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Indian Journal of Surgical Oncology

Erschienen in:

25.08.2020 | Review Article

Pancreatic Cancer Immuno-oncology in the Era of Precision Medicine

verfasst von: Samarth Hegde

Erschienen in: Indian Journal of Surgical Oncology | Sonderheft 1/2021

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Abstract

Pancreatic malignancies carry a dismal prognosis globally, with pancreatic adenocarcinomas (PDAC) being particularly aggressive and stubborn. Unfortunately, several therapeutic strategies that show promise in other cancers have failed to make sizeable impact on pancreatic tumor outcomes. Responses to immunotherapies are especially rare in pancreatic cancer, and patients are in need of innovative approaches that can result in more durable responses. Current research in preclinical models and humans has suggested this resistance is due to a uniquely inflammatory and dysfunctional tumor microenvironment; these findings lay the groundwork for targeting these barriers and improving outcomes. Clinical analyses have also revealed unprecedented heterogeneity in tumor and stromal biology of PDAC, underscoring the need for more personalized approaches and combinatorial therapies. This review will highlight the current state of translational research focusing on PDAC immunity, summarize ongoing clinical efforts to tackle PDAC vulnerabilities, and underscore some unresolved challenges in implementing therapies more broadly. A better understanding of immune contexture and tumor heterogeneity in this disease will greatly accelerate drug discovery and implementation of precision medicine for PDAC.

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Titel: Pancreatic Cancer Immuno-oncology in the Era of Precision Medicine
verfasst von: Samarth Hegde
Publikationsdatum: 25.08.2020
Verlag: Springer India
Erschienen in: Indian Journal of Surgical Oncology / Ausgabe Sonderheft 1/2021
Print ISSN: 0975-7651
Elektronische ISSN: 0976-6952
DOI: https://doi.org/10.1007/s13193-020-01192-6

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