Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Background
The adequate extent of lymphadenectomy in gastric cancer was a controversial topic when Asian authors tried to show benefits of this approach to their Western peers, as the data came mostly from low evidence-based retrospective series. The first randomized clinical trial conducted in the West failed to show benefits, therefore increasing the controversy [1]. These studies were lately criticized, long-term results reviewed, and new trials came out showing real benefits of lymphadenectomy, making gastrectomy with extended lymphadenectomy the standard treatment for gastric cancer today [2]. After the value of lymphadenectomy was accepted, authors focused on how perform it better. Both the laparoscopic and the robotic approach proved to be similar to open surgery in the number of harvested lymph nodes, while providing the advantages of minimally invasive operations [3, 4].
Indocyanine green has been used to guide lymphadenectomy in gastric cancer cases since the beginning of the century, with the purpose of identifying sentinel lymph nodes [5], a tactic that never proved to be very useful. With open surgery, indocyanine was only a vital dye that colored the lymph nodes in green. With minimally invasive surgery, indocyanine became a fluorescent marker that glitters under near-infrared light. This has been shown to enable the retrieval of a higher number of lymph nodes as demonstrated by the same group from China [6], although we have questioned how indocyanine helps: does it illuminate smaller lymph nodes or increase the area of dissection? [7]
Anzeige
Main text
Chen et al. [8] went beyond the question of the safety and utility of indocyanine green for gastric lymphadenectomy to try to evaluate the best site to inject the dye, either via the submucosal or subserosal route. The authors randomized 259 patients to either have an endoscopy to inject the tracer the day before the operation (submucosal group) or having the tracer injected during laparoscopy 20 minutes before the beginning of the lymphadenectomy (subserosal group). The number of retrieved lymph nodes was not different between groups (49.8 vs. 49.2, p=0.713). This shows that the diffusion of the tracer is the same irrespective of the technique. The drug is probably injected in the same layer, by either technique. It is surprising that the drug injection time was not an influence on the number of retrieved lymph nodes. The authors concluded that submucosal injection is more costly and associated with decreased patient satisfaction, due to the necessity to do an endoscopy before the operation. The authors recommend that the submucosa injection should not be abandoned as it is still important when dealing with small tumors when a preoperative endoscopy is needed to locate and mark the tumor.
Conclusion
There are still some questions to be answered and we hope this group working extensively on the topic will be able to teach us more. We are curious to know if other markers are better than indocyanine, and if a different marker will be able to distinguish metastatic lymph nodes from normal ones.
Acknowledgements
None
Declarations
Ethics approval and consent to participate
Not applicable.
Anzeige
Competing interests
The authors declare that they have no competing interests.
Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Bei Reizdarmsyndrom scheinen Diäten, wie etwa die FODMAP-arme oder die kohlenhydratreduzierte Ernährung, effektiver als eine medikamentöse Therapie zu sein. Das hat eine Studie aus Schweden ergeben, die die drei Therapieoptionen im direkten Vergleich analysierte.
Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.
Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.
Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.
Update Allgemeinmedizin
Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.