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Inflammation Research
Erschienen in: Inflammation Research 9/2015

01.09.2015 | Original Research Paper

Inhibitory effects of polyozellin from Polyozellus multiplex on HMGB1-mediated septic responses

verfasst von: Eun-Ju Yang, Sae-Kwang Ku, Wonhwa Lee, Kyung-Sik Song, Jong-Sup Bae

Erschienen in: Inflammation Research | Ausgabe 9/2015

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Abstract

Aim and objective

The ubiquitous nuclear protein, high-mobility group box 1 (HMGB1), is released by activated macrophages and human umbilical vein endothelial cells (HUVECs) and functions as a late mediator of experimental sepsis. Polyozellin, which has been reported to have a variety of biological activities including antioxidant and anticancer activity, is the major active compound found in edible mushroom (Polyozellus multiplex). In this study, we investigated the antiseptic effects and underlying mechanisms of polyozellin against HMGB1-mediated septic responses in HUVECs and mice.

Methods

The anti-inflammatory activities of polyozellin were determined by measuring permeability, human neutrophil adhesion and migration, and activation of proinflammatory proteins in HMGB1-activated HUVECs and mice.

Results

According to the results, polyozellin effectively inhibited lipopolysaccharide (LPS)-induced release of HMGB1, and suppressed HMGB1-mediated septic responses, such as hyperpermeability, adhesion and migration of leukocytes, and expression of cell adhesion molecules. In addition, polyozellin suppressed the production of tumor necrosis factor-α and interleukin (IL)-6, and the activation of nuclear factor-κB and extracellular signal-regulated kinases 1/2 by HMGB1.

Conclusion

Collectively, these results indicate that P. multiplex containing polyozellin could be commercialized as functional food for preventing and treatment of various severe vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway.
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Metadaten
Titel
Inhibitory effects of polyozellin from Polyozellus multiplex on HMGB1-mediated septic responses
verfasst von
Eun-Ju Yang
Sae-Kwang Ku
Wonhwa Lee
Kyung-Sik Song
Jong-Sup Bae
Publikationsdatum
01.09.2015
Verlag
Springer Basel
Erschienen in
Inflammation Research / Ausgabe 9/2015
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-015-0856-3

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