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Der Schmerz

Erschienen in:

10.09.2021 | Neuropathischer Schmerz | Pain Clinical Updates

Nervenkompressionssyndrome – eine aktuelle Betrachtung von Pathophysiologie, klinischer Untersuchung und Management

Deutsche Fassung

verfasst von: Annina B. Schmid, Joel Fundaun, Brigitte Tampin

Erschienen in: Der Schmerz | Ausgabe 6/2021

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Zusammenfassung

Nervenkompressionssyndrome („Engpass-Syndrome“) wie Karpaltunnelsyndrom, Radikulopathien oder radikulärer Schmerz sind die häufigsten peripheren Nervenläsionen und auch die häufigste Ursache für neuropathischen Schmerz. Trotz ihrer hohen Prävalenz stellen sie diagnostisch und therapeutisch weiterhin oft eine klinische Herausforderung dar. Die vorliegende Übersicht bietet aktuelle Informationen zur Ätiologie und Pathophysiologie von Nervenkompressionssyndromen; dafür wird die Evidenz aus präklinischen wie auch klinischen Studien zusammengefasst. Mögliche Mechanismen werden in den Kontext klinischer Befunde gestellt. Das aktuelle diagnostische Vorgehen wird erörtert, diagnostische Fallstricke werden beleuchtet. Zuletzt fasst der Beitrag die Evidenz für die nichtinvasive und chirurgische Therapie häufiger Nervenkompressionssyndrome zusammen und zeigt zukünftige Forschungsbereiche auf.

Abzug JM, Jacoby SM, Osterman AL (2012) Surgical options for recalcitrant carpal tunnel syndrome with perineural fibrosis. Hand (N Y) 7:23–29

Ala-Kokko L (2002) Genetic risk factors for lumbar disc disease. Ann Med 34:42–47PubMed

Albrecht DS, Ahmed SU, Kettner NW, Borra RJH, Cohen-Adad J, Deng H, Houle TT, Opalacz A, Roth SA, Melo MFV, Chen L, Mao J, Hooker JM, Loggia ML, Zhang Y (2018) Neuroinflammation of the spinal cord and nerve roots in chronic radicular pain patients. Pain 159:968–977PubMedPubMedCentral

Allison GT, Nagy BM, Hall T (2002) A randomized clinical trial of manual therapy for cervico-brachial pain syndrome—a pilot study. Man Ther 7:95–102PubMed

American Academy of Orthopaedic Surgeons (2007) Clinical practice guideline on the diagnosis of carpal tunnel syndrome. AAOS, Rosemont

Amir R, Michaelis M, Devor M (1999) Membrane potential oscillations in dorsal root ganglion neurons: role in normal electrogenesis and neuropathic pain. J Neurosci 19:8589–8596PubMedPubMedCentral

Ando Y (1990) Experimental study on chronic entrapment neuropathy [in Japanese]. Nippon Seikeigeka Gakkai Zasshi 64:633–647PubMed

Andrasinova T, Kalikova E, Kopacik R, Srotova I, Vlckova E, Dusek L, Bednarik J, Adamova B (2019) Evaluation of the neuropathic component of chronic low back pain. Clin J Pain 35:7–17PubMed

Arendt-Nielsen L, Gregersen H, Toft E, Bjerring P (1991) Involvement of thin afferents in carpal tunnel syndrome: evaluated quantitatively by argon laser stimulation. Muscle Nerve 14:508–514PubMed

10.

Armstrong BD, Hu Z, Abad C, Yamamoto M, Rodriguez WI, Cheng J, Lee M, Chhith S, Gomariz RP, Waschek JA (2004) Induction of neuropeptide gene expression and blockade of retrograde transport in facial motor neurons following local peripheral nerve inflammation in severe combined immunodeficiency and BALB/C mice. Neuroscience 129:93–99PubMed

11.

Ashworth J, Konstantinou K, Dunn KM (2011) Prognostic factors in non-surgically treated sciatica: a systematic review. BMC Musculoskelet Disord 12:208PubMedPubMedCentral

12.

Baron R, Hans G, Dickenson AH (2013) Peripheral input and its importance for central sensitization. Ann Neurol 74:630–636PubMed

13.

Baron R, Maier C, Attal N, Binder A, Bouhassira D, Cruccu G, Finnerup NB, Haanpaa M, Hansson P, Hullemann P, Jensen TS, Freynhagen R, Kennedy JD, Magerl W, Mainka T, Reimer M, Rice AS, Segerdahl M, Serra J, Sindrup S, Sommer C, Tolle T, Vollert J, Treede RD (2017) Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles. Pain 158:261–272PubMed

14.

Baselgia LT, Bennett DL, Silbiger RM, Schmid AB (2017) Negative neurodynamic tests do not exclude neural dysfunction in patients with entrapment neuropathies. Arch Phys Med Rehabil 98:480–486PubMedPubMedCentral

15.

Baskozos G, Sandy-Hindmarch O, Clark A, Windsor K, Karlsson P, Weir G, McDermott L, Burchall J, Wiberg A, Furniss D, Bennett D, Schmid A (2020) Molecular and cellular correlates of human nerve regeneration: ADCYAP1 encoding PACAP enhances sensory neuron outgrowth. Brain 143:2009–2026PubMedPubMedCentral

16.

Basson A, Olivier B, Ellis R, Coppieters M, Stewart A, Mudzi W (2017) The effectiveness of neural mobilization for neuromusculoskeletal conditions: a systematic review and meta-analysis. J Orthop Sports Phys Ther 47:593–615PubMed

17.

Bebbington E, Furniss D (2015) Linear regression analysis of hospital episode statistics predicts a large increase in demand for elective hand surgery in england. J Plast Reconstr Aesthet Surg 68:243–251PubMedPubMedCentral

18.

Bland JD (2007) Treatment of carpal tunnel syndrome. Muscle Nerve 36:167–171PubMed

19.

Bogduk N (2009) On the definitions and physiology of back pain, referred pain, and radicular pain. Pain 147:17–19PubMed

20.

Bono CM, Ghiselli G, Gilbert TJ, Kreiner DS, Reitman C, Summers JT, Baisden JL, Easa J, Fernand R, Lamer T, Matz PG, Mazanec DJ, Resnick DK, Shaffer WO, Sharma AK, Timmons RB, Toton JF, North American Spine S (2011) An evidence-based clinical guideline for the diagnosis and treatment of cervical radiculopathy from degenerative disorders. Spine J 11:64–72PubMed

21.

Bove GM, Ransil BJ, Lin HC, Leem JG (2003) Inflammation induces ectopic mechanical sensitivity in axons of nociceptors innervating deep tissues. J Neurophysiol 90:1949–1955PubMed

22.

Butler DS (2000) The sensitive nervous system. NOIgroup publications, Adelaide

23.

Caliandro P, La Torre G, Aprile I, Pazzaglia C, Commodari I, Tonali P, Padua L (2006) Distribution of paresthesias in carpal tunnel syndrome reflects the degree of nerve damage at wrist. Clin Neurophysiol 117:228–231PubMed

24.

Calvo M, Richards N, Schmid AB, Barroso A, Zhu L, Ivulic D, Zhu N, Anwandter P, Bhat MA, Court FA, McMahon SB, Bennett DL (2016) Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury. Elife 5:e12661PubMedPubMedCentral

25.

Cappelen-Smith C, Lin CS, Burke D (2003) Activity-dependent hyperpolarization and impulse conduction in motor axons in patients with carpal tunnel syndrome. Brain 126:1001–1008PubMed

26.

Chen Y, Devor M (1998) Ectopic mechanosensitivity in injured sensory axons arises from the site of spontaneous electrogenesis. Eur J Pain 2:165–178PubMed

27.

Chen IJ, Chang KV, Wu WT, Ozcakar L (2019) Ultrasound parameters other than the direct measurement of ulnar nerve size for diagnosing cubital tunnel syndrome: a systemic review and meta-analysis. Arch Phys Med Rehabil 100:1114–1130PubMed

28.

Chhabra A, Wadhwa V, Thakkar RS, Carrino JA, Dellon AL (2013) Recurrent ulnar nerve entrapment at the elbow: correlation of surgical findings and 3‑Tesla magnetic resonance neurography. Can J Plast Surg 21:186–189PubMedPubMedCentral

29.

Chien A, Eliav E, Sterling M (2008) Whiplash (grade II) and cervical radiculopathy share a similar sensory presentation: an investigation using quantitative sensory testing. Clin J Pain 24:595–603PubMed

30.

Cho SC, Ferrante MA, Levin KH, Harmon RL, So YT (2010) Utility of electrodiagnostic testing in evaluating patients with lumbosacral radiculopathy: an evidence-based review. Muscle Nerve 42:276–282PubMed

31.

Coppieters MW, Schmid AB, Kubler PA, Hodges PW (2012) Description, reliability and validity of a novel method to measure carpal tunnel pressure in patients with carpal tunnel syndrome. Man Ther 17:589–592PubMed

32.

Cudlip SA, Howe FA, Clifton A, Schwartz MS, Bell BA (2002) Magnetic resonance neurography studies of the median nerve before and after carpal tunnel decompression. J Neurosurg 96:1046–1051PubMed

33.

Dahlin LB, McLean WG (1986) Effects of graded experimental compression on slow and fast axonal transport in rabbit vagus nerve. J Neurol Sci 72:19–30PubMed

34.

Dahlin LB, Rydevik B, McLean WG, Sjostrand J (1984) Changes in fast axonal transport during experimental nerve compression at low pressures. Exp Neurol 84:29–36PubMed

35.

Dahlin LB, Sjostrand J, McLean WG (1986) Graded inhibition of retrograde axonal transport by compression of rabbit vagus nerve. J Neurol Sci 76:221–230PubMed

36.

Dahlin LB, Shyu BC, Danielsen N, Andersson SA (1989) Effects of nerve compression or ischaemia on conduction properties of myelinated and non-myelinated nerve fibres. An experimental study in the rabbit common peroneal nerve. Acta Physiol Scand 136:97–105PubMed

37.

de la Llave-Rincon AI, Fernandez-de-Las-Penas C, Fernandez-Carnero J, Padua L, Arendt-Nielsen L, Pareja JA (2009) Bilateral hand/wrist heat and cold hyperalgesia, but not hypoesthesia, in unilateral carpal tunnel syndrome. Exp Brain Res 198:455–463PubMed

38.

Deville WL, van der Windt DA, Dzaferagic A, Bezemer PD, Bouter LM (2000) The test of Lasegue: systematic review of the accuracy in diagnosing herniated discs. Spine (Phila Pa 1976) 25:1140–1147

39.

Dilley A, Bove GM (2008) Disruption of axoplasmic transport induces mechanical sensitivity in intact rat C‑fibre nociceptor axons. J Physiol 586:593–604PubMed

40.

Dilley A, Lynn B, Pang SJ (2005) Pressure and stretch mechanosensitivity of peripheral nerve fibres following local inflammation of the nerve trunk. Pain 117:462–472PubMedPubMedCentral

41.

Dove L, Jones G, Kelsey L, Cairns M, Schmid AB (2019) How effective is physiotherapy for sciatica? A systematic review and meta-analysis. 7th International Congress on Neuropathic Pain, London

42.

Drummond PD, Drummond ES, Dawson LF, Mitchell V, Finch PM, Vaughan CW, Phillips JK (2014) Upregulation of alpha1-adrenoceptors on cutaneous nerve fibres after partial sciatic nerve ligation and in complex regional pain syndrome type II. Pain 155:606–616PubMed

43.

Druschky K, Kaltenhauser M, Hummel C, Druschky A, Huk WJ, Stefan H, Neundorfer B (2000) Alteration of the somatosensory cortical map in peripheral mononeuropathy due to carpal tunnel syndrome. Neuroreport 11:3925–3930PubMed

44.

Dworkin RH, O’Connor AB, Kent J, Mackey SC, Raja SN, Stacey BR, Levy RM, Backonja M, Baron R, Harke H, Loeser JD, Treede RD, Turk DC, Wells CD (2013) Interventional management of neuropathic pain: NeuPSIG recommendations. Pain 154:2249–2261PubMedPubMedCentral

45.

Elective JM (2017) Surgery waiting times 2016–2017: Australian hospital statistics. Australian institute of health and wellness. https://www.aihw.gov.au/reports/hospitals/elective-surgery-waiting-times-ahs-2016-17/data. Zugegriffen: 7. März 2018

46.

Ellis R, Blyth R, Arnold N, Miner-Williams W (2017) Is there a relationship between impaired median nerve excursion and carpal tunnel syndrome? A systematic review. J Hand Ther 30:3–12PubMed

47.

Elvey RL (1997) Physical evaluation of the peripheral nervous system in disorders of pain and dysfunction. J Hand Ther 10:122–129PubMed

48.

Endean A, Palmer KT, Coggon D (2011) Potential of magnetic resonance imaging findings to refine case definition for mechanical low back pain in epidemiological studies: a systematic review. Spine (Phila Pa 1976) 36:160–169

49.

England JD, Gamboni F, Ferguson MA, Levinson SR (1994) Sodium channels accumulate at the tips of injured axons. Muscle Nerve 17:593–598PubMed

50.

Erdem Tilki H, Coskun M, Unal Akdemir N, Incesu L (2014) Axon count and sympathetic skin responses in lumbosacral radiculopathy. J Clin Neurol 10:10–16PubMedPubMedCentral

51.

Erickson M, Lawrence M, Jansen CWS, Coker D, Amadio P, Cleary C (2019) Hand pain and sensory deficits: carpal tunnel syndrome. J Orthop Sports Phys Ther 49:CPG1–CPG85PubMed

52.

Fernandez-de-Las Penas C, Ortega-Santiago R, de la Llave-Rincon AI, Martinez-Perez A, Fahandezh-Saddi Diaz H, Martinez-Martin J, Pareja JA, Cuadrado-Perez ML (2015) Manual physical therapy versus surgery for carpal tunnel syndrome: a randomized parallel-group trial. J Pain 16:1087–1094PubMed

53.

Fernandez-de-las-Penas C, de la Llave-Rincon AI, Fernandez-Carnero J, Cuadrado ML, Arendt-Nielsen L, Pareja JA (2009) Bilateral widespread mechanical pain sensitivity in carpal tunnel syndrome: evidence of central processing in unilateral neuropathy. Brain 132:1472–1479PubMed

54.

Fernandez-de-Las-Penas C, Cleland J, Palacios-Cena M, Fuensalida-Novo S, Pareja JA, Alonso-Blanco C (2017) The effectiveness of manual therapy versus surgery on self-reported function, cervical range of motion, and pinch grip force in carpal tunnel syndrome: a randomized clinical trial. J Orthop Sports Phys Ther 47:151–161PubMed

55.

Finnerup NB, Haroutounian S, Kamerman P, Baron R, Bennett DL, Bouhassira D, Cruccu G, Freeman R, Hansson P, Nurmikko T, Raja SN, Rice AS, Serra J, Smith BH, Treede RD, Jensen TS (2016) Neuropathic pain: an updated grading system for research and clinical practice. Pain 157:1599–1606PubMedPubMedCentral

56.

Finucane L, Downie A, Mercer C, Greenhalgh S, Boissonnault WG, Pool-Goudzwaard A, Beneciuk JM, Leech R, Selfe J (2020) International framework for red flags for potential serious spinal pathologies. J Orthop Sports Phys Ther 50:350–372PubMed

57.

Fjeld O, Grotle M, Siewers V, Pedersen LM, Nilsen KB, Zwart JA (2017) Prognostic factors for persistent leg-pain in patients hospitalized with acute sciatica. Spine (Phila Pa 1976) 42:E272–9

58.

Foix C, Marie P (1913) Atrophie isolée de l’éminence thénar d’origin névritique. Rôle du ligament annulaire antérieur du carpe dans la pathogénie de la lésion. Rev Neurol 26:647–648

59.

Freynhagen R, Rolke R, Baron R, Tolle TR, Rutjes AK, Schu S, Treede RD (2008) Pseudoradicular and radicular low-back pain—a disease continuum rather than different entities? Answers from quantitative sensory testing. Pain 135:65–74PubMed

60.

Gelberman RH, Hergenroeder PT, Hargens AR, Lundborg GN, Akeson WH (1981) The carpal tunnel syndrome. A study of carpal canal pressures. J Bone Joint Surg Am 63:380–383PubMed

61.

Gupta R, Channual JC (2006) Spatiotemporal pattern of macrophage recruitment after chronic nerve compression injury. J Neurotrauma 23:216–226PubMed

62.

Gupta R, Steward O (2003) Chronic nerve compression induces concurrent apoptosis and proliferation of Schwann cells. J Comp Neurol 461:174–186PubMed

63.

Gupta R, Rowshan K, Chao T, Mozaffar T, Steward O (2004) Chronic nerve compression induces local demyelination and remyelination in a rat model of carpal tunnel syndrome. Exp Neurol 187:500–508PubMed

64.

Hall TM, Elvey RL (1999) Nerve trunk pain: physical diagnosis and treatment. Man Ther 4:63–73PubMed

65.

Haugen AJ, Brox JI, Grovle L, Keller A, Natvig B, Soldal D, Grotle M (2012) Prognostic factors for non-success in patients with sciatica and disc herniation. BMC Musculoskelet Disord 13:183PubMedPubMedCentral

66.

van der Heide B, Bourgoin C, Eils G, Garnevall B, Blackmore M (2006) Test-retest reliability and face validity of a modified neural tissue provocation test in patients with cervicobrachial pain syndrome. J Man Manip Ther 14:30–36

67.

Heindel P, Tuchman A, Hsieh PC, Pham MH, D’Oro A, Patel NN, Jakoi AM, Hah R, Liu JC, Buser Z, Wang JC (2017) Reoperation rates after single-level lumbar discectomy. Spine (Phila Pa 1976) 42:E496–501

68.

Hu P, Bembrick AL, Keay KA, McLachlan EM (2007) Immune cell involvement in dorsal root ganglia and spinal cord after chronic constriction or transection of the rat sciatic nerve. Brain Behav Immun 21:599–616PubMed

69.

Ido K, Urushidani H (2001) Fibrous adhesive entrapment of lumbosacral nerve roots as a cause of sciatica. Spinal Cord 39:269–273PubMed

70.

Iversen T, Solberg TK, Wilsgaard T, Waterloo K, Brox JI, Ingebrigtsen T (2015) Outcome prediction in chronic unilateral lumbar radiculopathy: prospective cohort study. BMC Musculoskelet Disord 16:17PubMedPubMedCentral

71.

Jacobs WC, van Tulder M, Arts M, Rubinstein SM, van Middelkoop M, Ostelo R, Verhagen A, Koes B, Peul WC (2011) Surgery versus conservative management of sciatica due to a lumbar herniated disc: a systematic review. Eur Spine J 20:513–522PubMed

72.

Jiang YQ, Xing GG, Wang SL, Tu HY, Chi YN, Li J, Liu FY, Han JS, Wan Y (2008) Axonal accumulation of hyperpolarization-activated cyclic nucleotide-gated cation channels contributes to mechanical allodynia after peripheral nerve injury in rat. Pain 137:495–506PubMed

73.

Kendall N, Linton S, Main C (1997) Guide to assessing psychosocial yellow flags in acute low back pain: risk factors for long-term disability and work loss. Accident Rehabilitation and Compensation Insurance Corporation of New Zealand and the National Health Committee, Wellington

74.

Kiernan MC, Mogyoros I, Burke D (1999) Conduction block in carpal tunnel syndrome. Brain 122(5):933–941PubMed

75.

Kiylioglu N (2007) Sympathetic skin response and axon counting in carpal tunnel syndrome. J Clin Neurophysiol 24:424 (author reply 424)PubMed

76.

Konstantinou K, Dunn KM (2008) Sciatica: review of epidemiological studies and prevalence estimates. Spine (Phila Pa 1976) 33:2464–2472

77.

Konstantinou K, Dunn KM, Ogollah R, Lewis M, van der Windt D, Hay EM, Team AS (2018) Prognosis of sciatica and back-related leg pain in primary care: the ATLAS cohort. Spine J 18:1030–1040PubMedPubMedCentral

78.

Kozak A, Schedlbauer G, Wirth T, Euler U, Westermann C, Nienhaus A (2015) Association between work-related biomechanical risk factors and the occurrence of carpal tunnel syndrome: an overview of systematic reviews and a meta-analysis of current research. BMC Musculoskelet Disord 16:231PubMedPubMedCentral

79.

Latremoliere A, Woolf CJ (2009) Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain 10:895–926PubMedPubMedCentral

80.

LeBlanc BW, Zerah ML, Kadasi LM, Chai N, Saab CY (2011) Minocycline injection in the ventral posterolateral thalamus reverses microglial reactivity and thermal hyperalgesia secondary to sciatic neuropathy. Neurosci Lett 498:138–142PubMed

81.

Lemmela S, Solovieva S, Shiri R, Benner C, Heliovaara M, Kettunen J, Anttila V, Ripatti S, Perola M, Seppala I, Juonala M, Kahonen M, Salomaa V, Viikari J, Raitakari OT, Lehtimaki T, Palotie A, Viikari-Juntura E, Husgafvel-Pursiainen K (2016) Genome-wide meta-analysis of sciatica in Finnish population. PLoS ONE 11:e163877PubMedPubMedCentral

82.

Lewis AM, Layzer R, Engstrom JW, Barbaro NM, Chin CT (2006) Magnetic resonance neurography in extraspinal sciatica. Arch Neurol 63:1469–1472PubMed

83.

Lewis KJ, Coppieters MW, Ross L, Hughes I, Vicenzino B, Schmid AB (2020) Group education, night splinting and home exercises reduce conversion to surgery for carpal tunnel syndrome: a multicentre randomised trial. J Physiother 66:97–104PubMed

84.

Liu X, Zhou JL, Chung K, Chung JM (2001) Ion channels associated with the ectopic discharges generated after segmental spinal nerve injury in the rat. Brain Res 900:119–127PubMed

85.

Lozano-Calderon S, Anthony S, Ring D (2008) The quality and strength of evidence for etiology: example of carpal tunnel syndrome. J Hand Surg Am 33:525–538PubMed

86.

Luchtmann M, Steinecke Y, Baecke S, Lutzkendorf R, Bernarding J, Kohl J, Jollenbeck B, Tempelmann C, Ragert P, Firsching R (2014) Structural brain alterations in patients with lumbar disc herniation: a preliminary study. PLoS One 9:e90816PubMedPubMedCentral

87.

MacDermid J (1991) Accuracy of clinical tests used in the detection of carpal tunnel syndrome: a literature review. J Hand Ther 4:169–176

88.

Machado GC, Witzleb AJ, Fritsch C, Maher CG, Ferreira PH, Ferreira ML (2016) Patients with sciatica still experience pain and disability 5 years after surgery: a systematic review with meta-analysis of cohort studies. Eur J Pain 20:1700–1709PubMed

89.

Mackinnon SE, Dellon AL, Hudson AR, Hunter DA (1984) Chronic nerve compression—an experimental model in the rat. Ann Plast Surg 13:112–120PubMed

90.

Mackinnon SE, Dellon AL, Hudson AR, Hunter DA (1986) Chronic human nerve compression—a histological assessment. Neuropathol Appl Neurobiol 12:547–565PubMed

91.

Mackinnon SE (2002) Pathophysiology of nerve compression. Hand Clin 18:231–241PubMed

92.

Maeda Y, Kettner N, Sheehan J, Kim J, Cina S, Malatesta C, Gerber J, McManus C, Mezzacappa P, Morse LR, Audette J, Napadow V (2013) Altered brain morphometry in carpal tunnel syndrome is associated with median nerve pathology. Neuroimage Clin 2:313–319PubMedPubMedCentral

93.

Mahn F, Hullemann P, Gockel U, Brosz M, Freynhagen R, Tolle TR, Baron R (2011) Sensory symptom profiles and co-morbidities in painful radiculopathy. PLoS One 6:e18018PubMedPubMedCentral

94.

Mallik A, Weir AI (2005) Nerve conduction studies: essentials and pitfalls in practice. J Neurol Neurosurg Psychiatry 76(2):ii23–31PubMedPubMedCentral

95.

Mansfield M, Thacker M, Sandford F (2018) Psychosocial risk factors and the association with carpal tunnel syndrome: a systematic review. Hand (N Y) 13:501–508

96.

Marshall S, Tardif G, Ashworth N (2007) Local corticosteroid injection for carpal tunnel syndrome. Cochrane Database Syst Rev 2:CD1554

97.

Middleton SD, Anakwe RE (2014) Carpal tunnel syndrome. BMJ 349:g6437PubMed

98.

Moalem G, Tracey DJ (2006) Immune and inflammatory mechanisms in neuropathic pain. Brain Res Rev 51:240–264PubMed

99.

Mondelli M, Giannini F, Ballerini M, Ginanneschi F, Martorelli E (2005) Incidence of ulnar neuropathy at the elbow in the province of Siena (Italy). J Neurol Sci 234:5–10PubMed

100.

Mor D, Bembrick AL, Austin PJ, Keay KA (2011) Evidence for cellular injury in the midbrain of rats following chronic constriction injury of the sciatic nerve. J Chem Neuroanat 41:158–169PubMed

101.

Murphy DR, Hurwitz EL, Gerrard JK, Clary R (2009) Pain patterns and descriptions in patients with radicular pain: does the pain necessarily follow a specific dermatome? Chiropr Osteopat 17:9PubMedPubMedCentral

102.

Nakamichi KI, Tachibana S (2000) Enlarged median nerve in idiopathic carpal tunnel syndrome. Muscle Nerve 23:1713–1718PubMed

103.

Napadow V, Kettner N, Ryan A, Kwong KK, Audette J, Hui KK (2006) Somatosensory cortical plasticity in carpal tunnel syndrome‑a cross-sectional fMRI evaluation. Neuroimage 31:520–530PubMed

104.

Napadow V, Kettner N, Liu J, Li M, Kwong KK, Vangel M, Makris N, Audette J, Hui KK (2007) Hypothalamus and amygdala response to acupuncture stimuli in carpal tunnel syndrome. Pain 130:254–266PubMedPubMedCentral

105.

National Guideline Centre (2016) NICE guideline NG59: low back pain and sciatica in over 16s: assessment and management. National Institute for Health and Care Excellence UK, London

106.

Neary D (1975) The pathology of ulnar nerve compression in men. Neuropathol Appl Neurobiol 1:69–88

107.

Nee RJ, Jull GA, Vicenzino B, Coppieters MW (2012) The validity of upper-limb neurodynamic tests for detecting peripheral neuropathic pain. J Orthop Sports Phys Ther 42:413–424PubMed

108.

O’Brien JP, Mackinnon SE, MacLean AR, Hudson AR, Dellon AL, Hunter DA (1987) A model of chronic nerve compression in the rat. Ann Plast Surg 19:430–435PubMed

109.

O’Connor D, Marshall S, Massy-Westropp N (2003) Non-surgical treatment (other than steroid injection) for carpal tunnel syndrome. Cochrane Database Syst Rev 1:CD3219

110.

Ortiz-Corredor F, Enriquez F, Diaz-Ruiz J, Calambas N (2008) Natural evolution of carpal tunnel syndrome in untreated patients. Clin Neurophysiol 119:1373–1378PubMed

111.

Otoshi K, Kikuchi S, Konno S, Sekiguchi M (2010) The reactions of glial cells and endoneurial macrophages in the dorsal root ganglion and their contribution to pain-related behavior after application of nucleus pulposus onto the nerve root in rats. Spine (Phila Pa 1976) 35:264–271

112.

Page MJ, Massy-Westropp N, O’Connor D, Pitt V (2012) Splinting for carpal tunnel syndrome. Cochrane Database Syst Rev 7:CD10003

113.

Page MJ, O’Connor D, Pitt V, Massy-Westropp N (2012) Exercise and mobilisation interventions for carpal tunnel syndrome. Cochrane Database Syst Rev 6:CD9899

114.

Parreira P, Maher CG, Steffens D, Hancock MJ, Ferreira ML (2018) Risk factors for low back pain and sciatica: an umbrella review. Spine J 18:1715–1721PubMed

115.

van Paassen BW, van der Kooi AJ, van Spaendonck-Zwarts KY, Verhamme C, Baas F, de Visser M (2014) PMP22 related neuropathies: charcot-Marie-tooth disease type 1A and hereditary neuropathy with liability to pressure palsies. Orphanet J Rare Dis 9:38PubMedPubMedCentral

116.

Pinto RZ, Maher CG, Ferreira ML, Ferreira PH, Hancock M, Oliveira VC, McLachlan AJ, Koes B (2012) Drugs for relief of pain in patients with sciatica: systematic review and meta-analysis. BMJ 344:e497PubMedPubMedCentral

117.

Pinto RZ, Maher CG, Ferreira ML, Hancock M, Oliveira VC, McLachlan AJ, Koes B, Ferreira PH (2012) Epidural corticosteroid injections in the management of sciatica: a systematic review and meta-analysis. Ann Intern Med 157:865–877PubMed

118.

Pourmemari MH, Shiri R (2016) Diabetes as a risk factor for carpal tunnel syndrome: a systematic review and meta-analysis. Diabet Med 33:10–16PubMed

119.

Rasmussen-Barr E, Held U, Grooten WJ, Roelofs PD, Koes BW, van Tulder MW, Wertli MM (2017) Nonsteroidal anti-inflammatory drugs for sciatica: an updated Cochrane review. Spine (Phila Pa 1976) 42:586–594

120.

Ridehalgh C, Sandy-Hindmarch OP, Schmid AB (2018) Validity of clinical small-fiber sensory testing to detect small-nerve fiber degeneration. J Orthop Sports Phys Ther 48:767–774PubMed

121.

van Rijn JC, Klemetso N, Reitsma JB, Majoie CB, Hulsmans FJ, Peul WC, Bossuyt PM, Heeten GJ, Stam J (2006) Symptomatic and asymptomatic abnormalities in patients with lumbosacral radicular syndrome: clinical examination compared with MRI. Clin Neurol Neurosurg 108:553–557PubMed

122.

Roll SC, Case-Smith J, Evans KD (2011) Diagnostic accuracy of ultrasonography vs. electromyography in carpal tunnel syndrome: a systematic review of literature. Ultrasound Med Biol 37:1539–1553PubMed

123.

Rothman SM, Winkelstein BA (2007) Chemical and mechanical nerve root insults induce differential behavioral sensitivity and glial activation that are enhanced in combination. Brain Res 1181:30–43PubMedPubMedCentral

124.

Rothman SM, Nicholson KJ, Winkelstein BA (2010) Time-dependent mechanics and measures of glial activation and behavioral sensitivity in a rodent model of radiculopathy. J Neurotrauma 27:803–814PubMed

125.

Ryan C, Roberts L (2019) Life on hold: the lived experience of radicular symptoms. A qualitative, interpretative inquiry. Musculoskelet Sci Pract 39:51–57PubMed

126.

Rydevik B, Lundborg G, Bagge U (1981) Effects of graded compression on intraneural blood blow. An in vivo study on rabbit tibial nerve. J Hand Surg Am 6:3–12PubMed

127.

Samuelsson L, Lundin A (2002) Thermal quantitative sensory testing in lumbar disc herniation. Eur Spine J 11:71–75PubMed

128.

Schafer A, Hall T, Muller G, Briffa K (2011) Outcomes differ between subgroups of patients with low back and leg pain following neural manual therapy: a prospective cohort study. Eur Spine J 20:482–490PubMed

129.

Schmid AB, Coppieters MW (2012) Left/right judgment of body parts is selectively impaired in patients with unilateral carpal tunnel syndrome. Clin J Pain 28:615–622PubMed

130.

Schmid AB, Tampin B (2018) Spinally referred back and leg pain. http://www.wheelessonline.com/ISSLS/section-10-chapter-10-spinally-referred-back-and-leg-pain/. Zugegriffen: 1. Sept. 2019

131.

Schmid AB, Coppieters MW, Ruitenberg MJ, McLachlan EM (2013) Local and remote immune-mediated inflammation after mild peripheral nerve compression in rats. J Neuropathol Exp Neurol 72:662–680PubMed

132.

Schmid AB, Bland JD, Bhat MA, Bennett DL (2014) The relationship of nerve fibre pathology to sensory function in entrapment neuropathy. Brain 137:3186–3199PubMedPubMedCentral

133.

Seradge H, Jia YC, Owens W (1995) In vivo measurement of carpal tunnel pressure in the functioning hand. J Hand Surg Am 20:855–859PubMed

134.

Shamji MF, Allen KD, So S, Jing L, Adams SB Jr, Schuh R, Huebner J, Kraus VB, Friedman AH, Setton LA, Richardson WJ (2009) Gait abnormalities and inflammatory cytokines in an autologous nucleus pulposus model of radiculopathy. Spine (Phila Pa 1976) 34:648–654

135.

Shiri R, Pourmemari MH, Falah-Hassani K, Viikari-Juntura E (2015) The effect of excess body mass on the risk of carpal tunnel syndrome: a meta-analysis of 58 studies. Obes Rev 16:1094–1104PubMed

136.

Singh R, Gamble G, Cundy T (2005) Lifetime risk of symptomatic carpal tunnel syndrome in type 1 diabetes. Diabet Med 22:625–630PubMed

137.

Sirvanci M, Kara B, Duran C, Ozturk E, Karatoprak O, Onat L, Ulusoy OL, Mutlu A (2009) Value of perineural edema/inflammation detected by fat saturation sequences in lumbar magnetic resonance imaging of patients with unilateral sciatica. Acta Radiol 50:205–211PubMed

138.

Solberg TK, Nygaard OP, Sjaavik K, Hofoss D, Ingebrigtsen T (2005) The risk of getting worse after lumbar microdiscectomy. Eur Spine J 14:49–54PubMed

139.

Soon B, Vicenzino B, Schmid AB, Coppieters MW (2017) Facilitatory and inhibitory pain mechanisms are altered in patients with carpal tunnel syndrome. PLoS ONE 12:e183252PubMedPubMedCentral

140.

Takahashi K, Shima I, Porter RW (1999) Nerve root pressure in lumbar disc herniation. Spine (Phila Pa 1976) 24:2003–2006

141.

Takahata S, Takebayashi T, Terasima Y, Tanimoto K, Wada T, Sohma H, Kokai Y, Yamashita T (2011) Activation of glial cells in the spinal cord of a model of lumbar radiculopathy. J Orthop Sci 16:313–320PubMed

142.

Tamburin S, Cacciatori C, Praitano ML, Cazzarolli C, Foscato C, Fiaschi A, Zanette G (2010) Median nerve small- and large-fiber damage in carpal tunnel syndrome: a quantitative sensory testing study. J Pain 12:205–212PubMed

143.

Tampin B, Slater H, Hall T, Lee G, Briffa NK (2012) Quantitative sensory testing somatosensory profiles in patients with cervical radiculopathy are distinct from those in patients with nonspecific neck-arm pain. Pain 153:2403–2414PubMed

144.

Tampin B, Briffa NK, Slater H (2013) Self-reported sensory descriptors are associated with quantitative sensory testing parameters in patients with cervical radiculopathy, but not in patients with fibromyalgia. Eur J Pain 17:621–633PubMed

145.

Tampin B, Slater H, Briffa NK (2013) Neuropathic pain components are common in patients with painful cervical radiculopathy, but not in patients with nonspecific neck-arm pain. Clin J Pain 29:846–856PubMed

146.

Tampin B, Slater H, Jacques A, Lind C (2020) Association of quantitative sensory testing parameters with clinical outcome in patients with lumbar radiculopathy undergoing microdiscectomy. Eur J Pain. https://doi.org/10.1002/ejp.1586CrossRefPubMedPubMedCentral

147.

Tampin B, Vollert J, Schmid AB (2018) Sensory profiles are comparable in patients with distal and proximal entrapment neuropathies, while the pain experience differs. Curr Med Res Opin 34:1899–1906PubMed

148.

Tampin B, Broe RE, Seow LL, George SG, Tan J, Menon R, Jacques A, Slater H (2019) Field testing of the revised neuropathic pain grading system in a cohort of patients with neck and upper limb pain. Scand J Pain 19:523–532PubMed

149.

Tampin B, Royle J, Bharat C, Trevenen M, Olsen L, Goucke R (2019) Psychological factors can cause false pain classification on painDETECT. Scand J Pain 19:501–512PubMed

150.

Tampin B (2015) Integration of peripheral nerves in the examination of the locomotor system. In: Hueter-Becker A, Doelken M (Hrsg) Physical therapy examination and assessment. Thieme, Stuttgart, S 76–104

151.

Tecchio F, Padua L, Aprile I, Rossini PM (2002) Carpal tunnel syndrome modifies sensory hand cortical somatotopy: a MEG study. Hum Brain Mapp 17:28–36PubMedPubMedCentral

152.

Thacker MA, Clark AK, Marchand F, McMahon SB (2007) Pathophysiology of peripheral neuropathic pain: immune cells and molecules. Anesth Analg 105:838–847PubMed

153.

The Royal College of Surgeons of England and British Orthopaedic Association (2017) Commissioning guide: treatment of carpal tunnel syndrome. RCS, London

154.

Thoomes EJ, van Geest S, van der Windt DA, Falla D, Verhagen AP, Koes BW, Thoomes-de Graaf M, Kuijper B, Scholten-Peeters WGM, Vleggeert-Lankamp CL (2018) Value of physical tests in diagnosing cervical radiculopathy: a systematic review. Spine J 18:179–189PubMed

155.

Tousignant-Laflamme Y, Martel MO, Joshi AB, Cook CE (2017) Rehabilitation management of low back pain—it’s time to pull it all together! J Pain Res 10:2373–2385PubMedPubMedCentral

156.

Tschugg A, Lener S, Hartmann S, Neururer S, Wildauer M, Thome C, Loscher WN (2016) Improvement of sensory function after sequestrectomy for lumbar disc herniation: a prospective clinical study using quantitative sensory testing. Eur Spine J 25:3543–3549PubMed

157.

Tubach F, Beaute J, Leclerc A (2004) Natural history and prognostic indicators of sciatica. J Clin Epidemiol 57:174–179PubMed

158.

Vasiliadis HS, Georgoulas P, Shrier I, Salanti G, Scholten RJ (2014) Endoscopic release for carpal tunnel syndrome. Cochrane Database Syst Rev 1:CD8265

159.

Vroomen PC, de Krom MC, Slofstra PD, Knottnerus JA (2000) Conservative treatment of sciatica: a systematic review. J Spinal Disord 13:463–469PubMed

160.

Wang YF, Chen PY, Chang W, Zhu FQ, Xu LL, Wang SL, Chang LY, Luo J, Liu GJ (2014) Clinical significance of tumor necrosis factor-alpha inhibitors in the treatment of sciatica: a systematic review and meta-analysis. PLoS One 9:e103147PubMedPubMedCentral

161.

Watkins LR, Maier SF (2002) Beyond neurons: evidence that immune and glial cells contribute to pathological pain states. Physiol Rev 82:981–1011PubMed

162.

Weber H, Holme I, Amlie E (1993) The natural course of acute sciatica with nerve root symptoms in a double-blind placebo-controlled trial evaluating the effect of piroxicam. Spine (Phila Pa 1976) 18:1433–1438

163.

Wiberg A, Ng M, Schmid AB, Smillie RW, Baskozos G, Holmes MV, Kunnapuu K, Magi R, Bennett DL, Furniss D (2019) A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome. Nat Commun 10:1030PubMedPubMedCentral

164.

Wieseler-Frank J, Maier SF, Watkins LR (2005) Immune-to-brain communication dynamically modulates pain: physiological and pathological consequences. Brain Behav Immun 19:104–111PubMed

165.

Wilder-Smith EP, Fook-Chong S, Chew SE, Chow A, Guo Y (2003) Vasomotor dysfunction in carpal tunnel syndrome. Muscle Nerve 28:582–586PubMed

166.

Wilson CA, Roffey DM, Chow D, Alkherayf F, Wai EK (2016) A systematic review of preoperative predictors for postoperative clinical outcomes following lumbar discectomy. Spine J 16:1413–1422PubMed

167.

Yoon JS, Walker FO, Cartwright MS (2010) Ulnar neuropathy with normal electrodiagnosis and abnormal nerve ultrasound. Arch Phys Med Rehabil 91:318–320PubMedPubMedCentral

168.

Yoshii Y, Nishiura Y, Terui N, Hara Y, Saijilafu ON (2010) The effects of repetitive compression on nerve conduction and blood flow in the rabbit sciatic nerve. J Hand Surg Eur Vol 35:269–278PubMed

169.

Zanette G, Marani S, Tamburin S (2006) Extra-median spread of sensory symptoms in carpal tunnel syndrome suggests the presence of pain-related mechanisms. Pain 122:264–270PubMed

170.

Zanette G, Cacciatori C, Tamburin S (2010) Central sensitization in carpal tunnel syndrome with extraterritorial spread of sensory symptoms. Pain 148:227–236PubMed

171.

Zhu GC, Bottger K, Slater H, Cook C, Farrell SF, Hailey L, Tampin B, Schmid AB (2019) Concurrent validity of a low-cost and time-efficient clinical sensory test battery to evaluate somatosensory dysfunction. Eur J Pain 23:1826–1838PubMedPubMedCentral

172.

Zyluk A, Kosowiec L (2008) Regional sympathetic disturbances in carpal tunnel syndrome—a review [in Polish]. Chir Narzadow Ruchu Ortop Pol 73:30–36PubMed

Titel: Nervenkompressionssyndrome – eine aktuelle Betrachtung von Pathophysiologie, klinischer Untersuchung und Management
Deutsche Fassung
verfasst von: Annina B. Schmid
Joel Fundaun
Brigitte Tampin
Publikationsdatum: 10.09.2021
Verlag: Springer Medizin
Schlagwörter: Neuropathischer Schmerz
Karpaltunnelsyndrom
Impingement-Syndrome
Schädigung einzelner Nerven
Karpaltunnelsyndrom
Ischialgie
Erschienen in: Der Schmerz / Ausgabe 6/2021
Print ISSN: 0932-433X
Elektronische ISSN: 1432-2129
DOI: https://doi.org/10.1007/s00482-021-00584-z

Passend zum Thema

Nervengesundheit

Regeneration peripherer Nerven ist möglich

Während sich Nervenzellen des zentralen Nervensystems nach Schädigungen kaum wieder erholen, können sich periphere Nerven nach Verletzungen oder Kompressionen regenerieren. Neurotrope Nährstoffe wie Uridinmonophosphat und B-Vitamine können den Regenerationsprozess geschädigter Nervenfasern unterstützen.

Springer Medizin

Zusammenfassung

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Regeneration peripherer Nerven ist möglich