Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Typ-2-Diabetes und Adipositas Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Die Highlights vom Kongress des American College of Cardiology 2024

Im April diskutierten die Herz-Kreislauf-Spezialisten aus der ganzen Welt auf dem  Kongress des American College of Cardiology (ACC) u.a. neue Therapieansätze bei akutem Myokardinfarkt, koronarer Herzerkrankung, kardiogenem Schock oder Aortenklappenstenose. In unserem Kongress-Dossier haben wir für Sie Berichte über die „Late-Breaking Trials“ und andere wichtige Studien zusammengestellt. 
Erweiterte Suche
Anmelden
nach oben
Archives of Virology
Erschienen in: Archives of Virology 12/2022

21.10.2022 | Original Article

Long non-coding RNA ENST00000469812 promotes Enterovirus type 71 replication via targeting the miR-4443/NUPR1 axis in rhabdomyosarcoma cells

verfasst von: Yanzhi Lu, Min Long, Zhaowei Gao, Chong Liu, Ke Dong, Huizhong Zhang

Erschienen in: Archives of Virology | Ausgabe 12/2022

Einloggen, um Zugang zu erhalten

Abstract

Hand, foot, and mouth disease (HFMD) caused by Enterovirus type 71 (EV71) is a serious threat to children’s health. However, the pathogenic mechanism of EV71 is still unclear. Long non-coding RNAs (lncRNAs), some of which bind to miRNA as competitive endogenous RNAs (ceRNA) and weaken the silencing effect on the mRNA of downstream target genes, play a key role in regulating the viral infection process. In this study, through experimental verification, we found miR-4443 to be downregulated in cells infected with EV71. Next, by predicting lncRNAs that potentially regulate miR-4443, we found that EV71 infection induced upregulation of lncRNA ENST00000469812 and then further downregulated miR-4443 expression by direct interaction. We also demonstrated that nuclear protein 1 (NUPR1) is one of the target genes of miR-4443 and is involved in the ENST00000469812/miR-4443/NUPR1 regulatory axis. Finally, the ENST00000469812/miR-4443/NUPR1 regulatory axis exhibited a positive effect on EV71 replication. Here, we lay a foundation for exploring the pathogenic mechanism of EV71 and identify potential targets for HFMD treatment.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Guerra AM, Orille E, Waseem M (2021) Hand Foot And Mouth Disease. StatPearls, Treasure Island (FL)
2.
Min N, Ong YHB, Han AX, Ho SX, Yen EWP, Ban KHK, Maurer-Stroh S, Chong CY, Chu JJH (2021) An epidemiological surveillance of hand foot and mouth disease in paediatric patients and in community: A Singapore retrospective cohort study, 2013–2018. PLoS Negl Trop Dis 15:e0008885CrossRef
3.
Fong SY, Mori D, Rundi C, Yap JF, Jikal M, Latip A, Johnny V, Ahmed K (2021) A five-year retrospective study on the epidemiology of hand, foot and mouth disease in Sabah. Malaysia Sci Rep 11:17814CrossRef
4.
Verma S, Razzaque MA, Sangtongdee U, Arpnikanondt C, Tassaneetrithep B, Arthan D, Paratthakonkun C, Soonthornworasiri N (2021) Hand, Foot, and Mouth Disease in Thailand: A Comprehensive Modelling of Epidemic Dynamics. Comput Math Methods Med 2021:6697522
5.
Gonzalez G, Carr MJ, Kobayashi M, Hanaoka N, Fujimoto T (2019) Enterovirus-Associated Hand-Foot and Mouth Disease and Neurological Complications in Japan and the Rest of the World. Int J Mol Sci 20:5201CrossRef
6.
Baek S, Park S, Park HK, Chun BC (2020) The epidemiological characteristics and spatio-temporal analysis of childhood hand, foot and mouth disease in Korea, 2011–2017. PLoS ONE 15:e0227803CrossRef
7.
Ni XF, Li X, Xu C, Xiong Q, Xie BY, Wang LH, Peng YH, Li XW (2020) Risk factors for death from hand-foot-mouth disease: a meta-analysis. Epidemiol Infect 148:e44CrossRef
8.
Cui JZ, Nie TR, Ren MR, Liu FF, Li Y, Wang LP, Tan JB, Chang ZR, Li ZJ (2020) [Epidemiological characteristics of fatal cases of hand, foot, and mouth disease in children under 5 years old in China, 2008–2018]. Zhonghua Liu Xing Bing Xue Za Zhi 41:1041–1046
9.
Sun X, Xu Y, Zhu Y, Tang F (2021) Impact of non-pharmaceutical interventions on the incidences of vaccine-preventable diseases during the COVID-19 pandemic in the eastern of China. Hum Vaccin Immunother 17:1–7CrossRef
10.
Kataoka SY, Kataoka Y, Tochitani K, Miyakoshi C, Yamamoto Y (2021) Influence of anti-COVID-19 policies on 10 pediatric infectious diseases. Pediatr Int 64:e14958
11.
Chen B, Wang M, Huang X, Xie M, Pan L, Liu H, Liu Z, Zhou P (2021) Changes in Incidence of Notifiable Infectious Diseases in China Under the Prevention and Control Measures of COVID-19. Front Public Health 9:728768CrossRef
12.
Yu SB, Luo KW, Zhou YH, Dai BB, Liu FF, Yang H, Luo L, Liu J, Wang LL, Li Q, Ren LS, Liao QH, Yu HJ (2019) [Hospitalization burden of hand, foot and mouth disease in Anhua county of Hunan province, 2013–2016]. Zhonghua Liu Xing Bing Xue Za Zhi 40:79–83
13.
Chen L, Zhou Y, Li H (2018) LncRNA, miRNA and lncRNA-miRNA interaction in viral infection. Virus Res 257:25–32CrossRef
14.
Thomson DW, Dinger ME (2016) Endogenous microRNA sponges: evidence and controversy. Nat Rev Genet 17:272–283CrossRef
15.
Landeras-Bueno S, Ortin J (2016) Regulation of influenza virus infection by long non-coding RNAs. Virus Res 212:78–84CrossRef
16.
Ray RM, Morris KV (2020) Long Non-coding RNAs Mechanisms of Action in HIV-1 Modulation and the Identification of Novel Therapeutic Targets. Noncoding RNA 6:12CrossRef
17.
Unfried JP, Fortes P (2020) LncRNAs in HCV Infection and HCV-Related Liver Disease. Int J Mol Sci 21:2255CrossRef
18.
Maranon DG, Anderson JR, Maranon AG, Wilusz J (2020) The interface between coronaviruses and host cell RNA biology: Novel potential insights for future therapeutic intervention. Wiley Interdiscip Rev RNA 11:e1614CrossRef
19.
Li Y, Zhang C, Qin L, Li D, Zhou G, Dang D, Chen S, Sun T, Zhang R, Wu W, Xi Y, Jin Y, Duan G (2018) Characterization of critical functions of long non-coding RNAs and mRNAs in rhabdomyosarcoma cells and mouse skeletal muscle infected by Enterovirus 71 using RNA-Seq. Viruses 10:556CrossRef
20.
Yin Z, Guan D, Fan Q, Su J, Zheng W, Ma W, Ke C (2013) LncRNA expression signatures in response to enterovirus 71 infection. Biochem Biophys Res Commun 430:629–633CrossRef
21.
Meng J, Yao Z, He Y, Zhang R, Yang H, Yao X, Chen L, Zhang H, Cheng J (2017) Long non-coding RNA expression profiles in different severity EV71-infected hand foot and mouth disease patients. Biochem Biophys Res Commun 493:1594–1600CrossRef
22.
Zheng C, Zheng Z, Sun J, Zhang Y, Wei C, Ke X, Liu Y, Deng L, Wang H (2017) MiR-16-5p mediates a positive feedback loop in EV71-induced apoptosis and suppresses virus replication. Sci Rep 7:16422CrossRef
23.
Tang WF, Huang RT, Chien KY, Huang JY, Lau KS, Jheng JR, Chiu CH, Wu TY, Chen CY, Horng JT (2016) Host MicroRNA miR-197 Plays a Negative Regulatory Role in the Enterovirus 71 Infectious Cycle by Targeting the RAN Protein. J Virol 90:1424–1438CrossRef
24.
Chu M, Zhou B, Tu H, Li M, Huang L, He Y, Liu L, Han S, Yin J, Peng B, He X, Liu W (2021) The Upregulation of a Novel Long Noncoding RNA AK097647 Promotes Enterovirus 71 Replication and Decreases IFN-lambda1 Secretion. Intervirology 64:147–155CrossRef
25.
Liao YW, Ho BC, Chen MH, Yu SL (2019) Host relieves lnc-IRAK3-3-sequestered miR-891b to attenuate apoptosis in Enterovirus 71 infection. Cell Microbiol 21:e13043CrossRef
26.
Ye W, Yao M, Dong Y, Ye C, Wang D, Liu H, Ma H, Zhang H, Qi L, Yang Y, Wang Y, Zhang L, Cheng L, Lv X, Xu Z, Lei Y, Zhang F (2020) Remdesivir (GS-5734) Impedes Enterovirus Replication Through Viral RNA Synthesis Inhibition. Front Microbiol 11:1105CrossRef
27.
Lin S, Yang L, Wang S, Weng B, Lin M (2020) Bioinformatics Analysis of Key micro-RNAs and mRNAs under the Hand, Foot, and Mouth Disease Virus Infection. Pol J Microbiol 69:479–490CrossRef
28.
Cui L, Guo X, Qi Y, Qi X, Ge Y, Shi Z, Wu T, Shan J, Shan Y, Zhu Z, Wang H (2010) Identification of microRNAs involved in the host response to enterovirus 71 infection by a deep sequencing approach. J Biomed Biotechnol 2010:425939
29.
Hu Y, Song J, Liu L, Zhang Y, Wang L, Li Q (2018) microRNA-4516 Contributes to Different Functions of Epithelial Permeability Barrier by Targeting Poliovirus Receptor Related Protein 1 in Enterovirus 71 and Coxsackievirus A16 Infections. Front Cell Infect Microbiol 8:110CrossRef
30.
Hu Y, Song J, Liu L, Li J, Tang B, Zhang Y, Wang J, Wang L, Fan S, Feng M, Li Q (2017) Comparison analysis of microRNAs in response to EV71 and CA16 infection in human bronchial epithelial cells by high-throughput sequencing to reveal differential infective mechanisms. Virus Res 228:90–101CrossRef
31.
Yang D, Wang X, Gao H, Chen B, Si C, Wang S (2020) Downregulation of miR-155-5p facilitates enterovirus 71 replication through suppression of type I IFN response by targeting FOXO3/IRF7 pathway. Cell Cycle 19:179–192CrossRef
32.
Zhu Z, Qi Y, Fan H, Cui L, Shi Z (2016) Systematic Identification and Bioinformatic Analysis of MicroRNAs in Response to Infections of Coxsackievirus A16 and Enterovirus 71. Biomed Res Int 2016:4302470
33.
Xun M, Ma CF, Du QL, Ji YH, Xu JR (2015) Differential expression of miRNAs in enterovirus 71-infected cells. Virol J 12:56CrossRef
34.
Wang Y, Dan K, Xue X, Chen B, Chen C (2022) Curcumin assists anti-EV71 activity of IFN-alpha by inhibiting IFNAR1 reduction in SH-SY5Y cells. Gut Pathog 14:8CrossRef
35.
Tyring SK (2020) Hand foot and mouth disease: Enteroviral load and disease severity. EBioMedicine 62:103115CrossRef
36.
Wongsa A, Noulsri E, Phawong C, Puthavathana P, Tassaneetrithep B (2019) Replication and cytokine profiles of different subgenotypes of enterovirus 71 isolated from Thai patients in peripheral blood mononuclear cells. Microb Pathog 132:215–221CrossRef
37.
Wang H, Guo T, Yang Y, Yu L, Pan X, Li Y (2019) Lycorine Derivative LY-55 Inhibits EV71 and CVA16 Replication Through Downregulating Autophagy. Front Cell Infect Microbiol 9:277CrossRef
38.
Xu J, Qian Y, Ye M, Fu Z, Jia X, Li W, Xu P, Lv M, Huang L, Wang L, Ruan H, Lv J (2016) Distinct expression profile of lncRNA in endometrial carcinoma. Oncol Rep 36:3405–3412CrossRef
39.
Wang J, Wang J, Gu Q, Yang Y, Ma Y, Zhu J, Zhang Q (2020) [MiR-4443 promotes migration and invasion of breast cancer cells by inhibiting PEBP1 expression]. Nan Fang Yi Ke Da Xue Xue Bao 40:1712–1719
40.
Chen X, Zhong SL, Lu P, Wang DD, Zhou SY, Yang SJ, Shen HY, Zhang L, Zhang XH, Zhao JH, Tang JH (2016) miR-4443 Participates in the Malignancy of Breast Cancer. PLoS ONE 11:e0160780CrossRef
41.
Wang J, Zhang Q, Wang D, Yang S, Zhou S, Xu H, Zhang H, Zhong S, Feng J (2020) Microenvironment-induced TIMP2 loss by cancer-secreted exosomal miR-4443 promotes liver metastasis of breast cancer. J Cell Physiol 235:5722–5735CrossRef
42.
Zhang W, Qiao B, Fan J (2018) Overexpression of miR-4443 promotes the resistance of non-small cell lung cancer cells to epirubicin by targeting INPP4A and regulating the activation of JAK2/STAT3 pathway. Pharmazie 73:386–392
43.
Ebrahimi SO, Reiisi S (2019) Downregulation of miR-4443 and miR-5195-3p in ovarian cancer tissue contributes to metastasis and tumorigenesis. Arch Gynecol Obstet 299:1453–1458CrossRef
44.
Gong J, Wang J, Liu T, Hu J, Zheng J (2018) lncRNA FEZF1AS1 contributes to cell proliferation, migration and invasion by sponging miR4443 in hepatocellular carcinoma. Mol Med Rep 18:5614–5620
45.
Qi Y, Zhou Y, Chen X, Ye L, Zhang Q, Huang F, Cui B, Lin D, Ning G, Wang W, Wang S (2017) MicroRNA-4443 Causes CD4 + T Cells Dysfunction by Targeting TNFR-Associated Factor 4 in Graves’ Disease. Front Immunol 8:1440CrossRef
46.
Zhu L, Li W, Qi G, Liu N, Sheng L, Shang L, Qi B (2017) The immune mechanism of intestinal tract Toll-like receptor in mediating EV71 virus type severe hand-foot-and-mouth disease and the MAPK pathway. Exp Ther Med 13:2263–2266CrossRef
47.
Yao C, Hu K, Xi C, Li N, Wei Y (2019) Transcriptomic analysis of cells in response to EV71 infection and 2A(pro) as a trigger for apoptosis via TXNIP gene. Genes Genomics 41:343–357CrossRef
48.
Zhang Z, Wang B, Wu S, Wen Y, Wang X, Song X, Zhang J, Hou L, Chen W (2017) PD169316, a specific p38 inhibitor, shows antiviral activity against Enterovirus71. Virology 508:150–158CrossRef
49.
Wang HQ, Hu J, Yan HY, Wu S, Li YH (2017) Corydaline inhibits enterovirus 71 replication by regulating COX-2 expression. J Asian Nat Prod Res 19:1124–1133CrossRef
50.
Zhou C, Xu J, Lin J, Lin R, Chen K, Kong J, Shui X (2018) Long Noncoding RNA FEZF1-AS1 Promotes Osteosarcoma Progression by Regulating the miR-4443/NUPR1 Axis. Oncol Res 26:1335–1343CrossRef
51.
Santofimia-Castano P, Xia Y, Peng L, Velazquez-Campoy A, Abian O, Lan W, Lomberk G, Urrutia R, Rizzuti B, Soubeyran P, Neira JL, Iovanna J (2019) Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma. Cells 8:1453CrossRef
52.
Jing Z, Yu W, Li A, Chen X, Chen Y, Chen J (2022) Trifluoperazine Synergistically Potentiates Bortezomib-Induced Anti-Cancer Effect in Multiple Myeloma via Inhibiting P38 MAPK/NUPR1. Tohoku J Exp Med 257: 315-326.CrossRef
53.
Li J, Ren S, Liu Y, Lian Z, Dong B, Yao Y, Xu Y (2017) Knockdown of NUPR1 inhibits the proliferation of glioblastoma cells via ERK1/2, p38 MAPK and caspase-3. J Neurooncol 132:15–26CrossRef
54.
Tan L, Yammani RR (2019) Nupr1 regulates palmitate-induced apoptosis in human articular chondrocytes. Biosci Rep 39:BSR20181473CrossRef
55.
Huang C, Santofimia-Castano P, Iovanna J (2021) NUPR1: A Critical Regulator of the Antioxidant System. Cancers (Basel) 13:3670CrossRef
56.
Fan T, Chen Y, He Z, Wang Q, Yang X, Ren Z, Zhang S (2019) Inhibition of ROS/NUPR1-dependent autophagy antagonises repeated cadmium exposure -induced oral squamous cell carcinoma cell migration and invasion. Toxicol Lett 314:142–152CrossRef
57.
Path G, Mehana AE, Pilz IH, Alt M, Baumann J, Sommerer I, Hoffmeister A, Seufert J (2020) NUPR1 preserves insulin secretion of pancreatic beta-cells during inflammatory stress by multiple low-dose streptozotocin and high-fat diet. Am J Physiol Endocrinol Metab 319:E338–E344CrossRef
58.
Shiraki M, Xu X, Iovanna JL, Kukita T, Hirata H, Kamohara A, Kubota Y, Miyamoto H, Mawatari M, Kukita A (2019) Deficiency of stress-associated gene Nupr1 increases bone volume by attenuating differentiation of osteoclasts and enhancing differentiation of osteoblasts. FASEB J 33:8836–8852CrossRef
59.
Zeng C, Li X, Li A, Yi B, Peng X, Huang X, Chen J (2018) Knockdown of NUPR1 inhibits the growth of U266 and RPMI8226 multiple myeloma cell lines via activating PTEN and caspase activationdependent apoptosis. Oncol Rep 40:1487–1494
60.
Jheng JR, Lau KS, Tang WF, Wu MS, Horng JT (2010) Endoplasmic reticulum stress is induced and modulated by enterovirus 71. Cell Microbiol 12:796–813CrossRef
61.
Li P, Yang S, Hu D, Wei D, Lu J, Zheng H, Nie S, Liu G, Yang H (2019) Enterovirus 71 VP1 promotes mouse Schwann cell autophagy via ER stressmediated PMP22 upregulation. Int J Mol Med 44:759–767
62.
Du N, Li XH, Bao WG, Wang B, Xu G, Wang F (2019) Resveratrolloaded nanoparticles inhibit enterovirus 71 replication through the oxidative stressmediated ERS/autophagy pathway. Int J Mol Med 44:737–749
Metadaten
Titel
Long non-coding RNA ENST00000469812 promotes Enterovirus type 71 replication via targeting the miR-4443/NUPR1 axis in rhabdomyosarcoma cells
verfasst von
Yanzhi Lu
Min Long
Zhaowei Gao
Chong Liu
Ke Dong
Huizhong Zhang
Publikationsdatum
21.10.2022
Verlag
Springer Vienna
Erschienen in
Archives of Virology / Ausgabe 12/2022
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-022-05596-3

Weitere Artikel der Ausgabe 12/2022

Archives of Virology 12/2022 Zur Ausgabe

Original Article

Genetic diversity, reassortment, and recombination of mammalian orthoreoviruses from Japanese porcine fecal samples

Annotated Sequence Record

Analysis of the genomic diversity of human papillomavirus type 31 in cervical samples reveals the presence of novel sublineages in clade C

Brief Report

Multiple novel smaco-like viruses identified in chicken cloaca swabs

Review

The origin and continuing adaptive evolution of chikungunya virus

Original Article

Transcription analysis of chicken embryo fibroblast cells infected with the recombinant avian leukosis virus isolate GX14FF03

Annotated Sequence Record

Molecular characterization of a novel polymycovirus identified in the phytopathogenic fungus Colletotrichum gloeosporioides

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

„Jeder Fall von plötzlichem Tod muss obduziert werden!“

17.05.2024 Plötzlicher Herztod Nachrichten

Ein signifikanter Anteil der Fälle von plötzlichem Herztod ist genetisch bedingt. Um ihre Verwandten vor diesem Schicksal zu bewahren, sollten jüngere Personen, die plötzlich unerwartet versterben, ausnahmslos einer Autopsie unterzogen werden.

Hirnblutung unter DOAK und VKA ähnlich bedrohlich

17.05.2024 Direkte orale Antikoagulanzien Nachrichten

Kommt es zu einer nichttraumatischen Hirnblutung, spielt es keine große Rolle, ob die Betroffenen zuvor direkt wirksame orale Antikoagulanzien oder Marcumar bekommen haben: Die Prognose ist ähnlich schlecht.

Schlechtere Vorhofflimmern-Prognose bei kleinem linken Ventrikel

17.05.2024 Vorhofflimmern Nachrichten

Nicht nur ein vergrößerter, sondern auch ein kleiner linker Ventrikel ist bei Vorhofflimmern mit einer erhöhten Komplikationsrate assoziiert. Der Zusammenhang besteht nach Daten aus China unabhängig von anderen Risikofaktoren.

Semaglutid bei Herzinsuffizienz: Wie erklärt sich die Wirksamkeit?

17.05.2024 Herzinsuffizienz Nachrichten

Bei adipösen Patienten mit Herzinsuffizienz des HFpEF-Phänotyps ist Semaglutid von symptomatischem Nutzen. Resultiert dieser Benefit allein aus der Gewichtsreduktion oder auch aus spezifischen Effekten auf die Herzinsuffizienz-Pathogenese? Eine neue Analyse gibt Aufschluss.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise