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Current Allergy and Asthma Reports
Erschienen in: Current Allergy and Asthma Reports 5/2017

01.05.2017 | Otitis (DP Skoner, Section Editor)

Eosinophilic Otitis Media: the Aftermath of Eosinophil Extracellular Trap Cell Death

verfasst von: Shigeharu Ueki, Nobuo Ohta, Masahide Takeda, Yasunori Konno, Makoto Hirokawa

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 5/2017

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Abstract

Purpose of Review

Eosinophilic otitis media (EOM) is a refractory disease characterized by the accumulation of eosinophils in middle ear effusion and mucosa. We summarize current knowledge regarding the clinical characteristics and management of EOM. Although eosinophil activation in inflamed foci is involved in the pathogenesis of EOM, little is known about the fate of the eosinophils and aftermath of their cell death. We discuss the possibility that eosinophils undergo non-apoptotic cell death that worsens tissue damage and increases effusion viscosity.

Recent Findings

Unlike chronic otitis media, EOM is strongly associated with an allergic background. Corticosteroids are currently the only effective pharmacological treatment, and surgical intervention is often required. Mucosal eosinophils infiltrate extensively into the middle ear cavity where they are stimulated by locally produced activators including interleukin-5 and eotaxin. The eosinophils undergo cytolysis in the effusion, which represents a major fate of activated eosinophils in vivo. Recent data revealed cytolysis could be renamed as extracellular trap cell death (ETosis). ETosis represents suicidal cell death involving total cell degranulation and development of sticky chromatin structures (extracellular traps (ETs)). The characteristics of eosinophil- and neutrophil-derived ET polymers might contribute to the difference in viscosity of secretions between EOM and common chronic otitis media.

Summary

The extracellular products remaining after eosinophil ETosis are an important aspect of EOM pathology. The concept of ETosis also has novel implications for potential therapeutic modalities in various eosinophilic disorders.
Literatur
1.
Iino Y, Tomioka-Matsutani S, Matsubara A, Nakagawa T, Nonaka M. Diagnostic criteria of eosinophilic otitis media, a newly recognized middle ear disease. Auris Nasus Larynx. 2011;38(4):456–61.CrossRefPubMed
2.
• Ohta N, Ishida A, Kurakami K, et al. Expressions and roles of periostin in otolaryngological diseases. Allergol Int: Off J Jpn Soc Allergol. 2014;63(2):171–80. Integrates the periostin expression and discuss its roles in otolaryngological diseases.CrossRef
3.
Okano M, Kariya S, Ohta N, Imoto Y, Fujieda S, Nishizaki K. Association and management of eosinophilic inflammation in upper and lower airways. Allergol Int. 2015;64(2):131–8.
4.
Slavin RG. Sinusitis: viral, bacterial, or fungal and what is the role of Staph? Allergy Asthma Proc. 2006;27(6):447–50.
5.
Tokunaga T, Sakashita M, Haruna T, et al. Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC study. Allergy. 2015;70(8):995–1003.CrossRefPubMedPubMedCentral
6.
Kanazawa H, Yoshida N, Hara N, et al. Risk factors for eosinophilic otitis media in patients with eosinophilic chronic rhinosinusitis. Int Adv Otol. 2013;9(3):353–8.
7.
Kanazawa H, Yoshida N, Yamamoto H, et al. Risk factors associated with severity of eosinophilic otitis media. Auris Nasus Larynx. 2014;41(6):513–7.
8.
Iino Y. Role of IgE in eosinophilic otitis media. Allergol Int. 2010;59(3):233–8.
9.
Iino Y, Nagamine H, Kakizaki K, et al. Effectiveness of instillation of triamcinolone acetonide into the middle ear for eosinophilic otitis media associated with bronchial asthma. Ann Allergy Asthma Immunol. 2006;97(6):761–6.
10.
Azadarmaki R, Westra W, Prasad S. Eosinophilic mucin otomastoiditis and otopolyposis: a progressive form of eosinophilic otitis media. Ann Otol Rhinol Laryngol. 2015;124(9):752–6.CrossRefPubMed
11.
Chung WJ, Lee JH, Lim HK, Yoon TH, Cho KJ, Baek JH. Eosinophilic otitis media: CT and MRI findings and literature review. Korean J Radiol. 2012;13(3):363–7.CrossRefPubMedPubMedCentral
12.
Iwasaki S, Nagura M, Mizuta K. Cochlear implantation in a patient with eosinophilic otitis media. Eur Arch Otorhinolaryngol. 2006;263(4):365–9.CrossRefPubMed
13.
Altuna X, Navarro JJ, Goiburu M, Palicio I. Management of chronic otitis media by subtotal petrosectomy. Acta Otorrinolaringol Esp. 2016;67(5):249–53.CrossRefPubMed
14.
Sugimoto H, Hatano M, Noda M, Hasegawa H, Yoshizaki T. Cochlear implantation in deaf patients with eosinophilic otitis media using subtotal petrosectomy and mastoid obliteration. Eur Arch Otorhinolaryngol. 2017;274(2):1173–7.CrossRefPubMed
15.
Ishitoya J, Sakuma Y, Tsukuda M. Eosinophilic chronic rhinosinusitis in Japan. Allergol Int. 2010;59(3):239–45.
16.
Nakagawa T, Matsubara A, Shiratsuchi H, et al. Intractable otitis media with eosinophils: importance of diagnosis and validity of treatment for hearing preservation. ORL J Otorhinolaryngol Relat Spec. 2006;68(2):118–22.CrossRefPubMed
17.
Wada T, Uemaetomari I, Murashita H, et al. Successful treatment of eosinophilic otitis media using ramatroban: report of two cases. Auris Nasus Larynx. 2006;33(4):455–60.CrossRefPubMed
18.
Iino Y, Hara M, Hasegawa M, et al. Effect of omalizumab on biomarkers in middle ear effusion in patients with eosinophilic otitis media. Acta Otolaryngol. 2014;134(4):366–72.CrossRefPubMed
19.
Iino Y, Hara M, Hasegawa M, et al. Clinical efficacy of anti-IgE therapy for eosinophilic otitis media. Otol Neurotol. 2012;33(7):1218–24.CrossRefPubMed
20.
Shah SA, Ishinaga H, Takeuchi K. Pathogenesis of eosinophilic chronic rhinosinusitis. J Inflamm (Lond). 2016;13:11.CrossRef
21.
Tamaki M, Konno Y, Kobayashi Y, et al. Expression and functional roles of G-protein-coupled estrogen receptor (GPER) in human eosinophils. Immunol Lett. 2014;160(1):72–8.CrossRefPubMed
22.
Legrand F, Klion AD. Biologic therapies targeting eosinophils: current status and future prospects. J Allergy Clin Immunol Pract. 2015;3(2):167–74.CrossRefPubMedPubMedCentral
23.
Ueki S, Mahemuti G, Oyamada H, et al. Retinoic acids are potent inhibitors of spontaneous human eosinophil apoptosis. J Immunol. 2008;181(11):7689–98.CrossRefPubMed
24.
Pavord ID, Korn S, Howarth P, et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet. 2012;380(9842):651–9.CrossRefPubMed
25.
Iino Y, Kakizaki K, Saruya S, et al. Eustachian tube function in patients with eosinophilic otitis media associated with bronchial asthma evaluated by sonotubometry. Arch Otolaryngol Head Neck Surg. 2006;132(10):1109–14.CrossRefPubMed
26.
Iino Y, Kakizaki K, Katano H, Saigusa H, Kanegasaki S. Eosinophil chemoattractants in the middle ear of patients with eosinophilic otitis media. Clin Exp Allergy: J Br Soc Allergy Clin Immunol. 2005;35(10):1370–6.CrossRef
27.
Nonaka M, Fukumoto A, Ozu C, et al. IL-5 and eotaxin levels in middle ear effusion and blood from asthmatics with otitis media with effusion. Acta Otolaryngol. 2003;123(3):383–7.CrossRef
28.
Morita H, Moro K, Koyasu S. Innate lymphoid cells in allergic and nonallergic inflammation. J Allergy Clin Immunol. 2016;138(5):1253–64.CrossRefPubMed
29.
Kabata H, Moro K, Koyasu S, Asano K. Group 2 innate lymphoid cells and asthma. Allergol Int. 2015;64(3):227–34.
30.
31.
Ueki S, Nishikawa J, Yamauchi Y, et al. Retinoic acids up-regulate functional eosinophil-driving receptor CCR3. Allergy. 2013;68(7):953–6.CrossRefPubMed
32.
Saito H, Honda K, Asaka C, Ueki S, Ishikawa K. Eosinophil chemotaxis assay in nasal polyps by using a novel optical device EZ-TAXIScan: role of CC-chemokine receptor 3. Allergol Int. 2016;65:280–5.
33.
Yamamoto R, Ueki S, Moritoki Y, et al. Adiponectin attenuates human eosinophil adhesion and chemotaxis: implications in allergic inflammation. J Asthma. 2013;50(8):828–35.
34.
Takeda M, Ueki S, Kato H, et al. Obesity and eosinophilic inflammation: does leptin play a role. Int Arch Allergy Immunol. 2012;158(Suppl 1):87–91.CrossRefPubMed
35.
Kato H, Ueki S, Kamada R, et al. Leptin has a priming effect on eotaxin-induced human eosinophil chemotaxis. Int Arch Allergy Immunol. 2011;155(4):335–44.CrossRefPubMed
36.
Matsumoto R, Matsumoto H, Seki M, et al. Human ecalectin, a variant of human galectin-9, is a novel eosinophil chemoattractant produced by T lymphocytes. J Biol Chem. 1998;273(27):16976–84.CrossRefPubMed
37.
Kanazawa H, Yoshida N, Shinnabe A, Iino Y. Antigen-specific IgE in middle ear effusion of patients with eosinophilic otitis media. Ann Allergy Asthma Immunol. 2014;113(1):88–92.
38.
Nguyen LH, Manoukian JJ, Sobol SE, et al. Similar allergic inflammation in the middle ear and the upper airway: evidence linking otitis media with effusion to the united airways concept. J Allergy Clin Immunol. 2004;114(5):1110–5.CrossRefPubMed
39.
Izuhara K, Ohta S, Ono J. Using Periostin as a biomarker in the treatment of asthma. Allergy, Asthma Immunol Res. 2016;8(6):491–8.CrossRef
40.
Nishizawa H, Matsubara A, Nakagawa T, et al. The role of periostin in eosinophilic otitis media. Acta Otolaryngol. 2012;132(8):838–44.PubMed
41.
Noguchi T, Nakagome K, Kobayashi T, et al. Periostin upregulates the effector functions of eosinophils. J Allergy Clin Immunol. 2016;138(5):1449–52. e5CrossRefPubMed
42.
Moqbel RLP, Adamko DJ, Odemuyiwa SO. Biology of eosinophils. 7th ed. Philadelphia: Elsevier Science; 2009.
43.
•• Ueki S, Melo RC, Ghiran I, Spencer LA, Dvorak AM, Weller PF. Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans. Blood. 2013;121(11):2074–83. First report showing EETosis-mediates cytolysis and production of intact free granules.CrossRefPubMedPubMedCentral
44.
45.
Matsubara A, Nishizawa H, Kurose A, Nakagawa T, Takahata J, Sasaki A. An experimental study of inner ear injury in an animal model of eosinophilic otitis media. Acta Otolaryngol. 2014;134(3):227–32.CrossRefPubMed
46.
Ponikau JU, Sherris DA, Kephart GM, et al. Striking deposition of toxic eosinophil major basic protein in mucus: implications for chronic rhinosinusitis. J Allergy Clin Immunol. 2005;116(2):362–9.CrossRefPubMed
47.
Nagamine H, Iino Y, Kojima C, Miyazawa T, Iida T. Clinical characteristics of so called eosinophilic otitis media. Auris Nasus Larynx. 2002;29(1):19–28.CrossRefPubMed
48.
Persson C. Eosinophil apoptosis-inducing drugs risk worsening rather than resolving asthma. J Allergy Clin Immunol. 2015;135(6):1662.CrossRefPubMed
49.
Saffari H, Hoffman LH, Peterson KA, et al. Electron microscopy elucidates eosinophil degranulation patterns in patients with eosinophilic esophagitis. J Allergy Clin Immunol. 2014;133(6):1728–34. e1CrossRefPubMed
50.
• Persson C, Uller L. Theirs but to die and do: primary lysis of eosinophils and free eosinophil granules in asthma. Am J Respir Crit Care Med. 2014;189(6):628–33. Up-to-date review for current knowledge for eosinophil lysis and free eosinophil granules.CrossRefPubMed
51.
Erjefalt JS, Greiff L, Andersson M, et al. Allergen-induced eosinophil cytolysis is a primary mechanism for granule protein release in human upper airways. Am J Respir Crit Care Med. 1999;160(1):304–12.CrossRefPubMed
52.
Uller L, Andersson M, Greiff L, Persson CG, Erjefalt JS. Occurrence of apoptosis, secondary necrosis, and cytolysis in eosinophilic nasal polyps. Am J Respir Crit Care Med. 2004;170(7):742–7.CrossRefPubMed
53.
54.
Yamauchi Y, Ueki S, Konno Y, et al. The effect of hepatocyte growth factor on secretory functions in human eosinophils. Cytokine. 2016;88:45–50.CrossRefPubMed
55.
Persson C, Uller L. Primary lysis of eosinophils as a major mode of activation of eosinophils in human diseased tissues. Nat Rev Immunol. 2013;13(12):902.CrossRefPubMed
56.
Neves JS, Perez SA, Spencer LA, et al. Eosinophil granules function extracellularly as receptor-mediated secretory organelles. Proc Natl Acad Sci U S A. 2008;105(47):18478–83.CrossRefPubMedPubMedCentral
57.
Neves JS, Radke AL, Weller PF. Cysteinyl leukotrienes acting via granule membrane-expressed receptors elicit secretion from within cell-free human eosinophil granules. J Allergy Clin Immunol. 2010;125(2):477–82.CrossRefPubMedPubMedCentral
58.
Shamri R, Melo RC, Young KM, et al. CCL11 elicits secretion of RNases from mouse eosinophils and their cell-free granules. FASEB J. 2012;26(5):2084–93.CrossRefPubMedPubMedCentral
59.
Muniz VS, Baptista-Dos-Reis R, Neves JS. Functional extracellular eosinophil granules: a bomb caught in a trap. Int Arch Allergy Immunol. 2013;162(4):276–82.CrossRefPubMed
60.
Persson CG, Erjefalt JS. “Ultimate activation” of eosinophils in vivo: lysis and release of clusters of free eosinophil granules (Cfegs). Thorax. 1997;52(6):569–74.CrossRefPubMedPubMedCentral
61.
62.
63.
64.
Thornton RB, Wiertsema SP, Kirkham LA, et al. Neutrophil extracellular traps and bacterial biofilms in middle ear effusion of children with recurrent acute otitis media—a potential treatment target. PLoS One. 2013;8(2):e53837.CrossRefPubMedPubMedCentral
65.
Val S, Poley M, Brown K, et al. Proteomic characterization of middle ear fluid confirms neutrophil extracellular traps as a predominant innate immune response in chronic otitis media. PLoS One. 2016;11(4):e0152865.CrossRefPubMedPubMedCentral
66.
Manzenreiter R, Kienberger F, Marcos V, et al. Ultrastructural characterization of cystic fibrosis sputum using atomic force and scanning electron microscopy. J Cyst Fibros. 2012;11(2):84–92.CrossRefPubMed
67.
George PM, Banya W, Pareek N, et al. Improved survival at low lung function in cystic fibrosis: cohort study from 1990 to 2007. BMJ. 2011;342:d1008.CrossRefPubMedPubMedCentral
68.
Vlaminck S, Vauterin T, Hellings PW, et al. The importance of local eosinophilia in the surgical outcome of chronic rhinosinusitis: a 3-year prospective observational study. Am J Rhinol Allergy. 2014;28(3):260–4.CrossRefPubMed
69.
Healy DY, Leid JG, Sanderson AR, Hunsaker DH. Biofilms with fungi in chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2008;138(5):641–7.CrossRefPubMed
70.
•• Ueki S, Konno Y, Takeda M, et al. Eosinophil extracellular trap cell death-derived DNA traps: their presence in secretions and functional attributes. J Allergy Clin Immunol. 2016;137(1):258–67. First report on the abundance of EETs in clinical secretions and their trapping capacities, stability, and structure.CrossRefPubMed
71.
•• Ueki S, Tokunaga T, Fujieda S, et al. Eosinophil ETosis and DNA traps: a new look at eosinophilic inflammation. Curr Allergy Asthma Rep. 2016;16(8):54. Reviews current perspective of eosinophil ETosis.CrossRefPubMedPubMedCentral
72.
Granville L, Chirala M, Cernoch P, Ostrowski M, Truong LD. Fungal sinusitis: histologic spectrum and correlation with culture. Hum Pathol. 2004;35(4):474–81.CrossRefPubMed
73.
Schubert MS, Goetz DW. Evaluation and treatment of allergic fungal sinusitis. I. Demographics and diagnosis. J Allergy Clin Immunol. 1998;102(3):387–94.CrossRefPubMed
74.
Persson CG, Erjefalt JS. Eosinophil lysis and free granules: an in vivo paradigm for cell activation and drug development. Trends Pharmacol Sci. 1997;18(4):117–23.CrossRefPubMed
75.
Kay AB. The early history of the eosinophil. Clin Exp Allergy: J Br Soc Allergy Clin Immunol. 2015;45(3):575–82.CrossRef
76.
Druilhe A, Letuve S, Pretolani M. Glucocorticoid-induced apoptosis in human eosinophils: mechanisms of action. Apoptosis. 2003;8(5):481–95.CrossRefPubMed
Metadaten
Titel
Eosinophilic Otitis Media: the Aftermath of Eosinophil Extracellular Trap Cell Death
verfasst von
Shigeharu Ueki
Nobuo Ohta
Masahide Takeda
Yasunori Konno
Makoto Hirokawa
Publikationsdatum
01.05.2017
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 5/2017
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-017-0702-5

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