nach oben

Erschienen in:

01.12.2024 | Original Article

Long-term effects of photobiomodulation therapy on blood pressure in obese rats induced by a high-fat diet

verfasst von: Jorge Camargo Oishi, Luis Henrique Oliveira de Moraes, Julio Cesar Conceição Filho, Thiago Francisco de Moraes, Barbara Terroni, Cynthia Aparecida de Castro, Luciana Almeida-Lopes, Gerson Jhonatan Rodrigues

Erschienen in: Lasers in Medical Science | Ausgabe 1/2024

Einloggen, um Zugang zu erhalten

Abstract

The main cardiovascular disease risk associated with obesity is hypertension. The therapeutic use of photobiomodulation therapy (PBM) is suggested for the treatment of wound healing, osteoarthritis, and arterial diseases. However, few studies have measured how red laser (at 660 nm) acts over hypertension, and any of those studies used experimental obesity model. The aim of the study was an attempt to evaluate the long-term effect of PBM on systolic blood pressure in an animal model of obesity, induced by a high-fat diet (HFD). Our results indicate that PBM carried out 3 days a week was able to prevent the increase in blood pressure (133.75 ± 4.82 mmHg, n = 8) induced by a high-fat diet (150.00 ± 4.57 mmHg, n = 8; p < 0.05), restore nitric oxide levels (control: 31.7 ± 5.5 μM, n = 8; HFD + PBM: 29.9 ± 3.7 μM, n = 8 > HFD: 22.2 ± 2.9 μM, n = 8, p < 0.05), decrease lipoperoxidation (control: 1.65 ± 0.25 nM, n = 8; HFD + PBM: 2.05 ± 0.55 nM, n = 8 < HFD: 3.20 ± 0.47 nM, n = 8; p < 0.05), and improve endothelial function (pD2 control: 7.39 ± 0.08, n = 8 > pD2 HFD + PBM: 7.15 ± 0.07, n = 8 > HFD: 6.94 ± 0.07, n = 8; p < 0.05). Our results indicate that PBM prevents the elevation of blood pressure in an obese animal model by a mechanism that involves improvement of endothelial function through an antioxidant effect.

Middlemiss JE, McEniery CM (2017) Feeling the pressure: (patho) physiological mechanisms of weight gain and weight loss in humans. Hypertens Res 40(3):226–236

Whitworth JA, I.S.o.H.W.G. World Health Organization (2003) 2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension. J Hypertens 21:1983–1992CrossRefPubMed

Kalil GZ, Haynes WG (2012) Sympathetic nervous system in obesity-related hypertension: mechanisms and clinical implications. Hypertens Res 35:4–16CrossRefPubMed

Vasan RS, Larson MG, Leip EP, Kannel WB, Levy D (2001) Assessment of frequency of progression to hypertension in non-hypertensive participants in the Framingham Heart Study: a cohort study. Lancet 358:1682–1686CrossRefPubMed

Canella DS, Novaes HM, Levy RB (2016) Medicine expenses and obesity in Brazil: an analysis based on the household budget survey. BMC Public Health 16:54CrossRefPubMedPubMedCentral

Nagase M, Fujita T (2009) Mineralocorticoid receptor activation in obesity hypertension. Hypertens Res 32:649–657CrossRefPubMed

Oishi JC, Castro CA, Silva KA, Fabricio V, Cárnio EC, Phillips SA, Duarte ACGO, Rodrigues GJ (2018) Endothelial dysfunction and inflammation precedes elevations in blood pressure induced by a high-fat diet. Arq Bras Cardiol. 110(6):558–567. https://doi.org/10.5935/abc.20180086CrossRefPubMedPubMedCentral

Schindl M, Kerschan K, Schindl A, Schon H, Heinzl H, Schindl L (1999) Induction of complete wound healing in recalcitrant ulcers by low-intensity laser irradiation depends on ulcer cause and size. Photodermatol Photoimmunol Photomed 15:18–21CrossRefPubMed

Gupta A, Dai T, Hamblin MR (2014) Effect of red and near-infrared wavelengths on low-level laser (light) therapy-induced healing of partial-thickness dermal abrasion in mice. Lasers Med Sci 29(1):257–265. https://doi.org/10.1007/s10103-013-1319-0CrossRefPubMed

10.

Yamada EF, Bobinski F, Martins DF, Palandi J, Folmer V, da Silva MD (2020) Photobiomodulation therapy in knee osteoarthritis reduces oxidative stress and inflammatory cytokines in rats. J Biophotonics 13(1):e201900204. https://doi.org/10.1002/jbio.201900204CrossRefPubMed

11.

Gavish L, Perez LS, Reissman P, Gertz SD (2008) Irradiation with 780 nm diode laser attenuates inflammatory cytokines but upregulates nitric oxide in lipopolysaccharide-stimulated macrophages: implications for the prevention of aneurysm progression. Lasers Surg Med 40:371–378CrossRefPubMed

12.

Colombo E, Signore A, Aicardi S, Zekiy A, Utyuzh A, Benedicenti S, Amaroli A (2021) Experimental and clinical applications of red and near-infrared photobiomodulation on endothelial dysfunction: a review. Biomedicines 9(3):274. https://doi.org/10.3390/biomedicines9030274CrossRefPubMedPubMedCentral

13.

Bagheri HS, Mousavi M, Rezabakhsh A, Rezaie J, Rasta SH, Nourazarian A, Avci ÇB, Tajalli H, Talebi M, Oryan A, Khaksar M, Kazemi M, Nassiri SM, Ghaderi S, Bagca BG, Rahbarghazi R, Sokullu E (2018) Low-level laser irradiation at a high power intensity increased human endothelial cell exosome secretion via Wnt signaling. Lasers Med Sci. 33(5):1131–1145. https://doi.org/10.1007/s10103-018-2495-8. (Erratum in: Lasers Med Sci. 2020 Feb;35(1):295-296)CrossRefPubMed

14.

Szymczyszyn A, Doroszko A, Szahidewicz-Krupska E, Rola P, Gutherc R, Jasiczek J, Mazur G, Derkacz A (2016) Effect of the transdermal low-level laser therapy on endothelial function. Lasers Med Sci 31:1301–1307CrossRefPubMedPubMedCentral

15.

Buzinari TC, de Moraes TF, Cárnio EC et al (2020) Photobiomodulation induces hypotensive effect in spontaneously hypertensive rats. Lasers Med Sci 35:567–572CrossRefPubMed

16.

De Moraes TF, Filho JCC, Oishi JC, Almeida-Lopes L, Parizotto NA, Rodrigues GJ (2020) Energy-dependent effect trial of photobiomodulation on blood pressure in hypertensive rats. Lasers Med Sci 35(5):1041–1046. https://doi.org/10.1007/s10103-019-02883-5CrossRefPubMed

17.

Tomimura S, Silva BP, Sanches IC, Canal M, Consolim-Colombo F, Conti FF, De Angelis K, Chavantes MC (2014) Hemodynamic effect of laser therapy in spontaneously hypertensive rats. Arq Bras Cardiol 103:161–164PubMedPubMedCentral

18.

Speretta GF, Rosante MC, Duarte FO, Leite RD, Lino AD, Andre RA, Silvestre JG, Araujo HS, Duarte AC (2012) The effects of exercise modalities on adiposity in obese rats. Clinics 67:1469–1477CrossRefPubMedPubMedCentral

19.

Oishi JC, De Moraes TF, Buzinari TC, Carnio EC, Parizotto NA, Rodrigues GJ (2017) Hypotensive acute effect of photobiomodulation therapy on hypertensive rats. Life Sci 178:56–60CrossRefPubMed

20.

Rodrigues GJ, Pereira AC, Vercesi JA, Lima RG, Silva RS, Bendhack LM (2012) Long-lasting hypotensive effect in renal hypertensive rats induced by nitric oxide released from a ruthenium complex. J Cardiovasc Pharmacol 60:193–198CrossRefPubMed

21.

Cinti S (2005) Prostaglandins Leukot Essent Fatty Acids 73:9–15CrossRefPubMed

22.

Jiang Z-Y, Woollard ACS, Wolff SP (1991) Lipid hydroperoxide measurement by oxidation of Fe2+ in the presence of xylenol orange Comparison with the TBA assay and an iodometric method. Lipids 26:853–856CrossRefPubMed

23.

Pereira FH, Batalhao ME, Carnio EC (2014) Correlation between body temperature, blood pressure and plasmatic nitric oxide in septic patients. Rev Lat Am Enfermagem 22:123–128CrossRefPubMedPubMedCentral

24.

Oishi JC, Buzinnari TC, Pestana CR, De Moraes TF, Vatanabe IP, Wink DA, Da Silva RS et al (2015) In vitro treatment with cis-[(Ru(H-dcbpy-)2(Cl)(NO)]) improves the endothelial function in aortic rings with endothelial dysfunction. J Pharm Pharm Sci 18(5):696–704CrossRefPubMed

25.

Vaneckova I, Maletinska L, Behuliak M, Nagelova V, Zicha J, Kunes J (2014) Obesity-related hypertension: possible pathophysiological mechanisms. J Endocrinol 223:R63-78CrossRefPubMed

26.

van der Heijden RA, Sheedfar F, Morrison MC, Hommelberg PP, Kor D, Kloosterhuis NJ, Gruben N, Youssef SA, de Bruin A, Hofker MH, Kleemann R, Koonen DP, Heeringa P (2015) High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice. Aging 7:256–268CrossRefPubMedPubMedCentral

27.

Tofolo LP, da Silva Ribeiro TA, Malta A, Miranda RA, Gomes RM, de Oliveira JC, Abdennebi-Najar L, de Almeida DL, Trombini AB, da Silva Franco CC, Pavanello A, Fabricio GS, Rinaldi W, Barella LF, de Freitas Mathias PC, Palma-Rigo K (2015) Short-term moderate exercise provides long-lasting protective effects against metabolic dysfunction in rats fed a high-fat diet. Eur J Nutr 54:1353–1362CrossRefPubMed

28.

Virdis A (2016) Endothelial dysfunction in obesity: role of inflammation. High Blood Press Cardiovasc Prev 23:83–85CrossRefPubMed

29.

Prieto D, Contreras C, Sanchez A (2014) Endothelial dysfunction, obesity and insulin resistance. Curr Vasc Pharmacol 12:412–426CrossRefPubMed

30.

Garcia-Prieto CF, Hernandez-Nuno F, Rio DD, Ruiz-Hurtado G, Aranguez I, Ruiz-Gayo M, Somoza B, Fernandez-Alfonso MS (2015) High-fat diet induces endothelial dysfunction through a down-regulation of the endothelial AMPK-PI3K-Akt-eNOS pathway. Mol Nutr Food Res 59:520–532CrossRefPubMed

31.

Fernandez-Sanchez A, Madrigal-Santillan E, Bautista M, Esquivel-Soto J, Morales-Gonzalez A, Esquivel-Chirino C, Durante-Montiel I, Sanchez-Rivera G, Valadez-Vega C, Morales-Gonzalez JA (2011) Inflammation, oxidative stress, and obesity. Int J Mol Sci 12:3117–3132CrossRefPubMedPubMedCentral

32.

Vanhoutte PM (2018) Nitric oxide: from good to bad. Ann Vasc Dis 11(1):41–51. https://doi.org/10.3400/avd.ra.17-00134CrossRefPubMedPubMedCentral

33.

Griendling KK, FitzGerald GA (2003) Oxidative stress and cardiovascular injury: part II: animal and human studies. Circulation 108:2034–2040CrossRefPubMed

34.

Volotovskaia AV, Ulashchik VS, Filipovich VN (2003) Antioxidant action and therapeutic efficacy of laser irradiation of blood in patients with ischemic heart disease, Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury 22–25

35.

Tomazoni SS, Machado CDSM, De Marchi T, Casalechi HL, Bjordal JM, de Carvalho PTC, Leal-Junior ECP (2019) Infrared low-level laser therapy (photobiomodulation therapy) before intense progressive running test of high-level soccer players: effects on functional, muscle damage, inflammatory, and oxidative stress markers-a randomized controlled trial. Oxid Med Cell Longev 2019:6239058

36.

Samoilova KA, Zhevago NA, Petrishchev NN, Zimin AA (2008) Role of nitric oxide in the visible light-induced rapid increase of human skin microcirculation at the local and systemic levels: II. Healthy volunteers. Photomed Laser Surg 26:443–449CrossRefPubMed

37.

Samoilova KA, Zhevago NA, Menshutina MA, Grigorieva NB (2008) Role of nitric oxide in the visible light-induced rapid increase of human skin microcirculation at the local and systemic level: I Diabetic patients. Photomed Laser Surg 26:433–442CrossRefPubMed

38.

Vladimirov Y, Borisenko G, Boriskina N, Kazarinov K, Osipov A (2000) NO-hemoglobin may be a light-sensitive source of nitric oxide both in solution and in red blood cells. J Photochem Photobiol B 59:115–122CrossRefPubMed

39.

de Moraes LHO, Terroni B, da Silva Mayer NF, Rodrigues GJ (2022) Multidrug-resistant protein inhibitor and phosphodiesterase inhibitor potentiate the vasodilator effect induced by photobiomodulation in isolated aortic rings. Lasers Med Sci 37(2):1209–1216CrossRefPubMed

40.

Melo Mde O, Pompeo KD, Brodt GA, Baroni BM, da Silva Junior DP, Vaz MA (2015) Effects of neuromuscular electrical stimulation and low-level laser therapy on the muscle architecture and functional capacity in elderly patients with knee osteoarthritis: a randomized controlled trial. Clin Rehabil 29:570–580CrossRefPubMed

Titel: Long-term effects of photobiomodulation therapy on blood pressure in obese rats induced by a high-fat diet
verfasst von: Jorge Camargo Oishi
Luis Henrique Oliveira de Moraes
Julio Cesar Conceição Filho
Thiago Francisco de Moraes
Barbara Terroni
Cynthia Aparecida de Castro
Luciana Almeida-Lopes
Gerson Jhonatan Rodrigues
Publikationsdatum: 01.12.2024
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 1/2024
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-023-03950-8

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Long-term effects of photobiomodulation therapy on blood pressure in obese rats induced by a high-fat diet

Abstract

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2024

Advantages of the co2 laser use in the rare condition of nasal mucosa squamous cell carcinoma surgery in dogs—a clinical prospective study

Root surface roughness evaluation following application of different periodontal instruments and Er:YAG laser: A profilometry and SEM study

Q-switched Nd:YAG laser protects human keratinocytes from oxidative stress and inflammation via AhR–Nrf2 pathway

Red light-emitting diode therapy minimizes the functional deleterious effects of the antiretroviral ritonavir on osteoblasts in vitro

The Photobiomodulation effect of 980 nm Diode Laser on Patients with Xerostomia

In vivo attenuation profile of 660 nm and 830 nm wavelengths on human elbow skin and calcaneus tendon of different phototypes