Background
Methods
Patient selection
Patient treatment
Baseline characteristics
Study end points
Statistical analysis
Results
Characteristic | N = 270, n (%) | OR (95% CI) | P-value |
---|---|---|---|
Patient Characteristics | |||
Agea (years) | |||
Median | 66.6 | 1.0 (1.0–1.0) | 0.80 |
Range | 31–88 | ||
Gender | |||
Female (reference) | 134 (49.6) | ||
Male | 136 (50.4) | 1.1 (0.6–2.1) | 0.69 |
Race | |||
Black (reference) | 76 (28.1) | ||
Caucasian | 168 (62.2) | 1.4 (0.7–2.8) | 0.39 |
Other | 26 (9.6) | 0.10 (0.01–1.8) | 0.12 |
Marital Status | |||
Partnered (reference) | 163 (60.4) | ||
Un-partnered | 107 (39.6) | 0.8 (0.4–1.5) | 0.41 |
Tumor Characteristics | |||
Stage Summary | |||
I-III (reference) | 206 (76.3) | ||
IV | 32 (11.9) | 0.9 (0.3–2.4) | 0.79 |
Loco-regional recurrence | 32 (11.9) | 0.7 (0.2–2.0) | 0.50 |
Histology | |||
Adenocarcinoma (reference) | 144 (53.3) | ||
Squamous cell carcinoma | 88 (32.6) | 1.9 (1.0–3.8) | 0.06 |
Small cell carcinoma | 11 (4.1) | 1.7 (0.4–7.8) | 0.50 |
Other | 27 (10) | 2.0 (0.7–5.4) | 0.12 |
Treatment Characteristics | |||
Concurrent chemo summary | |||
Full Dose (reference) | 141(52.2) | ||
Sensitizing | 93 (34.4) | 1.0 (0.5–1.9) | 0.89 |
No chemo | 36 (13.3) | 0.4 (0.1–1.4) | 0.17 |
Baseline Frailty Markers | |||
ECOG PSa | N = 257 | ||
Median | 1 | 1.7 (1.0–2.9) | 0.07 |
Range | 0–3 | ||
CCIa | N = 270 | ||
Median | 5 | 1.0 (0.9–1.2) | 0.73 |
Range | 2–16 | ||
Patient reported weight loss | N = 269 | ||
No (reference) | 100 (37.2) | ||
Yes | 169 (62.8) | 1.0 (0.5–1.8) | 0.90 |
BMI (kg/m2) | N = 270 | ||
> 20 (reference) | 244 (90.4) | ||
≤ 20 | 26 (9.6) | 1.9 (0.8–4.9) | 0.16 |
Hemoglobin (g/dL) | N = 259 | ||
> 10 (reference) | 233 (90.0) | ||
≤ 10 | 26 (10.0) | 3.3 (1.4–7.9) | 0.01 |
Creatinine (mg/dL) | N = 258 | ||
≤ 1.1 (reference) | 206 (79.8) | ||
> 1.1 | 52 (20.2) | 1.1 (0.5–2.3) | 0.91 |
Albuminb (g/dL) | N = 254 | ||
Median | 3.7 | 3.1 (1.6–5.9) | < 0.01 |
Range | 2.3–4.8 |
Frailty markers
Cancer-related hospitalization
Any Hospitalization | Multiple Hospitalizations | |||
---|---|---|---|---|
Variable | OR (95% CI) | P-value | Coefficient (95% CI) | P-value |
Race | ||||
Black (reference) | ||||
Caucasian | 1.4 (0.6–3.4) | 0.46 | 1.7 (0.8–3.6) | 0.13 |
Other | 0.1 (0.01–2.1) | 0.15 | 0.1 (0.01–2.4) | 0.17 |
Marital Status | ||||
Partnered (reference) | ||||
Un-partnered | 0.6 (0.3–1.3) | 0.16 | 0.6 (0.3–1.2) | 0.13 |
ECOG PS a | 1.6 (0.9–2.9) | 0.15 | 1.4 (0.9–2.2) | 0.11 |
Hemoglobin (g/dL) | ||||
> 10 (reference) | ||||
≤ 10 | 2.4 (0.8–7.1) | 0.11 | 2.7 (1.3–5.4) | 0.01 |
Albumin b (g/dL) | 2.4 (1.2–5.0) | 0.01 | 1.5 (0.9–1.5) | 0.11 |
Survival
Univariable | Multivariable | |||
---|---|---|---|---|
Variable | HR (95% CI) | P-value | HR (95% CI) | P-value |
Patient Characteristics | ||||
Age a (years) | 1.0 (1.0–1.1) | 0.02 | 1.0 (1.0–1.1) | 0.19 |
Gender | ||||
Female (reference) | ||||
Male | 1.7 (1.1–2.7) | 0.01 | 2.1 (1.3–3.4) | < 0.01 |
Race | ||||
Black (reference) | ||||
Caucasian | 0.9 (0.6–1.4) | 0.54 | – | |
Other | 0.6 (0.2–1.4) | 0.21 | – | |
Marital Status | ||||
Partnered (reference) | ||||
Un-partnered | 1.1 (0.7–1.7) | 0.56 | – | |
Tumor Characteristics | ||||
Stage Summary | ||||
I-III (reference) | ||||
IV | 1.6 (0.8–2.9) | 0.17 | – | |
Loco-regional recurrence | 1.2 (0.7–2.3) | 0.53 | – | |
Histology | ||||
Adenocarcinoma (reference) | ||||
Squamous cell carcinoma | 1.6 (1.0–2.6) | 0.04 | – | |
Small cell carcinoma | 2.3 (0.9–5.6) | 0.08 | – | |
Other | 1.6 (0.8–3.5) | 0.21 | – | |
Treatment Characteristics | ||||
Cancer related hospitalization | ||||
No (reference) | ||||
Yes | 1.8 (1.1–3.1) | 0.02 | 1.8 (1.0–3.1) | 0.04 |
Relative weight loss during treatment | ||||
≤ 5% weight loss (reference) | ||||
> 5% weight loss | 1.5 (1.0–2.4) | 0.08 | – | |
Concurrent chemo summary | ||||
Full Dose (reference) | ||||
Sensitizing | 2.0 (1.3–3.2) | < 0.01 | 1.4 (0.8–2.5) | 0.21 |
No chemo | 1.4 (0.7–2.6) | 0.32 | 1.3 (0.5–3.3) | 0.56 |
Baseline Frailty Markers | ||||
ECOG PSa | 1.7 (1.2–2.4) | 0.01 | 1.6 (1.1–2.4) | 0.02 |
CCIa | 1.2 (1.1–1.3) | < 0.01 | 1.1 (1.0–1.2) | 0.25 |
Patient reported weight loss | ||||
No (reference) | ||||
Yes | 1.5 (1.0–2.3) | 0.08 | – | |
BMI (kg/m2) | ||||
> 20 (reference) | ||||
≤ 20 | 2.7 (1.5–4.8) | < 0.01 | 3.2 (1.7–6.1) | < 0.01 |
Hemoglobin (g/dL) | ||||
> 10 (reference) | ||||
≤ 10 | 2.5 (1.4–4.5) | < 0.01 | 1.2 (0.6–2.4) | 0.65 |
Creatinine (g/dL) | ||||
≤ 1.1 (reference) | ||||
> 1.1 | 1.4 (0.9–2.4) | 0.14 | – | |
Albuminb (g/dL) | 3.2 (1.0–5.0) | < 0.01 | 2.9 (1.7–4.5) | < 0.01 |