Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Current Allergy and Asthma Reports
Erschienen in: Current Allergy and Asthma Reports 4/2021

01.04.2021 | Rhinosinusitis (J Mullol, Section Editor)

Herbal Medicines for Allergic Rhinitis: a Systematic Review and Meta-analysis

verfasst von: Minh Phuoc Hoang, Wirach Chitsuthipakorn, Kornkiat Snidvongs

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 4/2021

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

To assess the effects of herbal medicine (HM) therapy in various durations and analyze the effects of HM separately by mechanism of action in the treatment of allergic rhinitis (AR).

Recent Findings

Thirty-two studies were included (2,697 patients, mean age 34.6 years). For the ≤ 4 weeks of treatment duration, HM brought greater benefits over placebo in reduction of total nasal symptoms score (standardized mean difference (SMD) −0.68; 95% confidence interval (CI) −0.98, −0.38; p <0.01) and improvement in Rhinoconjunctivitis Quality of Life Questionnaire score (SMD −0.53; 95% CI −0.81, −0.25; p <0.01). For the 4–12 weeks duration, total nasal symptoms score (SMD −0.22; 95%CI −0.4, −0.05; p =0.01) and Rhinoconjunctivitis Quality of Life Questionnaire score (SMD −0.48; 95% CI −0.89, −0.06; p =0.03) favored the HM. However, HM therapy for longer than 12 weeks was related to tachyphylaxis and showed no benefit over placebo in any outcomes. There was no difference between the HM and standard treatment on symptoms improvement. Anti-allergic effect, anti-inflammatory effect, anti-leukotriene effect, and anti-histaminic effect of HM were revealed. HM was safe and their adverse effects were comparable placebo.

Summary

HM therapy is safe and provides better results than placebo in improving nasal symptoms and disease-specific quality of life in patients with AR. Its beneficial effects are demonstrated only in less than 12 weeks of treatment.

Trial Registration

PROSPERO ID: CRD42020168367
Literatur
1.
Seidman MD, Gurgel RK, Lin SY, Schwartz SR, Baroody FM, Bonner JR, et al. Clinical practice guideline: allergic rhinitis. Otolaryngol Head Neck Surg. 2015;152(1_Suppl):S1–S43.PubMedCrossRef
2.
Cheng L, Chen J, Fu Q, He S, Li H, Liu Z, et al. Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis. Allergy Asthma Immunol Res. 2018;10(4):300–53.PubMedPubMedCentralCrossRef
3.
MacLennan AH, Wilson DH, Taylor AW. The escalating cost and prevalence of alternative medicine. Prev Med. 2002;35(2):166–73.PubMedCrossRef
4.
Schaefer T, Riehle A, Wichmann HE, Ring J. Alternative medicine in allergies–prevalence, patterns of use, and costs. Allergy. 2002;57(8):694–700.CrossRef
5.
Luo Q, Zhang CS, Yang L, Zhang AL, Guo X, Xue CC, et al. Potential effectiveness of Chinese herbal medicine Yu ping feng san for adult allergic rhinitis: a systematic review and meta-analysis of randomized controlled trials. BMC Complement Altern Med. 2017;17(1):485.PubMedPubMedCentralCrossRef
6.•
Wu AW, Gettelfinger JD, Ting JY, Mort C, Higgins TS. Alternative therapies for sinusitis and rhinitis: a systematic review utilizing a modified Delphi method. Int Forum Allergy Rhinol. 2020;10(4):496–504 A good review yielded the experts’ recommendation of alternative treatments for sinusitis and rhinitis. Butterbur is recommended as an adjunctive treatment for allergic rhinitis.PubMedCrossRef
7.
Xue CC, Hugel HM, Li CG, Story DF. Efficacy, chemistry and pharmacology of chinese herbal medicine for allergic rhinitis. Curr Med Chem. 2004;11(11):1403–21.PubMedCrossRef
8.•
Guo R, Pittler MH, Ernst E. Herbal medicines for the treatment of allergic rhinitis: a systematic review. Ann Allergy Asthma Immunol. 2007;99(6):483–95. https://​doi.​org/​10.​1016/​S1081-1206(10)60375-4. The first systematic review investigated a wide spectrum of herbal medicine in the field treating allergic rhinitis.
9.
Wang S, Tang Q, Qian W, Fan Y. Meta-analysis of clinical trials on traditional Chinese herbal medicine for treatment of persistent allergic rhinitis. Allergy. 2012;67(5):583–92.PubMedCrossRef
10.
Brozek JL, Bousquet J, Agache I, Agarwal A, Bachert C, Bosnic-Anticevich S, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines-2016 revision. J Allergy Clin Immunol. 2017;140(4):950–8.PubMedCrossRef
11.•
Kern J, Bielory L. Complementary and alternative therapy (CAM) in the treatment of allergic rhinitis. Curr Allergy Asthma Rep. 2014;14(12):479 The comprehensive review of the literature regarding the efficacy and safety of herbal medicine in treating allergic rhinitis.PubMedCrossRef
12.•
Zhang X, Lan F, Zhang Y, Zhang L. Chinese Herbal Medicine to Treat Allergic Rhinitis: Evidence From a Meta-Analysis. Allergy Asthma Immunol Res. 2018;10(1):34–42 The latest meta-analysis displays the efficacy of Chinese herbal medicine and the limitation of lacking well-designed randomized controlled studies.PubMedCrossRef
13.
Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097.PubMedPubMedCentralCrossRef
14.
Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy. 2008;63(Suppl 86):8–160.PubMedCrossRef
15.
Seresirikachorn K, Chitsuthipakorn W, Kanjanawasee D, Khattiyawittayakun L, Snidvongs K. Leukotriene Receptor Antagonist Addition to H1-Antihistamine Is Effective for Treating Allergic Rhinitis: A Systematic Review and Meta-analysis. Am J Rhinol Allergy. 2019;33(5):591–600.PubMedCrossRef
16.
Chauhan BF, Ducharme FM. Anti-leukotriene agents compared to inhaled corticosteroids in the management of recurrent and/or chronic asthma in adults and children. Cochrane Database Syst Rev. 2012;5.
17.
Wise SK, Lin SY, Toskala E, Orlandi RR, Akdis CA, Alt JA, et al. International consensus statement on allergy and rhinology: allergic rhinitis. Int Forum Allergy Rhinol. 2018;8(2):108–352.PubMedPubMedCentral
18.
Higgins JPT, Green S. Assessing risk of bias in included studies. In: Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The Cochrane Collaboration. 2011. https://​handbook-5-1.​cochrane.​org. Accessed 13 Apr 2020.
19.
Bernstein DI, Bernstein CK, Deng C, Murphy KJ, Bernstein IL, Bernstein JA, et al. Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study. Ann Allergy Asthma Immunol. 2002;88(3):272–8.PubMedCrossRef
20.
Hu G, Walls RS, Bass D, Ramon B, Grayson D, Jones M, et al. The Chinese herbal formulation biminne in management of perennial allergic rhinitis: a randomized, double-blind, placebo-controlled, 12-week clinical trial. Ann Allergy Asthma Immunol. 2002;88(5):478–87.PubMedCrossRef
21.
Schapowal A, Petasites SG. Randomised controlled trial of butterbur and cetirizine for treating seasonal allergic rhinitis. BMJ. 2002;324(7330):144–6.PubMedPubMedCentralCrossRef
22.
Xue CC, Thien FC, Zhang JJ, Da Costa C, Li CG. Treatment for seasonal allergic rhinitis by Chinese herbal medicine: a randomized placebo controlled trial. Altern Ther Health Med. 2003;9(5):80–7.PubMed
23.
Brinkhaus B, Hummelsberger J, Kohnen R, Seufert J, Hempen CH, Leonhardy H, et al. Acupuncture and Chinese herbal medicine in the treatment of patients with seasonal allergic rhinitis: a randomized-controlled clinical trial. Allergy. 2004;59(9):953–60.PubMedCrossRef
24.
Lee DK, Gray RD, Robb FM, Fujihara S, Lipworth BJ. A placebo-controlled evaluation of butterbur and fexofenadine on objective and subjective outcomes in perennial allergic rhinitis. Clin Exp Allergy. 2004;34(4):646–9.PubMedCrossRef
25.
Schapowal A, Petasites SG. Butterbur Ze339 for the treatment of intermittent allergic rhinitis: dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study. Arch Otolaryngol Head Neck Surg. 2004;130(12):1381–6.PubMedCrossRef
26.
Takano H, Osakabe N, Sanbongi C, Yanagisawa R, Inoue K, Yasuda A, et al. Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, inhibits seasonal allergic rhinoconjunctivitis in humans. Exp Biol Med (Maywood). 2004;229(3):247–54.PubMedCrossRef
27.
Schapowal A, Study G. Treating intermittent allergic rhinitis: a prospective, randomized, placebo and antihistamine-controlled study of Butterbur extract Ze 339. Phytother Res. 2005;19(6):530–7.PubMedCrossRef
28.
Enomoto T, Nagasako-Akazome Y, Kanda T, Ikeda M, Dake Y. Clinical effects of apple polyphenols on persistent allergic rhinitis: A randomized double-blind placebo-controlled parallel arm study. J Investig Allergol Clin Immunol. 2006;16(5):283–9.PubMed
29.
Segawa S, Takata Y, Wakita Y, Kaneko T, Kaneda H, Watari J, et al. Clinical effects of a hop water extract on Japanese cedar pollinosis during the pollen season: a double-blind, placebo-controlled trial. Biosci Biotechnol Biochem. 2007;71(8):1955–62.PubMedCrossRef
30.
Yoshimura M, Enomoto T, Dake Y, Okuno Y, Ikeda H, Cheng L, et al. An evaluation of the clinical efficacy of tomato extract for perennial allergic rhinitis. Allergol Int. 2007;56(3):225–30.PubMedCrossRef
31.
Zhao Y, Woo KS, Ma KH, van Hansselt CA, Wong KC, Cheng KF, et al. Treatment of perennial allergic rhinitis using Shi-Bi-Lin, a Chinese herbal formula. J Ethnopharmacol. 2009;122(1):100–5.PubMedCrossRef
32.
Hsu WH, Ho TJ, Huang CY, Ho HC, Liu YL, Liu HJ, et al. Chinese medicine acupoint herbal patching for allergic rhinitis: a randomized controlled clinical trial. Am J Chin Med. 2010;38(4):661–73.PubMedCrossRef
33.
Matkovic Z, Zivkovic V, Korica M, Plavec D, Pecanic S, Tudoric N. Efficacy and safety of Astragalus membranaceus in the treatment of patients with seasonal allergic rhinitis. Phytother Res. 2010;24(2):175–81.PubMedCrossRef
34.
Wilson D, Evans M, Guthrie N, Sharma P, Baisley J, Schonlau F, et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res. 2010;24(8):1115–9.PubMed
35.
Yang SH, Yu CL, Chen YL, Chiao SL, Chen ML. Traditional Chinese medicine, Xin-yi-san, reduces nasal symptoms of patients with perennial allergic rhinitis by its diverse immunomodulatory effects. Int Immunopharmacol. 2010;10(8):951–8.PubMedCrossRef
36.
Jung JW, Kang HR, Ji GE, Park MS, Song WJ, Kim MH, et al. Therapeutic effects of fermented red ginseng in allergic rhinitis: a randomized, double-blind, placebo-controlled study. Allergy Asthma Immunol Res. 2011;3(2):103–10.PubMedPubMedCentralCrossRef
37.
Nikakhlagh S, Rahim F, Aryani FH, Syahpoush A, Brougerdnya MG, Saki N. Herbal treatment of allergic rhinitis: the use of Nigella sativa. Am J Otolaryngol. 2011;32(5):402–7.PubMedCrossRef
38.
Yonekura S, Okamoto Y, Yamasaki K, Horiguchi S, Hanazawa T, Matsune S, et al. A randomized, double-blind, placebo-controlled study of ten-cha (Rubus suavissimus) on house dust mite allergic rhinitis. Auris Nasus Larynx. 2011;38(5):600–7.PubMedCrossRef
39.
Lenon GB, Li CG, Da Costa C, Thien FC, Shen Y, Xue CC. Lack of efficacy of a herbal preparation (RCM-102) for seasonal allergic rhinitis: a double blind, randomised, placebo-controlled trial. Asia Pac Allergy. 2012;2(3):187–94.PubMedPubMedCentralCrossRef
40.
Masuda S, Maeda-Yamamoto M, Usui S, Fujisawa T. ‘Benifuuki’ green tea containing o-methylated catechin reduces symptoms of Japanese cedar pollinosis: a randomized, double-blind, placebo-controlled trial. Allergol Int. 2014;63(2):211–7.PubMedCrossRef
41.
Min CY, Peng CJ, Wei GJ, Huang XH, Fu TT, Du Y, et al. Moxibustion with Chinese herbal has good effect on allergic rhinitis. Int J Clin Exp Med. 2015;8(9):16480–7.PubMedPubMedCentral
42.
Choi SY, Park K. Effect of Inhalation of Aromatherapy Oil on Patients with Perennial Allergic Rhinitis: A Randomized Controlled Trial. Evid Based Complement Alternat Med. 2016;2016:7896081.PubMedPubMedCentral
43.
Fujiwara T, Nishida N, Nota J, Kitani T, Aoishi K, Takahashi H, et al. Efficacy of chlorophyll c2 for seasonal allergic rhinitis: single-center double-blind randomized control trial. Eur Arch Otorhinolaryngol. 2016;273(12):4289–94.PubMedCrossRef
44.
Hoffmann A, Klein SD, Grundemann C, Garcia-Kaufer M, Wolf U, Huber R. Efficacy of a Nasal Spray from Citrus limon and Cydonia oblonga for the Treatment of Hay Fever Symptoms-A Randomized, Placebo Controlled Cross-Over Study. Phytother Res. 2016;30(9):1481–6.PubMedCrossRef
45.
Arpornchayanon W, Klinprung S, Chansakaow S, Hanprasertpong N, Chaiyasate S, Tokuda M, et al. Antiallergic activities of shallot (Allium ascalonicum L.) and its therapeutic effects in allergic rhinitis. Asian Pac J Allergy Immunol. 2019;18 [Epub ahead of print].
46.
Dai L, Zhong LLD, Kun W, Lam WC, Yang Z, Huang T, et al. An External CAM Therapy (Tian Jiu) versus Placebo in Treatment of Allergic Rhinitis: A Pilot Single-Blinded, Three-Arm, Randomized Controlled Study. Evid Based Complement Alternat Med. 2019;2019:6369754.PubMedPubMedCentral
47.
Kim MH, Hong SU, Kim HT, Seo HS, Kim K, Ko SG, et al. A multicenter study on the efficacy and safety of So-Cheong-Ryong-Tang for perennial allergic rhinitis. Complement Ther Med. 2019;45:50–6.PubMedCrossRef
48.
Steels E, Steels E, Deshpande P, Thakurdesai P, Dighe S, Collet T. A randomized, double-blind placebo-controlled study of intranasal standardized cinnamon bark extract for seasonal allergic rhinitis. Complement Ther Med. 2019;47:102198.PubMedCrossRef
49.
Tandhavadhana S, Maek ANW, Phonrat B, Picheansoonthon C, Pitisuttithum P. Preliminary study on safety and efficacy of a Thai herbal remedy in persistent allergic rhinitis: A Randomized Double-blind Placebo-controlled Trial. J Med Assoc Thai. 2019;102(8):24–9.
50.
Zhao J, Yan X, Gai J, Han J, Zhang H, Luo H, et al. Efficacy of Bimin decoction for patients with perennial allergic rhinitis: an open-label non-inferiority randomized controlled trial. Trials. 2019;20(1):802.PubMedPubMedCentralCrossRef
51.
Thomet OA, Schapowal A, Heinisch IV, Wiesmann UN, Simon HU. Anti-inflammatory activity of an extract of Petasites hybridus in allergic rhinitis. Int Immunopharmacol. 2002;2(7):997–1006.PubMedCrossRef
52.
Zheng Z, Sun Z, Zhou X, Zhou Z. Efficacy of Chinese herbal medicine in treatment of allergic rhinitis in children: a meta-analysis of 19 randomized controlled trials. J Int Med Res. 2018;46(10):4006–18.PubMedPubMedCentralCrossRef
Metadaten
Titel
Herbal Medicines for Allergic Rhinitis: a Systematic Review and Meta-analysis
verfasst von
Minh Phuoc Hoang
Wirach Chitsuthipakorn
Kornkiat Snidvongs
Publikationsdatum
01.04.2021
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 4/2021
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-021-00999-9

Weitere Artikel der Ausgabe 4/2021

Current Allergy and Asthma Reports 4/2021 Zur Ausgabe

Rhinosinusitis (J Mullol, Section Editor)

The COVID-19 Pandemic—an Epidemiological Perspective

Occupational Allergies (JA Poole, Section Editor)

What Is New in Occupational Allergic Contact Dermatitis in the Year of the COVID Pandemic?

Autoimmunity (TK Tarrant, Section Editor)

Fatal Anaphylaxis: Epidemiology and Risk Factors

Rhinosinusitis (J Mullol, Section Editor)

Multidisciplinary Care for Severe or Uncontrolled Chronic Upper Airway Diseases

Immunotherapy and Immunomodulators (B Vickery, Section Editor)

How to Incorporate Oral Immunotherapy into Your Clinical Practice

Autoimmunity (TK Tarrant, Section Editor)

Paget’s Disease of Bone: Osteoimmunology and Osteoclast Pathology

Neu im Fachgebiet HNO

Kinder mit anhaltender Sinusitis profitieren häufig von Antibiotika

30.04.2024 Rhinitis und Sinusitis Nachrichten

Persistieren Sinusitisbeschwerden bei Kindern länger als zehn Tage, ist eine Antibiotikatherapie häufig gut wirksam: Ein Therapieversagen ist damit zu über 40% seltener zu beobachten als unter Placebo.

CUP-Syndrom: Künstliche Intelligenz kann Primärtumor finden

30.04.2024 Künstliche Intelligenz Nachrichten

Krebserkrankungen unbekannten Ursprungs (CUP) sind eine diagnostische Herausforderung. KI-Systeme können Pathologen dabei unterstützen, zytologische Bilder zu interpretieren, um den Primärtumor zu lokalisieren.

Sind Frauen die fähigeren Ärzte?

30.04.2024 Gendermedizin Nachrichten

Patienten, die von Ärztinnen behandelt werden, dürfen offenbar auf bessere Therapieergebnisse hoffen als Patienten von Ärzten. Besonders gilt das offenbar für weibliche Kranke, wie eine Studie zeigt.

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen
Bildnachweise