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07.11.2017 | Review

Pharmacological aspects and spectrum of action of ceftazidime–avibactam: a systematic review

verfasst von: Felipe Francisco Tuon, Jaime L. Rocha, Marcelo R. Formigoni-Pinto

Erschienen in: Infection | Ausgabe 2/2018

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Abstract

Purpose

Ceftazidime–avibactam is an antimicrobial association active against several Enterobacteriaceae species, including those resistant to carbapenem. Considering the importance of this drug in the current panorama of multidrug-resistant bacteria, we performed a systematic review about ceftazidime–avibactam with emphasis on clinical and pharmacological published data.

Methods

A systematic search of the medical literature was performed. The databases searched included MEDLINE, EMBASE and Web of Science (until September 2017). The search terms used were ‘avibactam’, ‘NXL104’ and ‘AVE1330A’. Bibliographies from those studies were also reviewed. Ceftazidime was not included as a search term, once relevant studies about avibactam in association with other drugs could be excluded. Only articles in English were selected. No statistical analysis or quality validation was included in this review.

Results

A total of 151 manuscripts were included. Ceftazidime–avibactam has limited action against anaerobic bacteria. Avibactam is a potent inhibitor of class A, class C, and some class D enzymes, which includes KPC-2. The best pharmacodynamic profile of ceftazidime–avibactam is ƒT > MIC, validated in an animal model of soft tissue infection. Three clinical trials showed the efficacy of ceftazidime–avibactam in patients with intra-abdominal and urinary infections. Ceftazidime–avibactam has been evaluated versus meropenem/doripenem in hospitalized adults with nosocomial pneumonia, neutropenic patients and pediatric patients.

Conclusion

Ceftazidime–avibactam has a favorable pharmacokinetic profile for severe infections and highly active against carbapenemases of KPC-2 type.

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Titel: Pharmacological aspects and spectrum of action of ceftazidime–avibactam: a systematic review
verfasst von: Felipe Francisco Tuon
Jaime L. Rocha
Marcelo R. Formigoni-Pinto
Publikationsdatum: 07.11.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Infection / Ausgabe 2/2018
Print ISSN: 0300-8126
Elektronische ISSN: 1439-0973
DOI: https://doi.org/10.1007/s15010-017-1096-y

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17.05.2024 Vorhofflimmern Nachrichten

Nicht nur ein vergrößerter, sondern auch ein kleiner linker Ventrikel ist bei Vorhofflimmern mit einer erhöhten Komplikationsrate assoziiert. Der Zusammenhang besteht nach Daten aus China unabhängig von anderen Risikofaktoren.

Semaglutid bei Herzinsuffizienz: Wie erklärt sich die Wirksamkeit?

17.05.2024 Herzinsuffizienz Nachrichten

Bei adipösen Patienten mit Herzinsuffizienz des HFpEF-Phänotyps ist Semaglutid von symptomatischem Nutzen. Resultiert dieser Benefit allein aus der Gewichtsreduktion oder auch aus spezifischen Effekten auf die Herzinsuffizienz-Pathogenese? Eine neue Analyse gibt Aufschluss.

Update Innere Medizin

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Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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