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International Journal of Colorectal Disease

Erschienen in:

20.07.2022 | Research

Ovarian metastases in young women with colorectal cancer: a retrospective multicenter cohort study

verfasst von: R. van der Meer, C. Bakkers, J. A. Wegdam, T. Lettinga, E. G. Boerma, F. Aarts, I. H. J. T. de Hingh, R. M. H. Roumen

Erschienen in: International Journal of Colorectal Disease | Ausgabe 8/2022

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Abstract

Background and purpose

Previous studies indicated that approximately 3.4% of female colorectal cancer (CRC) patients are at increased risk of developing ovarian metastases (OM). It has been suggested that young women more frequently develop this form of metastatic disease.

Methods

This study evaluated, in 6 Dutch hospitals, the proportion of young women with CRC who developed OM.

Results

In a cohort of 200 young (age ≤ 55) women with CRC, the proportion of patients diagnosed with synchronous or metachronous OM was calculated. This study revealed that 5% (n = 10) of young female CRC patients developed ovarian metastases resulting in a 5-year overall survival rate of approximately 40%. Furthermore, six patients had concurrent peritoneal metastases, five patients had bilateral ovarian metastases, and five patients had synchronous metastases, while the median time of the occurrence of metachronous metastases (n = 5) was 19 months.

Conclusion

This retrospective multicenter cohort study indicates that 5% of young women with CRC either present with or develop OM. This result appears to be clinically relevant and demonstrates the need for improved surveillance for young women diagnosed with CRC.

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Titel: Ovarian metastases in young women with colorectal cancer: a retrospective multicenter cohort study
verfasst von: R. van der Meer
C. Bakkers
J. A. Wegdam
T. Lettinga
E. G. Boerma
F. Aarts
I. H. J. T. de Hingh
R. M. H. Roumen
Publikationsdatum: 20.07.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: International Journal of Colorectal Disease / Ausgabe 8/2022
Print ISSN: 0179-1958
Elektronische ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-022-04217-4

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