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Cardiovascular Toxicology
Erschienen in: Cardiovascular Toxicology 1/2019

17.11.2018

Nano-medicine and Vascular Endothelial Dysfunction: Options and Delivery Strategies

verfasst von: Gaurav Taneja, Akash Sud, Narayan Pendse, Bishnu Panigrahi, Ashish Kumar, Arun K. Sharma

Erschienen in: Cardiovascular Toxicology | Ausgabe 1/2019

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Abstract

The endothelium is a thin innermost layer of flat cells which release various mediators including endothelin-1 (ET-1), prostanoids, von Willebrand factor (vWF) and endothelium-derived relaxing factor (EDRF; nitric oxide) to regulate vascular tone. Endothelial nitric oxide synthase (eNOS) is a key enzyme that generates nitric oxide (NO). NO maintains vascular homeostasis and cardiac functions by influencing major vascular protective properties such as anti-platelet, anti-proliferative, anti-migratory, antioxidant and anti-inflammatory action in vessels. Abnormal endothelial production and release of NO lead to vascular endothelial dysfunction (VED) and further leads to pathogenesis in myocardial and other tissues. Numerous pharmacological agents such as angiotensin-converting enzyme inhibitors, statins, calcium channel blockers, ET-1 receptor antagonists, insulin sensitizers, antioxidants and supplements like tetrahydrobiopterin, arginine and folate have been implicated in the treatment of VED, but their therapeutic potency was restricted due to some unavoidable adverse effects. The new era with advances in nanotechnology and its ability to target a specific disease, nano-medicine explored an innovative gateway for advanced therapy for VED. The present commentary reveals the various available, pipeline nano-medicine, their interaction with endothelium and in other associated pathological conditions and their delivery strategies for target-specific treatment of VED.
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Metadaten
Titel
Nano-medicine and Vascular Endothelial Dysfunction: Options and Delivery Strategies
verfasst von
Gaurav Taneja
Akash Sud
Narayan Pendse
Bishnu Panigrahi
Ashish Kumar
Arun K. Sharma
Publikationsdatum
17.11.2018
Verlag
Springer US
Erschienen in
Cardiovascular Toxicology / Ausgabe 1/2019
Print ISSN: 1530-7905
Elektronische ISSN: 1559-0259
DOI
https://doi.org/10.1007/s12012-018-9491-x

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