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Erschienen in: Clinical Hypertension 1/2023

Open Access 01.12.2023 | Review

Fok I and Bsm I gene polymorphism of vitamin D receptor and essential hypertension: a mechanistic link

verfasst von: Richa Awasthi, Priyanka Thapa Manger, Rajesh Kumar Khare

Erschienen in: Clinical Hypertension | Ausgabe 1/2023

Abstract

The vitamin D receptor (VDR) gene serves as a good candidate gene for susceptibility to essential hypertension. The gene regulates the renin angiotensin system by influencing blood pressure regulation. Around 3% of the human genome is regulated by the vitamin D endocrine system. Several studies have reported mixed results with respect to relationship of VDR gene and hypertension. Observational evidence supports the concept that vitamin D plays a role in the pathogenesis of cardiovascular disease and arterial hypertension which is further supported by meta-analysis and case control studies reporting how VDR polymorphism leads to the onset and development of hypertension. In this review, we summarize the existing literature on the link between VDR and hypertension, including mechanistic studies, observational data, and clinical trials showing relationship of vitamin D level and hypertension with a focus on recent findings related to genetic studies that showed the relationship of VDR gene polymorphism with vitamin D level in hypertensive and normotensive groups. As a result, determining the association of VDR polymorphisms with essential hypertension is expected to aid in the risk assessment for the condition.
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Abkürzungen
1,25(OH)2D3
1,25-Dihydroxyvitamin D
25(OH)D
25-Hydroxyvitamin D
AC
Adenylate cyclase
BP
Blood pressure
CAD
Coronary artery disease
cAMP
Cyclic adenosine monophosphate
CBP
Cyclic adenosine monophosphate binding protein
CI
Confidence interval
CRE
Cyclic adenosine monophosphate response element
CREB
Cyclic adenosine monophosphate dependent response element binding protein
CREM
Cyclic adenosine monophosphate response element modulator
CVD
Cardiovascular disease
DBP
Diastolic blood pressure
DM
Diabetes mellitus
s
Gs protein α subunit
GDM
Gestational diabetes mellitus
GH
Gestational hypertension
GWAS
Genome-wide association studies
HR
Hazard ratio
mRNA
Messenger RNA
OHase
Hydroxylase
OR
Odds ratio
P
Phosphate
PKA
Protein kinase A
Pol
Polymerase
RA
Rheumatoid arthritis
RAAS
Renin-angiotensin-aldosterone system
RXR
Retinoid X receptor
SBP
Systolic blood pressure
SNP
Single nucleotide polymorphism
UTR
untranslated region
VDR
Vitamin D receptor

Introduction

Hypertension is a global public health problem with high morbidity and mortality. According to the World Health Organization, one in every three adults worldwide has high blood pressure (BP), which accounts for approximately half of all deaths from cardiac disease and stroke [1]. Hypertension is expected to be 60% more prevalent worldwide by 2025, affecting 1.56 billion people [2]. It is predicted that over 90% of patients with high BP have primary hypertension [3]. Primary hypertension is a polygenic disease caused by the interaction of genetic and environmental factors [4]. Although primary hypertension cannot be cured, it can be managed with appropriate therapy (including lifestyle modifications and medications) [5].
Multiple factors that control BP contribute to developing primary hypertension. The two primary factors include problems in either hormonal (natriuretic hormone, renin-angiotensin-aldosterone system [RAAS]) mechanisms or disturbances in electrolytes (sodium, chloride, potassium). Natriuretic hormone causes an increase in sodium concentrations in cells, which causes BP to rise. The RAAS regulates sodium, potassium, and blood volume, which in turn regulates arterial BP. Angiotensin II and aldosterone are two hormones involved in the RAAS. Angiotensin II causes blood vessel narrowing, increases the release of chemicals that raise BP, and increases aldosterone production. Aldosterone maintains sodium and water levels in the blood. As a result, there is more blood, which puts more pressure on the heart and raises BP [3]. Meanwhile, evidence suggests that genetic factors may play an important role in the development of primary hypertension [1]. It has been estimated that the heritability of hypertension ranges from 31 to 68%. Genome-wide association studies (GWAS) in several multinational cohorts have identified a large number of single nucleotide polymorphisms (SNPs) associated with hypertension [6].
Prospective studies showed that subjects with low vitamin D level was three times more likely to have hypertension than those with high vitamin D concentrations and also suggested that vitamin D receptor (VDR) polymorphism is associated with hypertension [7]. Since the VDR is widely distributed in vascular endothelial cells, vascular smooth muscle cells and cardiomyocytes, the role of vitamin D and VDR in hypertension has received extensive attention [1].

Vitamin D and vitamin D receptor

Vitamin D is a group of fat-soluble molecules, and the most important of which are vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). A large amount of vitamin D is converted to vitamin D3 from 7-dehydrocholesterol after exposure to ultraviolet B in the skin. Furthermore, just 10 to 20% of vitamin D comes from the diet as vitamin D2 or vitamin D3 [8]. Foods rich in vitamin D are mainly cod-liver oil, fish, animal liver, eggs, and fortified milk [1].
After entering the body, vitamin D is hydroxylated in the liver to 25-hydroxyvitamin D (25(OH)D, calcidiol), which is the major circulating form of vitamin D and is used to assess overall vitamin D status. The kidney converts 25(OH)D to its bioactive form, 1,25-dihydroxyvitamin D (1,25(OH)2D3, calcitriol), which has much stronger specificity with VDR and is responsible for the majority of vitamin D metabolic actions [9].
VDR is a nuclear receptor protein that has a high affinity and specificity for binding to vitamin D3 (a form of vitamin D). When occupied by vitamin D3, VDR is phosphorylated, resulting in a change in surface conformation. The activated VDR then binds to the retinoid X receptor (RXR) to form a heterodimer that binds to vitamin D-responsive elements in the gene promoter region [10]. Activated VDR/RXR regulates the transcription of genes encoding proteins that perform traditional and nontraditional D3 functions such as maintaining musculoskeletal health, calcium homeostasis, normal BP, and cardiovascular function by recruiting complexes of either coactivators or corepressors [11]. Surprisingly, liganded 1,25(OH)2D3-VDR can interact directly with cyclic adenosine monophosphate (cAMP) dependent response element (CRE) binding protein (CREB), blunting its binding to CRE. These activities appear to be carried out in the absence of liganded-VDR heterodimerization with RXR. As a result, the expression of specific target genes will be regulated, facilitating the synthesis of vitamin D-regulated proteins (Fig. 1) [12, 13].
Human VDR is encoded by a single gene on chromosome 12 at 12q12–14. By modulating the expression of target genes, this protein mediates the pleiotropic effects of 1,25(OH)2D3 [14]. 1,25(OH)2D3 is a negative endocrine-regulating hormone in the RAAS that acts by inhibiting renin messenger RNA (mRNA) expression regardless of calcium metabolism, which is involved in bone function. Biological activities of vitamin D are mediated by binding to the VDR, where SNPs can cause changes in arterial BP and contribute to the onset of hypertension [15]. In recent decades, it has been found VDR exists in almost all human cells and modulates about 3% of human genes by activating a transcription of target gene. So, more and more attention has been paid to the role of vitamin D in non-skeletal diseases, including diabetes mellitus, autoimmune disease, hypertension, and cardiovascular disease (CVD).
The genes that control vitamin D levels are thought to be responsible for 30 to 50% of BP fluctuations [13]. Identifying the genes that control vitamin D levels in essential hypertension may thus provide a better factor in determining the disease molecular pathogenesis.
The RAAS is critical in the physiologic regulation of sodium and potassium balance, intravascular volume, and BP [16]. It is now well established that excessive RAAS activity increases the risk of cardiovascular disease, which can be reduced by inhibiting or blocking the RAAS [17].

Renin-angiotensin-aldosterone system

Increased activation of the RAAS, which is a key regulator of electrolyte and volume homeostasis, contributes to the development of arterial hypertension. Renin is primarily produced by the kidney’s juxtaglomerular cells and stimulates the production of angiotensin II and aldosterone, both of which increase BP directly through vasoconstriction and indirectly through salt and water retention and other mechanisms [18].
Low vitamin D status has been linked to clinical outcomes that have previously been linked to excess RAAS activity, such as hypertension, inflammation, and CVD [19]. Animal studies and human genetic association studies have provided mechanistic support for these observations; however, conflicting data exist, and large-scale studies are needed to confirm the effect of vitamin D therapy on the RAAS and RAAS-mediated clinical outcomes.
Animal studies have shown that the 1,25(OH)2D3-VDR complex negatively regulates renin expression and that this vitamin D-induced reduction in RAAS activity can prevent adverse vascular outcomes to the same extent as pharmacologic angiotensin receptor antagonism [20]. In VDR and 1α-hydroxylase knockout mice, inappropriate, increased RAAS activation has been reported. Importantly, VDR and 1α-hydroxylase knockout mice developed arterial hypertension and myocardial hypertrophy, even after calcium homeostasis was restored; however, blocking the RAAS with angiotensin-converting enzyme inhibitors normalized BP and cardiac abnormalities [21, 22]. Furthermore, in 1α-hydroxylase knockout mice, increased RAAS activation, arterial hypertension, and myocardial abnormalities could be successfully treated with 1,25(OH)2D3 [22].
Human studies have supported this theory, demonstrating that low circulating vitamin D concentration are associated with higher plasma renin activity and angiotensin II concentrations [23, 24], and that vitamin D deficiency is associated with higher RAAS activity, which can be reduced with vitamin D3 therapy intervention [20, 25]. Extrapolating from these findings, vitamin D therapy may help to lower RAAS activity and improve complications associated with excess RAAS activity, such as hypertension, insulin resistance, and nephropathy [26].

Cyclic adenosine monophosphate protein kinase a signaling pathway

cAMP has long been recognized as a significant intracellular signal that stimulates renin production in juxtaglomerular cells. It is well established that cAMP signals through CRE located in target gene promoters, which interact in homodimeric or heterodimeric forms with members of the activating transcriptional factor/CREB/CRE modulator (CREM)/basic leucine zipper domain transcription factor family. Intracellular cAMP is synthesized from ATP by adenylate cyclase, which is activated by membrane receptors; cAMP binds to the regulatory subunit of protein kinase A, releasing the catalytic subunit, which enters the nucleus and phosphorylates CREB at serine 133 or CREM at serine 117, resulting in the recruitment of ubiquitous coactivators cyclic binding protein and p300 to promote gene transcription [27].
The discovery that liganded VDR suppresses renin expression in the presence of 1,25(OH)2D3 by binding to the transcription factor CREB sheds light on the molecular effects of vitamin D on the RAAS. CREB can no longer stimulate renin transcription by binding to CRE in the renin gene promoter region, so renin transcription is inhibited [27]. In patients with arterial hypertension, renin activity was found to be inversely related to 1,25(OH)2D3 levels [28]. Importantly, reduced renin and angiotensin II levels were observed in several, but not all, studies that investigated RAAS activity after treatment with 1,25(OH)2D3 (Fig. 2) [12, 29]. As a result, more research is needed to determine the clinical significance of vitamin D.
Increasing molecular and clinical evidence suggests that vitamin D deficiency contributes to insulin resistance, which is thought to play a role in the pathogenesis of arterial hypertension. Furthermore, the renoprotective effects of vitamin, such as decreased podocyte loss and hypertrophy or suppression of mesangial cell proliferation, may prevent the development of arterial hypertension in the course of renal failure [30].

Vitamin D receptor polymorphisms

All the mechanisms discussed play a role in developing hypertension as well as polymorphism in the VDR gene which binds to high-affinity receptors mediates the biological activities of 1,25(OH)2D3, and polymorphisms in the gene encoding the VDR appear to predispose the onset of hypertension [31, 32].
The expression and nuclear activation of the VDR are required for vitamin D effects. Several genetic variations in the VDR have been discovered. DNA sequence variations, which occur frequently in the population, are referred to as “polymorphisms” and can have biological effects. To see whether there is a linkage between VDR polymorphisms and diseases, epidemiological studies are performed. In these studies, the presence of a variation of the gene is studied in a case and control group [33]. Since the discovery of VDR polymorphism a number of papers have been published studying VDR gene and the position of different SNPs and their role in various diseases (Table 1, Fig. 3) [15, 3441].
Table 1
Association studies of known SNPs of VDR gene with chronic disease
Study
Year
Country
Type of study
SNP
Disease
Outcome
Liu et al. [34]
2021
China
Meta-analysis
Bsm I, Apa I, Taq I, Fok I
GDM
Taq I and Apa I associated with risk of GDM.
No association found between Bsm I and Taq I with the risk of GDM.
Tizaoui et al. [35]
2015
Tunisia
Meta-analysis (PRISMA)
Taq I, Bsm I, Fok I
RA
Taq I and Fok I VDR polymorphisms significantly associated with RA risk.
Bsm I, marginal association seen with RA.
Magiełda-Stola et al. [36]
2021
Poland
Case control
Bsm I, Apa I, Fok I, Taq I
Preeclampsia
Bsm I is significantly found more frequent in preeclamptic women.
Taq I/Apa I/Bsm I was significantly associated with higher systolic and diastolic blood pressure.
Bsm I polymorphism is closely associated with a higher predisposition to hypertension.
Nam et al. [37]
2021
Republic of Korea
Cross sectional
Bsm I, Apa I
Obesity DM
Bsm I and Apa I were highly associated with obesity.
Both SNPs were not associated with DM.
Abouzid et al. [38]
2021
Poland
Preliminary
Bsm I, Apa I, Fok I, Taq I
CVD
Apa I, Tag I, and Bsm I was found to be associated with an increased risk of obesity.
Fok I was associated with a higher incidence of heart failure and hypertension.
Bsm I was found to be associated with lower risk of CVD.
Eweida et al. [39]
2021
Egypt
Case control
Bsm I, Fok I
CVD
Both SNPs are associated with risk of CVD in Egyptian patients with or without diabetes.
Caccamo et al. [40]
2020
Italy
Case control
Fok I, Bsm I
GH
Significant association was found between Fok I and Bsm I with GH.
Aristizabal-Pachon et al. [41]
2022
Colombia
Case control
Fok I, Taq I
Melanoma cancer
Fok I polymorphism was associated with melonma cancer risk.
Taq I polymorphism was associated with a protective effect against this cancer.
SNP single nucleotide polymorphism, VDR vitamin D receptor, GDM gestational diabetes mellitus, RA rheumatoid arthritis, DM diabetes mellitus, CVD cardiovascular disease, GH gestational hypertension
Among the many described SNPs of VDR, two diallelic polymorphisms have been reported to affect VDR molecular signaling, namely Fok I (C > T, rs2228750) within the first coding exon, and Bsm I (A > G, rs1544410) lying in the last intron [33]. The VDR Fok I-F mutated allele has been shown to increase VDR protein transcriptional activity, while the Bsm I-B mutated allele affects VDR mRNA stability leading to a reduction of VDR protein amount in tissues. It has been shown that these genetic changes in the VDR can significantly reduce the effectiveness of vitamin D action [33]; thus, contributing to the development of several cardiovascular diseases, in particular, the Bsm I-B allele has been strongly associated with hypertension [42, 43]. The purpose of this review is to summarize the vast amount of information regarding VDR polymorphisms and essential hypertension and discuss its possible role as diagnostic tools.

Fok I polymorphism and essential hypertension

One of the most studied SNP of the VDR gene is Fok I (rs2228570). This polymorphism, which consisted of a T to C change in exon 2, was described in the early 1990s. Because the change occurs within a start codon (ATG), when the C variant is present, an alternate start site is used, resulting in a protein of a different size [33]. Fok I polymorphism can generate truncated proteins and is associated with increased risk for hypertension [15, 44, 45]. Fok I polymorphism is caused by a thymine-to-cytosine transition, which leads to a translational frameshift characterized by an extension of the open reading frame to the next initiation codon (ATG), resulting in the synthesis of a truncated 424-amino acid protein. In the 427-amino acid protein, ATG-encoded methionine (M1 form) was present in the f allele, whereas ACG-encoded methionine (M4 form) was present in the F allele [46]. The truncated protein in individuals with the FF genotype is thought to promote the development of essential hypertension by increasing the production of renin and angiotensin II (Fig. 4) [47, 48]. The transcriptional activity of the truncated protein is suggested to be higher than that of the full-length protein. Moreover, the increased responsiveness of the truncated protein to 1,25(OH)2D3 might alter the function of VDR and vitamin D in cells and tissues [49]. Low levels of 25(OH)D combined with Fok I polymorphism have been associated with increased plasmatic renin activity [12]. This suggests that 1,25(OH)2D3 can downregulate renin expression in humans, and increase cardiovascular and metabolic disease risk [50].
Regarding the role of SNP Fok I in other diseases, Liu et al. [51] analyzed its association with psoriasis but the results were not significant for Caucasians and East Asians. In contrast, Alizadeh et al. [52] found no significant association between SNP Fok I and coronary artery disease (CAD) based on a general analysis in Caucasians and East Asians. Recently, Shi et al. [53] observed no relation between this SNP and susceptibility to polycystic ovary syndrome. However, Liu et al. [54] showed that Fok I is a susceptibility factor for ovarian cancer. Further, Zhao et al. [55] found an increased risk of intervertebral disc degeneration in Hispanics and Asians with the f allele and Lu et al. [56] suggested that Fok I protects against CAD. Cao et al. [57] found that homozygosis is associated with an increased risk of tuberculosis, particularly in East and Southeast Asia, and Jiao et al. [58] observed that the F allele is associated with a decreased risk of diabetic retinopathy in Chinese subjects. However, Tizaoui et al. [35] in their study reported that Fok I VDR polymorphisms is associated with rheumatoid arthritis risk. Liu et al. [34] reported that Fok I (rs2228570) polymorphisms increase susceptibility to gestational diabetes mellitus in Asian and African population. Another study conducted by Caccamo et al. [40] suggested an association between gestational hypertension and the VDR FF haplotype. In accordance with previous study Abouzid et al. [38] reported that Fok I SNP TT genotype was associated with a higher incidence of heart failure and hypertension.
In the mid-2000s, an in vitro study demonstrated that the transcriptional activity of VDR with Fok I-F SNP was lower than that of TFIIB factor (an RNA polymerase II-specific transcript) with Fok I-F SNP. Thus, the Fok I polymorphism appears to be functional, and the 424 aa VDR variant appears to be slightly more active than the 427 aa variants in terms of transactivation capacity as a transcription factor. Some promoter regions of vitamin D target genes may be more sensitive to this VDR genotype-dependent difference in activity than others [59]. Due to the importance of the association between hypertension and Fok I polymorphism, we performed a review to find out whether this SNP of VDR gene plays a protective role in hypertension or should be considered as a risk factor for the onset of the disease.

Bsm I polymorphism and essential hypertension

Bsm I is a nucleotide substitution from A to G found in intron 8 that affects transcript stability. It is in linkage disequilibrium with other polymorphisms, and its association with certain diseases is most likely the result of this phenomenon (Fig. 5) [60].
A previous GWAS reported that the SNP Bsm I (rs1544410) in the VDR gene is associated with hypertension in Spanish population, systolic BP (SBP) with Bsm I (rs1544410) CC genotype was higher than TC or TT genotypes in men but not in women [61]. On the contrary, in a Korean study, Bsm I T allele carriers had higher SBP, higher diastolic BP (DBP), and higher prevalence of hypertension than CC carriers [62]. Recently, a prospective cohort of American men found suggestive evidence for associations of VDR Bsm I and Fok I polymorphisms with hypertension risk [32].
Regarding the role of SNP Bsm I in other diseases, Abouzid et al. [38] analyzed its association with CVDs and reported that GA Bsm I genotypes had an increased risk of obesity and also found that AA Bsm I genotype can be protective against CVD. Recently, Nugroho et al. [63] reported no association of this SNP with diabetic kidney disease. However, Nam et al. [37] reported that Bsm I polymorphism VDR gene were associated with obesity in Korean patients with type 2 diabetes mellitus. Further Liu et al. [34] found that VDR Bsm I (rs1544410) polymorphism was associated with gestational diabetes mellitus in Asian and African population [34].
This review identified and analyzed studies that investigated the relationship of VDR (Fok I and Bsm I) polymorphisms with essential hypertension. Swapna et al. [31] examined the relationship between Fok I polymorphism and essential hypertension in South Indian population. A total of 480 subjects were included in the study, with 280 hypertensive subjects and 200 healthy controls ranging in age from 35 to 60 years. They observed a significant association of Fok I polymorphism with essential hypertension. They also observed a significant difference in the frequencies of genotypes and alleles at the VDR locus. The FF, ff, Ff exhibited frequencies of 53.6, 10.7, and 35.7%, respectively, in hypertensive individuals, and 34, 15, and 51%, respectively, in healthy normotensive subjects. The risk of hypertension was calculated from the odds ratio (OR). Notably, men and women with the FF genotype had a higher risk of hypertension (men: OR, 2.020; 95% confidence interval [CI], 1.228–3.322; women: OR, 2.467; 95% CI, 1.246–4.4881) and in individuals with a positive family history of hypertension (OR, 2.011; 95% CI, 1.119–3.616), smoking (OR, 3.686; 95% CI, 1.414–9.611), and alcohol consumption (OR, 2.239; 95% CI, 0.983–5.096) [31].
In accordance with the results of previous study, another study was undertaken by Prasad et al. [13] in southeast population of India to determine the status of Fok I VDR gene polymorphism along with vitamin D levels and BP in patients with essential hypertension. A total of 400 subjects were included in the study, with 200 hypertensive subjects (SBP ≥140 mmHg and DBP ≥90 mmHg) and 200 healthy controls ranging in age from 25 to 60 years. They observed a significant association of SBP with vitamin D levels. A reduced level of vitamin D was observed in essential hypertension patients. Risk of hypertension was calculated from ORs. The ff genotype was found to be 8.06 times more likely to have essential hypertension than FF genotypes (OR, 8.06; 95% CI, 3.71–17.47; P = 0.0001).
Glocke et al. [64] conducted a study to compare the prevalence of Fok I polymorphism in 101 elderly (> 90 years) and 208 young subjects (< 90 years) of both sexes (Caucasians of German descent). A negative effect of Fok I polymorphism on DBP was observed in the elderly group (P < 0.05), especially in those with the ff genotype because they had a lower mean BP of 70 ± 2.12 mmHg than those with FF genotype (82.9 ± 3.10 mmHg) and Ff genotype (76.17 ± 2.69 mmHg) [64]. The prevalence of hypertension was lower in subjects with ff and Ff genotypes than in those with FF genotype; however, the difference was not statistically significant. The lifespan of the subjects can also be affected by this polymorphism [13].
Wang et al. [32] conducted a prospective study in 1211 Caucasian American men with a minimum and maximum follow-up period of 15.2 and 27.4 years, respectively. In this study, 695 subjects were diagnosed with hypertension. The prevalence of Fok I and Bsm I polymorphism was investigated in 885 subjects and 998 subjects, respectively, and the majority of hypertensive patients had a polymorphism of the VDR gene. The association of Fok I polymorphism with the risk for hypertension was found only in the recessive model. The ff genotype in model 2 had a multivariate hazard ratio (HR) of 1.32 (95% CI, 1.03–1.70) for the incidence of hypertension. The correlation between 25(OH)D level and the risk for hypertension was higher in subjects with the ff genotype than in those with the Ff and FF genotypes. They also observed bB or BB genotype of the VDR Bsm I polymorphism were linked to an increased risk of hypertension. The bB and BB genotype in model 2 had a multivariable HR of 1.27 (95% CI, 1.04–1.55) and 1.19 (95% CI, 0.90–1.56), respectively, for incidence of hypertension. Combined bB and BB genotypes, the HR was 1.25 (95% CI, 1.04–1.51) found only in the recessive model. There was no significant interaction between circulating vitamin D metabolites and VDR gene polymorphisms in relation to hypertension risk [32].
Cottone et al. [60] conducted a study in 71 patients with essential hypertension and 72 control subjects of both sexes, aged 18 to 75 years, in Italy. The frequencies of FF, Ff, and ff genotypes in hypertensive patients were 50.7, 42.3, and 7.0%, respectively, and in control subjects were 40.3, 50.0, and 9.7%, respectively. The allelic frequencies of F and f were 71.8 and 28.2%, respectively, in hypertensive patients, and 65.3 and 34.7%, respectively, in normotensive individuals. The DBP was different for all three genotypes of Fok I polymorphism (P = 0.018). Patients with the ff genotype had a higher DBP than those with the Ff genotype (P = 0.002). A negative correlation was observed between 25(OH)D levels and pulse BP, and this correlation was statistically significant in patients with the Ff genotype (r = − 0.474, P = 0.035) and between 25(OH)D and 24-hour SBP in patients with Bb Bsm I genotypes (r = − 0.397, P = 0.020). The frequencies of BB, bb, and Bb genotypes in hypertensive patients were 22.5, 57.8, and 19.7%, respectively, and 20.8, 52.8, and 26.4%, respectively, in control subjects. In hypertensive patients, the allelic frequencies of B and b were 51.5 and 48.5%, respectively, and 47.2 and 52.8%, respectively, in normotensive individuals. There was no link found between a particular genotype or allele and hypertension. A link between polymorphism and plasma renin activity was also not found [60].
In another study, Errouagui et al. [65] examined 177 hypertensive (aged 45.47 to 68.41 years) and 222 normotensive subjects (aged 34.67 to 64.59 years) of both sexes in Morocco, and found a strong association between Fok I polymorphism and hypertension in codominant, dominant, and recessive genetic models, whereas no association was observed between Bsm I polymorphism and hypertension in all genetic models. The ff genotype was significantly less common in hypertensive patients than in controls (OR, 0.24; 95% CI, 0.10–0.58; P = 0.002). The average vitamin D concentrations in subjects with the FF, Ff, and ff genotypes were 28.06 ± 10.57, 29.04 ± 11.97, and 26.40 ± 19.15 ng/mL, respectively. However, the differences in vitamin D concentrations between subjects with FF and Ff were not statistically significant [65].
Jia et al. [66] studied 2409 hypertensive and 3063 normotensive people from a community-based epidemiological survey in Jiangsu Province, China. The majority of the population was Han. After controlling for confounding factors (sex, age, body mass index, total cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein cholesterol, and smoking), the correlation of Fok I polymorphism with lower risk of hypertension in men was significant. For the additive, dominant, and recessive models, the ORs (95% CI) were 0.828 (0.74–0.927, P = 0.001), 0.75 (0.631–0.89, P = 0.001), and 0.816 (0.67–0.995, P = 0.044), respectively. The Ff/ff genotype was associated with lower BP than the FF genotype (P = 0.002) [66].
Gussago et al. [67] conducted another study on 70-year-old subjects and centenarians of both sexes in northern Italy. The frequencies of the FF, Ff, and ff genotypes in centenarians were 47.4, 42.1, and 10.5%, respectively, with F being the most common allele (68.4%). In the control group, the frequencies of the FF, Ff, and ff genotypes were 48.4, 38.7, and 12.9%, respectively, with F being the most common allele (67.8%). Furthermore, the FF genotype was associated with a higher prevalence of hypertension than the Ff and ff genotypes (P = 0.015) [67].
A meta-analysis conducted by Nunes et al. [47] in Brazil reported a significant association of Fok I polymorphism with hypertension. F and f allele frequencies were 55.9 and 44.1% in hypertensive patients, respectively, and 54.3 and 44.7% in control subjects [47]. However, a meta-analysis conducted in Chinese population by Zhu et al. [43] found no correlation of Fok I polymorphism with susceptibility to hypertension. They also observed that Bsm I polymorphism was associated with susceptibility to hypertension. The frequency of VDR Bsm I AA genotype decreased in hypertension patients compared with healthy controls. The population carrying VDR Bsm I AA genotype (OR, 0.69; 95% CI, 0.54–0.89; P = 0.005) had lower susceptibility to hypertension relative to those carrying GA or GG genotype (OR, 1.32; 95% CI, 1.05–1.68; P = 0.02). The frequency of A allele was higher in the case group than that of control group (OR, 0.83; 95% CI, 0.69–0.99; P = 0.04) [43]. In accordance with findings in Chinese population, a preliminary study conducted by Abouzid et al. [38] reported Fok I TT genotype was associated with a higher incidence of hypertension whereas they did not observe a significant association between hypertension and Bsm I polymorphism.
Both of these polymorphisms have been linked to an increased risk of essential hypertension with conflicting results [13, 32, 68]. The Fok I polymorphism affects the length and function of the VDR protein, resulting in truncated protein formation. The inactivation of VDR is caused by a lack or excess of vitamin D and the inactivation of its biologically active form. Bsm I is a nucleotide substitution from A to G in intron 8 that affects transcript stability. It is in linkage disequilibrium with other polymorphisms, and its association with certain diseases is most likely due to this phenomenon. The findings of the studies support the hypothesis that VDR (Fok I and Bsm I) polymorphisms may be associated with susceptibility to essential hypertension. Furthermore, the age and ethnicity of an individual are important factors to consider when studying hypertension. High BP can be caused by the inhibition of renin activity and the subsequent increase in levels of angiotensin II, a potent vasoconstrictor. Surprisingly, 1,25(OH)2D3 levels influences renin expression, resulting in hypertension. However, the number of studies in this area is still limited. Understanding the molecular and functional consequences of VDR polymorphisms is crucial for fully appreciating their significance and understanding their potential clinical implications.
The most notable mechanism linking vitamin D to hypertension is its role as a negative regulator of the RAAS. A meta-analysis study has indicated Fok I polymorphism of the VDR gene results in formation of a truncated protein that evidently increases the synthesis of renin and angiotensin II, thereby promoting the development of hypertension [47]. Enhanced understanding of the genetic differences in hypertensive population may be a further step in developing individualized treatment strategy. More so, it is worth investigating if direct renin inhibitors e.g., Aliskerin (presently second line of drugs) may be better suited and effective in this set of patients.
Over and above, as genetic technology becomes increasingly inexpensive and accessible, Fok I and Bsm I genotyping can be used as a screening tool in at risk population to assess future risk of developing hypertension.

Conclusion

In India, hypertension has consistently been one of the leading causes of morbidity and mortality. Many studies have linked VDR gene polymorphism with essential however some studies have focused on the triangular relationship of vitamin D, VDR polymorphism, and essential hypertension, but the results of these studies were conflicting. As these studies have certain limitations, such as the fact that the individuals included in the study are of various age and ethnicities. These studies do not yield consistent findings regarding the risk of hypertension and its association with the frequency of Fok I and Bsm I genotypes. More research with larger samples is needed after removing confounding factors to determine whether VDR gene polymorphism is protective or a risk factor for the development of essential hypertension.

Acknowledgements

The authors are grateful to Prof. Abha Chandra, the Head of the Institution of Integral Institute of Medical Sciences and Research, Integral University, Lucknow, India.

Declarations

Not applicable.
Not applicable.

Competing interests

The authors declare that they have no competing interests.
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Literatur
1.
Zurück zum Zitat Lin L, Zhang L, Li C, Gai Z, Li Y. Vitamin D and vitamin D receptor: new insights in the treatment of hypertension. Curr Protein Pept Sci. 2019;20:984–95.CrossRef Lin L, Zhang L, Li C, Gai Z, Li Y. Vitamin D and vitamin D receptor: new insights in the treatment of hypertension. Curr Protein Pept Sci. 2019;20:984–95.CrossRef
2.
Zurück zum Zitat Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365:217–23.CrossRef Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365:217–23.CrossRef
3.
Zurück zum Zitat Saseen JJ, MacLaughlin EJ. Hypetension. In: DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM, editors. Pharmacotherapy: a pathophysiologic approach. 9th ed. New York: McGraw-Hill; 2014. p. 87–101. Saseen JJ, MacLaughlin EJ. Hypetension. In: DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM, editors. Pharmacotherapy: a pathophysiologic approach. 9th ed. New York: McGraw-Hill; 2014. p. 87–101.
4.
Zurück zum Zitat Scriabine A. Hypertension. In: Taylor JB, Triggle DJ, editors. Comprehensive medicinal chemistry II. Amsterdam: Elsevier; 2007. p. 705–28.CrossRef Scriabine A. Hypertension. In: Taylor JB, Triggle DJ, editors. Comprehensive medicinal chemistry II. Amsterdam: Elsevier; 2007. p. 705–28.CrossRef
5.
Zurück zum Zitat Bell K, Twiggs J, Olin BR, Date IR. Hypertension: the silent killer: updated JNC-8 guideline recommendations. Ala Pharm Assoc. 2015;334:4222. Bell K, Twiggs J, Olin BR, Date IR. Hypertension: the silent killer: updated JNC-8 guideline recommendations. Ala Pharm Assoc. 2015;334:4222.
6.
Zurück zum Zitat Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, et al. Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nat Genet. 2017;49:403–15.CrossRef Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, et al. Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nat Genet. 2017;49:403–15.CrossRef
7.
Zurück zum Zitat Forman JP, Giovannucci E, Holmes MD, Bischoff-Ferrari HA, Tworoger SS, Willett WC, et al. Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension. 2007;49:1063–9.CrossRef Forman JP, Giovannucci E, Holmes MD, Bischoff-Ferrari HA, Tworoger SS, Willett WC, et al. Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension. 2007;49:1063–9.CrossRef
8.
Zurück zum Zitat Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, et al. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int. 2009;20:1807–20.CrossRef Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, et al. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int. 2009;20:1807–20.CrossRef
9.
Zurück zum Zitat Dusso AS, Brown AJ, Slatopolsky E. Vitamin D. Am J Physiol Renal Physiol. 2005;289:F8–28.CrossRef Dusso AS, Brown AJ, Slatopolsky E. Vitamin D. Am J Physiol Renal Physiol. 2005;289:F8–28.CrossRef
10.
Zurück zum Zitat Mutchie TR, Yu OB, Di Milo ES, Arnold LA. Alternative binding sites at the vitamin D receptor and their ligands. Mol Cell Endocrinol. 2019;485:1–8.CrossRef Mutchie TR, Yu OB, Di Milo ES, Arnold LA. Alternative binding sites at the vitamin D receptor and their ligands. Mol Cell Endocrinol. 2019;485:1–8.CrossRef
11.
Zurück zum Zitat Meyer MB, Pike JW. Corepressors (NCoR and SMRT) as well as coactivators are recruited to positively regulated 1α,25-dihydroxyvitamin D3-responsive genes. J Steroid Biochem Mol Biol. 2013;136:120–4.CrossRef Meyer MB, Pike JW. Corepressors (NCoR and SMRT) as well as coactivators are recruited to positively regulated 1α,25-dihydroxyvitamin D3-responsive genes. J Steroid Biochem Mol Biol. 2013;136:120–4.CrossRef
12.
Zurück zum Zitat Legarth C, Grimm D, Wehland M, Bauer J, Krüger M. The impact of vitamin D in the treatment of essential hypertension. Int J Mol Sci. 2018;19:455.CrossRef Legarth C, Grimm D, Wehland M, Bauer J, Krüger M. The impact of vitamin D in the treatment of essential hypertension. Int J Mol Sci. 2018;19:455.CrossRef
13.
Zurück zum Zitat Prasad M, Rajarajeswari D, Aruna P, Ramalingam K, Viswakumar R, Fathima N, et al. Status of vitamin D receptor gene polymorphism and 25-hydroxy vitamin D deficiency with essential hypertension. Indian J Clin Biochem. 2022;37:335–41.CrossRef Prasad M, Rajarajeswari D, Aruna P, Ramalingam K, Viswakumar R, Fathima N, et al. Status of vitamin D receptor gene polymorphism and 25-hydroxy vitamin D deficiency with essential hypertension. Indian J Clin Biochem. 2022;37:335–41.CrossRef
14.
Zurück zum Zitat Miyamoto K, Kesterson RA, Yamamoto H, Taketani Y, Nishiwaki E, Tatsumi S, et al. Structural organization of the human vitamin D receptor chromosomal gene and its promoter. Mol Endocrinol. 1997;11:1165–79.CrossRef Miyamoto K, Kesterson RA, Yamamoto H, Taketani Y, Nishiwaki E, Tatsumi S, et al. Structural organization of the human vitamin D receptor chromosomal gene and its promoter. Mol Endocrinol. 1997;11:1165–79.CrossRef
15.
Zurück zum Zitat Uitterlinden AG, Fang Y, Van Meurs JB, Pols HA, Van Leeuwen JP. Genetics and biology of vitamin D receptor polymorphisms. Gene. 2004;338:143–56.CrossRef Uitterlinden AG, Fang Y, Van Meurs JB, Pols HA, Van Leeuwen JP. Genetics and biology of vitamin D receptor polymorphisms. Gene. 2004;338:143–56.CrossRef
16.
Zurück zum Zitat Laragh JH, Sealey JE. The plasma renin test reveals the contribution of body sodium-volume content (V) and renin-angiotensin (R) vasoconstriction to long-term blood pressure. Am J Hypertens. 2011;24:1164–80.CrossRef Laragh JH, Sealey JE. The plasma renin test reveals the contribution of body sodium-volume content (V) and renin-angiotensin (R) vasoconstriction to long-term blood pressure. Am J Hypertens. 2011;24:1164–80.CrossRef
17.
Zurück zum Zitat Vaidya A, Brown JM, Williams JS. The renin-angiotensin-aldosterone system and calcium-regulatory hormones. J Hum Hypertens. 2015;29:515–21.CrossRef Vaidya A, Brown JM, Williams JS. The renin-angiotensin-aldosterone system and calcium-regulatory hormones. J Hum Hypertens. 2015;29:515–21.CrossRef
18.
Zurück zum Zitat Connell JM, MacKenzie SM, Freel EM, Fraser R, Davies E. A lifetime of aldosterone excess: long-term consequences of altered regulation of aldosterone production for cardiovascular function. Endocr Rev. 2008;29:133–54.CrossRef Connell JM, MacKenzie SM, Freel EM, Fraser R, Davies E. A lifetime of aldosterone excess: long-term consequences of altered regulation of aldosterone production for cardiovascular function. Endocr Rev. 2008;29:133–54.CrossRef
19.
Zurück zum Zitat Vaidya A, Williams JS. The relationship between vitamin D and the renin-angiotensin system in the pathophysiology of hypertension, kidney disease, and diabetes. Metabolism. 2012;61:450–8.CrossRef Vaidya A, Williams JS. The relationship between vitamin D and the renin-angiotensin system in the pathophysiology of hypertension, kidney disease, and diabetes. Metabolism. 2012;61:450–8.CrossRef
20.
Zurück zum Zitat Vaidya A, Forman JP. Vitamin D and vascular disease: the current and future status of vitamin D therapy in hypertension and kidney disease. Curr Hypertens Rep. 2012;14:111–9.CrossRef Vaidya A, Forman JP. Vitamin D and vascular disease: the current and future status of vitamin D therapy in hypertension and kidney disease. Curr Hypertens Rep. 2012;14:111–9.CrossRef
21.
Zurück zum Zitat Simpson RU, Hershey SH, Nibbelink KA. Characterization of heart size and blood pressure in the vitamin D receptor knockout mouse. J Steroid Biochem Mol Biol. 2007;103:521–4.CrossRef Simpson RU, Hershey SH, Nibbelink KA. Characterization of heart size and blood pressure in the vitamin D receptor knockout mouse. J Steroid Biochem Mol Biol. 2007;103:521–4.CrossRef
22.
Zurück zum Zitat Zhou C, Lu F, Cao K, Xu D, Goltzman D, Miao D. Calcium-independent and 1,25(OH)2D3-dependent regulation of the renin-angiotensin system in 1alpha- hydroxylase knockout mice. Kidney Int. 2008;74:170–9.CrossRef Zhou C, Lu F, Cao K, Xu D, Goltzman D, Miao D. Calcium-independent and 1,25(OH)2D3-dependent regulation of the renin-angiotensin system in 1alpha- hydroxylase knockout mice. Kidney Int. 2008;74:170–9.CrossRef
23.
Zurück zum Zitat Forman JP, Williams JS, Fisher ND. Plasma 25-hydroxyvitamin D and regulation of the renin-angiotensin system in humans. Hypertension. 2010;55:1283–8.CrossRef Forman JP, Williams JS, Fisher ND. Plasma 25-hydroxyvitamin D and regulation of the renin-angiotensin system in humans. Hypertension. 2010;55:1283–8.CrossRef
24.
Zurück zum Zitat Vaidya A, Forman JP, Hopkins PN, Seely EW, Williams JS. 25-Hydroxyvitamin D is associated with plasma renin activity and the pressor response to dietary sodium intake in Caucasians. J Renin-Angiotensin-Aldosterone Syst. 2011;12:311–9.CrossRef Vaidya A, Forman JP, Hopkins PN, Seely EW, Williams JS. 25-Hydroxyvitamin D is associated with plasma renin activity and the pressor response to dietary sodium intake in Caucasians. J Renin-Angiotensin-Aldosterone Syst. 2011;12:311–9.CrossRef
25.
Zurück zum Zitat Carrara D, Bernini M, Bacca A, Rugani I, Duranti E, Virdis A, et al. Cholecalciferol administration blunts the systemic renin-angiotensin system in essential hypertensives with hypovitaminosis D. J Renin-Angiotensin-Aldosterone Syst. 2014;15:82–7.CrossRef Carrara D, Bernini M, Bacca A, Rugani I, Duranti E, Virdis A, et al. Cholecalciferol administration blunts the systemic renin-angiotensin system in essential hypertensives with hypovitaminosis D. J Renin-Angiotensin-Aldosterone Syst. 2014;15:82–7.CrossRef
26.
Zurück zum Zitat Vaidya A, Sun B, Larson C, Forman JP, Williams JS. Vitamin D3 therapy corrects the tissue sensitivity to angiotensin ii akin to the action of a converting enzyme inhibitor in obese hypertensives: an interventional study. J Clin Endocrinol Metab. 2012;97:2456–65.CrossRef Vaidya A, Sun B, Larson C, Forman JP, Williams JS. Vitamin D3 therapy corrects the tissue sensitivity to angiotensin ii akin to the action of a converting enzyme inhibitor in obese hypertensives: an interventional study. J Clin Endocrinol Metab. 2012;97:2456–65.CrossRef
27.
Zurück zum Zitat Yuan W, Pan W, Kong J, Zheng W, Szeto FL, Wong KE, et al. 1,25-Dihydroxyvitamin D3 suppresses renin gene transcription by blocking the activity of the cyclic AMP response element in the renin gene promoter. J Biol Chem. 2007;282:29821–30.CrossRef Yuan W, Pan W, Kong J, Zheng W, Szeto FL, Wong KE, et al. 1,25-Dihydroxyvitamin D3 suppresses renin gene transcription by blocking the activity of the cyclic AMP response element in the renin gene promoter. J Biol Chem. 2007;282:29821–30.CrossRef
28.
Zurück zum Zitat Burgess ED, Hawkins RG, Watanabe M. Interaction of 1,25-dihydroxyvitamin D and plasma renin activity in high renin essential hypertension. Am J Hypertens. 1990;3(12 Pt 1):903–5.CrossRef Burgess ED, Hawkins RG, Watanabe M. Interaction of 1,25-dihydroxyvitamin D and plasma renin activity in high renin essential hypertension. Am J Hypertens. 1990;3(12 Pt 1):903–5.CrossRef
29.
Zurück zum Zitat Freundlich M, Quiroz Y, Zhang Z, Zhang Y, Bravo Y, Weisinger JR, et al. Suppression of renin-angiotensin gene expression in the kidney by paricalcitol. Kidney Int. 2008;74:1394–402.CrossRef Freundlich M, Quiroz Y, Zhang Z, Zhang Y, Bravo Y, Weisinger JR, et al. Suppression of renin-angiotensin gene expression in the kidney by paricalcitol. Kidney Int. 2008;74:1394–402.CrossRef
30.
Zurück zum Zitat Kuhlmann A, Haas CS, Gross ML, Reulbach U, Holzinger M, Schwarz U, et al. 1,25-Dihydroxyvitamin D3 decreases podocyte loss and podocyte hypertrophy in the subtotally nephrectomized rat. Am J Physiol Renal Physiol. 2004;286:F526–33.CrossRef Kuhlmann A, Haas CS, Gross ML, Reulbach U, Holzinger M, Schwarz U, et al. 1,25-Dihydroxyvitamin D3 decreases podocyte loss and podocyte hypertrophy in the subtotally nephrectomized rat. Am J Physiol Renal Physiol. 2004;286:F526–33.CrossRef
31.
Zurück zum Zitat Swapna N, Vamsi UM, Usha G, Padma T. Risk conferred by FokI polymorphism of vitamin D receptor (VDR) gene for essential hypertension. Indian J Hum Genet. 2011;17:201–6.CrossRef Swapna N, Vamsi UM, Usha G, Padma T. Risk conferred by FokI polymorphism of vitamin D receptor (VDR) gene for essential hypertension. Indian J Hum Genet. 2011;17:201–6.CrossRef
32.
Zurück zum Zitat Wang L, Ma J, Manson JE, Buring JE, Gaziano JM, Sesso HD. A prospective study of plasma vitamin D metabolites, vitamin D receptor gene polymorphisms, and risk of hypertension in men. Eur J Nutr. 2013;52:1771–9.CrossRef Wang L, Ma J, Manson JE, Buring JE, Gaziano JM, Sesso HD. A prospective study of plasma vitamin D metabolites, vitamin D receptor gene polymorphisms, and risk of hypertension in men. Eur J Nutr. 2013;52:1771–9.CrossRef
33.
Zurück zum Zitat Valdivielso JM, Fernandez E. Vitamin D receptor polymorphisms and diseases. Clin Chim Acta. 2006;371:1–12.CrossRef Valdivielso JM, Fernandez E. Vitamin D receptor polymorphisms and diseases. Clin Chim Acta. 2006;371:1–12.CrossRef
34.
Zurück zum Zitat Liu S. The role of vitamin D receptor gene polymorphisms in gestational diabetes mellitus susceptibility: a meta-analysis. Diabetol Metab Syndr. 2021;13:144.CrossRef Liu S. The role of vitamin D receptor gene polymorphisms in gestational diabetes mellitus susceptibility: a meta-analysis. Diabetol Metab Syndr. 2021;13:144.CrossRef
35.
Zurück zum Zitat Tizaoui K, Hamzaoui K. Association between VDR polymorphisms and rheumatoid arthritis disease: systematic review and updated meta-analysis of case-control studies. Immunobiology. 2015;220:807–16.CrossRef Tizaoui K, Hamzaoui K. Association between VDR polymorphisms and rheumatoid arthritis disease: systematic review and updated meta-analysis of case-control studies. Immunobiology. 2015;220:807–16.CrossRef
36.
Zurück zum Zitat Magiełda-Stola J, Kurzawińska G, Ożarowski M, Karpiński TM, Drews K, Seremak-Mrozikiewicz A. The significance of VDR genetic polymorphisms in the etiology of preeclampsia in pregnant Polish women. Diagnostics. 2021;11:1698.CrossRef Magiełda-Stola J, Kurzawińska G, Ożarowski M, Karpiński TM, Drews K, Seremak-Mrozikiewicz A. The significance of VDR genetic polymorphisms in the etiology of preeclampsia in pregnant Polish women. Diagnostics. 2021;11:1698.CrossRef
37.
Zurück zum Zitat Nam SW, Choi J, Jeon HJ, Oh TK, Lee DH. The associations between vitamin D receptor BsmI and ApaI polymorphisms and obesity in Korean patients with type 2 diabetes mellitus. Diabetes Metab Syndr Obes. 2021;14:557–64.CrossRef Nam SW, Choi J, Jeon HJ, Oh TK, Lee DH. The associations between vitamin D receptor BsmI and ApaI polymorphisms and obesity in Korean patients with type 2 diabetes mellitus. Diabetes Metab Syndr Obes. 2021;14:557–64.CrossRef
38.
Zurück zum Zitat Abouzid M, Kruszyna M, Burchardt P, Kruszyna Ł, Główka FK, Karaźniewicz-Łada M. Vitamin D receptor gene polymorphism and vitamin D status in population of patients with cardiovascular disease: a preliminary study. Nutrients. 2021;13:3117.CrossRef Abouzid M, Kruszyna M, Burchardt P, Kruszyna Ł, Główka FK, Karaźniewicz-Łada M. Vitamin D receptor gene polymorphism and vitamin D status in population of patients with cardiovascular disease: a preliminary study. Nutrients. 2021;13:3117.CrossRef
39.
Zurück zum Zitat Eweida SM, Salem A, Shaker YM, Samy N, Yassen I, Mohamed RH. Vitamin D levels and vitamin D receptor genetic variants in Egyptian cardiovascular disease patients with and without diabetes. Egypt J Med Hum Genet. 2021;22:1–2.CrossRef Eweida SM, Salem A, Shaker YM, Samy N, Yassen I, Mohamed RH. Vitamin D levels and vitamin D receptor genetic variants in Egyptian cardiovascular disease patients with and without diabetes. Egypt J Med Hum Genet. 2021;22:1–2.CrossRef
40.
Zurück zum Zitat Caccamo D, Cannata A, Ricca S, Catalano LM, Montalto AF, Alibrandi A, et al. Role of vitamin-D receptor (VDR) single nucleotide polymorphisms in gestational hypertension development: a case-control study. PLoS One. 2020;15:e0239407.CrossRef Caccamo D, Cannata A, Ricca S, Catalano LM, Montalto AF, Alibrandi A, et al. Role of vitamin-D receptor (VDR) single nucleotide polymorphisms in gestational hypertension development: a case-control study. PLoS One. 2020;15:e0239407.CrossRef
41.
Zurück zum Zitat Aristizabal-Pachon AF, Gonzalez-Giraldo Y, Garcia AY, Suarez DX, Rodriguez A, Gonzalez-Santos J. Association between VDR gene polymorphisms and melanoma susceptibility in a colombian population. Asian Pac J Cancer Prev. 2022;23:79–85.CrossRef Aristizabal-Pachon AF, Gonzalez-Giraldo Y, Garcia AY, Suarez DX, Rodriguez A, Gonzalez-Santos J. Association between VDR gene polymorphisms and melanoma susceptibility in a colombian population. Asian Pac J Cancer Prev. 2022;23:79–85.CrossRef
42.
Zurück zum Zitat Santoro D, Buemi M, Gagliostro G, Vecchio M, Currò M, Ientile R, et al. Association of VDR gene polymorphisms with heart disease in chronic kidney disease patients. Clin Biochem. 2015;48:1028–32.CrossRef Santoro D, Buemi M, Gagliostro G, Vecchio M, Currò M, Ientile R, et al. Association of VDR gene polymorphisms with heart disease in chronic kidney disease patients. Clin Biochem. 2015;48:1028–32.CrossRef
43.
Zurück zum Zitat Zhu YB, Li ZQ, Ding N, Yi HL. The association between vitamin D receptor gene polymorphism and susceptibility to hypertension: a meta-analysis. Eur Rev Med Pharmacol Sci. 2019;23:9066–74. Zhu YB, Li ZQ, Ding N, Yi HL. The association between vitamin D receptor gene polymorphism and susceptibility to hypertension: a meta-analysis. Eur Rev Med Pharmacol Sci. 2019;23:9066–74.
44.
Zurück zum Zitat Kulah E, Dursun A, Acikgoz S, Can M, Kargi S, Ilikhan S, et al. The relationship of target organ damage and 24-hour ambulatory blood pressure monitoring with vitamin D receptor gene Fok-I polymorphism in essential hypertension. Kidney Blood Press Res. 2006;29:344–50.CrossRef Kulah E, Dursun A, Acikgoz S, Can M, Kargi S, Ilikhan S, et al. The relationship of target organ damage and 24-hour ambulatory blood pressure monitoring with vitamin D receptor gene Fok-I polymorphism in essential hypertension. Kidney Blood Press Res. 2006;29:344–50.CrossRef
45.
Zurück zum Zitat Abd El Gawad SS. Abdul Samee ER, Metwali AA, Abd El Gawad MS. vitamin D receptor gene polymorphism and its association with 1,25-dihydroxyvitamin D3 in patients with graves disease in an Egyptian population: a pilot study. Endocr Pract. 2012;18:132–9.CrossRef Abd El Gawad SS. Abdul Samee ER, Metwali AA, Abd El Gawad MS. vitamin D receptor gene polymorphism and its association with 1,25-dihydroxyvitamin D3 in patients with graves disease in an Egyptian population: a pilot study. Endocr Pract. 2012;18:132–9.CrossRef
46.
Zurück zum Zitat Arai H, Miyamoto K, Taketani Y, Yamamoto H, Iemori Y, Morita K, et al. A vitamin D receptor gene polymorphism in the translation initiation codon: effect on protein activity and relation to bone mineral density in Japanese women. J Bone Miner Res. 1997;12:915–21.CrossRef Arai H, Miyamoto K, Taketani Y, Yamamoto H, Iemori Y, Morita K, et al. A vitamin D receptor gene polymorphism in the translation initiation codon: effect on protein activity and relation to bone mineral density in Japanese women. J Bone Miner Res. 1997;12:915–21.CrossRef
47.
Zurück zum Zitat Nunes IF, Cavalcante AA, Alencar MV, Carvalho MD, Sarmento JL, Teixeira NS, et al. Meta-analysis of the association between the rs228570 vitamin D receptor gene polymorphism and arterial hypertension risk. Adv Nutr. 2020;11:1211–20.CrossRef Nunes IF, Cavalcante AA, Alencar MV, Carvalho MD, Sarmento JL, Teixeira NS, et al. Meta-analysis of the association between the rs228570 vitamin D receptor gene polymorphism and arterial hypertension risk. Adv Nutr. 2020;11:1211–20.CrossRef
48.
Zurück zum Zitat Jurutka PW, Remus LS, Whitfield GK, Thompson PD, Hsieh JC, Zitzer H, et al. The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB. Mol Endocrinol. 2000;14:401–20.CrossRef Jurutka PW, Remus LS, Whitfield GK, Thompson PD, Hsieh JC, Zitzer H, et al. The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB. Mol Endocrinol. 2000;14:401–20.CrossRef
49.
Zurück zum Zitat Whitfield GK, Remus LS, Jurutka PW, Zitzer H, Oza AK, Dang HT, et al. Functionally relevant polymorphisms in the human nuclear vitamin D receptor gene. Mol Cell Endocrinol. 2001;177:145–59.CrossRef Whitfield GK, Remus LS, Jurutka PW, Zitzer H, Oza AK, Dang HT, et al. Functionally relevant polymorphisms in the human nuclear vitamin D receptor gene. Mol Cell Endocrinol. 2001;177:145–59.CrossRef
50.
Zurück zum Zitat Wang L, Song Y, Manson JE, Pilz S, März W, Michaëlsson K, et al. Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease: a meta- analysis of prospective studies. Circ Cardiovasc Qual Outcomes. 2012;5:819–29.CrossRef Wang L, Song Y, Manson JE, Pilz S, März W, Michaëlsson K, et al. Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease: a meta- analysis of prospective studies. Circ Cardiovasc Qual Outcomes. 2012;5:819–29.CrossRef
51.
Zurück zum Zitat Liu JL, Zhang SQ, Zeng HM. ApaI, BsmI, FokI and TaqI polymorphisms in the vitamin D receptor (VDR) gene and the risk of psoriasis: a meta-analysis. J Eur Acad Dermatol Venereol. 2013;27:739–46.CrossRef Liu JL, Zhang SQ, Zeng HM. ApaI, BsmI, FokI and TaqI polymorphisms in the vitamin D receptor (VDR) gene and the risk of psoriasis: a meta-analysis. J Eur Acad Dermatol Venereol. 2013;27:739–46.CrossRef
52.
Zurück zum Zitat Alizadeh S, Djafarian K, Alizadeh H, Mohseni R, Shab-Bidar S. Common variants of vitamin D receptor gene polymorphisms and susceptibility to coronary artery disease: a systematic review and meta-analysis. J Nutrigenet Nutrigenomics. 2017;10:9–18. Alizadeh S, Djafarian K, Alizadeh H, Mohseni R, Shab-Bidar S. Common variants of vitamin D receptor gene polymorphisms and susceptibility to coronary artery disease: a systematic review and meta-analysis. J Nutrigenet Nutrigenomics. 2017;10:9–18.
53.
Zurück zum Zitat Shi XY, Huang AP, Xie DW, Yu XL. Association of vitamin D receptor gene variants with polycystic ovary syndrome: a meta-analysis. BMC Med Genet. 2019;20:32.CrossRef Shi XY, Huang AP, Xie DW, Yu XL. Association of vitamin D receptor gene variants with polycystic ovary syndrome: a meta-analysis. BMC Med Genet. 2019;20:32.CrossRef
54.
Zurück zum Zitat Liu Y, Li C, Chen P, Li X, Li M, Guo H, et al. Polymorphisms in the vitamin D receptor (VDR) and the risk of ovarian cancer: a meta-analysis. PLoS One. 2013;8:e66716.CrossRef Liu Y, Li C, Chen P, Li X, Li M, Guo H, et al. Polymorphisms in the vitamin D receptor (VDR) and the risk of ovarian cancer: a meta-analysis. PLoS One. 2013;8:e66716.CrossRef
55.
Zurück zum Zitat Zhao J, Yang M, Shao J, Bai Y, Li M. Association between VDR FokI polymorphism and intervertebral disk degeneration. Genomics Proteomics Bioinformatics. 2015;13:371–6.CrossRef Zhao J, Yang M, Shao J, Bai Y, Li M. Association between VDR FokI polymorphism and intervertebral disk degeneration. Genomics Proteomics Bioinformatics. 2015;13:371–6.CrossRef
56.
Zurück zum Zitat Lu S, Guo S, Hu F, Guo Y, Yan L, Ma W, et al. The associations between the polymorphisms of vitamin D receptor and coronary artery disease: a systematic review and meta-analysis. Medicine. 2016;95:e3467.CrossRef Lu S, Guo S, Hu F, Guo Y, Yan L, Ma W, et al. The associations between the polymorphisms of vitamin D receptor and coronary artery disease: a systematic review and meta-analysis. Medicine. 2016;95:e3467.CrossRef
57.
Zurück zum Zitat Cao Y, Wang X, Cao Z, Cheng X. Vitamin D receptor gene FokI polymorphisms and tuberculosis susceptibility: a meta-analysis. Arch Med Sci. 2016;12:1118–34.CrossRef Cao Y, Wang X, Cao Z, Cheng X. Vitamin D receptor gene FokI polymorphisms and tuberculosis susceptibility: a meta-analysis. Arch Med Sci. 2016;12:1118–34.CrossRef
58.
Zurück zum Zitat Jiao J, Li Y, Xu S, Wu J, Yue S, Liu L. Association of FokI, TaqI, BsmI and ApaI polymorphisms with diabetic retinopathy: a pooled analysis of case-control studies. Afr Health Sci. 2018;18:891–9.CrossRef Jiao J, Li Y, Xu S, Wu J, Yue S, Liu L. Association of FokI, TaqI, BsmI and ApaI polymorphisms with diabetic retinopathy: a pooled analysis of case-control studies. Afr Health Sci. 2018;18:891–9.CrossRef
59.
Zurück zum Zitat Colin EM, Weel AE, Uitterlinden AG, Buurman CJ, Birkenhäger JC, Pols HA, et al. Consequences of vitamin D receptor gene polymorphisms for growth inhibition of cultured human peripheral blood mononuclear cells by 1, 25-dihydroxyvitamin D3. Clin Endocrinol (Oxf). 2000;52:211–6.CrossRef Colin EM, Weel AE, Uitterlinden AG, Buurman CJ, Birkenhäger JC, Pols HA, et al. Consequences of vitamin D receptor gene polymorphisms for growth inhibition of cultured human peripheral blood mononuclear cells by 1, 25-dihydroxyvitamin D3. Clin Endocrinol (Oxf). 2000;52:211–6.CrossRef
60.
Zurück zum Zitat Cottone S, Guarino L, Arsena R, Scazzone C, Tornese F, Guarneri M, et al. Vitamin D receptor gene polymorphisms and plasma renin activity in essential hypertensive individuals. J Hum Hypertens. 2015;29:483–7.CrossRef Cottone S, Guarino L, Arsena R, Scazzone C, Tornese F, Guarneri M, et al. Vitamin D receptor gene polymorphisms and plasma renin activity in essential hypertensive individuals. J Hum Hypertens. 2015;29:483–7.CrossRef
61.
Zurück zum Zitat Muray S, Parisi E, Cardús A, Craver L, Fernández E. Influence of vitamin D receptor gene polymorphisms and 25-hydroxyvitamin D on blood pressure in apparently healthy subjects. J Hypertens. 2003;21:2069–75.CrossRef Muray S, Parisi E, Cardús A, Craver L, Fernández E. Influence of vitamin D receptor gene polymorphisms and 25-hydroxyvitamin D on blood pressure in apparently healthy subjects. J Hypertens. 2003;21:2069–75.CrossRef
62.
Zurück zum Zitat Lee BK, Lee GS, Stewart WF, Ahn KD, Simon D, Kelsey KT, et al. Associations of blood pressure and hypertension with lead dose measures and polymorphisms in the vitamin D receptor and delta-aminolevulinic acid dehydratase genes. Environ Health Perspect. 2001;109:383–9. Lee BK, Lee GS, Stewart WF, Ahn KD, Simon D, Kelsey KT, et al. Associations of blood pressure and hypertension with lead dose measures and polymorphisms in the vitamin D receptor and delta-aminolevulinic acid dehydratase genes. Environ Health Perspect. 2001;109:383–9.
63.
Zurück zum Zitat Nugroho P, Lydia A, Suhardjono S, Harimurti K. Association of BsmI polymorphisms in the vitamin D receptor gene among Indonesian population with diabetic kidney disease. Acta Med Indones. 2021;53:149–55. Nugroho P, Lydia A, Suhardjono S, Harimurti K. Association of BsmI polymorphisms in the vitamin D receptor gene among Indonesian population with diabetic kidney disease. Acta Med Indones. 2021;53:149–55.
64.
Zurück zum Zitat Glocke M, Lang F, Schaeffeler E, Lang T, Schwab M, Lang UE. Impact of vitamin D receptor VDR rs2228570 polymorphism in oldest old. Kidney Blood Press Res. 2013;37:311–22.CrossRef Glocke M, Lang F, Schaeffeler E, Lang T, Schwab M, Lang UE. Impact of vitamin D receptor VDR rs2228570 polymorphism in oldest old. Kidney Blood Press Res. 2013;37:311–22.CrossRef
65.
Zurück zum Zitat Errouagui A, Charoute H, Ghalim N, Barakat A, Kandil M, Rouba H. Relationship with vitamin D receptor (RVD) gene and essential arterial hypertension in Moroccan population. Int J Innov Appl Stud. 2014;8:556. Errouagui A, Charoute H, Ghalim N, Barakat A, Kandil M, Rouba H. Relationship with vitamin D receptor (RVD) gene and essential arterial hypertension in Moroccan population. Int J Innov Appl Stud. 2014;8:556.
66.
Zurück zum Zitat Jia J, Shen C, Mao L, Yang K, Men C, Zhan Y. Vitamin D receptor genetic polymorphism is significantly associated with decreased risk of hypertension in a Chinese Han population. J Clin Hypertens (Greenwich). 2014;16:634–9.CrossRef Jia J, Shen C, Mao L, Yang K, Men C, Zhan Y. Vitamin D receptor genetic polymorphism is significantly associated with decreased risk of hypertension in a Chinese Han population. J Clin Hypertens (Greenwich). 2014;16:634–9.CrossRef
67.
Zurück zum Zitat Gussago C, Arosio B, Guerini FR, Ferri E, Costa AS, Casati M, et al. Impact of vitamin D receptor polymorphisms in centenarians. Endocrine. 2016;53:558–64.CrossRef Gussago C, Arosio B, Guerini FR, Ferri E, Costa AS, Casati M, et al. Impact of vitamin D receptor polymorphisms in centenarians. Endocrine. 2016;53:558–64.CrossRef
68.
Zurück zum Zitat Wang L, Chu A, Buring JE, Ridker PM, Chasman DI, Sesso HD. Common genetic variations in the vitamin D pathway in relation to blood pressure. Am J Hypertens. 2014;27:1387–95.CrossRef Wang L, Chu A, Buring JE, Ridker PM, Chasman DI, Sesso HD. Common genetic variations in the vitamin D pathway in relation to blood pressure. Am J Hypertens. 2014;27:1387–95.CrossRef
Metadaten
Titel
Fok I and Bsm I gene polymorphism of vitamin D receptor and essential hypertension: a mechanistic link
verfasst von
Richa Awasthi
Priyanka Thapa Manger
Rajesh Kumar Khare
Publikationsdatum
01.12.2023
Verlag
BioMed Central
Erschienen in
Clinical Hypertension / Ausgabe 1/2023
Elektronische ISSN: 2056-5909
DOI
https://doi.org/10.1186/s40885-022-00229-y

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