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Pediatric Surgery International

Erschienen in:

01.12.2023 | Original Article

Outcomes of adult native liver survivors with biliary atresia: the current situation in Japan

verfasst von: Yunosuke Kawaguchi, Keita Terui, Ayako Takenouchi, Shugo Komatsu, Takeshi Saito, Tomoro Hishiki

Erschienen in: Pediatric Surgery International | Ausgabe 1/2023

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Abstract

Purpose

This study aimed to elucidate the difficulties faced by adult native liver survivors with biliary atresia (BA) in Japan.

Methods

A single-center, retrospective, observational study of 57 adult patients with BA was conducted. The clinical course of BA was compared between native liver survivors and non-survivors who reached adulthood. Indications and outcomes of liver transplantation (LT) among non-survivors were assessed.

Results

A significantly larger portion of non-survivors (n = 10) met the criteria for LT (p < 0.001) and received treatment for portal hypertension after reaching 20 years of age (p < 0.01) compared with the survivors. Causes of death included liver cirrhosis (n = 8), graft failure of living donor liver transplantation (LDLT) (n = 1), and hepatocarcinoma (n = 1). Two of the non-survivors who died of liver cirrhosis had no indication for LT because of alcohol dependence and uncontrolled infection. An appropriate donor candidate could not be found for the five patients who opted for LDLT. All six patients waitlisted for deceased donor liver transplantation (DDLT) died after a median waiting period of 17 months.

Conclusion

Adult BA patients in Japan have limited options for LT, mainly owing to low donor candidate availability for LDLT and a low prevalence of DDLT.

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Titel: Outcomes of adult native liver survivors with biliary atresia: the current situation in Japan
verfasst von: Yunosuke Kawaguchi
Keita Terui
Ayako Takenouchi
Shugo Komatsu
Takeshi Saito
Tomoro Hishiki
Publikationsdatum: 01.12.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Surgery International / Ausgabe 1/2023
Print ISSN: 0179-0358
Elektronische ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-023-05551-6

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Outcomes of adult native liver survivors with biliary atresia: the current situation in Japan

Abstract

Purpose

Methods

Results

Conclusion

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Purpose

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Results

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