Introduction
Materials and methods
Patient population
Thoracoscopic surgery
Overall survival and progression free survival
Statistical analysis
Results
Patient characteristics
Parameters | Pulmonary metastasis | |||
---|---|---|---|---|
Resection
|
Systemic
treatment only
|
p-value
| ||
Number | 14 | 30 | ||
Age | 60.3 ± 6.2 | 59.4 ± 9.7 | 0.83 | |
Clinical T classification | T1/2 | 0 | 3 | 0.23 |
T3/4 | 14 | 27 | ||
Clinical N classification | N0 | 2 | 2 | 0.42 |
N positive | 12 | 28 | ||
Tumor grade | Grade 1 | 1 | 3 | 0.95 |
Grade 2 | 11 | 23 | ||
Grade 3 | 2 | 4 | ||
Primary tumor location | Cervical | 3 | 0 | 0.017* |
Upper | 2 | 12 | ||
Middle | 7 | 12 | ||
Lower | 2 | 10 | ||
Performance Status | 0 | 14 | 25 | 0.268 |
1 | 0 | 4 | ||
2 | 0 | 1 | ||
Lung Metastasis Number | 1 | 8 | 8 | 0.352 |
2 | 2 | 5 | ||
3 | 1 | 1 | ||
4 | 1 | 1 | ||
>=5 | 2 | 15 |
Overall survival and progression free survival
Factors | No. of patients | Overall survival (OS) | Progression-free survival (DFS) | ||
---|---|---|---|---|---|
1-year OS rate (%) | p-value | 1-year PFS rate (%) | p-value | ||
Age | |||||
> 60 | 19 | 67 | 0.43 | 45 | 0.93 |
≦ 60 | 25 | 62 | 35 | ||
Clinical T classification | |||||
T1/2 | 3 | 66 | 0.83 | 66% | 0.46 |
T3/4 | 41 | 64 | 37% | ||
Clinical N classification | |||||
N0 | 4 | 67 | 0.90 | 25% | 0.60 |
N positive | 40 | 64 | 42% | ||
Tumor grade | |||||
Grade 1 | 4 | 100 | 0.18 | 75 | 0.019* |
Grade 2 | 34 | 62 | 41 | ||
Grade 3 | 6 | 50 | 0 | ||
Primary tumor location | |||||
Cervical | 3 | 100 | 0.11 | 0 | 0.18 |
Upper | 11 | 40 | 18 | ||
Middle | 18 | 71 | 49 | ||
Lower | 12 | 66 | 50 | ||
Resection or Systemic Treatment | |||||
Resection | 14 | 100 | < 0.0001* | 48 | 0.038* |
Only Systemic Treatment | 30 | 49 | 33 | ||
Performance Status | |||||
0 | 39 | 70 | < 0.0001* | 45 | 0.0024* |
1 | 4 | 25 | 0 | ||
2 | 1 | 0 | 0 | ||
Lung Metastasis Number | |||||
1 | 16 | 75 | 0.061 | 35 | 0.6032 |
2 | 7 | 67 | 40 | ||
3 | 2 | 100 | 100 | ||
4 | 2 | 100 | 100 | ||
>=5 | 17 | 44 | 34 |
(a) Overall Survival
| |||||
Covariate | b | Std. Error | Exp(b) | 95%CI of Exp(b) | p value |
Tumor grade | 1.0510 | 0.4651 | 2.8604 | 1.1495 to 7.1189 | 0.0238* |
Resection or Systemic Treatment | -2.5500 | 0.7407 | 0.0781 | 0.0183 to 0.3335 | 0.0006* |
(b) Progression-free Survival
| |||||
Covariate | b | Std. Error | Exp(b) | 95%CI of Exp(b) | p value |
Tumor grade | 1.0285 | 0.4461 | 2.7968 | 1.1665 to 6.7054 | 0.0212* |
Resection or Systemic Treatment | -1.0148 | 0.4946 | 0.3625 | 0.1375 to 0.9555 | 0.0402* |
Thoracoscopic surgery
Parameters | Thoracoscopic metastasectomy | |||||
---|---|---|---|---|---|---|
Single Port | Two or Three Port | p-value | ||||
Number | 11 | 4 | ||||
Age (Mean ± Std. Deviation) | 60.18 ± 6.4 | 62.25 ± 5.9 | 0.58 | |||
Tumor Pathology | SCC | 10 | 4 | 0.55 | ||
Adeno | 1 | 0 | ||||
Clinical 7th AJCC stage | III | 6 | 3 | 0.49 | ||
IV | 5 | 1 | ||||
Clinical T classification | T3 | 6 | 1 | 0.33 | ||
T4b | 5 | 3 | ||||
Clinical N classification | N0 | 4 | 0 | 0.17 | ||
N1-3 | 7 | 4 | ||||
Clinical M classification | M0 | 6 | 3 | 0.49 | ||
M1 | 5 | 1 | ||||
Treatment before diagnosis | Yes | 5 | 2 | 0.88 | ||
No | 6 | 2 | ||||
Tumor grade | 1 | 0 | 1 | 0.03* | ||
2 | 6 | 3 | ||||
3 | 5 | 0 | ||||
Primary tumor location | Cervical | 5 | 2 | 0.67 | ||
Upper | 1 | 0 | ||||
Middle | 3 | 2 | ||||
Lower | 2 | 0 | ||||
Post-operative hospital stay | 7.91 ± 2.8 | 5.25 ± 1.3 | 0.09 | |||
Post-operative NRS | 0 | 2 | 0 | 0.38 | ||
1 | 3 | 0 | ||||
2 | 4 | 2 | ||||
3 | 2 | 2 | ||||
Post-operative complication | 0 | 0 |