 (0.0%) |
Diarrhea (watery, runny poop) | 0 (0.0%) | 0 (0.0%) | 1 (3.6%) |
Patient-Reported Outcome Scores | |||
Median PROMIS fatigue scale (IQR) | 56.2 (50.7 to 59.9) | 53.4 (45.1 to 58.5) | 47.7 (41.7 to 54.0) |
Median Total PedsQL 3.0 Acute Cancer Module Score (IQR) | 70.8 (58.1 to 77.8) | 74.1 (59.3 to 80.1) | 71.8 (59.5 to 86.1) |
Pain and hurt | 81.3 (62.5 to 87.5) | 75.0 (62.5 to 100.0) | 87.5 (75.0 to 100.0) |
Nausea | 70.0 (56.3 to 80.0) | 75.0 (60.0 to 85.0) | 75.0 (55.0 to 90.0) |
Procedural anxiety | 66.7 (33.3 to 91.7) | 66.7 (50.0 to 91.7) | 70.8 (50.0 to 91.7) |
Treatment anxiety | 87.5 (66.7 to 100.0) | 83.3 (66.7 to 100.0) | 91.7 (64.6 to 100.0) |
Worry | 66.7 (50.0 to 83.3) | 66.7 (50.0 to 83.3) | 66.7 (56.3 to 91.7) |
Cognitive Problems | 65.0 (50.0 to 80.0) | 70.0 (50.0 to 85.0) | 70.0 (53.8 to 85.0) |
Communication | 75.0 (66.7 to 91.7) | 66.7 (58.3 to 91.7) | 79.2 (66.7 to 91.7) |
Perceived physical appearance | 75.0 (58.3 to 91.7) | 91.7 (58.3 to 100.0) | 91.7 (58.3 to 100.0) |
Week 4 | Week 8 | |
---|---|---|
n = 29 | n = 29 | |
Number Patients with Symptom Documentation (%) | ||
Feeling disappointed or sad | 1 (3.4%) | 1 (3.4%) |
Feeling scared or worried | 2 (6.9%) | 4 (13.8%) |
Feeling cranky or angry | 1 (3.4%) | 1 (3.4%) |
Problems with thinking or remembering things | 0 (0.0%) | 2 (6.9%) |
Changes in how your body or face look | 0 (0.0%) | 0 (0.0%) |
Feeling tired | 6 (20.7%) | 5 (17.2%) |
Mouth sores | 0 (0.0%) | 0 (0.0%) |
Headache | 2 (6.9%) | 1 (3.4%) |
Hurt or pain (other than headache) | 9 (31.0%) | 6 (20.7%) |
Tingly or numb hands or feet | 2 (6.9%) | 3 (10.3%) |
Throwing up or feeling like you may throw up | 7 (24.1%) | 5 (17.2%) |
Feeling more or less hungry than you usually do | 3 (10.3%) | 3 (10.3%) |
Changes in taste | 0 (0.0%) | 0 (0.0%) |
Constipation (hard to poop) | 1 (3.4%) | 0 (0.0%) |
Diarrhea (watery, runny poop) | 0 (0.0%) | 3 (10.3%) |
Number Patients with Symptom Intervention (%) | ||
Feeling disappointed or sad | 2 (6.9%) | 3 (10.3%) |
Feeling scared or worried | 2 (6.9%) | 3 (10.3%) |
Feeling cranky or angry | 2 (6.9%) | 3 (10.3%) |
Problems with thinking or remembering things | 1 (3.4%) | 2 (6.9%) |
Changes in how your body or face look | 0 (0.0%) | 0 (0.0%) |
Feeling tired | 0 (0.0%) | 0 (0.0%) |
Mouth sores | 1 (3.4%) | 2 (6.9%) |
Headache | 7 (24.1%) | 4 (13.8%) |
Hurt or pain (other than headache) | 11 (37.9%) | 7 (24.1%) |
Tingly or numb hands or feet | 3 (10.3%) | 2 (6.9%) |
Throwing up or feeling like you may throw up | 17 (58.6%) | 12 (41.4%) |
Feeling more or less hungry than you usually do | 0 (0.0%) | 0 (0.0%) |
Changes in taste | 0 (0.0%) | 0 (0.0%) |
Constipation (hard to poop) | 6 (20.7%) | 3 (10.3%) |
Diarrhea (watery, runny poop) | 0 (0.0%) | 0 (0.0%) |