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Erschienen in: InFo Hämatologie + Onkologie 10/2020

18.10.2020 | Melanom | Schwerpunkt

Schwerpunkt malignes Melanom

Nebenwirkungsmanagement unter einer dermatoonkologischen Systemtherapie

verfasst von: Dr. med. Ann-Sophie Bohne, Dr. med. Katharina C. Kähler

Erschienen in: InFo Hämatologie + Onkologie | Ausgabe 10/2020

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Zielgerichtete und Immuntherapien haben in den letzten Dekaden zweifelslos die Melanombehandlung revolutioniert. Nichtsdestotrotz können beide Therapieformen schwere und potenziell lebensbedrohliche Nebenwirkungen auslösen, die Behandelnde kennen sollten, um zusammen mit ihren Patienten die jeweils optimale Therapie auszuwählen - und natürlich, um im Falle von Toxizitäten angemessen reagieren zu können. …
Literatur
1.
Zurück zum Zitat Curtin JA et al. Distinct Sets of Genetic Alterations in Melanoma. N Engl J Med. 2005;353(20):2135-47 Curtin JA et al. Distinct Sets of Genetic Alterations in Melanoma. N Engl J Med. 2005;353(20):2135-47
2.
Zurück zum Zitat Davies H et al. Mutations of the BRAF gene in human cancer. Nature. 2002;417(6892):949-54 Davies H et al. Mutations of the BRAF gene in human cancer. Nature. 2002;417(6892):949-54
3.
Zurück zum Zitat Hauschild A et al. Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet. 2012;380(9839):358-65 Hauschild A et al. Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet. 2012;380(9839):358-65
4.
Zurück zum Zitat McArthur GA et al. Safety and efficacy of vemurafenib in BRAFV600E and BRAFV600K mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study. Lancet Oncol. 2014;15(3):323-32 McArthur GA et al. Safety and efficacy of vemurafenib in BRAFV600E and BRAFV600K mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study. Lancet Oncol. 2014;15(3):323-32
5.
Zurück zum Zitat Hamid O et al. Efficacy, Safety, and Tolerability of Approved Combination BRAF and MEK Inhibitor Regimens for BRAF-Mutant Melanoma. Cancers (Basel). 2019;11(11):1642. Hamid O et al. Efficacy, Safety, and Tolerability of Approved Combination BRAF and MEK Inhibitor Regimens for BRAF-Mutant Melanoma. Cancers (Basel). 2019;11(11):1642.
6.
Zurück zum Zitat Heinzerling L et al. Tolerability of BRAF/MEK inhibitor combinations: adverse event evaluation and management. ESMO Open. 2019;4(3):e000491 Heinzerling L et al. Tolerability of BRAF/MEK inhibitor combinations: adverse event evaluation and management. ESMO Open. 2019;4(3):e000491
8.
Zurück zum Zitat Cosgarea I et al. Update on the clinical use of kinase inhibitors in melanoma. J Dtsch Dermatol Ges. 2017;15(9):887-93 Cosgarea I et al. Update on the clinical use of kinase inhibitors in melanoma. J Dtsch Dermatol Ges. 2017;15(9):887-93
9.
Zurück zum Zitat Daud A, Tsai K. Management of Treatment-Related Adverse Events with Agents Targeting the MAPK Pathway in Patients with Metastatic Melanoma. Oncologist. 2017;22(7):823-33 Daud A, Tsai K. Management of Treatment-Related Adverse Events with Agents Targeting the MAPK Pathway in Patients with Metastatic Melanoma. Oncologist. 2017;22(7):823-33
10.
Zurück zum Zitat Zimmer L et. al. Side effects of systemic oncological therapies in dermatology. JDDG: Journal der Deutschen Dermatologischen Gesellschaft. 2012;10(7):475-86 Zimmer L et. al. Side effects of systemic oncological therapies in dermatology. JDDG: Journal der Deutschen Dermatologischen Gesellschaft. 2012;10(7):475-86
12.
Zurück zum Zitat Hassel JC et al. Combined immune checkpoint blockade (anti-PD-1/anti-CTLA-4): Evaluation and management of adverse drug reactions. Cancer Treat Rev. 2017;57:36-49 Hassel JC et al. Combined immune checkpoint blockade (anti-PD-1/anti-CTLA-4): Evaluation and management of adverse drug reactions. Cancer Treat Rev. 2017;57:36-49
13.
Zurück zum Zitat Haanen J et al. Autoimmune diseases and immune-checkpoint inhibitors for cancer therapy: review of the literature and personalized risk-based prevention strategy. Ann Oncol. 2020;S0923-7534(20)36364-X Haanen J et al. Autoimmune diseases and immune-checkpoint inhibitors for cancer therapy: review of the literature and personalized risk-based prevention strategy. Ann Oncol. 2020;S0923-7534(20)36364-X
14.
Zurück zum Zitat Abdel-Wahab N et al. Checkpoint inhibitor therapy for cancer in solid organ transplantation recipients: an institutional experience and a systematic review of the literature. J Immunother Cancer. 2019;7(1):106 Abdel-Wahab N et al. Checkpoint inhibitor therapy for cancer in solid organ transplantation recipients: an institutional experience and a systematic review of the literature. J Immunother Cancer. 2019;7(1):106
15.
Zurück zum Zitat De Bruyn P et al. Immune checkpoint blockade for organ transplant patients with advanced cancer. Curr Opin Oncol. 2019;31(2):54-64 De Bruyn P et al. Immune checkpoint blockade for organ transplant patients with advanced cancer. Curr Opin Oncol. 2019;31(2):54-64
16.
Zurück zum Zitat Kähler KC et al. Side effect management during immune checkpoint blockade using CTLA-4 and PD-1 antibodies for metastatic melanoma - an update. J Dtsch Dermatol Ges. 2020;18(6):582-609 Kähler KC et al. Side effect management during immune checkpoint blockade using CTLA-4 and PD-1 antibodies for metastatic melanoma - an update. J Dtsch Dermatol Ges. 2020;18(6):582-609
17.
Zurück zum Zitat Lafabregue E et al. Two cases of pneumonitis induced by targeted therapy. Melanoma Res. 2019;29(4):441-3 Lafabregue E et al. Two cases of pneumonitis induced by targeted therapy. Melanoma Res. 2019;29(4):441-3
18.
Zurück zum Zitat Ros J, Muñoz-Couselo E. DRESS syndrome due to vemurafenib treatment: switching BRAF inhibitor to solve a big problem. BMJ Case Rep. 2018;2018:bcr2018224379 Ros J, Muñoz-Couselo E. DRESS syndrome due to vemurafenib treatment: switching BRAF inhibitor to solve a big problem. BMJ Case Rep. 2018;2018:bcr2018224379
20.
Zurück zum Zitat Weiss J et al. Therapy preferences in melanoma treatment—Willingness to pay and preference of quality versus length of life of patients, physicians, healthy individuals and physicians with oncological disease. Cancer Med. 2020; https://doi.org/ 10.1002/cam4.3191 Weiss J et al. Therapy preferences in melanoma treatment—Willingness to pay and preference of quality versus length of life of patients, physicians, healthy individuals and physicians with oncological disease. Cancer Med. 2020; https://​doi.​org/​ 10.​1002/​cam4.​3191
Metadaten
Titel
Schwerpunkt malignes Melanom
Nebenwirkungsmanagement unter einer dermatoonkologischen Systemtherapie
verfasst von
Dr. med. Ann-Sophie Bohne
Dr. med. Katharina C. Kähler
Publikationsdatum
18.10.2020
Verlag
Springer Medizin
Schlagwörter
Melanom
Melanom
Erschienen in
InFo Hämatologie + Onkologie / Ausgabe 10/2020
Print ISSN: 2662-1754
Elektronische ISSN: 2662-1762
DOI
https://doi.org/10.1007/s15004-020-8244-8

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