Skip to main content
Erschienen in: Pneumo News 8/2018

17.12.2018 | Lungenkarzinome | cme fortbildung

Immuntherapie beim Nichtkleinzeller

Der Einsatz von Checkpoint-Hemmern beim Lungenkarzinom wird breiter

verfasst von: Dr. med. Justyna Rawluk, Prof. Dr. med. Cornelius F. Waller

Erschienen in: Pneumo News | Ausgabe 8/2018

Einloggen, um Zugang zu erhalten

Zusammenfassung

Checkpoint-Inhibitoren werden in der Therapie bei nichtkleinzelligen Lungenkarzinomen in metastasierten wie lokal fortgeschrittenen Stadien und in neuen Kombinationen geprüft. Die Zulassung dieser Antikörper beruht auf der signifikanten Verlängerung des progressionsfreien bzw. des Gesamtüberlebens. Was kann man je nach klinischer Situation derzeit von ihnen erwarten?
Literatur
1.
Zurück zum Zitat Tsao AS, Scagliotti GV, Bunn PA Jr. et al. Scientific Advances in Lung Cancer 2015. J Thorac Oncol. 2016;11(5):613–38CrossRef Tsao AS, Scagliotti GV, Bunn PA Jr. et al. Scientific Advances in Lung Cancer 2015. J Thorac Oncol. 2016;11(5):613–38CrossRef
2.
Zurück zum Zitat Forde PM, Chaft JE, Smith KN et al. Neoadjuvant PD-1 Blockade in Resectable Lung Cancer. N Engl J Med. 2018;378(21):1976–86CrossRef Forde PM, Chaft JE, Smith KN et al. Neoadjuvant PD-1 Blockade in Resectable Lung Cancer. N Engl J Med. 2018;378(21):1976–86CrossRef
3.
Zurück zum Zitat Antonia SJ, Ozguroglu M. Durvalumab in Stage III Non-Small-Cell Lung Cancer. N Engl J Med. 2018;378(9):869–70PubMed Antonia SJ, Ozguroglu M. Durvalumab in Stage III Non-Small-Cell Lung Cancer. N Engl J Med. 2018;378(9):869–70PubMed
4.
Zurück zum Zitat Chen DS, Mellman I. Oncology meets immunology: the cancer-immunity cycle. Immunity. 2013;39(1):1–10CrossRef Chen DS, Mellman I. Oncology meets immunology: the cancer-immunity cycle. Immunity. 2013;39(1):1–10CrossRef
5.
Zurück zum Zitat Hellmann MD, Ciuleanu T-E, Pluzanski A et al. Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden. N Engl J Med. 2018;378(22):2093–104CrossRef Hellmann MD, Ciuleanu T-E, Pluzanski A et al. Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden. N Engl J Med. 2018;378(22):2093–104CrossRef
6.
Zurück zum Zitat Gabrilovich DI, Ostrand-Rosenberg S, Bronte V. Coordinated regulation of myeloid cells by tumours. Nat Rev Immunol. 2012;12(4):253–68CrossRef Gabrilovich DI, Ostrand-Rosenberg S, Bronte V. Coordinated regulation of myeloid cells by tumours. Nat Rev Immunol. 2012;12(4):253–68CrossRef
7.
Zurück zum Zitat Gajewski TF, Schreiber H, Fu YX. Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol. 2013;14(10):1014–22CrossRef Gajewski TF, Schreiber H, Fu YX. Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol. 2013;14(10):1014–22CrossRef
8.
Zurück zum Zitat Derosa L, Hellmann MD, Spaziano M et al. Negative association of antibiotics on clinical activity of immune checkpoint inhibitors in patients with advanced renal cell and non-small-cell lung cancer. Ann Oncol. 2018;29(6):1437–44CrossRef Derosa L, Hellmann MD, Spaziano M et al. Negative association of antibiotics on clinical activity of immune checkpoint inhibitors in patients with advanced renal cell and non-small-cell lung cancer. Ann Oncol. 2018;29(6):1437–44CrossRef
9.
Zurück zum Zitat Reck M, Rodriguez-Abreu D, Robinson AG et al. Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer. N Engl J Med. 2016;375(19):1823–33CrossRef Reck M, Rodriguez-Abreu D, Robinson AG et al. Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer. N Engl J Med. 2016;375(19):1823–33CrossRef
10.
Zurück zum Zitat Brahmer JR, Rodriguez-Abreu D, Robinson AG et al. Health-related quality-of-life results for pembrolizumab versus chemotherapy in advanced, PD-L1-positive NSCLC (KEYNOTE-024): a multicentre, international, randomised, open-label phase 3 trial. Lancet Oncol. 2017;18(12):1600–9CrossRef Brahmer JR, Rodriguez-Abreu D, Robinson AG et al. Health-related quality-of-life results for pembrolizumab versus chemotherapy in advanced, PD-L1-positive NSCLC (KEYNOTE-024): a multicentre, international, randomised, open-label phase 3 trial. Lancet Oncol. 2017;18(12):1600–9CrossRef
11.
Zurück zum Zitat Carbone DP, Reck M, Paz-Ares L et al. First-Line Nivolumab in Stage IV or Recurrent Non-Small-Cell Lung Cancer. N Engl J Med. 2017;376(25):2415–26CrossRef Carbone DP, Reck M, Paz-Ares L et al. First-Line Nivolumab in Stage IV or Recurrent Non-Small-Cell Lung Cancer. N Engl J Med. 2017;376(25):2415–26CrossRef
12.
Zurück zum Zitat Galluzzi L, Zitvogel L, Kroemer G. Immunological Mechanisms Underneath the Efficacy of Cancer Therapy. Cancer Immunol Res. 2016;4(11):895–902CrossRef Galluzzi L, Zitvogel L, Kroemer G. Immunological Mechanisms Underneath the Efficacy of Cancer Therapy. Cancer Immunol Res. 2016;4(11):895–902CrossRef
13.
Zurück zum Zitat Gandhi L, Rodríguez-Abreu D, Gadgeel S et al. Pembrolizumab plus Chemotherapy in Metastatic Non-Small-Cell Lung Cancer. N Engl J Med. 2018;378(22):2078–92CrossRef Gandhi L, Rodríguez-Abreu D, Gadgeel S et al. Pembrolizumab plus Chemotherapy in Metastatic Non-Small-Cell Lung Cancer. N Engl J Med. 2018;378(22):2078–92CrossRef
14.
Zurück zum Zitat Paz Ares L et al. Phase 3 study of carboplatin-paclitaxel/nab-paclitaxel (Chemo) with or without pembrolizumab (Pembro) for patients (Pts) with metastatic squamous (Sq) non-small cell lung cancer (NSCLC). J Clin Oncol. 2018;36(Suppl):ASCO 2018, Abstract #105 Paz Ares L et al. Phase 3 study of carboplatin-paclitaxel/nab-paclitaxel (Chemo) with or without pembrolizumab (Pembro) for patients (Pts) with metastatic squamous (Sq) non-small cell lung cancer (NSCLC). J Clin Oncol. 2018;36(Suppl):ASCO 2018, Abstract #105
15.
Zurück zum Zitat Socinski MA, Jotte RM, Cappuzzo F et al. Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC. N Engl J Med. 2018;378(24):2288–301CrossRef Socinski MA, Jotte RM, Cappuzzo F et al. Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC. N Engl J Med. 2018;378(24):2288–301CrossRef
16.
Zurück zum Zitat Horn L, Spigel DR, Vokes EE et al. Nivolumab Versus Docetaxel in Previously Treated Patients With Advanced Non-Small-Cell Lung Cancer: Two-Year Outcomes From Two Randomized, Open-Label, Phase III Trials (CheckMate 017 and CheckMate 057). J Clin Oncol. 2017;35(35):3924–33CrossRef Horn L, Spigel DR, Vokes EE et al. Nivolumab Versus Docetaxel in Previously Treated Patients With Advanced Non-Small-Cell Lung Cancer: Two-Year Outcomes From Two Randomized, Open-Label, Phase III Trials (CheckMate 017 and CheckMate 057). J Clin Oncol. 2017;35(35):3924–33CrossRef
17.
Zurück zum Zitat Herbst RS, Baas P, Kim DW et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet. 2016;387(10027):1540–50CrossRef Herbst RS, Baas P, Kim DW et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet. 2016;387(10027):1540–50CrossRef
18.
Zurück zum Zitat Rittmeyer A, Barlesi F, Waterkamp D et al. Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial. Lancet. 2017;389(10066):255–65CrossRef Rittmeyer A, Barlesi F, Waterkamp D et al. Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial. Lancet. 2017;389(10066):255–65CrossRef
19.
Zurück zum Zitat Antonia SJ, Villegas A, Daniel D et al. Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC. N Engl J Med. 2018 Sep 25. https://doi.org/10.1056/NEJMoa1809697 Antonia SJ, Villegas A, Daniel D et al. Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC. N Engl J Med. 2018 Sep 25. https://​doi.​org/​10.​1056/​NEJMoa1809697
20.
Zurück zum Zitat Naidoo J, Page DB, Li BT et al. Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies. Ann Oncol. 2015;26(12):2375–91PubMedPubMedCentral Naidoo J, Page DB, Li BT et al. Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies. Ann Oncol. 2015;26(12):2375–91PubMedPubMedCentral
Metadaten
Titel
Immuntherapie beim Nichtkleinzeller
Der Einsatz von Checkpoint-Hemmern beim Lungenkarzinom wird breiter
verfasst von
Dr. med. Justyna Rawluk
Prof. Dr. med. Cornelius F. Waller
Publikationsdatum
17.12.2018
Verlag
Springer Medizin
Erschienen in
Pneumo News / Ausgabe 8/2018
Print ISSN: 1865-5467
Elektronische ISSN: 2199-3866
DOI
https://doi.org/10.1007/s15033-018-0819-9

Weitere Artikel der Ausgabe 8/2018

Pneumo News 8/2018 Zur Ausgabe