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Current Allergy and Asthma Reports
Erschienen in: Current Allergy and Asthma Reports 5/2017

01.05.2017 | Allergies and the Environment (M Hernandez, Section Editor)

Microbes and the Role of Antibiotic Treatment for Wheezy Lower Respiratory Tract Illnesses in Preschool Children

verfasst von: Christina G. Kwong, Leonard B. Bacharier

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 5/2017

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Abstract

Purpose of Review

Antibiotics are commonly used to treat wheezy lower respiratory tract illnesses in preschoolers, although these infections have been traditionally thought to be predominantly of viral origin. Our purpose is to review recent research pertaining to the role of antibiotics in lower respiratory tract illnesses and on subsequent asthma development, as well as the possible mechanisms of their effects.

Recent Findings

Increasing evidence suggests that asthma pathogenesis is associated with events during infancy and early childhood, particularly respiratory tract infections. While viruses are frequently detected in children with lower respiratory tract infections, the presence of potentially pathogenic bacteria is also often detected and may play a role in asthma pathogenesis. Recent evidence suggests that use of macrolides, particularly azithromycin, may decrease the risk of and duration of lower respiratory tract illnesses and prevent future episodes in specific high-risk populations.

Summary

Infants and preschoolers who have wheezy lower respiratory tract illnesses have a higher risk of asthma development. Alterations in the microbiome are thought to be influential. While several recent studies identify azithromycin as a therapeutic option in these illnesses, additional research is needed.
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Metadaten
Titel
Microbes and the Role of Antibiotic Treatment for Wheezy Lower Respiratory Tract Illnesses in Preschool Children
verfasst von
Christina G. Kwong
Leonard B. Bacharier
Publikationsdatum
01.05.2017
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 5/2017
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-017-0701-6

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