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Zeitschrift

BMC Medicine

BMC Medicine 1/2021

Ausgabe 1/2021

Inhaltsverzeichnis ( 323 Artikel )

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Development and validation of a lifestyle-based model for colorectal cancer risk prediction: the LiFeCRC score

Krasimira Aleksandrova, Robin Reichmann, Rudolf Kaaks, Mazda Jenab, H. Bas Bueno-de-Mesquita, Christina C. Dahm, Anne Kirstine Eriksen, Anne Tjønneland, Fanny Artaud, Marie-Christine Boutron-Ruault, Gianluca Severi, Anika Hüsing, Antonia Trichopoulou, Anna Karakatsani, Eleni Peppa, Salvatore Panico, Giovanna Masala, Sara Grioni, Carlotta Sacerdote, Rosario Tumino, Sjoerd G. Elias, Anne M. May, Kristin B. Borch, Torkjel M. Sandanger, Guri Skeie, Maria-Jose Sánchez, José María Huerta, Núria Sala, Aurelio Barricarte Gurrea, José Ramón Quirós, Pilar Amiano, Jonna Berntsson, Isabel Drake, Bethany van Guelpen, Sophia Harlid, Tim Key, Elisabete Weiderpass, Elom K. Aglago, Amanda J. Cross, Konstantinos K. Tsilidis, Elio Riboli, Marc J. Gunter

01.12.2021 | Opinion | Ausgabe 1/2021 Open Access

Vaccination strategies for measles control and elimination: time to strengthen local initiatives

F. T. Cutts, M. J. Ferrari, L. K. Krause, A. J. Tatem, J. F. Mosser

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Targeting body composition in an older population: do changes in movement behaviours matter? Longitudinal analyses in the PREDIMED-Plus trial

Aina M. Galmes-Panades, Jadwiga Konieczna, Veronica Varela-Mato, Itziar Abete, Nancy Babio, Miquel Fiol, José Antonio de Paz, Rosa Casas, Romina Olbeyra, Miguel Ruiz-Canela, Antoni Palau-Galindo, Olga Castañer, Arturo Martín-García, Ramón Estruch, Josep Vidal, Pilar Buil-Cosiales, Julia Wärnberg, Jordi Salas-Salvadó, J. Alfredo Martínez, Dora Romaguera, on behalf of the PREDIMED-Plus investigators

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems

Local Burden of Disease HIV Collaborators

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Association of sickle cell disease with anthropometric indices among under-five children: evidence from 2018 Nigeria Demographic and Health Survey

Mohammad Redwanul Islam, Md Moinuddin, Ayeda Ahmed, Syed Moshfiqur Rahman

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Non-genetic risk and protective factors and biomarkers for neurological disorders: a meta-umbrella systematic review of umbrella reviews

Alexios-Fotios A. Mentis, Efthimios Dardiotis, Vasiliki Efthymiou, George P. Chrousos

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Associations of six adiposity-related markers with incidence and mortality from 24 cancers—findings from the UK Biobank prospective cohort study

Solange Parra-Soto, Emma S. Cowley, Leandro F. M. Rezende, Catterina Ferreccio, John C. Mathers, Jill P. Pell, Frederick K. Ho, Carlos Celis-Morales

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Association between patterns of alcohol consumption (beverage type, frequency and consumption with food) and risk of adverse health outcomes: a prospective cohort study

Bhautesh Dinesh Jani, Ross McQueenie, Barbara I. Nicholl, Ryan Field, Peter Hanlon, Katie I. Gallacher, Frances S. Mair, Jim Lewsey

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Body mass index and waist circumference in relation to the risk of 26 types of cancer: a prospective cohort study of 3.5 million adults in Spain

Martina Recalde, Veronica Davila-Batista, Yesika Díaz, Michael Leitzmann, Isabelle Romieu, Heinz Freisling, Talita Duarte-Salles

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Model-based comorbidity clusters in patients with heart failure: association with clinical outcomes and healthcare utilization

Claudia Gulea, Rosita Zakeri, Jennifer K. Quint

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

rs1990622 variant associates with Alzheimer’s disease and regulates TMEM106B expression in human brain tissues

Yang Hu, Jing-yi Sun, Yan Zhang, Haihua Zhang, Shan Gao, Tao Wang, Zhifa Han, Longcai Wang, Bao-liang Sun, Guiyou Liu

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

In utero Zika virus exposure and neurodevelopment at 24 months in toddlers normocephalic at birth: a cohort study

Rebecca Grant, Olivier Fléchelles, Benoît Tressières, Mama Dialo, Narcisse Elenga, Nicolas Mediamolle, Adeline Mallard, Jean-Christophe Hebert, Noémie Lachaume, Elvire Couchy, Bruno Hoen, Arnaud Fontanet

01.12.2021 | Review | Ausgabe 1/2021 Open Access

The gut microbiome: a key player in the complexity of amyotrophic lateral sclerosis (ALS)

Sarah L. Boddy, Ilaria Giovannelli, Matilde Sassani, Johnathan Cooper-Knock, Michael P. Snyder, Eran Segal, Eran Elinav, Lynne A. Barker, Pamela J. Shaw, Christopher J. McDermott

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

The rates and medical necessity of cesarean delivery in China, 2012–2019: an inspiration from Jiangsu

Ci Song, Yan Xu, Yuqing Ding, Yanfang Zhang, Na Liu, Lin Li, Zhun Li, Jiangbo Du, Hua You, Hongxia Ma, Guangfu Jin, Xudong Wang, Hongbing Shen, Yuan Lin, Xiaoqing Jiang, Zhibin Hu

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Development of a predictive model for integrated medical and long-term care resource consumption based on health behaviour: application of healthcare big data of patients with circulatory diseases

Tomoyuki Takura, Keiko Hirano Goto, Asao Honda

01.12.2021 | Commentary | Ausgabe 1/2021 Open Access

Consumer-grade electroencephalography devices as potential tools for early detection of brain tumors

Nardin Samuel, Emily So, Ugljesa Djuric, Phedias Diamandis

01.12.2021 | Commentary | Ausgabe 1/2021 Open Access

Undernutrition: a major but potentially preventable cause of poor outcomes in children living with sickle cell disease in Africa

Thomas N. Williams

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Plasma sex hormones and risk of conventional and serrated precursors of colorectal cancer in postmenopausal women

Dong Hang, Xiaosheng He, Ane Sørlie Kværner, Andrew T. Chan, Kana Wu, Shuji Ogino, Zhibin Hu, Hongbing Shen, Edward L. Giovannucci, Mingyang Song

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Potential impact of individual exposure histories to endemic human coronaviruses on age-dependent severity of COVID-19

Francesco Pinotti, Paul S. Wikramaratna, Uri Obolski, Robert S. Paton, Daniel S. C. Damineli, Luiz C. J. Alcantara, Marta Giovanetti, Sunetra Gupta, José Lourenço

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

COVID-19 pandemic and violence: rising risks and decreasing urgent care-seeking for sexual assault and domestic violence survivors

Katherine A. Muldoon, Kathryn M. Denize, Robert Talarico, Deshayne B. Fell, Agnes Sobiesiak, Melissa Heimerl, Kari Sampsel

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

A heart failure phenotype stratified model for predicting 1-year mortality in patients admitted with acute heart failure: results from an individual participant data meta-analysis of four prospective European cohorts

Yuntao Chen, Adriaan A. Voors, Tiny Jaarsma, Chim C. Lang, Iziah E. Sama, K. Martijn Akkerhuis, Eric Boersma, Hans L. Hillege, Douwe Postmus

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

A systematic assessment of the association between frequently prescribed medicines and the risk of common cancers: a series of nested case-control studies

R. D. McDowell, C. Hughes, P. Murchie, C. Cardwell

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Evaluation and improvement of the National Early Warning Score (NEWS2) for COVID-19: a multi-hospital study

Ewan Carr, Rebecca Bendayan, Daniel Bean, Matt Stammers, Wenjuan Wang, Huayu Zhang, Thomas Searle, Zeljko Kraljevic, Anthony Shek, Hang T. T. Phan, Walter Muruet, Rishi K. Gupta, Anthony J. Shinton, Mike Wyatt, Ting Shi, Xin Zhang, Andrew Pickles, Daniel Stahl, Rosita Zakeri, Mahdad Noursadeghi, Kevin O’Gallagher, Matt Rogers, Amos Folarin, Andreas Karwath, Kristin E. Wickstrøm, Alvaro Köhn-Luque, Luke Slater, Victor Roth Cardoso, Christopher Bourdeaux, Aleksander Rygh Holten, Simon Ball, Chris McWilliams, Lukasz Roguski, Florina Borca, James Batchelor, Erik Koldberg Amundsen, Xiaodong Wu, Georgios V. Gkoutos, Jiaxing Sun, Ashwin Pinto, Bruce Guthrie, Cormac Breen, Abdel Douiri, Honghan Wu, Vasa Curcin, James T. Teo, Ajay M. Shah, Richard J. B. Dobson

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Impact of multiple cardiovascular medications on mortality after an incidence of ischemic stroke or transient ischemic attack

Tian-Tian Ma, Ian C. K. Wong, Cate Whittlesea, Kenneth K. C. Man, Wallis Lau, Zixuan Wang, Ruth Brauer, Thomas M. MacDonald, Isla S. Mackenzie, Li Wei

01.12.2021 | COVID-19 | Commentary | Ausgabe 1/2021 Open Access

Efficient SARS-CoV-2 surveillance strategies to prevent deadly outbreaks in vulnerable populations

Damon J. A. Toth, Karim Khader

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

EPHA7 mutation as a predictive biomarker for immune checkpoint inhibitors in multiple cancers

Zhen Zhang, Hao-Xiang Wu, Wu-Hao Lin, Zi-Xian Wang, Lu-Ping Yang, Zhao-Lei Zeng, Hui-Yan Luo

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Genome-wide genetic links between amyotrophic lateral sclerosis and autoimmune diseases

Chun Yu Li, Tian Mi Yang, Ru Wei Ou, Qian Qian Wei, Hui Fang Shang

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Development and validation of a novel circular RNA as an independent prognostic factor in acute myeloid leukemia

Jinghan Wang, Jiajia Pan, Shujuan Huang, Fenglin Li, Jiansong Huang, Xia Li, Qing Ling, Wenle Ye, Yungui Wang, Wenjuan Yu, Jie Jin

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Course of frailty stratified by physical and mental multimorbidity patterns: a 5-year follow-up of 92,640 participants of the LifeLines cohort study

R. C. Oude Voshaar, H. W. Jeuring, M. K. Borges, R. H. S. van den Brink, R. M. Marijnissen, E. O. Hoogendijk, B. van Munster, I. Aprahamian

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Poor cardiovascular health is associated with subclinical atherosclerosis in apparently healthy sub-Saharan African populations: an H3Africa AWI-Gen study

Engelbert A. Nonterah, Nigel J. Crowther, Abraham Oduro, Godfred Agongo, Lisa K. Micklesfield, Palwendé R. Boua, Solomon S. R. Choma, Shukri F. Mohamed, Herman Sorgho, Stephen M. Tollman, Shane A. Norris, Frederick J. Raal, Diederick E. Grobbee, Michelé Ramsay, Michiel L. Bots, Kerstin Klipstein-Grobusch, as part of the H3Africa AWI-Gen study

01.12.2021 | COVID-19 | Opinion | Ausgabe 1/2021 Open Access

When a pandemic and an epidemic collide: COVID-19, gut microbiota, and the double burden of malnutrition

Paula Littlejohn, B. Brett Finlay

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Development of the reproduction number from coronavirus SARS-CoV-2 case data in Germany and implications for political measures

Sahamoddin Khailaie, Tanmay Mitra, Arnab Bandyopadhyay, Marta Schips, Pietro Mascheroni, Patrizio Vanella, Berit Lange, Sebastian C. Binder, Michael Meyer-Hermann

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Maternal dietary quality, inflammatory potential and childhood adiposity: an individual participant data pooled analysis of seven European cohorts in the ALPHABET consortium

Ling-Wei Chen, Adrien M. Aubert, Nitin Shivappa, Jonathan Y. Bernard, Sara M. Mensink-Bout, Aisling A. Geraghty, John Mehegan, Matthew Suderman, Kinga Polanska, Wojciech Hanke, Agnieszka Jankowska, Caroline L. Relton, Sarah R. Crozier, Nicholas C. Harvey, Cyrus Cooper, Mark Hanson, Keith M. Godfrey, Romy Gaillard, Liesbeth Duijts, Barbara Heude, James R. Hébert, Fionnuala M. McAuliffe, Cecily C. Kelleher, Catherine M. Phillips

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Pattern and trend of five major musculoskeletal disorders in China from 1990 to 2017: findings from the Global Burden of Disease Study 2017

Dongze Wu, Priscilla Wong, Cui Guo, Lai-Shan Tam, Jieruo Gu

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

The importance of supplementary immunisation activities to prevent measles outbreaks during the COVID-19 pandemic in Kenya

C. N. Mburu, J. Ojal, R. Chebet, D. Akech, B. Karia, J. Tuju, A. Sigilai, K. Abbas, M. Jit, S. Funk, G. Smits, P. G. M. van Gageldonk, F. R. M. van der Klis, C. Tabu, D. J. Nokes, JAG Scott, S. Flasche, IMO Adetifa, LSHTM CMMID COVID-19 Working Group

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

The Southern European Atlantic Diet and all-cause mortality in older adults

Adrián Carballo-Casla, Rosario Ortolá, Esther García-Esquinas, Andreia Oliveira, Mercedes Sotos-Prieto, Carla Lopes, Esther Lopez-Garcia, Fernando Rodríguez-Artalejo

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

High intake of vegetables is linked to lower white blood cell profile and the effect is mediated by the gut microbiome

Cristina Menni, Panayiotis Louca, Sarah E. Berry, Amrita Vijay, Stuart Astbury, Emily R. Leeming, Rachel Gibson, Francesco Asnicar, Gianmarco Piccinno, Jonathan Wolf, Richard Davies, Massimo Mangino, Nicola Segata, Tim D. Spector, Ana M. Valdes

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Serum neurofilament light and tau as prognostic markers for all-cause mortality in the elderly general population—an analysis from the MEMO study

Nicole Rübsamen, Aleksandra Maceski, David Leppert, Pascal Benkert, Jens Kuhle, Heinz Wiendl, Annette Peters, André Karch, Klaus Berger

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Serum transferrin as a biomarker of hepatocyte nuclear factor 4 alpha activity and hepatocyte function in liver diseases

Nurdan Guldiken, Josepmaria Argemi, Berivan Gurbuz, Stephen R. Atkinson, Martin Oliverius, Petr Fila, Karim Hamesch, Tony Bruns, Joaquín Cabezas, Juan J. Lozano, Jelena Mann, Sheng Cao, Philippe Mathurin, Vijay H. Shah, Christian Trautwein, Mark R. Thursz, Ramon Bataller, Pavel Strnad

08.02.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

The impact of non-pharmaceutical interventions on SARS-CoV-2 transmission across 130 countries and territories

Yang Liu, Christian Morgenstern, James Kelly, Rachel Lowe, Mark Jit, CMMID COVID-19 Working Group

01.12.2021 | Commentary | Ausgabe 1/2021 Open Access

Vertical transmission of Zika virus and the repercussions on children: the knowledge is not complete

M. I. Moreira, S. H. Villela, M. D. B. B. Meio

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Early maternal care restores LINE-1 methylation and enhances neurodevelopment in preterm infants

Camilla Fontana, Federica Marasca, Livia Provitera, Sara Mancinelli, Nicola Pesenti, Shruti Sinha, Sofia Passera, Sergio Abrignani, Fabio Mosca, Simona Lodato, Beatrice Bodega, Monica Fumagalli

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Implications of the ACC/AHA risk score for prediction of heart failure: the Rotterdam Study

Banafsheh Arshi, Jan C. van den Berge, Bart van Dijk, Jaap W. Deckers, M. Arfan Ikram, Maryam Kavousi

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

C2HEST score predicts clinical outcomes in heart failure with preserved ejection fraction: a secondary analysis of the TOPCAT trial

Weihao Liang, Yuzhong Wu, Ruicong Xue, Zexuan Wu, Dexi Wu, Jiangui He, Yugang Dong, Gregory Y. H. Lip, Wengen Zhu, Chen Liu

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Who should be prioritized for COVID-19 vaccination in China? A descriptive study

Juan Yang, Wen Zheng, Huilin Shi, Xuemei Yan, Kaige Dong, Qian You, Guangjie Zhong, Hui Gong, Zhiyuan Chen, Mark Jit, Cecile Viboud, Marco Ajelli, Hongjie Yu

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Following the science? Comparison of methodological and reporting quality of covid-19 and other research from the first wave of the pandemic

Terence J. Quinn, Jennifer K. Burton, Ben Carter, Nicola Cooper, Kerry Dwan, Ryan Field, Suzanne C. Freeman, Claudia Geue, Ping-Hsuan Hsieh, Kris McGill, Clareece R. Nevill, Dikshyanta Rana, Alex Sutton, Martin Taylor Rowan, Yiqiao Xin

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Lower iodine storage in the placenta is associated with gestational diabetes mellitus

Kristof Y. Neven, Bianca Cox, Charlotte Cosemans, Wilfried Gyselaers, Joris Penders, Michelle Plusquin, Harry A. Roels, Karen Vrijens, Ann Ruttens, Tim S. Nawrot

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Characteristics and mortality rates among patients requiring intermediate care: a national cohort study using linked databases

Catherine J. Evans, Laura Potts, Ursula Dalrymple, Andrew Pring, Julia Verne, Irene J. Higginson, Wei Gao, on behalf of SPACE

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Independent and combined associations between fast-food outlet exposure and genetic risk for obesity: a population-based, cross-sectional study in the UK

Thomas Burgoine, Pablo Monsivais, Stephen J. Sharp, Nita G. Forouhi, Nicholas J. Wareham

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Exit strategies: optimising feasible surveillance for detection, elimination, and ongoing prevention of COVID-19 community transmission

K. Lokuge, E. Banks, S. Davis, L. Roberts, T. Street, D. O’Donovan, G. Caleo, K. Glass

23.02.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Relation of severe COVID-19 to polypharmacy and prescribing of psychotropic drugs: the REACT-SCOT case-control study

Paul M. McKeigue, Sharon Kennedy, Amanda Weir, Jen Bishop, Stuart J. McGurnaghan, David McAllister, Chris Robertson, Rachael Wood, Nazir Lone, Janet Murray, Thomas M. Caparrotta, Alison Smith-Palmer, David Goldberg, Jim McMenamin, Bruce Guthrie, Sharon Hutchinson, Helen M. Colhoun, on behalf of Public Health Scotland COVID-19 Health Protection Study Group

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

The impact of local and national restrictions in response to COVID-19 on social contacts in England: a longitudinal natural experiment

Christopher I. Jarvis, Amy Gimma, Kevin van Zandvoort, Kerry L. M. Wong, W. John Edmunds, CMMID COVID-19 working group

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Meat consumption and risk of 25 common conditions: outcome-wide analyses in 475,000 men and women in the UK Biobank study

Keren Papier, Georgina K. Fensom, Anika Knuppel, Paul N. Appleby, Tammy Y. N. Tong, Julie A. Schmidt, Ruth C. Travis, Timothy J. Key, Aurora Perez-Cornago

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Optimizing antiviral treatment for seasonal influenza in the USA: a mathematical modeling analysis

Matan Yechezkel, Martial L. Ndeffo Mbah, Dan Yamin

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Automated detection of lung nodules and coronary artery calcium using artificial intelligence on low-dose CT scans for lung cancer screening: accuracy and prognostic value

Jordan Chamberlin, Madison R. Kocher, Jeffrey Waltz, Madalyn Snoddy, Natalie F. C. Stringer, Joseph Stephenson, Pooyan Sahbaee, Puneet Sharma, Saikiran Rapaka, U. Joseph Schoepf, Andres F. Abadia, Jonathan Sperl, Phillip Hoelzer, Megan Mercer, Nayana Somayaji, Gilberto Aquino, Jeremy R. Burt

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Vegetable intake and the risk of bladder cancer in the BLadder Cancer Epidemiology and Nutritional Determinants (BLEND) international study

Evan Yi-Wen Yu, Anke Wesselius, Siamak Mehrkanoon, Mieke Goosens, Maree Brinkman, Piet van den Brandt, Eric J. Grant, Emily White, Elisabete Weiderpass, Florence Le Calvez-Kelm, Marc J. Gunter, Inge Huybrechts, Elio Riboli, Anne Tjonneland, Giovanna Masala, Graham G. Giles, Roger L. Milne, Maurice P. Zeegers

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Cost-effectiveness of a stepwise cardiometabolic disease prevention program: results of a randomized controlled trial in primary care

Daphne M. Stol, Eelco A. B. Over, Ilse F. Badenbroek, Monika Hollander, Mark M. J. Nielen, Roderik A. Kraaijenhagen, François G. Schellevis, Niek J. de Wit, G. Ardine de Wit

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Sex differences in systemic metabolites at four life stages: cohort study with repeated metabolomics

Joshua A. Bell, Diana L. Santos Ferreira, Abigail Fraser, Ana Luiza G. Soares, Laura D. Howe, Deborah A. Lawlor, David Carslake, George Davey Smith, Linda M. O’Keeffe

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Glycolysis-associated lncRNAs identify a subgroup of cancer patients with poor prognoses and a high-infiltration immune microenvironment

Kuo-Hao Ho, Tzu-Wen Huang, Chwen-Ming Shih, Yi-Ting Lee, Ann-Jeng Liu, Peng-Hsu Chen, Ku-Chung Chen

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

The epidemiologic impact and cost-effectiveness of new tuberculosis vaccines on multidrug-resistant tuberculosis in India and China

Chathika K Weerasuriya, Rebecca C Harris, C Finn McQuaid, Fiammetta Bozzani, Yunzhou Ruan, Renzhong Li, Tao Li, Kirankumar Rade, Raghuram Rao, Ann M Ginsberg, Gabriela B Gomez, Richard G White

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Reducing youth suicide: systems modelling and simulation to guide targeted investments across the determinants

Jo-An Occhipinti, Adam Skinner, Frank Iorfino, Kenny Lawson, Julie Sturgess, Warren Burgess, Tracey Davenport, Danica Hudson, Ian Hickie

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Effectiveness and cost-effectiveness of eliminating cervical cancer through a tailored optimal pathway: a modeling study

Changfa Xia, Xiaoqian Xu, Xuelian Zhao, Shangying Hu, Youlin Qiao, Yong Zhang, Raymond Hutubessy, Partha Basu, Nathalie Broutet, Mark Jit, Fanghui Zhao

01.12.2021 | Correction | Ausgabe 1/2021 Open Access

Correction to: Built environmental characteristics and diabetes: a systematic review and meta-analysis

N. R. den Braver, J. Lakerveld, F. Rutters, L. J. Schoonmade, J. Brug, J. W. J. Beulens

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Relationship between diet quality scores and the risk of frailty and mortality in adults across a wide age spectrum

Kulapong Jayanama, Olga Theou, Judith Godin, Leah Cahill, Nitin Shivappa, James R. Hébert, Michael D. Wirth, Yong-Moon Park, Teresa T. Fung, Kenneth Rockwood

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Sensitivity and specificity of the Bamberg Dementia Screening Test’s (BDST) full and short versions: brief screening instruments for geriatric patients that are suitable for infectious environments

Wolfgang Trapp, Susanne Röder, Andreas Heid, Pia Billman, Susanne Daiber, Göran Hajak

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Insulin resistance, diabetic kidney disease, and all-cause mortality in individuals with type 2 diabetes: a prospective cohort study

Giuseppe Penno, Anna Solini, Emanuela Orsi, Enzo Bonora, Cecilia Fondelli, Roberto Trevisan, Monica Vedovato, Franco Cavalot, Gianpaolo Zerbini, Olga Lamacchia, Antonio Nicolucci, Giuseppe Pugliese, for the Renal Insufficiency And Cardiovascular Events (RIACE) Study Group

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Severe mental illness and mortality and coronary revascularisation following a myocardial infarction: a retrospective cohort study

Kelly Fleetwood, Sarah H. Wild, Daniel J. Smith, Stewart W. Mercer, Kirsty Licence, Cathie L. M. Sudlow, Caroline A. Jackson

01.12.2021 | Commentary | Ausgabe 1/2021 Open Access

Understanding the value of dietary indices prior to research application

Mary Foong-Fong Chong

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Investigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses

Maxime M. Bos, Neil J. Goulding, Matthew A. Lee, Amy Hofman, Mariska Bot, René Pool, Lisanne S. Vijfhuizen, Xiang Zhang, Chihua Li, Rima Mustafa, Matt J. Neville, Ruifang Li-Gao, Stella Trompet, Marian Beekman, Nienke R. Biermasz, Dorret I. Boomsma, Irene de Boer, Constantinos Christodoulides, Abbas Dehghan, Ko Willems van Dijk, Ian Ford, Mohsen Ghanbari, Bastiaan T. Heijmans, M. Arfan Ikram, J. Wouter Jukema, Dennis O. Mook-Kanamori, Fredrik Karpe, Annemarie I. Luik, L. H. Lumey, Arn M. J. M. van den Maagdenberg, Simon P. Mooijaart, Renée de Mutsert, Brenda W. J. H. Penninx, Patrick C. N. Rensen, Rebecca C. Richmond, Frits R. Rosendaal, Naveed Sattar, Robert A. Schoevers, P. Eline Slagboom, Gisela M. Terwindt, Carisha S. Thesing, Kaitlin H. Wade, Carolien A. Wijsman, Gonneke Willemsen, Aeilko H. Zwinderman, Diana van Heemst, Raymond Noordam, Deborah A. Lawlor

01.12.2021 | MedViews | Ausgabe 1/2021 Open Access

Mendelian randomization—a powerful tool to study the causal effects of atrial fibrillation on loss of brain volume

Laura Andreasen

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Excess mortality for care home residents during the first 23 weeks of the COVID-19 pandemic in England: a national cohort study

Marcello Morciano, Jonathan Stokes, Evangelos Kontopantelis, Ian Hall, Alex J. Turner

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Evaluation of glycemic traits in susceptibility to COVID-19 risk: a Mendelian randomization study

Shiu Lun Au Yeung, Jie V Zhao, C Mary Schooling

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Effects of maternal folic acid supplementation during the second and third trimesters of pregnancy on neurocognitive development in the child: an 11-year follow-up from a randomised controlled trial

Aoife Caffrey, Helene McNulty, Mark Rollins, Girijesh Prasad, Pramod Gaur, Joel B. Talcott, Caroline Witton, Tony Cassidy, Barry Marshall, James Dornan, Adrian J. Moore, Mary Ward, J. J. Strain, Anne M. Molloy, Marian McLaughlin, Diane J. Lees-Murdock, Colum P. Walsh, Kristina Pentieva

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

The trends and associated adverse maternal and perinatal outcomes of labour neuraxial analgesia among vaginal deliveries in China between 2012 and 2019: a real-world observational evidence

Yi Mu, Xiaodong Wang, Yanping Wang, Zheng Liu, Mingrong Li, Xiaohong Li, Qi Li, Jun Zhu, Juan Liang, Haidong Wang

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Quantifying the potential value of antigen-detection rapid diagnostic tests for COVID-19: a modelling analysis

Saskia Ricks, Emily A. Kendall, David W. Dowdy, Jilian A. Sacks, Samuel G. Schumacher, Nimalan Arinaminpathy

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Accurate diagnosis of colorectal cancer based on histopathology images using artificial intelligence

K. S. Wang, G. Yu, C. Xu, X. H. Meng, J. Zhou, C. Zheng, Z. Deng, L. Shang, R. Liu, S. Su, X. Zhou, Q. Li, J. Li, J. Wang, K. Ma, J. Qi, Z. Hu, P. Tang, J. Deng, X. Qiu, B. Y. Li, W. D. Shen, R. P. Quan, J. T. Yang, L. Y. Huang, Y. Xiao, Z. C. Yang, Z. Li, S. C. Wang, H. Ren, C. Liang, W. Guo, Y. Li, H. Xiao, Y. Gu, J. P. Yun, D. Huang, Z. Song, X. Fan, L. Chen, X. Yan, Z. Li, Z. C. Huang, J. Huang, J. Luttrell, C. Y. Zhang, W. Zhou, K. Zhang, C. Yi, C. Wu, H. Shen, Y. P. Wang, H. M. Xiao, H. W. Deng

16.03.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

A follow-up study shows that recovered patients with re-positive PCR test in Wuhan may not be infectious

Xiaomin Wu, Zengmiao Wang, Zhenyu He, Yapin Li, Yating Wu, Huaiji Wang, Yonghong Liu, Fanghua Hao, Huaiyu Tian

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Puberty timing and markers of cardiovascular structure and function at 25 years: a prospective cohort study

Gillian M. Maher, Lisa Ryan, Fergus P. McCarthy, Alun Hughes, Chloe Park, Abigail Fraser, Laura D. Howe, Patricia M. Kearney, Linda M. O’Keeffe

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Using Mendelian randomization study to assess the renal effects of antihypertensive drugs

Jie V. Zhao, C. Mary Schooling

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Deep learning-based six-type classifier for lung cancer and mimics from histopathological whole slide images: a retrospective study

Huan Yang, Lili Chen, Zhiqiang Cheng, Minglei Yang, Jianbo Wang, Chenghao Lin, Yuefeng Wang, Leilei Huang, Yangshan Chen, Sui Peng, Zunfu Ke, Weizhong Li

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Dietary intake of trans fatty acids and breast cancer risk in 9 European countries

Michèle Matta, Inge Huybrechts, Carine Biessy, Corinne Casagrande, Sahar Yammine, Agnès Fournier, Karina Standahl Olsen, Marco Lukic, Inger Torhild Gram, Eva Ardanaz, Maria-José Sánchez, Laure Dossus, Renée T. Fortner, Bernard Srour, Franziska Jannasch, Matthias B. Schulze, Pilar Amiano, Antonio Agudo, Sandra Colorado-Yohar, J. Ramón Quirós, Rosario Tumino, Salvatore Panico, Giovanna Masala, Valeria Pala, Carlotta Sacerdote, Anne Tjønneland, Anja Olsen, Christina C. Dahm, Ann H. Rosendahl, Signe Borgquist, Maria Wennberg, Alicia K. Heath, Dagfinn Aune, Julie Schmidt, Elisabete Weiderpass, Veronique Chajes, Marc J. Gunter, Neil Murphy

01.12.2021 | COVID-19 | Commentary | Ausgabe 1/2021 Open Access

Greater public health impact of COVID-19 antigen detection tests

Akiko Kowada

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Associations between dietary patterns and the incidence of total and fatal cardiovascular disease and all-cause mortality in 116,806 individuals from the UK Biobank: a prospective cohort study

Min Gao, Susan A. Jebb, Paul Aveyard, Gina L. Ambrosini, Aurora Perez-Cornago, Jennifer Carter, Xinying Sun, Carmen Piernas

01.12.2021 | COVID-19 | Commentary | Ausgabe 1/2021 Open Access

Research priorities for Long Covid: refined through an international multi-stakeholder forum

Gail Carson, Long Covid Forum Group

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Machine learning for subtype definition and risk prediction in heart failure, acute coronary syndromes and atrial fibrillation: systematic review of validity and clinical utility

Amitava Banerjee, Suliang Chen, Ghazaleh Fatemifar, Mohamad Zeina, R. Thomas Lumbers, Johanna Mielke, Simrat Gill, Dipak Kotecha, Daniel F. Freitag, Spiros Denaxas, Harry Hemingway

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Cost-effectiveness modelling to optimise active screening strategy for gambiense human African trypanosomiasis in endemic areas of the Democratic Republic of Congo

Christopher N. Davis, Kat S. Rock, Marina Antillón, Erick Mwamba Miaka, Matt J. Keeling

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Dexamethasone induces an imbalanced fetal-placental-maternal bile acid circulation: involvement of placental transporters

Wen Huang, Jin Zhou, Juanjuan Guo, Wen Hu, Guanghui Chen, Bin Li, Yajie Wen, Yimin Jiang, Kaili Fu, Huichang Bi, Yuanzhen Zhang, Hui Wang

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Reporting of harms in oncological clinical study reports submitted to the European Medicines Agency compared to trial registries and publications—a methodological review

Asger S. Paludan-Müller, Perrine Créquit, Isabelle Boutron

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Modeling the interplay between demography, social contact patterns, and SARS-CoV-2 transmission in the South West Shewa Zone of Oromia Region, Ethiopia

Filippo Trentini, Giorgio Guzzetta, Margherita Galli, Agnese Zardini, Fabio Manenti, Giovanni Putoto, Valentina Marziano, Worku Nigussa Gamshie, Ademe Tsegaye, Alessandro Greblo, Alessia Melegaro, Marco Ajelli, Stefano Merler, Piero Poletti

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Breastfeeding and the risk of childhood cancer: a systematic review and dose-response meta-analysis

Qing Su, Xiaohui Sun, Liwen Zhu, Qin Yan, Peiwen Zheng, Yingying Mao, Ding Ye

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Novel associations between parental and newborn cord blood metabolic profiles in the Norwegian Mother, Father and Child Cohort Study

Linn K. L. Øyri, Martin P. Bogsrud, Jacob J. Christensen, Stine M. Ulven, Anne Lise Brantsæter, Kjetil Retterstøl, Hilde K. Brekke, Trond M. Michelsen, Tore Henriksen, Jeanine E. Roeters van Lennep, Per Magnus, Marit B. Veierød, Kirsten B. Holven

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Cooking oil/fat consumption and deaths from cardiometabolic diseases and other causes: prospective analysis of 521,120 individuals

Yu Zhang, Pan Zhuang, Fei Wu, Wei He, Lei Mao, Wei Jia, Yiju Zhang, Xiaoqian Chen, Jingjing Jiao

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Associations between attainment of incentivised primary care indicators and incident diabetic retinopathy in England: a population-based historical cohort study

Ailsa J. McKay, Laura H. Gunn, Thirunavukkarasu Sathish, Eszter Vamos, Manjula Nugawela, Azeem Majeed, German Molina, Sobha Sivaprasad

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Reducing travel-related SARS-CoV-2 transmission with layered mitigation measures: symptom monitoring, quarantine, and testing

Michael A. Johansson, Hannah Wolford, Prabasaj Paul, Pamela S. Diaz, Tai-Ho Chen, Clive M. Brown, Martin S. Cetron, Francisco Alvarado-Ramy

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

The positive externalities of migrant-based TB control strategy in a Chinese urban population with internal migration: a transmission-dynamic modeling study

Chongguang Yang, Jian Kang, Liping Lu, Xiaoqin Guo, Xin Shen, Ted Cohen, Nicolas A. Menzies

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Changes over time in latent patterns of childhood-to-adulthood BMI development in Great Britain: evidence from three cohorts born in 1946, 1958, and 1970

T. Norris, M. Hamer, R. Hardy, L. Li, K. K. Ong, G. B. Ploubidis, R. Viner, W. Johnson

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Homocysteine, B vitamins, and cardiovascular disease: a Mendelian randomization study

Shuai Yuan, Amy M. Mason, Paul Carter, Stephen Burgess, Susanna C. Larsson

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Falciparum but not vivax malaria increases the risk of hypertensive disorders of pregnancy in women followed prospectively from the first trimester

Whitney E. Harrington, Kerryn A. Moore, Aung Myat Min, Mary Ellen Gilder, Nay Win Tun, Moo Kho Paw, Jacher Wiladphaingern, Stephane Proux, Kesinee Chotivanich, Marcus J. Rijken, Nicholas J. White, François Nosten, Rose McGready

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Prediction of individuals at high risk of chronic kidney disease during treatment with lithium for bipolar disorder

Joseph F. Hayes, David P. J. Osborn, Emma Francis, Gareth Ambler, Laurie A. Tomlinson, Magnus Boman, Ian C. K. Wong, John R. Geddes, Christina Dalman, Glyn Lewis

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Shared genetic etiology and causality between body fat percentage and cardiovascular diseases: a large-scale genome-wide cross-trait analysis

Zhenhuang Zhuang, Minhao Yao, Jason Y. Y. Wong, Zhonghua Liu, Tao Huang

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Metabolic signatures of greater body size and their associations with risk of colorectal and endometrial cancers in the European Prospective Investigation into Cancer and Nutrition

Nathalie Kliemann, Vivian Viallon, Neil Murphy, Rebecca J. Beeken, Joseph A. Rothwell, Sabina Rinaldi, Nada Assi, Eline H. van Roekel, Julie A. Schmidt, Kristin Benjaminsen Borch, Claudia Agnoli, Ann H. Rosendahl, Hanna Sartor, José María Huerta, Anne Tjønneland, Jytte Halkjær, Bas Bueno-de-Mesquita, Audrey Gicquiau, David Achaintre, Krasimira Aleksandrova, Matthias B. Schulze, Alicia K. Heath, Konstantinos K. Tsilidis, Giovanna Masala, Salvatore Panico, Rudolf Kaaks, Renée T. Fortner, Bethany Van Guelpen, Laure Dossus, Augustin Scalbert, Hector C. Keun, Ruth C. Travis, Mazda Jenab, Mattias Johansson, Pietro Ferrari, Marc J. Gunter

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

The impact of child health interventions and risk factors on child survival in Kenya, 1993–2014: a Bayesian spatio-temporal analysis with counterfactual scenarios

Peter M. Macharia, Noel K. Joseph, Robert W. Snow, Benn Sartorius, Emelda A. Okiro

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Functional connectivity changes in cerebral small vessel disease - a systematic review of the resting-state MRI literature

Maximilian Schulz, Caroline Malherbe, Bastian Cheng, Götz Thomalla, Eckhard Schlemm

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Associations of sleep apnoea with glaucoma and age-related macular degeneration: an analysis in the United Kingdom Biobank and the Canadian Longitudinal Study on Aging

Xikun Han, Samantha Sze-Yee Lee, Nathan Ingold, Nigel McArdle, Anthony P. Khawaja, Stuart MacGregor, David A. Mackey

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Association between HIV infection and hypertension: a global systematic review and meta-analysis of cross-sectional studies

Katherine Davis, Pablo Perez-Guzman, Annika Hoyer, Ralph Brinks, Edward Gregg, Keri N. Althoff, Amy C. Justice, Peter Reiss, Simon Gregson, Mikaela Smit

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Estimating the effectiveness of routine asymptomatic PCR testing at different frequencies for the detection of SARS-CoV-2 infections

Joel Hellewell, Timothy W. Russell, Rupert Beale, Gavin Kelly, Catherine Houlihan, Eleni Nastouli, Adam J. Kucharski, The SAFER Investigators and Field Study Team, The Crick COVID-19 Consortium, CMMID COVID-19 working group

01.12.2021 | COVID-19 | MedViews | Ausgabe 1/2021 Open Access

What neurological and psychiatric effects does COVID-19 have on its survivors?

Alexios-Fotios A. Mentis

01.12.2021 | Commentary | Ausgabe 1/2021 Open Access

Nutritional research is moving to a whole-diet approach, time for food policy

Briar L. McKenzie, Lindsay M. Jaacks

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

The importance of transdiagnostic symptom level assessment to understanding prognosis for depressed adults: analysis of data from six randomised control trials

C. O’Driscoll, J. E. J. Buckman, E. I. Fried, R. Saunders, Z. D. Cohen, G. Ambler, R. J. DeRubeis, S. Gilbody, S. D. Hollon, T. Kendrick, D. Kessler, G. Lewis, E. Watkins, N. Wiles, S. Pilling

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Sex differences in the association between major cardiovascular risk factors in midlife and dementia: a cohort study using data from the UK Biobank

Jessica Gong, Katie Harris, Sanne A. E. Peters, Mark Woodward

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Swedish snuff (snus) and risk of cardiovascular disease and mortality: prospective cohort study of middle-aged and older individuals

Olga E. Titova, John A. Baron, Karl Michaëlsson, Susanna C. Larsson

01.12.2021 | Commentary | Ausgabe 1/2021 Open Access

Global burden of hypertension in people living with HIV

Jean Joel Bigna, Jean Jacques Noubiap

01.12.2021 | Technical advance | Ausgabe 1/2021 Open Access

Evaluation of a serum-based antigen test for tuberculosis in HIV-exposed infants: a diagnostic accuracy study

Liyan Mao, Sylvia M. LaCourse, Soyeon Kim, Chang Liu, Bo Ning, Duran Bao, Jia Fan, Christopher J. Lyon, Ziyong Sun, Sharon Nachman, Charles D. Mitchell, Tony Y. Hu

01.12.2021 | Correction | Ausgabe 1/2021 Open Access

Correction to: Genetic architecture of cardiometabolic risks in people living with HIV

Haoxiang Cheng, Anshuman Sewda, Carla Marquez-Luna, Sierra R. White, Bridget M. Whitney, Jessica Williams-Nguyen, Robin M. Nance, Won Jun Lee, Mari M. Kitahata, Michael S. Saag, Amanda Willig, Joseph J. Eron, W. Christopher Mathews, Peter W. Hunt, Richard D. Moore, Allison Webel, Kenneth H. Mayer, Joseph A. Delaney, Paul K. Crane, Heidi M. Crane, Ke Hao, Inga Peter

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Prevalence and predictors of vitamin D deficiency in young African children

Reagan M. Mogire, Alireza Morovat, John Muthii Muriuki, Alexander J. Mentzer, Emily L. Webb, Wandia Kimita, Francis M. Ndungu, Alex W. Macharia, Clare L. Cutland, Sodiomon B. Sirima, Amidou Diarra, Alfred B. Tiono, Swaib A. Lule, Shabir A. Madhi, Manjinder S. Sandhu, Andrew M. Prentice, Philip Bejon, John M. Pettifor, Alison M. Elliott, Adebowale Adeyemo, Thomas N. Williams, Sarah H. Atkinson

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Comparison of infection control strategies to reduce COVID-19 outbreaks in homeless shelters in the United States: a simulation study

Lloyd A. C. Chapman, Margot Kushel, Sarah N. Cox, Ashley Scarborough, Caroline Cawley, Trang Q. Nguyen, Isabel Rodriguez-Barraquer, Bryan Greenhouse, Elizabeth Imbert, Nathan C. Lo

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Variation in hypertension clinical practice guidelines: a global comparison

Richu Philip, Thomas Beaney, Nick Appelbaum, Carmen Rodriguez Gonzalvez, Charlotte Koldeweij, Amelia Kataria Golestaneh, Neil Poulter, Jonathan M. Clarke

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Impact of in-hospital discontinuation with angiotensin receptor blockers or converting enzyme inhibitors on mortality of COVID-19 patients: a retrospective cohort study

Francisco J. de Abajo, Antonio Rodríguez-Miguel, Sara Rodríguez-Martín, Victoria Lerma, Alberto García-Lledó, on behalf of MED-ACE2-COVID19 Study Group

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Clinical indications of premenstrual disorders and subsequent risk of injury: a population-based cohort study in Sweden

Qian Yang, Arvid Sjölander, Yuchen Li, Alexander Viktorin, Elizabeth R. Bertone-Johnson, Weimin Ye, Fang Fang, Unnur A. Valdimarsdóttir, Donghao Lu

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Gestational diabetes mellitus is associated with the neonatal gut microbiota and metabolome

Ting Chen, Yufeng Qin, Minjian Chen, Yuqing Zhang, Xu Wang, Tianyu Dong, Guanglin Chen, Xian Sun, Ting Lu, Richard Allen White III, Peng Ye, Hein M. Tun, Yankai Xia

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Community-based molecular and serological surveillance of subclinical malaria in Myanmar

Katherine O’Flaherty, Win Han Oo, Sophie G. Zaloumis, Julia C. Cutts, Kyaw Zayar Aung, Myat Mon Thein, Damien R. Drew, Zahra Razook, Alyssa E. Barry, Naanki Parischa, Nyi Nyi Zaw, Htin Kyaw Thu, Aung Thi, Wai Yan Min Htay, Aung Paing Soe, Julie A. Simpson, James G. Beeson, Paul A. Agius, Freya J. I. Fowkes

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Clinical features of bacterial meningitis among hospitalised children in Kenya

Christina W. Obiero, Neema Mturi, Salim Mwarumba, Moses Ngari, Charles R. Newton, Michaël Boele van Hensbroek, James A. Berkley

01.12.2021 | Correspondence | Ausgabe 1/2021 Open Access

Training for outbreak response through the Global Outbreak Alert and Response Network

Renee Christensen, Dale Fisher, Sharon Salmon, Patrick Drury, Paul Effler

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Impact of COVID-19 lockdown on the incidence and mortality of acute exacerbations of chronic obstructive pulmonary disease: national interrupted time series analyses for Scotland and Wales

Mohammad A. Alsallakh, Shanya Sivakumaran, Sharon Kennedy, Eleftheria Vasileiou, Ronan A. Lyons, Chris Robertson, Aziz Sheikh, Gwyneth A. Davies, on behalf of the EAVE II Collaborators

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Hand hygiene intervention to optimise soil-transmitted helminth infection control among primary school children: the Mikono Safi cluster randomised controlled trial in northwestern Tanzania

Kenneth Makata, Jeroen Ensink, Philip Ayieko, Christian Hansen, Simon Sichalwe, Julius Mngara, Onike Mcharo, Humphrey Mazigo, Jeremiah Seni, Robert Dreibelbis, Sarah Rockowitz, Elialilia Okello, Heiner Grosskurth, Safari Kinung’hi, Saidi Kapiga

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Risk of major labour-related complications for pregnancies progressing to 42 weeks or beyond

Anthea C. Lindquist, Roxanne M. Hastie, Richard J. Hiscock, Natasha L. Pritchard, Susan P. Walker, Stephen Tong

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Long-term impact of a conditional cash transfer programme on maternal mortality: a nationwide analysis of Brazilian longitudinal data

Davide Rasella, Flávia Jôse Oliveira Alves, Poliana Rebouças, Gabriela Santos de Jesus, Maurício L. Barreto, Tereza Campello, Enny S. Paixao

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

The effects of dietary and lifestyle interventions among pregnant women with overweight or obesity on early childhood outcomes: an individual participant data meta-analysis from randomised trials

Jennie Louise, Amanda J. Poprzeczny, Andrea R. Deussen, Christina Vinter, Mette Tanvig, Dorte Moller Jensen, Annick Bogaerts, Roland Devlieger, Fionnuala M. McAuliffe, Kristina M. Renault, Emma Carlsen, Nina Geiker, Lucilla Poston, Annette Briley, Shakila Thangaratinam, Jodie M. Dodd

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Sequelae, persistent symptomatology and outcomes after COVID-19 hospitalization: the ANCOHVID multicentre 6-month follow-up study

Álvaro Romero-Duarte, Mario Rivera-Izquierdo, Inmaculada Guerrero-Fernández de Alba, Marina Pérez-Contreras, Nicolás Francisco Fernández-Martínez, Rafael Ruiz-Montero, Álvaro Serrano-Ortiz, Rocío Ortiz González-Serna, Inmaculada Salcedo-Leal, Eladio Jiménez-Mejías, Antonio Cárdenas-Cruz

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Promoting physical activity in a multi-ethnic population at high risk of diabetes: the 48-month PROPELS randomised controlled trial

Kamlesh Khunti, Simon Griffin, Alan Brennan, Helen Dallosso, Melanie J. Davies, Helen C. Eborall, Charlotte L. Edwardson, Laura J. Gray, Wendy Hardeman, Laura Heathcote, Joe Henson, Daniel Pollard, Stephen J. Sharp, Stephen Sutton, Jacqui Troughton, Tom Yates

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Serum anti-DIDO1, anti-CPSF2, and anti-FOXJ2 antibodies as predictive risk markers for acute ischemic stroke

Takaki Hiwasa, Hao Wang, Ken-ichiro Goto, Seiichiro Mine, Toshio Machida, Eiichi Kobayashi, Yoichi Yoshida, Akihiko Adachi, Tomoo Matsutani, Mizuki Sata, Kazumasa Yamagishi, Hiroyasu Iso, Norie Sawada, Shoichiro Tsugane, Mitoshi Kunimatsu, Ikuo Kamitsukasa, Masahiro Mori, Kazuo Sugimoto, Akiyuki Uzawa, Mayumi Muto, Satoshi Kuwabara, Yoshio Kobayashi, Mikiko Ohno, Eiichiro Nishi, Akiko Hattori, Masashi Yamamoto, Yoshiro Maezawa, Kazuki Kobayashi, Ryoichi Ishibashi, Minoru Takemoto, Koutaro Yokote, Hirotaka Takizawa, Takashi Kishimoto, Kazuyuki Matsushita, Sohei Kobayashi, Fumio Nomura, Takahiro Arasawa, Akiko Kagaya, Tetsuro Maruyama, Hisahiro Matsubara, Minako Tomiita, Shinsaku Hamanaka, Yushi Imai, Tomoo Nakagawa, Naoya Kato, Jiro Terada, Takuma Matsumura, Yusuke Katsumata, Akira Naito, Nobuhiro Tanabe, Seiichiro Sakao, Koichiro Tatsumi, Masaaki Ito, Fumiaki Shiratori, Makoto Sumazaki, Satoshi Yajima, Hideaki Shimada, Mikako Shirouzu, Shigeyuki Yokoyama, Takashi Kudo, Hirofumi Doi, Katsuro Iwase, Hiromi Ashino, Shu-Yang Li, Masaaki Kubota, Go Tomiyoshi, Natsuko Shinmen, Rika Nakamura, Hideyuki Kuroda, Yasuo Iwadate

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

A randomized controlled trial of dihydroartemisinin-piperaquine, artesunate-mefloquine and extended artemether-lumefantrine treatments for malaria in pregnancy on the Thailand-Myanmar border

Makoto Saito, Verena I. Carrara, Mary Ellen Gilder, Aung Myat Min, Nay Win Tun, Mupawjay Pimanpanarak, Jacher Viladpai-nguen, Moo Kho Paw, Warat Haohankhunnatham, Kamonchanok Konghahong, Aung Pyae Phyo, Cindy Chu, Claudia Turner, Sue J. Lee, Jureeporn Duanguppama, Mallika Imwong, Germana Bancone, Stephane Proux, Pratap Singhasivanon, Nicholas J. White, François Nosten, Rose McGready

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Impact of replacing sedentary behaviour with other movement behaviours on depression and anxiety symptoms: a prospective cohort study in the UK Biobank

A. A. Kandola, B. del Pozo Cruz, D. P. J. Osborn, B. Stubbs, K. W. Choi, J. F. Hayes

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Adherence to international dietary recommendations in association with all-cause mortality and fatal and non-fatal cardiovascular disease risk: a prospective analysis of UK Biobank participants

Maryam Kebbe, Min Gao, Aurora Perez-Cornago, Susan A. Jebb, Carmen Piernas

01.12.2021 | Commentary | Ausgabe 1/2021 Open Access

Understanding menstrual cycle effects on suicide will require prospective studies of suicidal thoughts and behaviors in premenstrual disorders

Sarah A. Owens, Tory A. Eisenlohr-Moul

01.12.2021 | COVID-19 | Commentary | Ausgabe 1/2021 Open Access

Renin-angiotensin system blockers and COVID-19

Emmanuelle Vidal-Petiot, Nathalie Gault

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

An analysis of school absences in England during the COVID-19 pandemic

Emma Southall, Alex Holmes, Edward M. Hill, Benjamin D. Atkins, Trystan Leng, Robin N. Thompson, Louise Dyson, Matt J. Keeling, Michael J. Tildesley

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

A phase IV, multi-centre, randomized clinical trial comparing two pertussis-containing vaccines in pregnant women in England and vaccine responses in their infants

Christine Elizabeth Jones, Anna Calvert, Jo Southern, Mary Matheson, Nick Andrews, Asma Khalil, Hannah Cuthbertson, Bassam Hallis, Anna England, Paul T. Heath, Elizabeth Miller

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Association of statin use in older people primary prevention group with risk of cardiovascular events and mortality: a systematic review and meta-analysis of observational studies

Kamal Awad, Maged Mohammed, Mahmoud Mohamed Zaki, Abdelrahman I. Abushouk, Gregory Y. H. Lip, Michael J. Blaha, Carl J. Lavie, Peter P. Toth, J. Wouter Jukema, Naveed Sattar, Maciej Banach, on behalf of the Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group and the International Lipid Expert Panel (ILEP)

01.12.2021 | Review | Ausgabe 1/2021 Open Access

Perspectives of tumor-infiltrating lymphocyte treatment in solid tumors

Shuhang Wang, Jingwei Sun, Kun Chen, Peiwen Ma, Qi Lei, Shujun Xing, Zhongzheng Cao, Shujun Sun, Zicheng Yu, Yarong Liu, Ning Li

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Utilization of the evidence from studies with no events in meta-analyses of adverse events: an empirical investigation

Chang Xu, Xiaoqin Zhou, Liliane Zorzela, Ke Ju, Luis Furuya-Kanamori, Lifeng Lin, Cuncun Lu, Omran A. H. Musa, Sunita Vohra

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

The risk of ischemic stroke and hemorrhagic stroke in Chinese adults with low-density lipoprotein cholesterol concentrations < 70 mg/dL

Zhijun Wu, Zhe Huang, Alice H. Lichtenstein, Yesong Liu, Shuohua Chen, Yao Jin, Muzi Na, Le Bao, Shouling Wu, Xiang Gao

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

A core outcome set for studies evaluating interventions to prevent and/or treat delirium for adults requiring an acute care hospital admission: an international key stakeholder informed consensus study

Louise Rose, Lisa Burry, Meera Agar, Bronagh Blackwood, Noll L. Campbell, Mike Clarke, John W. Devlin, Jacques Lee, John C. Marshall, Dale M. Needham, Najma Siddiqi, Valerie Page

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Health inequities and clustering of fever, acute respiratory infection, diarrhoea and wasting in children under five in low- and middle-income countries: a Demographic and Health Surveys analysis

Peter Winskill, Alexandra B. Hogan, Julie Thwing, Lazaro Mwandigha, Patrick G. T. Walker, Ben Lambert

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Understanding the role of the paramedic in primary care: a realist review

Georgette Eaton, Geoff Wong, Stephanie Tierney, Nia Roberts, Veronika Williams, Kamal R. Mahtani

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Using syndromic measures of mortality to capture the dynamics of COVID-19 in Java, Indonesia, in the context of vaccination rollout

Bimandra A. Djaafara, Charles Whittaker, Oliver J. Watson, Robert Verity, Nicholas F. Brazeau, Widyastuti, Dwi Oktavia, Verry Adrian, Ngabila Salama, Sangeeta Bhatia, Pierre Nouvellet, Ellie Sherrard-Smith, Thomas S. Churcher, Henry Surendra, Rosa N. Lina, Lenny L. Ekawati, Karina D. Lestari, Adhi Andrianto, Guy Thwaites, J. Kevin Baird, Azra C. Ghani, Iqbal R. F. Elyazar, Patrick G. T. Walker

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Paediatric rotavirus vaccination, coeliac disease and type 1 diabetes in children: a population-based cohort study

Thomas Inns, Kate M. Fleming, Miren Iturriza-Gomara, Daniel Hungerford

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

The effects of increased dose of hepatitis B vaccine on mother-to-child transmission and immune response for infants born to mothers with chronic hepatitis B infection: a prospective, multicenter, large-sample cohort study

Xiaohui Zhang, Huaibin Zou, Yu Chen, Hua Zhang, Ruihua Tian, Jun Meng, Yunxia Zhu, Huimin Guo, Erhei Dai, Baoshen Zhu, Zhongsheng Liu, Yanxia Jin, Yujie Li, Liping Feng, Hui Zhuang, Calvin Q. Pan, Jie Li, Zhongping Duan

24.06.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Relation of severe COVID-19 in Scotland to transmission-related factors and risk conditions eligible for shielding support: REACT-SCOT case-control study

Paul M. McKeigue, David A. McAllister, David Caldwell, Ciara Gribben, Jen Bishop, Stuart McGurnaghan, Matthew Armstrong, Joke Delvaux, Sam Colville, Sharon Hutchinson, Chris Robertson, Nazir Lone, Jim McMenamin, David Goldberg, Helen M. Colhoun

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Investigating causal relationships between exposome and human longevity: a Mendelian randomization analysis

Shu-Yi Huang, Yu-Xiang Yang, Shi-Dong Chen, Hong-Qi Li, Xue-Qing Zhang, Kevin Kuo, Lan Tan, Lei Feng, Qiang Dong, Can Zhang, Jin-Tai Yu

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

A phenome-wide association study of genetically mimicked statins

Shun Li, C. M. Schooling

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Parental income gradients in adult health: a national cohort study

Miriam Evensen, Søren Toksvig Klitkou, Mette C. Tollånes, Simon Øverland, Torkild Hovde Lyngstad, Stein Emil Vollset, Jonas Minet Kinge

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Longitudinal change in lung function and subsequent risks of cardiovascular events: evidence from four prospective cohort studies

Yun-Jiu Cheng, Zhen-Guang Chen, Zhu-Yu Li, Wei-Yi Mei, Wen-Tao Bi, Dong-Ling Luo

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Identification of NOTCH4 mutation as a response biomarker for immune checkpoint inhibitor therapy

Junyu Long, Dongxu Wang, Xu Yang, Anqiang Wang, Yu Lin, Mingjun Zheng, Haohai Zhang, Xinting Sang, Hanping Wang, Ke Hu, Haitao Zhao

01.12.2021 | COVID-19 | Correspondence | Ausgabe 1/2021 Open Access

Persistence and baseline determinants of seropositivity and reinfection rates in health care workers up to 12.5 months after COVID-19

Carlota Dobaño, Anna Ramírez-Morros, Selena Alonso, Josep Vidal-Alaball, Gemma Ruiz-Olalla, Marta Vidal, Rocío Rubio, Emma Cascant, Daniel Parras, Natalia Rodrigo Melero, Pau Serra, Carlo Carolis, Pere Santamaria, Anna Forcada, Jacobo Mendioroz, Ruth Aguilar, Gemma Moncunill, Anna Ruiz-Comellas

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

The economic value of changing mortality risk in low- and middle-income countries: a systematic breakdown by cause of death

Aayush Khadka, Stéphane Verguet

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Validity of observational evidence on putative risk and protective factors: appraisal of 3744 meta-analyses on 57 topics

Perrine Janiaud, Arnav Agarwal, Ioanna Tzoulaki, Evropi Theodoratou, Konstantinos K. Tsilidis, Evangelos Evangelou, John P. A. Ioannidis

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Association of healthy lifestyle score with all-cause mortality and life expectancy: a city-wide prospective cohort study of cancer survivors

Ce Sun, Ke Li, Huan Xu, Xiangjun Wang, Pengzhe Qin, Suixiang Wang, Boheng Liang, Lin Xu

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Metagenome-wide association study of gut microbiome revealed potential microbial marker set for diagnosis of pediatric myasthenia gravis

Peng Liu, Yiqi Jiang, Shanshan Gu, Yinping Xue, Hongxia Yang, Yongzhao Li, Yaxuan Wang, Congya Yan, Pei Jia, Xiaoting Lin, Guoyan Qi

01.12.2021 | COVID-19 | Correspondence | Ausgabe 1/2021 Open Access

The East African Community (EAC) mobile laboratory networks in Kenya, Burundi, Tanzania, Rwanda, Uganda, and South Sudan—from project implementation to outbreak response against Dengue, Ebola, COVID-19, and epidemic-prone diseases

Muna Affara, Hakim Idris Lagu, Emmanuel Achol, Richard Karamagi, Neema Omari, Grace Ochido, Eric Kezakarayagwa, Francine Kabatesi, Anatole Nkeshimana, Abdi Roba, Millicent Nyakio Ndia, Mamo U. Abudo, Alice Kabanda, Etienne Mpabuka, Emil Ivan Mwikarago, Philip Ezekiel Kutjok, Donald Duku Samson, Lul Lojok Deng, Nyambura Moremi, Maria Ezekiely Kelly, Peter Bernard Mtesigwa Mkama, Alex Magesa, Stephen Karabyo Balinandi, Godfrey Pimundu, Susan Ndidde Nabadda, Dewi Ismajani Puradiredja, Julia Hinzmann, Sophie Duraffour, Martin Gabriel, Gerd Ruge, Wibke Loag, Rogers Ayiko, Stanley Serser Sonoiya, Juergen May, Michael J. Katende, Florian Gehre

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Salivary metabolites associated with a 5-year tooth loss identified in a population-based setting

Leonie Andörfer, Birte Holtfreter, Stefan Weiss, Rutger Matthes, Vinay Pitchika, Carsten Oliver Schmidt, Stefanie Samietz, Gabi Kastenmüller, Matthias Nauck, Uwe Völker, Henry Völzke, Laszlo N. Csonka, Karsten Suhre, Maik Pietzner, Thomas Kocher

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Optimal SARS-CoV-2 vaccine allocation using real-time attack-rate estimates in Rhode Island and Massachusetts

Thu Nguyen-Anh Tran, Nathan B. Wikle, Emmy Albert, Haider Inam, Emily Strong, Karel Brinda, Scott M. Leighow, Fuhan Yang, Sajid Hossain, Justin R. Pritchard, Philip Chan, William P. Hanage, Ephraim M. Hanks, Maciej F. Boni

15.07.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Dynamic changes of functional fitness, antibodies to SARS-CoV-2 and immunological indicators within 1 year after discharge in Chinese health care workers with severe COVID-19: a cohort study

Lijuan Xiong, Qian Li, Xiongjing Cao, Huangguo Xiong, Ming Huang, Fengwen Yang, Qingquan Liu, Daquan Meng, Mei Zhou, Gang Wang, Jun Tong, Tengfei Chen, Yanzhao Zhang, Xinliang He, Yunzhou Fan, Yupeng Zhang, Liang Tang, Yang Jin, Jiahong Xia, Yu Hu

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Real-world effectiveness of primary screening with high-risk human papillomavirus testing in the cervical cancer screening programme in China: a nationwide, population-based study

Yanxia Zhao, Heling Bao, Lan Ma, Bo Song, Jiangli Di, Linhong Wang, Yanqiu Gao, Wenhui Ren, Shi Wang, Hai-Jun Wang, Jiuling Wu

01.12.2021 | Commentary | Ausgabe 1/2021 Open Access

Human papillomavirus (HPV) testing for cervical cancer screening in a middle-income country: comment on a large real-world implementation study in China

Louise T. Thomsen, Susanne K. Kjær

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Variability of multi-omics profiles in a population-based child cohort

Marta Gallego-Paüls, Carles Hernández-Ferrer, Mariona Bustamante, Xavier Basagaña, Jose Barrera-Gómez, Chung-Ho E. Lau, Alexandros P. Siskos, Marta Vives-Usano, Carlos Ruiz-Arenas, John Wright, Remy Slama, Barbara Heude, Maribel Casas, Regina Grazuleviciene, Leda Chatzi, Eva Borràs, Eduard Sabidó, Ángel Carracedo, Xavier Estivill, Jose Urquiza, Muireann Coen, Hector C. Keun, Juan R. González, Martine Vrijheid, Léa Maitre

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Association of alcohol consumption with morbidity and mortality in patients with cardiovascular disease: original data and meta-analysis of 48,423 men and women

Chengyi Ding, Dara O’Neill, Steven Bell, Emmanuel Stamatakis, Annie Britton

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Parenteral artemisinins are associated with reduced mortality and neurologic deficits and improved long-term behavioral outcomes in children with severe malaria

Andrea L. Conroy, Robert O. Opoka, Paul Bangirana, Ruth Namazzi, Allen E. Okullo, Michael K. Georgieff, Sarah Cusick, Richard Idro, John M. Ssenkusu, Chandy C. John

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Humoral immune responses during SARS-CoV-2 mRNA vaccine administration in seropositive and seronegative individuals

Elizabeth Fraley, Cas LeMaster, Eric Geanes, Dithi Banerjee, Santosh Khanal, Elin Grundberg, Rangaraj Selvarangan, Todd Bradley

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Temporal trends in cause-specific mortality among individuals with newly diagnosed atrial fibrillation in the Framingham Heart Study

Jelena Kornej, Qiuxi Huang, Sarah R. Preis, Steven A. Lubitz, Darae Ko, Joanne M. Murabito, Emelia J. Benjamin, Ludovic Trinquart

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study

Yuanqing Fu, Fengzhe Xu, Longda Jiang, Zelei Miao, Xinxiu Liang, Jian Yang, Susanna C. Larsson, Ju-Sheng Zheng

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Adverse childhood experiences and child mental health: an electronic birth cohort study

Emily Lowthian, Rebecca Anthony, Annette Evans, Rhian Daniel, Sara Long, Amrita Bandyopadhyay, Ann John, Mark A. Bellis, Shantini Paranjothy

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Evaluation of the safety profile of COVID-19 vaccines: a rapid review

Qianhui Wu, Matthew Z. Dudley, Xinghui Chen, Xufang Bai, Kaige Dong, Tingyu Zhuang, Daniel Salmon, Hongjie Yu

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Oral vitamin D supplementation induces transcriptomic changes in rectal mucosa that are linked to anti-tumour effects

P. G. Vaughan-Shaw, G. Grimes, J. P. Blackmur, M. Timofeeva, M. Walker, L. Y. Ooi, Victoria Svinti, Kevin Donnelly, F. V. N. Din, S. M. Farrington, M. G. Dunlop

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Differential effect of pre-pregnancy low BMI on fetal macrosomia: a population-based cohort study

Guoju Li, Yuhan Xing, Guolan Wang, Jun Zhang, Qin Wu, Wei Ni, Na Jiao, Wenjing Chen, Qing Liu, Li Gao, Zhenhong Zhang, Yao Wang, Quansheng Xing

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

The establishment of a prognostic scoring model based on the new tumor immune microenvironment classification in acute myeloid leukemia

Tiansheng Zeng, Longzhen Cui, Wenhui Huang, Yan Liu, Chaozeng Si, Tingting Qian, Cong Deng, Lin Fu

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Genome-wide association study followed by trans-ancestry meta-analysis identify 17 new risk loci for schizophrenia

Jiewei Liu, Shiwu Li, Xiaoyan Li, Wenqiang Li, Yongfeng Yang, Suqin Guo, Luxian Lv, Xiao Xiao, Yong-Gang Yao, Fanglin Guan, Ming Li, Xiong-Jian Luo

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Pregnancies among women living with HIV using contraceptives and antiretroviral therapy in western Kenya: a retrospective, cohort study

Rena C. Patel, Gustavo Amorim, Beatrice Jakait, Bryan E. Shepherd, A. Rain Mocello, Beverly Musick, Caitlin Bernard, Maricianah Onono, Elizabeth A. Bukusi, Kara Wools-Kaloustian, Craig R. Cohen, Constantin T. Yiannoutsos, on behalf of the Implant/Efavirenz Study Group and the East Africa IeDEA Regional Consortium

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Under-recognition of heart failure in patients with atrial fibrillation and the impact of gender: a UK population-based cohort study

Rosita Zakeri, Ann D. Morgan, Varun Sundaram, Chloe Bloom, John G. F. Cleland, Jennifer K. Quint

01.12.2021 | Question and Answer | Ausgabe 1/2021 Open Access

Recent advances in diabetic kidney disease

Mohamad Hanouneh, Justin B. Echouffo Tcheugui, Bernard G. Jaar

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

National and provincial impact and cost-effectiveness of Haemophilus influenzae type b conjugate vaccine in China: a modeling analysis

Haijun Zhang, Cristina Garcia, Wenzhou Yu, Maria Deloria Knoll, Xiaozhen Lai, Tingting Xu, Rize Jing, Ying Qin, Zundong Yin, Brian Wahl, Hai Fang

01.12.2021 | MedViews | Ausgabe 1/2021 Open Access

Refining pancreatic ductal adenocarcinoma molecular subtype and precision therapeutics with single-nucleus RNA-seq

Lishu He

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Effects of the Norfolk diabetes prevention lifestyle intervention (NDPS) on glycaemic control in screen-detected type 2 diabetes: a randomised controlled trial

Michael Sampson, Allan Clark, Max Bachmann, Nikki Garner, Lisa Irvine, Amanda Howe, Colin Greaves, Sara Auckland, Jane Smith, Jeremy Turner, Dave Rea, Gerry Rayman, Ketan Dhatariya, W. Garry John, Garry Barton, Rebecca Usher, Clare Ferns, Melanie Pascale, on behalf of the NDPS group

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Choice of HbA1c threshold for identifying individuals at high risk of type 2 diabetes and implications for diabetes prevention programmes: a cohort study

Lauren R. Rodgers, Anita V. Hill, John M. Dennis, Zoe Craig, Benedict May, Andrew T. Hattersley, Timothy J. McDonald, Rob C. Andrews, Angus Jones, Beverley M. Shields

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Increased habitual flavonoid intake predicts attenuation of cognitive ageing in twins

Amy Jennings, Claire J. Steves, Alexander Macgregor, Tim Spector, Aedín Cassidy

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Use of systemic glucocorticoids and risk of breast cancer in a prospective cohort of postmenopausal women

Manon Cairat, Marie Al Rahmoun, Marc J. Gunter, Pierre-Etienne Heudel, Gianluca Severi, Laure Dossus, Agnès Fournier

01.12.2021 | Commentary | Ausgabe 1/2021 Open Access

Glucocorticoids and breast cancer risk

Kelly A. Hirko, A. Heather Eliassen

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Risk of incident fractures in individuals hospitalised due to unexplained syncope and orthostatic hypotension

Madeleine Johansson, Cecilia Rogmark, Richard Sutton, Artur Fedorowski, Viktor Hamrefors

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Prescribing of direct oral anticoagulants and warfarin to older people with atrial fibrillation in UK general practice: a cohort study

Anneka Mitchell, Julia Snowball, Tomas J. Welsh, Margaret C. Watson, Anita McGrogan

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Combined homologous recombination repair deficiency and immune activation analysis for predicting intensified responses of anthracycline, cyclophosphamide and taxane chemotherapy in triple-negative breast cancer

Gaoming Liao, Zedong Jiang, Yiran Yang, Cong Zhang, Meiting Jiang, Jiali Zhu, Liwen Xu, Aimin Xie, Min Yan, Yunpeng Zhang, Yun Xiao, Xia Li

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

One-year follow-up of chest CT findings in patients after SARS-CoV-2 infection

Yanfei Chen, Cheng Ding, Ling Yu, Wanru Guo, Xuewen Feng, Liang Yu, Junwei Su, Ting Xu, Cheng Ren, Ding Shi, Wenrui Wu, Ping Yi, Jun Liu, Jingjing Tao, Guanjing Lang, Yongtao Li, Min Xu, Jifang Sheng, Lanjuan Li, Kaijin Xu

01.12.2021 | Commentary | Ausgabe 1/2021 Open Access

Assessing the capacity and findings of routine programmatic data in Kenya to guide decision-making around contraceptives and antiretroviral therapy

Beth A. Tippett Barr

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Liquid biopsy posttreatment surveillance in endemic nasopharyngeal carcinoma: a cost-effective strategy to integrate circulating cell-free Epstein-Barr virus DNA

Chen-Fei Wu, Li Lin, Yan-Ping Mao, Bin Deng, Jia-Wei Lv, Wei-Hong Zheng, Dan-Wan Wen, Jia Kou, Fo-Ping Chen, Xing-Li Yang, Si-Si Xu, Jun Ma, Guan-Qun Zhou, Ying Sun

01.12.2021 | Review | Ausgabe 1/2021 Open Access

Bacterial vaginosis: drivers of recurrence and challenges and opportunities in partner treatment

Lenka A. Vodstrcil, Christina A. Muzny, Erica L. Plummer, Jack D. Sobel, Catriona S. Bradshaw

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Benefits and harms of Risperidone and Paliperidone for treatment of patients with schizophrenia or bipolar disorder: a meta-analysis involving individual participant data and clinical study reports

Alexander Hodkinson, Carl Heneghan, Kamal R. Mahtani, Evangelos Kontopantelis, Maria Panagioti

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Absolute quantitative proteomics using the total protein approach to identify novel clinical immunohistochemical markers in renal neoplasms

Susana Jorge, José L. Capelo, William LaFramboise, Swati Satturwar, Dimitrios Korentzelos, Sheldon Bastacky, Gabriela Quiroga-Garza, Rajiv Dhir, Jacek R. Wiśniewski, Carlos Lodeiro, Hugo M. Santos

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Development of models for cervical cancer screening: construction in a cross-sectional population and validation in two screening cohorts in China

Zeni Wu, Tingyuan Li, Yongli Han, Mingyue Jiang, Yanqin Yu, Huifang Xu, Lulu Yu, Jianfeng Cui, Bin Liu, Feng Chen, Jian Yin, Xun Zhang, Qinjing Pan, Youlin Qiao, Wen Chen

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

SARS-CoV-2 infection risk during delivery of childhood vaccination campaigns: a modelling study

Simon R. Procter, Kaja Abbas, Stefan Flasche, Ulla Griffiths, Brittany Hagedorn, Kathleen M. O’Reilly, Mark Jit, CMMID COVID-19 Working Group

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Physician-directed genetic screening to evaluate personal risk for medically actionable disorders: a large multi-center cohort study

Eden V. Haverfield, Edward D. Esplin, Sienna J. Aguilar, Kathryn E. Hatchell, Kelly E. Ormond, Andrea Hanson-Kahn, Paldeep S. Atwal, Sarah Macklin-Mantia, Stephanie Hines, Caron W.-M. Sak, Steven Tucker, Steven B. Bleyl, Peter J. Hulick, Ora K. Gordon, Lea Velsher, Jessica Y. J. Gu, Scott M. Weissman, Teresa Kruisselbrink, Christopher Abel, Michele Kettles, Anne Slavotinek, Bryce A. Mendelsohn, Robert C. Green, Swaroop Aradhya, Robert L. Nussbaum

01.12.2021 | COVID-19 | Commentary | Ausgabe 1/2021 Open Access

In for the long-haul? Seropositivity and sequelae 1 year post COVID-19

Jeremy Werner Deuel, Patricia Schlagenhauf

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Reduced risk of placental parasitemia associated with complement fixation on Plasmodium falciparum by antibodies among pregnant women

D. Herbert Opi, Michelle J. Boyle, Alistair R. D. McLean, Linda Reiling, Jo-Anne Chan, Danielle I. Stanisic, Alice Ura, Ivo Mueller, Freya J. I. Fowkes, Stephen J. Rogerson, James G. Beeson

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Tuberculosis related disability: a systematic review and meta-analysis

Kefyalew Addis Alene, Kinley Wangdi, Samantha Colquhoun, Kudakwashe Chani, Tauhid Islam, Kalpeshsinh Rahevar, Fukushi Morishita, Anthony Byrne, Justin Clark, Kerri Viney

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Renal function and lipid metabolism are major predictors of circumpapillary retinal nerve fiber layer thickness—the LIFE-Adult Study

Franziska G. Rauscher, Mengyu Wang, Mike Francke, Kerstin Wirkner, Anke Tönjes, Christoph Engel, Joachim Thiery, Peter Stenvinkel, Michael Stumvoll, Markus Loeffler, Tobias Elze, Thomas Ebert

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

The effects of selected inhibitors on human fetal adrenal steroidogenesis differs under basal and ACTH-stimulated conditions

Cecilie Melau, Malene Lundgaard Riis, John E. Nielsen, Signe Perlman, Lene Lundvall, Lea Langhoff Thuesen, Kristine Juul Hare, Mette Schou Hammerum, Rod T. Mitchell, Hanne Frederiksen, Anders Juul, Anne Jørgensen

01.12.2021 | Correspondence | Ausgabe 1/2021 Open Access

Reproductive issues in carriers of germline pathogenic variants in the BRCA1/2 genes: an expert meeting

Barbara Buonomo, Claudia Massarotti, Miriam Dellino, Paola Anserini, Alberta Ferrari, Maria Campanella, Mirosa Magnotti, Cristofaro De Stefano, Fedro Alessandro Peccatori, Matteo Lambertini

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Clinical and molecular factors that impact the efficacy of first-line crizotinib in ROS1-rearranged non-small-cell lung cancer: a large multicenter retrospective study

Yongchang Zhang, Xiangyu Zhang, Ruiguang Zhang, Qinqin Xu, Haiyan Yang, Analyn Lizaso, Chunwei Xu, Jun Liu, Wenxian Wang, Sai-Hong Ignatius Ou, Jiexia Zhang, Zhengbo Song, Nong Yang

01.12.2021 | COVID-19 | Correction | Ausgabe 1/2021 Open Access

Correction to: Following the science? Comparison of methodological and reporting quality of covid-19 and other research from the first wave of the pandemic

Terence J. Quin, Jennifer K. Burton, Ben Carter, Nicola Cooper, Kerry Dwan, Ryan Field, Suzane C. Freeman, Claudia Gue, Ping-Hsuan Hsieh, Kris McGill, Clareece R. Nevill, Dikshyanta Rana, Alex Sutton, Martin Taylor Rowan, Yiqiao Xin

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Comparative kinetics of SARS-CoV-2 anti-spike protein RBD IgGs and neutralizing antibodies in convalescent and naïve recipients of the BNT162b2 mRNA vaccine versus COVID-19 patients

Ioannis P. Trougakos, Evangelos Terpos, Christina Zirou, Aimilia D. Sklirou, Filia Apostolakou, Sentiljana Gumeni, Ioanna Charitaki, Eleni-Dimitra Papanagnou, Tina Bagratuni, Christine-Ivy Liacos, Andreas Scorilas, Eleni Korompoki, Ioannis Papassotiriou, Efstathios Kastritis, Meletios A. Dimopoulos

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

The value of innovation: association between improvements in survival of advanced and metastatic non-small cell lung cancer and targeted and immunotherapy

Sreeram Ramagopalan, Thomas P. Leahy, Joshua Ray, Samantha Wilkinson, Cormac Sammon, Vivek Subbiah

01.12.2021 | Commentary | Ausgabe 1/2021 Open Access

Exposure assessment in early life: it is about time for multi-omics approaches

Jantje Goerdten, Anna Floegel

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Interventions to control nosocomial transmission of SARS-CoV-2: a modelling study

Thi Mui Pham, Hannan Tahir, Janneke H. H. M. van de Wijgert, Bastiaan R. Van der Roest, Pauline Ellerbroek, Marc J. M. Bonten, Martin C. J. Bootsma, Mirjam E. Kretzschmar

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Pre-existing health conditions and severe COVID-19 outcomes: an umbrella review approach and meta-analysis of global evidence

Marina Treskova-Schwarzbach, Laura Haas, Sarah Reda, Antonia Pilic, Anna Borodova, Kasra Karimi, Judith Koch, Teresa Nygren, Stefan Scholz, Viktoria Schönfeld, Sabine Vygen-Bonnet, Ole Wichmann, Thomas Harder

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

The association between mechanical ventilator compatible bed occupancy and mortality risk in intensive care patients with COVID-19: a national retrospective cohort study

Harrison Wilde, Thomas Mellan, Iwona Hawryluk, John M. Dennis, Spiros Denaxas, Christina Pagel, Andrew Duncan, Samir Bhatt, Seth Flaxman, Bilal A. Mateen, Sebastian J. Vollmer

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Allergy-related diseases in childhood and risk for abdominal pain-related functional gastrointestinal disorders at 16 years—a birth cohort study

Jessica Sjölund, Inger Kull, Anna Bergström, Jacob Järås, Jonas F. Ludvigsson, Hans Törnblom, Magnus Simrén, Ola Olén

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Psychopathological symptom network structure in transgender and gender queer youth reporting parental psychological abuse: a network analysis

Yuanyuan Wang, Zhihao Ma, Amanda Wilson, Zhishan Hu, Xin Ying, Meng Han, Zaixu Cui, Runsen Chen

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Alcohol drinking and risks of liver cancer and non-neoplastic chronic liver diseases in China: a 10-year prospective study of 0.5 million adults

Pek Kei Im, Iona Y. Millwood, Christiana Kartsonaki, Yu Guo, Yiping Chen, Iain Turnbull, Canqing Yu, Huaidong Du, Pei Pei, Jun Lv, Robin G. Walters, Liming Li, Ling Yang, Zhengming Chen, on behalf of the China Kadoorie Biobank (CKB) collaborative group

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Estimating the annual dengue force of infection from the age of reporting primary infections across urban centres in endemic countries

Joseph R. Biggs, Ava Kristy Sy, Katharine Sherratt, Oliver J. Brady, Adam J. Kucharski, Sebastian Funk, Mary Anne Joy Reyes, Mary Ann Quinones, William Jones-Warner, Ferchito L. Avelino, Nemia L. Sucaldito, Amado O. Tandoc, Eva Cutiongco-de la Paz, Maria Rosario Z. Capeding, Carmencita D. Padilla, Julius Clemence R. Hafalla, Martin L. Hibberd

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Can we achieve better recruitment by providing better information? Meta-analysis of ‘studies within a trial’ (SWATs) of optimised participant information sheets

Vichithranie W. Madurasinghe, Peter Bower, Sandra Eldridge, David Collier, Jonathan Graffy, Shaun Treweek, Peter Knapp, Adwoa Parker, Jo Rick, Chris Salisbury, Mei See Man, David Torgerson, Rebecca Sheridan, Frank Sullivan, Sarah Cockayne, Charlotte Dack

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Educational associations with missed GP appointments for patients under 35 years old: administrative data linkage study

Ross McQueenie, David A. Ellis, Michael Fleming, Philip Wilson, Andrea E. Williamson

01.12.2021 | Correction | Ausgabe 1/2021 Open Access

Correction to: Idiopathic pulmonary fibrosis in BRIC countries: the cases of Brazil, Russia, India, and China

Luca Richeldi, Adalberto Sperb Rubin, Sergey Avdeev, Zarir F. Udwadia, Zuo Jun Xu

01.12.2021 | Commentary | Ausgabe 1/2021 Open Access

Advancing the diagnosis and classification of renal cell carcinomas

Joseph A. Rothwell

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Predicting the risk of mortality during hospitalization in sick severely malnourished children using daily evaluation of key clinical warning signs

Bijun Wen, Daniella Brals, Celine Bourdon, Lauren Erdman, Moses Ngari, Emmanuel Chimwezi, Isabel Potani, Johnstone Thitiri, Laura Mwalekwa, James A. Berkley, Robert H. J. Bandsma, Wieger Voskuijl

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Utility of comprehensive genomic profiling in directing treatment and improving patient outcomes in advanced non-small cell lung cancer

Shen Zhao, Zhonghan Zhang, Jianhua Zhan, Xin Zhao, Xinru Chen, Liyun Xiao, Kui Wu, Yuxiang Ma, Mengzhen Li, Yunpeng Yang, Wenfeng Fang, Hongyun Zhao, Li Zhang

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Decentralized facility financing versus performance-based payments in primary health care: a large-scale randomized controlled trial in Nigeria

Madhulika Khanna, Benjamin Loevinsohn, Elina Pradhan, Opeyemi Fadeyibi, Kevin McGee, Oluwole Odutolu, Gyorgy Bela Fritsche, Emmanuel Meribole, Christel M. J. Vermeersch, Eeshani Kandpal

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Estimating the health and economic effects of the voluntary sodium reduction targets in Brazil: microsimulation analysis

Eduardo Augusto Fernandes Nilson, Jonathan Pearson-Stuttard, Brendan Collins, Maria Guzman-Castillo, Simon Capewell, Martin O’Flaherty, Patrícia Constante Jaime, Chris Kypridemos

01.12.2021 | Correction | Ausgabe 1/2021 Open Access

Correction to: Impact of multiple cardiovascular medications on mortality after an incidence of ischemic stroke or transient ischemic attack

Tian-Tian Ma, Ian C. K. Wong, Cate Whittlesea, Kenneth K. C. Man, Wallis Lau, Zixuan Wang, Ruth Brauer, Thomas M. MacDonald, Isla S. Mackenzie, Li Wei

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Association of multimorbidity and changes in health-related quality of life following myocardial infarction: a UK multicentre longitudinal patient-reported outcomes study

T. Munyombwe, T. B. Dondo, S. Aktaa, C. Wilkinson, M. Hall, B. Hurdus, G. Oliver, R. M. West, A. S. Hall, C. P. Gale

01.12.2021 | Correction | Ausgabe 1/2021 Open Access

Correction to: Association between HIV infection and hypertension: a global systematic review and meta-analysis of cross-sectional studies

Katherine Davis, Pablo Perez-Guzman, Annika Hoyer, Ralph Brinks, Edward Gregg, Keri N. Althoff, Amy C. Justice, Peter Reiss, Simon Gregson, Mikaela Smit

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Elevated risk of attention deficit hyperactivity disorder (ADHD) in Japanese children with higher genetic susceptibility to ADHD with a birth weight under 2000 g

Md Shafiur Rahman, Nagahide Takahashi, Toshiki Iwabuchi, Tomoko Nishimura, Taeko Harada, Akemi Okumura, Nori Takei, Yoko Nomura, Kenji J. Tsuchiya

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Patient and health provider costs of integrated HIV, diabetes and hypertension ambulatory health services in low-income settings — an empirical socio-economic cohort study in Tanzania and Uganda

Tinevimbo Shiri, Josephine Birungi, Anupam V. Garrib, Sokoine L. Kivuyo, Ivan Namakoola, Janneth Mghamba, Joshua Musinguzi, Godfather Kimaro, Gerald Mutungi, Moffat J. Nyirenda, Joseph Okebe, Kaushik Ramaiya, M. Bachmann, Nelson K. Sewankambo, Sayoki Mfinanga, Shabbar Jaffar, Louis W. Niessen

01.12.2021 | Commentary | Ausgabe 1/2021 Open Access

Can complement fix placental malaria?

Justin Y. A. Doritchamou, Patrick E. Duffy

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci

Eric L. Harshfield, Eric B. Fauman, David Stacey, Dirk S. Paul, Daniel Ziemek, Rachel M. Y. Ong, John Danesh, Adam S. Butterworth, Asif Rasheed, Taniya Sattar, Zameer-ul-Asar, Imran Saleem, Zoubia Hina, Unzila Ishtiaq, Nadeem Qamar, Nadeem Hayat Mallick, Zia Yaqub, Tahir Saghir, Syed Nadeem Hasan Rizvi, Anis Memon, Mohammad Ishaq, Syed Zahed Rasheed, Fazal-ur-Rehman Memon, Anjum Jalal, Shahid Abbas, Philippe Frossard, Danish Saleheen, Angela M. Wood, Julian L. Griffin, Albert Koulman

13.09.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Estimating the impact of reopening schools on the reproduction number of SARS-CoV-2 in England, using weekly contact survey data

James D. Munday, Christopher I. Jarvis, Amy Gimma, Kerry L. M. Wong, Kevin van Zandvoort, Sebastian Funk, W. John Edmunds, CMMID COVID-19 Working Group

01.12.2021 | Question and Answer | Ausgabe 1/2021 Open Access

Q&A: First-hand perspectives as a member of the BMC Medicine Editorial Board scheme: an interview with Matthew Quaife and Shuai Li

Matthew Quaife, Shuai Li

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Socioeconomic position and prognosis in premenopausal breast cancer: a population-based cohort study in Denmark

Cathrine Fonnesbech Hjorth, Per Damkier, Bent Ejlertsen, Timothy Lash, Henrik Toft Sørensen, Deirdre Cronin-Fenton

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

The relationship between markers of antenatal iron stores and birth outcomes differs by malaria prevention regimen—a prospective cohort study

Holger W. Unger, Valentina Laurita Longo, Andie Bleicher, Maria Ome-Kaius, Stephan Karl, Julie A. Simpson, Amalia Karahalios, Elizabeth H. Aitken, Stephen J. Rogerson

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Activated gut-homing CD8+ T cells for coeliac disease diagnosis on a gluten-free diet

Fernando Fernández-Bañares, Natalia López-Palacios, María Corzo, Beatriz Arau, Mercedes Rubio, Marta Fernández-Prieto, Eva Tristán, Mar Pujals, Sergio Farrais, Saúl Horta, Juana María Hernández, Marta Gomez-Perosanz, Pedro A. Reche, María Esteve, Concepción Núñez

01.12.2021 | Commentary | Ausgabe 1/2021 Open Access

Exiting the pandemic: Singapore style

Dale Fisher, Kenneth Mak

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Identification and validation of tissue or ctDNA PTPRD phosphatase domain deleterious mutations as prognostic and predictive biomarkers for immune checkpoint inhibitors in non-squamous NSCLC

Yiting Sun, Jianchun Duan, Wenfeng Fang, Zhijie Wang, Xinyang Du, Xin Wang, Chengcheng Li, Shangli Cai, Jie Zhao, Sini Li, Li Zhang, Hua Bai, Jie Wang

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Exploring health in the UK Biobank: associations with sociodemographic characteristics, psychosocial factors, lifestyle and environmental exposures

Julian Mutz, Charlotte J. Roscoe, Cathryn M. Lewis

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Intensive lactation among women with recent gestational diabetes significantly alters the early postpartum circulating lipid profile: the SWIFT study

Ziyi Zhang, Mi Lai, Anthony L. Piro, Stacey E. Alexeeff, Amina Allalou, Hannes L. Röst, Feihan F. Dai, Michael B. Wheeler, Erica P. Gunderson

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Understanding the impact of exposure to adverse socioeconomic conditions on chronic stress from a complexity science perspective

Loes Crielaard, Mary Nicolaou, Alexia Sawyer, Rick Quax, Karien Stronks

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Discovery and validation of methylation signatures in circulating cell-free DNA for early detection of esophageal cancer: a case-control study

Guibin Qiao, Weitao Zhuang, Bo Dong, Chengcheng Li, Jiayue Xu, Guoqiang Wang, Liang Xie, Zihao Zhou, Dan Tian, Gang Chen, Jiming Tang, Haiyu Zhou, Dongkun Zhang, Ruiqing Shi, Rixin Chen, Weiqi Nian, Yuzi Zhang, Jing Zhao, Xiaofang Wen, Yu Xu, Bingsi Li, Zhihong Zhang, Shangli Cai, Xiaosong Ben, Yu Qi

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Achieving a “step change” in the tuberculosis epidemic through comprehensive community-wide intervention: a model-based analysis

Sourya Shrestha, Emily A. Kendall, Rebekah Chang, Roy Joseph, Parastu Kasaie, Laura Gillini, Anthony Todd Fojo, Michael Campbell, Nimalan Arinaminpathy, David W. Dowdy

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Clinical and molecular feature-based nomogram model for predicting benefit from bevacizumab combined with first-generation EGFR-tyrosine kinase inhibitor (TKI) in EGFR-mutant advanced NSCLC

Yongchang Zhang, Liang Zeng, Xiangyu Zhang, Yizhi Li, Lingli Liu, Qinqin Xu, Haiyan Yang, Wenjuan Jiang, Analyn Lizaso, Luting Qiu, Ting Hou, Jun Liu, Ling Peng, Nong Yang

01.12.2021 | COVID-19 | Correspondence | Ausgabe 1/2021 Open Access

The risk of COVID-19 in survivors of domestic violence and abuse

Joht Singh Chandan, Anuradhaa Subramanian, Jaidev Kaur Chandan, Krishna M. Gokhale, Alecs Vitoc, Julie Taylor, Caroline Bradbury-Jones, Siddhartha Bandyopadhyay, Krishnarajah Nirantharakumar

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

HBeAg mediates inflammatory functions of macrophages by TLR2 contributing to hepatic fibrosis

Xiaoyu Xie, Huanran Lv, Chenxi Liu, Xiaonan Su, Zhen Yu, Shouyang Song, Hongjun Bian, Miaomiao Tian, Chengyong Qin, Jianni Qi, Qiang Zhu

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Frailty and the risk of dementia: is the association explained by shared environmental and genetic factors?

Ge Bai, Yunzhang Wang, Ralf Kuja-Halkola, Xia Li, Yasutake Tomata, Ida K. Karlsson, Nancy L. Pedersen, Sara Hägg, Juulia Jylhävä

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Evolving phenotypes of non-hospitalized patients that indicate long COVID

Hossein Estiri, Zachary H. Strasser, Gabriel A. Brat, Yevgeniy R. Semenov, Chirag J. Patel, Shawn N. Murphy, The Consortium for Characterization of COVID-19 by EHR (4CE)

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

A fecal-based test for the detection of advanced adenoma and colorectal cancer: a case-control and screening cohort study

Lian-Jing Cao, Xiao-Lin Peng, Wen-Qiong Xue, Rong Zhang, Jiang-Bo Zhang, Ting Zhou, Zi-Yi Wu, Gai-Rui Li, Tong-Min Wang, Yong-Qiao He, Da-Wei Yang, Ying Liao, Xia-Ting Tong, Fang Wang, Ke-Xin Chen, Shi-Hong Zhang, Li-Qing Zhu, Pei-Rong Ding, Wei-Hua Jia

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Costs and staffing resource requirements for adaptive clinical trials: quantitative and qualitative results from the Costing Adaptive Trials project

Nina Wilson, Katie Biggs, Sarah Bowden, Julia Brown, Munyaradzi Dimairo, Laura Flight, Jamie Hall, Anna Hockaday, Thomas Jaki, Rachel Lowe, Caroline Murphy, Philip Pallmann, Mark A. Pilling, Claire Snowdon, Matthew R. Sydes, Sofía S. Villar, Christopher J. Weir, Jessica Welburn, Christina Yap, Rebecca Maier, Helen Hancock, James M. S. Wason

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

The impact of blood transcriptomic biomarker targeted tuberculosis preventive therapy in people living with HIV: a mathematical modelling study

Tom Sumner, Simon C. Mendelsohn, Thomas J. Scriba, Mark Hatherill, Richard G. White

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Rehabilitation of executive function in chronic paediatric brain injury: a randomized controlled trial

Anne E. Brandt, Torun G. Finnanger, Ruth E. Hypher, Torstein B. Rø, Eva Skovlund, Stein Andersson, Kari Risnes, Jan Stubberud

01.12.2021 | COVID-19 | Database | Ausgabe 1/2021 Open Access

SOCRATES-CoMix: a platform for timely and open-source contact mixing data during and in between COVID-19 surges and interventions in over 20 European countries

Frederik Verelst, Lisa Hermans, Sarah Vercruysse, Amy Gimma, Pietro Coletti, Jantien A. Backer, Kerry L. M. Wong, James Wambua, Kevin van Zandvoort, Lander Willem, Laurens Bogaardt, Christel Faes, Christopher I. Jarvis, Jacco Wallinga, W. John Edmunds, Philippe Beutels, Niel Hens

02.10.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Transmission event of SARS-CoV-2 delta variant reveals multiple vaccine breakthrough infections

Timothy Farinholt, Harsha Doddapaneni, Xiang Qin, Vipin Menon, Qingchang Meng, Ginger Metcalf, Hsu Chao, Marie-Claude Gingras, Vasanthi Avadhanula, Paige Farinholt, Charu Agrawal, Donna M. Muzny, Pedro A. Piedra, Richard A. Gibbs, Joseph Petrosino

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Impact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Research Programme in AF (EORP-AF) General Long-Term Registry

Marco Proietti, Marco Vitolo, Stephanie L. Harrison, Deirdre A. Lane, Laurent Fauchier, Francisco Marin, Michael Nabauer, Tatjana S. Potpara, Gheorghe-Andrei Dan, Giuseppe Boriani, Gregory Y. H. Lip, on behalf of the ESC-EHRA EORP-AF Long-Term General Registry Investigators

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Association between thyroid dysfunction and type 2 diabetes: a meta-analysis of prospective observational studies

Fen Rong, Hongji Dai, Yuwan Wu, Jibin Li, Guoping Liu, Hanbei Chen, Xi Zhang

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Association between cardiometabolic disease multimorbidity and all-cause mortality in 2 million women and men registered in UK general practices

Dexter Canoy, Jenny Tran, Mariagrazia Zottoli, Rema Ramakrishnan, Abdelaali Hassaine, Shishir Rao, Yikuan Li, Gholamreza Salimi-Khorshidi, Robyn Norton, Kazem Rahimi

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Modification effect of ideal cardiovascular health metrics on genetic association with incident heart failure in the China Kadoorie Biobank and the UK Biobank

Ruotong Yang, Jun Lv, Canqing Yu, Yu Guo, Pei Pei, Ninghao Huang, Ling Yang, Iona Y. Millwood, Robin G. Walters, Yiping Chen, Huaidong Du, Ran Tao, Junshi Chen, Zhengming Chen, Robert Clarke, Tao Huang, Liming Li, on behalf of the China Kadoorie Biobank Collaborative Group

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Placenta mediates the effect of maternal hypertension polygenic score on offspring birth weight: a study of birth cohort with fetal growth velocity data

Noriko Sato, Ayako Fudono, Chihiro Imai, Hidemi Takimoto, Iori Tarui, Tomoko Aoyama, Satoshi Yago, Motoko Okamitsu, Shuki Mizutani, Naoyuki Miyasaka

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Polygenic risk score across distinct colorectal cancer screening outcomes: from premalignant polyps to colorectal cancer

Mireia Obón-Santacana, Anna Díez-Villanueva, Maria Henar Alonso, Gemma Ibáñez-Sanz, Elisabet Guinó, Ana López, Lorena Rodríguez-Alonso, Alfredo Mata, Ana García-Rodríguez, Andrés García Palomo, Antonio J. Molina, Montse Garcia, Gemma Binefa, Vicente Martín, Victor Moreno

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Development of a model of medication review for use in clinical practice: Bristol medication review model

D. McCahon, R. E. Denholm, A. L. Huntley, S. Dawson, P. Duncan, R. A. Payne

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Accelerating Sustainable Development Goals for South African adolescents from high HIV prevalence areas: a longitudinal path analysis

Franziska Meinck, Mark Orkin, Lucie Cluver

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Prediction of P-tau/Aβ42 in the cerebrospinal fluid with blood microRNAs in Alzheimer’s disease

Longfei Jia, Min Zhu, Jianwei Yang, Yana Pang, Qi Wang, Ying Li, Tingting Li, Fangyu Li, Qigeng Wang, Yan Li, Yiping Wei

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

SToRytelling to Improve Disease outcomes in Gout (STRIDE-GO): a multicenter, randomized controlled trial in African American veterans with gout

Jasvinder A. Singh, Amy Joseph, Joshua Baker, Joshua S. Richman, Terrence Shaneyfelt, Kenneth G. Saag, Seth Eisen

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Higher thyrotropin leads to unfavorable lipid profile and somewhat higher cardiovascular disease risk: evidence from multi-cohort Mendelian randomization and metabolomic profiling

Nicolien A. van Vliet, Maxime M. Bos, Carisha S. Thesing, Layal Chaker, Maik Pietzner, Evelyn Houtman, Matt J. Neville, Ruifang Li-Gao, Stella Trompet, Rima Mustafa, Fariba Ahmadizar, Marian Beekman, Mariska Bot, Kathrin Budde, Constantinos Christodoulides, Abbas Dehghan, Christian Delles, Paul Elliott, Marina Evangelou, He Gao, Mohsen Ghanbari, Antonius E. van Herwaarden, M. Arfan Ikram, Martin Jaeger, J. Wouter Jukema, Ibrahim Karaman, Fredrik Karpe, Margreet Kloppenburg, Jennifer M. T. A. Meessen, Ingrid Meulenbelt, Yuri Milaneschi, Simon P. Mooijaart, Dennis O. Mook-Kanamori, Mihai G. Netea, Romana T. Netea-Maier, Robin P. Peeters, Brenda W. J. H. Penninx, Naveed Sattar, P. Eline Slagboom, H. Eka D. Suchiman, Henry Völzke, Ko Willems van Dijk, Raymond Noordam, Diana van Heemst, BBMRI Metabolomics Consortium

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

A better understanding of the association between maternal perception of foetal movements and late stillbirth—findings from an individual participant data meta-analysis

John M. D. Thompson, Jessica Wilson, Billie F. Bradford, Minglan Li, Robin S. Cronin, Adrienne Gordon, Camille H. Raynes-Greenow, Tomasina Stacey, Vicki M. Cullling, Lisa M. Askie, Louise M. O’Brien, Edwin A. Mitchell, Lesley M. E. McCowan, Alexander E. P. Heazell

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

The dose-response relationship between socioeconomic deprivation and alcohol-attributable mortality risk—a systematic review and meta-analysis

Charlotte Probst, Shannon Lange, Carolin Kilian, Celine Saul, Jürgen Rehm

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Clinicopathologic analysis of microscopic tumor extension in glioma for external beam radiotherapy planning

Shulun Nie, Yufang Zhu, Jia Yang, Tao Xin, Song Xue, Jujie Sun, Dianbin Mu, Zhaoqiu Chen, Pengpeng Sun, Jinming Yu, Man Hu

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Impact of baseline SARS-CoV-2 antibody status on syndromic surveillance and the risk of subsequent COVID-19—a prospective multicenter cohort study

Philipp Kohler, Sabine Güsewell, Marco Seneghini, Thomas Egger, Onicio Leal, Angela Brucher, Eva Lemmenmeier, J. Carsten Möller, Philip Rieder, Markus Ruetti, Reto Stocker, Danielle Vuichard-Gysin, Benedikt Wiggli, Ulrike Besold, Stefan P. Kuster, Allison McGeer, Lorenz Risch, Andrée Friedl, Matthias Schlegel, Pietro Vernazza, Christian R. Kahlert

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Individual social contact data and population mobility data as early markers of SARS-CoV-2 transmission dynamics during the first wave in Germany—an analysis based on the COVIMOD study

Damilola Victoria Tomori, Nicole Rübsamen, Tom Berger, Stefan Scholz, Jasmin Walde, Ian Wittenberg, Berit Lange, Alexander Kuhlmann, Johannes Horn, Rafael Mikolajczyk, Veronika K. Jaeger, André Karch

01.12.2021 | Commentary | Ausgabe 1/2021 Open Access

Optimal site for fluoroscopic tracer injection for laparoscopic lymphadenectomy

Fernando A. M. Herbella, Marco G. Patti

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Computer-assisted quantification of tumor-associated collagen signatures to improve the prognosis prediction of breast cancer

Gangqin Xi, Lida Qiu, Shuoyu Xu, Wenhui Guo, Fangmeng Fu, Deyong Kang, Liqin Zheng, Jiajia He, Qingyuan Zhang, Lianhuang Li, Chuan Wang, Jianxin Chen

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Causal effects of atrial fibrillation on brain white and gray matter volume: a Mendelian randomization study

Sehoon Park, Soojin Lee, Yaerim Kim, Semin Cho, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Soryoung Lee, Eue-Keun Choi, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim

18.10.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Effects of BNT162b2 mRNA vaccine on COVID-19 infection and hospitalisation amongst older people: matched case control study for England

Thomas F. D. Mason, Matt Whitston, Jack Hodgson, Ruth E. Watkinson, Yiu-Shing Lau, Omnia Abdulrazeg, Matt Sutton

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Comparison of submucosal and subserosal approaches toward optimized indocyanine green tracer-guided laparoscopic lymphadenectomy for patients with gastric cancer (FUGES-019): a randomized controlled trial

Qi-Yue Chen, Qing Zhong, Ping Li, Jian-Wei Xie, Zhi-Yu Liu, Xiao-Bo Huang, Guang-Tan Lin, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Qiao-Ling Zheng, Ru-Hong Tu, Ze-Ning Huang, Chao-Hui Zheng, Chang-Ming Huang

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Telomerase-positive circulating tumor cells are associated with poor prognosis via a neutrophil-mediated inflammatory immune environment in glioma

Wen Zhang, Tiancheng Qin, Zhenrong Yang, Liyuan Yin, Changyun Zhao, Lin Feng, Song Lin, Binlei Liu, Shujun Cheng, Kaitai Zhang

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Hospitalisation events in people with chronic kidney disease as a component of multimorbidity: parallel cohort studies in research and routine care settings

Michael K. Sullivan, Bhautesh Dinesh Jani, Alex McConnachie, Peter Hanlon, Philip McLoone, Barbara I. Nicholl, Juan-Jesus Carrero, Dorothea Nitsch, David McAllister, Frances S. Mair, Patrick B. Mark

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Risk of bias in observational studies using routinely collected data of comparative effectiveness research: a meta-research study

Van Thu Nguyen, Mishelle Engleton, Mauricia Davison, Philippe Ravaud, Raphael Porcher, Isabelle Boutron

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Adherence to the Mediterranean diet assessed by a novel dietary biomarker score and mortality in older adults: the InCHIANTI cohort study

Nicole Hidalgo-Liberona, Tomás Meroño, Raul Zamora-Ros, Montserrat Rabassa, Richard Semba, Toshiko Tanaka, Stefania Bandinelli, Luigi Ferrucci, Cristina Andres-Lacueva, Antonio Cherubini

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Effect of evidence updates on key determinants of measles vaccination impact: a DynaMICE modelling study in ten high-burden countries

Han Fu, Kaja Abbas, Petra Klepac, Kevin van Zandvoort, Hira Tanvir, Allison Portnoy, Mark Jit

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis

Zhenhua Zhang, Wim Trypsteen, Marc Blaauw, Xiaojing Chu, Sofie Rutsaert, Linos Vandekerckhove, Wouter van der Heijden, Jéssica Cristina dos Santos, Cheng-Jian Xu, Morris A. Swertz, Andre van der Ven, Yang Li

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Sulforaphane enhances the antitumor response of chimeric antigen receptor T cells by regulating PD-1/PD-L1 pathway

Chunyi Shen, Zhen Zhang, Yonggui Tian, Feng Li, Lingxiao Zhou, Wenyi Jiang, Li Yang, Bin Zhang, Liping Wang, Yi Zhang

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

m6A regulator expression profile predicts the prognosis, benefit of adjuvant chemotherapy, and response to anti-PD-1 immunotherapy in patients with small-cell lung cancer

Zhihui Zhang, Chaoqi Zhang, Yuejun Luo, Peng Wu, Guochao Zhang, Qingpeng Zeng, Lide Wang, Zhaoyang Yang, Liyan Xue, Bo Zheng, Hua Zeng, Fengwei Tan, Qi Xue, Shugeng Gao, Nan Sun, Jie He

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Diagnostic accuracy of pooling urine, anorectal, and oropharyngeal specimens for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae: a systematic review and meta-analysis

Lily Aboud, Yangqi Xu, Eric P. F. Chow, Teodora Wi, Rachel Baggaley, Maeve B. Mello, Christopher K. Fairley, Jason J. Ong

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Adult retrospective report of child abuse and prospective indicators of childhood harm: a population birth cohort study

Snehal M. Pinto Pereira, Nina T. Rogers, Christine Power

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Different hypertension thresholds and cognitive decline: a pooled analysis of three ageing cohorts

Yanjun Ma, Rong Hua, Zhenchun Yang, Baoliang Zhong, Li Yan, Wuxiang Xie

01.12.2021 | Correction | Ausgabe 1/2021 Open Access

Correction to: Physician-directed genetic screening to evaluate personal risk for medically actionable disorders: a large multi-center cohort study

Eden V. Haverfield, Edward D. Esplin, Sienna J. Aguilar, Kathryn E. Hatchell, Kelly E. Ormond, Andrea Hanson-Kahn, Paldeep S. Atwal, Sarah Macklin-Mantia, Stephanie Hines, Caron W.-M. Sak, Steven Tucker, Steven B. Bleyl, Peter J. Hulick, Ora K. Gordon, Lea Velsher, Jessica Y. J. Gu, Scott M. Weissman, Teresa Kruisselbrink, Christopher Abel, Michele Kettles, Anne Slavotinek, Bryce A. Mendelsohn, Robert C. Green, Swaroop Aradhya, Robert L. Nussbaum

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

5mC regulator-mediated molecular subtypes depict the hallmarks of the tumor microenvironment and guide precision medicine in bladder cancer

Jiao Hu, Belaydi Othmane, Anze Yu, Huihuang Li, Zhiyong Cai, Xu Chen, Wenbiao Ren, Jinbo Chen, Xiongbing Zu

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Nutritional risk factors for SARS-CoV-2 infection: a prospective study within the NutriNet-Santé cohort

Mélanie Deschasaux-Tanguy, Bernard Srour, Laurent Bourhis, Nathalie Arnault, Nathalie Druesne-Pecollo, Younes Esseddik, Fabien Szabo de Edelenyi, Julien Allègre, Benjamin Allès, Valentina A. Andreeva, Julia Baudry, Leopold K. Fezeu, Pilar Galan, Chantal Julia, Emmanuelle Kesse-Guyot, Sandrine Péneau, Serge Hercberg, Nathalie Bajos, Gianluca Severi, Marie Zins, Xavier de Lamballerie, Fabrice Carrat, Mathilde Touvier, on behalf of the SAPRIS-SERO study group

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Maternal lithium use and the risk of adverse pregnancy and neonatal outcomes: a Swedish population-based cohort study

Roxanne Hastie, Stephen Tong, Richard Hiscock, Anthea Lindquist, Linda Lindström, Anna-Karin Wikström, Inger Sundström-Poromaa

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Metabolite profiles and the risk of metabolic syndrome in early childhood: a case-control study

Sandi M. Azab, Russell J. de Souza, Amel Lamri, Meera Shanmuganathan, Zachary Kroezen, Karleen M. Schulze, Dipika Desai, Natalie C. Williams, Katherine M. Morrison, Stephanie A. Atkinson, Koon K. Teo, Philip Britz-McKibbin, Sonia S. Anand

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Safety, infectivity and immunogenicity of a genetically attenuated blood-stage malaria vaccine

Rebecca Webster, Silvana Sekuloski, Anand Odedra, Stephen Woolley, Helen Jennings, Fiona Amante, Katharine R. Trenholme, Julie Healer, Alan F. Cowman, Emily M. Eriksson, Priyanka Sathe, Jocelyn Penington, Adam J. Blanch, Matthew W. A. Dixon, Leann Tilley, Michael F. Duffy, Alister Craig, Janet Storm, Jo-Anne Chan, Krystal Evans, Anthony T. Papenfuss, Louis Schofield, Paul Griffin, Bridget E. Barber, Dean Andrew, Michelle J. Boyle, Fabian de Labastida Rivera, Christian Engwerda, James S. McCarthy

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Marked reduction in antibiotic usage following intensive malaria control in a cohort of Ugandan children

Paul J. Krezanoski, Michelle E. Roh, John Rek, Joaniter I. Nankabirwa, Emmanuel Arinaitwe, Sarah G. Staedke, Susan Nayiga, Michelle S. Hsiang, David Smith, Moses Kamya, Grant Dorsey

01.12.2021 | Commentary | Ausgabe 1/2021 Open Access

Models based on nucleic acid methylation regulators will contribute to facilitating cancer precision medicine

Wen Zhang

01.12.2021 | Commentary | Ausgabe 1/2021 Open Access

Peripheral blood RNAseq links neutrophilic inflammation to clinical glioma metastasis

Yuanyuan Wu, Zhichao Fan

01.12.2021 | Correction | Ausgabe 1/2021 Open Access

Correction to: Non-genetic risk and protective factors and biomarkers for neurological disorders: a meta-umbrella systematic review of umbrella reviews

Alexios-Fotios A. Mentis, Efthimios Dardiotis, Vasiliki Efthymiou, George P. Chrousos

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Durations of asymptomatic, symptomatic, and care-seeking phases of tuberculosis disease with a Bayesian analysis of prevalence survey and notification data

Chu-Chang Ku, Peter MacPherson, McEwen Khundi, Rebecca H. Nzawa Soko, Helena R. A. Feasey, Marriott Nliwasa, Katherine C. Horton, Elizabeth L. Corbett, Peter J. Dodd

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Predicted norovirus resurgence in 2021–2022 due to the relaxation of nonpharmaceutical interventions associated with COVID-19 restrictions in England: a mathematical modeling study

Kathleen M. O’Reilly, Frank Sandman, David Allen, Christopher I. Jarvis, Amy Gimma, Amy Douglas, Lesley Larkin, Kerry L. M. Wong, Marc Baguelin, Ralph S. Baric, Lisa C. Lindesmith, Richard A. Goldstein, Judith Breuer, W. John Edmunds

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Functional apoptosis profiling identifies MCL-1 and BCL-xL as prognostic markers and therapeutic targets in advanced thymomas and thymic carcinomas

Denise Müller, Paolo Mazzeo, Raphael Koch, Mark-Sebastian Bösherz, Stefan Welter, Alexander von Hammerstein-Equord, Marc Hinterthaner, Lucia Cordes, Djeda Belharazem, Alexander Marx, Philipp Ströbel, Stefan Küffer

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

COVID-19 and risk of subsequent life-threatening secondary infections: a matched cohort study in UK Biobank

Can Hou, Yihan Hu, Huazhen Yang, Wenwen Chen, Yu Zeng, Zhiye Ying, Yao Hu, Yajing Sun, Yuanyuan Qu, Magnús Gottfreðsson, Unnur A. Valdimarsdóttir, Huan Song

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

A combined genome-wide association and molecular study of age-related hearing loss in H. sapiens

Wei Liu, Åsa Johansson, Helge Rask-Andersen, Mathias Rask-Andersen

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

SARS-CoV-2 exposure in Malawian blood donors: an analysis of seroprevalence and variant dynamics between January 2020 and July 2021

Jonathan Mandolo, Jacquline Msefula, Marc Y. R. Henrion, Comfort Brown, Brewster Moyo, Aubrey Samon, Thandeka Moyo-Gwete, Zanele Makhado, Frances Ayres, Thopisang Motlou, Nonkululeko Mzindle, Newton Kalata, Adamson S. Muula, Gaurav Kwatra, Natasha Nsamala, Andrew Likaka, Thom Mfune, Penny L. Moore, Bridon Mbaya, Neil French, Robert S. Heyderman, Todd Swarthout, Kondwani C. Jambo

01.12.2021 | Guideline | Ausgabe 1/2021 Open Access

ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis

Virginia Chiocchia, Adriani Nikolakopoulou, Julian P. T. Higgins, Matthew J. Page, Theodoros Papakonstantinou, Andrea Cipriani, Toshi A. Furukawa, George C. M. Siontis, Matthias Egger, Georgia Salanti

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Dose-response association between device-measured physical activity and incident dementia: a prospective study from UK Biobank

Fanny Petermann-Rocha, Donald M. Lyall, Stuart R. Gray, Jason M. R. Gill, Naveed Sattar, Paul Welsh, Terence J. Quinn, William Stewart, Jill P. Pell, Frederick K. Ho, Carlos Celis-Morales

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Nocturnal dexmedetomidine alleviates post–intensive care syndrome following cardiac surgery: a prospective randomized controlled clinical trial

Chun-hui Dong, Chao-nan Gao, Xiao-hua An, Na Li, Le Yang, De-cai Li, Qi Tan

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Comparative effectiveness and safety of pharmaceuticals assessed in observational studies compared with randomized controlled trials

Yoon Duk Hong, Jeroen P. Jansen, John Guerino, Marc L. Berger, William Crown, Wim G. Goettsch, C. Daniel Mullins, Richard J. Willke, Lucinda S. Orsini

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Effects of prolonged incubation period and centralized quarantine on the COVID-19 outbreak in Shijiazhuang, China: a modeling study

Wenlong Zhu, Mengxi Zhang, Jinhua Pan, Ye Yao, Weibing Wang

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Antibody conversion rates to SARS-CoV-2 in saliva from children attending summer schools in Barcelona, Spain

Carlota Dobaño, Selena Alonso, Mariona Fernández de Sevilla, Marta Vidal, Alfons Jiménez, Gemma Pons Tomas, Chenjerai Jairoce, María Melé Casas, Rocío Rubio, María Hernández García, Gemma Ruiz-Olalla, Mònica Girona-Alarcón, Diana Barrios, Rebeca Santano, Robert A. Mitchell, Laura Puyol, Leonie Mayer, Jordi Chi, Natalia Rodrigo Melero, Carlo Carolis, Aleix Garcia-Miquel, Elisenda Bonet-Carne, Joana Claverol, Marta Cubells, Claudia Fortuny, Victoria Fumadó, Cristina Jou, Carmen Muñoz-Almagro, Luis Izquierdo, Quique Bassat, Eduard Gratacós, Ruth Aguilar, Juan José García-García, Gemma Moncunill, Iolanda Jordan

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Developing an integrated microsimulation model for the impact of fiscal policies on child health in Europe: the example of childhood obesity in Italy

Davide Rasella, Lorenzo Richiardi, Nicolai Brachowicz, H. Xavier Jara, Mark Hanson, Delia Boccia, Matteo G. Richiardi, Costanza Pizzi

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss

Caiyun Ge, Dan Xu, Pengxia Yu, Man Fang, Juanjuan Guo, Dan Xu, Yuan Qiao, Sijia Chen, Hui Wang, Yuanzhen Zhang

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Lifestyle correlates of eight breast cancer-related metabolites: a cross-sectional study within the EPIC cohort

Mathilde His, Vivian Viallon, Laure Dossus, Julie A. Schmidt, Ruth C. Travis, Marc J. Gunter, Kim Overvad, Cecilie Kyrø, Anne Tjønneland, Lucie Lécuyer, Joseph A. Rothwell, Gianluca Severi, Theron Johnson, Verena Katzke, Matthias B. Schulze, Giovanna Masala, Sabina Sieri, Salvatore Panico, Rosario Tumino, Alessandra Macciotta, Jolanda M. A. Boer, Evelyn M. Monninkhof, Karina Standahl Olsen, Therese H. Nøst, Torkjel M. Sandanger, Antonio Agudo, Maria-Jose Sánchez, Pilar Amiano, Sandra M. Colorado-Yohar, Eva Ardanaz, Linda Vidman, Anna Winkvist, Alicia K. Heath, Elisabete Weiderpass, Inge Huybrechts, Sabina Rinaldi

01.12.2021 | Review | Ausgabe 1/2021 Open Access

Ketone bodies: from enemy to friend and guardian angel

Hubert Kolb, Kerstin Kempf, Martin Röhling, Martina Lenzen-Schulte, Nanette C. Schloot, Stephan Martin

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

A comprehensive gene-centric pleiotropic association analysis for 14 psychiatric disorders with GWAS summary statistics

Haojie Lu, Jiahao Qiao, Zhonghe Shao, Ting Wang, Shuiping Huang, Ping Zeng

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Isoniazid or rifampicin preventive therapy with and without screening for subclinical TB: a modeling analysis

Emily A. Kendall, Hamidah Hussain, Amber Kunkel, Rachel W. Kubiak, Anete Trajman, Richard Menzies, Paul K. Drain

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Regular use of proton-pump inhibitors and risk of stroke: a population-based cohort study and meta-analysis of randomized-controlled trials

Man Yang, Qiangsheng He, Fang Gao, Krish Nirantharakumar, Tonny Veenith, Xiwen Qin, Amy T. Page, Martin C. S. Wong, Junjie Huang, Zi Chong Kuo, Bin Xia, Changhua Zhang, Yulong He, Wenbo Meng, Jinqiu Yuan, Yihang Pan

01.12.2021 | COVID-19 | Research article | Ausgabe 1/2021 Open Access

Within- and across-day patterns of interplay between depressive symptoms and related psychopathological processes: a dynamic network approach during the COVID-19 pandemic

Omid V. Ebrahimi, Julian Burger, Asle Hoffart, Sverre Urnes Johnson

01.12.2021 | COVID-19 | Review | Ausgabe 1/2021 Open Access

Models of COVID-19 vaccine prioritisation: a systematic literature search and narrative review

Nuru Saadi, Y-Ling Chi, Srobana Ghosh, Rosalind M. Eggo, Ciara V. McCarthy, Matthew Quaife, Jeanette Dawa, Mark Jit, Anna Vassall

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Is transcranial direct current stimulation, alone or in combination with antidepressant medications or psychotherapies, effective in treating major depressive disorder? A systematic review and meta-analysis

Jingying Wang, Huichun Luo, Rasmus Schülke, Xinyi Geng, Barbara J. Sahakian, Shouyan Wang

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies

Susanna C. Larsson, Stephen Burgess

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

The impact of high-risk medications on mortality risk among older adults with polypharmacy: evidence from the English Longitudinal Study of Ageing

Yun-Ting Huang, Andrew Steptoe, Li Wei, Paola Zaninotto

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

Assessment of anti-PD-(L)1 for patients with coexisting malignant tumor and tuberculosis classified by active, latent, and obsolete stage

Shan Su, Mei-Feng Ye, Xiao-Ting Cai, Xue Bai, Zhi-Hao Huang, Si-Cong Ma, Jian-Jun Zou, Yu-Xiang Wen, Li-Juan Wu, Xue-Jun Guo, Xian-Lan Zhang, Wen-Chang Cen, Duo-Hua Su, Hui-Yi Huang, Zhong-Yi Dong

01.12.2021 | Research article | Ausgabe 1/2021 Open Access

How robust are findings of pairwise and network meta-analysis in the presence of missing participant outcome data?

Loukia M. Spineli, Chrysostomos Kalyvas, Katerina Papadimitropoulou

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