Erschienen in:
15.09.2022 | Editorial Commentary
Maternal Colonization of Group B Streptococcus and Neonatal Sepsis
verfasst von:
Bethou Adhisivam
Erschienen in:
Indian Journal of Pediatrics
|
Ausgabe 12/2022
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Excerpt
Early-onset sepsis (EOS) is apparent within the first 72 h of birth and is usually caused by transmission of pathogens from the mother’s genitourinary system to the newborn or fetus. Neonates can also acquire the infection in utero or during delivery as they pass through the vaginal canal. According to the Delhi Neonatal Infection Study (DeNIS), EOS accounted for 83% of the total sepsis, and the most common bacteria isolated included acinetobacter (22%), klebsiella (17%), and
Escherichia coli (14%) [
1]. In the recently completed Global Neonatal Sepsis Observational Study (NeoOBS), among infants with a significant pathogen, 62.9% were gram-negative bacteria. The common microbes isolated were
Klebsiella pneumoniae and
Acinetobacter spp., which were resistant to WHO-recommended antibiotic regimens and had carbapenem resistance in 32.6% and 71.4% of cases, respectively. GBS was isolated in only 19 neonates (3.4%) [
2]. It would be worthwhile to develop local data on microbiological isolates to devise appropriate empiric antibiotic treatment regimes. …
