nach oben

Current Treatment Options in Oncology

Erschienen in:

06.04.2024

Photodynamic application in diagnostic procedures and treatment of non-melanoma skin cancers

verfasst von: Zhiya Yang, MEng, Dongmei Li, MD, Dongmei Shi, MD

Erschienen in: Current Treatment Options in Oncology | Ausgabe 5/2024

Einloggen, um Zugang zu erhalten

Opinion statement

Skin tumors commonly seen in dermatology are involved in all layers of the skin and appendages. While biopsy of affected skin remains an essential method to confirm diagnosis and to predicate tumor prognosis, it has its limitations. Recently, photodynamic diagnosis (PDD) has demonstrated high sensitivity in detecting affected skin and mucosal tissues, providing valuable guidance for precision surgery to resect skin and mucosal tumors. In this review, we summarized the literatures concerning the applications of PDD in diagnostic process and treatment of skin and mucosal conditions such as actinic keratoses (AK), basal cell carcinoma (BCC), squamous cell carcinoma (SCC), Bowen’s disease (BD) and extramammary Paget’s disease (EMPD). The findings suggest that PDD holds substantial promise for expanding clinical applications and deserves further research exploration.

Bhatt KD, Tambe SA, Jerajani HR, et al. Utility of high-frequency ultrasonography in the diagnosis of benign and malignant skin tumors. Indian J Dermatol Venereol Leprol. 2017;83(2):162–82. https://doi.org/10.4103/0378-6323.191136.CrossRefPubMed

Koh D, Wang H, Lee J, et al. Basal cell carcinoma, squamous cell carcinoma and melanoma of the skin: analysis of the Singapore Cancer Registry data 1968–97. Br J Dermatol. 2003;148(6):1161–6. https://doi.org/10.1046/j.1365-2133.2003.05223.CrossRefPubMed

Muzic JG, Schmitt AR, Wright AC, et al. Incidence and trends of basal cell carcinoma and cutaneous squamous cell carcinoma: a population-based study in Olmsted County, Minnesota, 2000 to 2010. Mayo Clin Proc. 2017;92(6):890–8. https://doi.org/10.1016/j.mayocp.2017.02.015.CrossRefPubMed

Strong LC. Genetic and environmental interactions. Cancer. 1977;40(S4):1861–6.CrossRefPubMed

Altamura D, Menzies SW, Argenziano G, et al. Dermatoscopy of basal cell carcinoma: morphologic variability of global and local features and accuracy of diagnosis. J Am Acad Dermatol. 2010;62(1):67–75. https://doi.org/10.1016/j.jaad.2009.05.035.CrossRefPubMed

Zalaudek I, Kreusch J, Giacomel J, et al. How to diagnose nonpigmented skin tumors: a review of vascular structures seen with dermoscopy: part II. Nonmelanocytic skin tumors. J Am Acad Dermatol. 2010;63(3):377–86. https://doi.org/10.1016/j.jaad.2009.11.697. quiz387-8.CrossRefPubMed

Wentzensen N, Walker JL, Gold MA, et al. Multiple biopsies and detection of cervical cancer precursors at colposcopy. J Clin Oncol. 2015;33(1):83–9. https://doi.org/10.1200/JCO.2014.55.9948.CrossRefPubMed

Tierney E, Petersen J, Hanke CW. Photodynamic diagnosis of tumor margins using methyl aminolevulinate before Mohs micrographic surgery. J Am Acad Dermatol. 2011;64(5):911–8. https://doi.org/10.1016/j.jaad.2010.03.045.CrossRefPubMed

Redondo P, Marquina M, Pretel M, et al. Methyl-ALA-induced fluorescence in photodynamic diagnosis of basal cell carcinoma prior to Mohs micrographic surgery. Arch Dermatol. 2008;144(1):115–7. https://doi.org/10.1001/archdermatol.2007.3.CrossRefPubMed

10.

Sieroń A, Kawczyk-Krupka A, Adamek M, et al. Photodynamic diagnosis (PDD) and photodynamic therapy (PDT) in dermatology: “how we do it.” Photodiagnosis Photodyn Ther. 2006;3(2):132–3. https://doi.org/10.1016/j.pdpdt.2006.03.009.CrossRefPubMed

11.

Nelson JS, Liaw LH, Lahlum RA, et al. Use of multiple photosensitizers and wavelengths during photodynamic therapy: a new approach to enhance tumor eradication. J Natl Cancer Inst. 1990;82(10):868–73. https://doi.org/10.1093/jnci/82.10.868.CrossRefPubMed

12.

Tappeiner HV, Joldlbauer A. On the effect of photodynamic (fluorescent) substance on protozoa and enzymes. Arch Klin Med. 1904;80:427–87.

13.

Policard A. Etude sur les aspects offers par des tumors expérimentales examinées à la lumière deWood. C R Soc Biol. 1924;91:1423–4.

14.

Manganiello LOJ, Figge FHJ. Cancer detection and therapy II methods of preparation and biological effects of metalloporphyrins. Bull Sch Med Univ Md. 1951;36:3–7.PubMed

15.

Katten Y, Koaka C, Ono S, et al. Pigment diagnosis and treatment. J Clin Surg. 1982;37:517–22.

16.

Xu S, Ma B. Laser technology and medical application. PMPH. 1989;1–10.

17.

• Yang Z, Liu C, Xiong H, et al. Photodynamic therapy, a promising treatment approach for cutaneous infectious granulomas. Photodiagnosis Photodyn Ther. 2022;39: 102952. https://doi.org/10.1016/j.pdpdt.2022.102952. This reference is of importance because the advantages of PDT can selectively target the lesions without invasive damages, PDT and PDD are inseparable. In addition, PDT can shorten the duration of treatment and reduce the side effects of antibiotics.CrossRefPubMed

18.

Hu Y, Masamune K. Flexible laser endoscope for minimally invasive photodynamic diagnosis (PDD) and therapy (PDT) toward efficient tumor removal. Opt Express. 2017;25(14):16795–812. https://doi.org/10.1364/OE.25.016795.CrossRefPubMed

19.

Fritsch C, Lang K, Neuse W, Ruzicka T, Lehmann P. Photodynamic diagnosis and therapy in dermatology. Skin Pharmacol Appl Skin Physiol. 1998;11(6):358–73. https://doi.org/10.1159/000029858.CrossRefPubMed

20.

Dobson J, de Queiroz GF, Golding JP. Photodynamic therapy and diagnosis: principles and comparative aspects. Vet J. 2018;233:8–18. https://doi.org/10.1016/j.tvjl.2017.11.012.CrossRefPubMed

21.

Motoori M, Yano M, Tanaka K, et al. Intraoperative photodynamic diagnosis of lymph node metastasis in esophageal cancer patients using 5-aminolevulinic acid. Oncol Lett. 2015;10(5):3035–9. https://doi.org/10.3892/ol.2015.3685.CrossRefPubMedPubMedCentral

22.

He J, Yang L, Yi W, et al. Combination of fluorescence-guided surgery with photodynamic therapy for the treatment of cancer. Mol Imaging. 2017;16. https://doi.org/10.1177/1536012117722911.

23.

•• Sasaki M, Tanaka M, Ichikawa H, et al. 5-Aminolaevulinic acid (5-ALA) accumulates in GIST-T1 cells and photodynamic diagnosis using 5-ALA identifies gastrointestinal stromal tumors (GISTs) in xenograft tumor models. PLoS ONE. 2021;16(4): e0249650. https://doi.org/10.1371/journal.pone.0249650. This reference is of importance because it demonstrates a strong potential for PDD and clinical applications of tumors (such as gastrointestinal stromal tumor) in the future.CrossRefPubMedPubMedCentral

24.

Fritsch C, Verwohlt B, Bolsen K, Ruzicka T, Goerz G. Influence of topical photodynamic therapy with 5-aminolevulinic acid on porphyrin metabolism. Arch Dermatol Res. 1996;288(9):517–21. https://doi.org/10.1007/BF02505247.CrossRefPubMed

25.

•• Woźniak Z, Trzeciakowski W, Chlebicka I, Ziółkowski P. Photodynamic diagnosis and photodynamic therapy in basal cell carcinoma using a novel laser light source. Photodiagnosis Photodyn Ther. 2020;31: 101883. https://doi.org/10.1016/j.pdpdt.2020.101883. This reference is of importance because it concluded that novel laser light source is safe, effective and convenient in photodynamic diagnosis and photodynamic therapy of basal cell carcinoma. It also seems like an efficient tool for treating actinic keratosis (AK) using conventional protocol PDT or new proposed protocol for PDT of AK.CrossRefPubMed

26.

Jeon SY, Kim KH, Song KH. Efficacy of photodynamic diagnosis-guided Mohs micrographic surgery in primary squamous cell carcinoma. Dermatol Surg. 2013;39(12):1774–83. https://doi.org/10.1111/dsu.12359.CrossRefPubMed

27.

Reinehr CPH, Bakos RM. Actinic keratoses: review of clinical, dermoscopic, and therapeutic aspects. An Bras Dermatol. 2019;94(6):637–57. https://doi.org/10.1016/j.abd.2019.10.004.CrossRefPubMedPubMedCentral

28.

•• Romero MP, Posso V, Ureña V, Inada N, Bagnato V, Cabrera F. Clinical and histopathological study of actinic keratosis treatment with photodynamic therapy VS 5-fluorouracil for face cancerization. Photodiagnosis Photodyn Ther. 2022;39:102967. https://doi.org/10.1016/j.pdpdt.2022.102967. This reference is of importance because the study showed fluorescence diagnosis, clinical and subclinical AK lesions were evidenced in the area called the "cancerization field." Two cycles of MALA-PDT were performed on each patient, and 5-FU was applied twice daily for 15 days. A 2-month follow-up post-MALA-PDT and post-5-FU was carried out. The treatment based on 5-Flu and MALA-PDT clinically shows the same response, but MALA-PDT is less aggressive than 5-FU. The treatment of AK based on MALA-PDT is a practical, inexpensive, and easy-to-use technique.CrossRefPubMed

29.

Tanese K. Diagnosis and management of basal cell carcinoma. Curr Treat Options Oncol. 2019;20(2):13. https://doi.org/10.1007/s11864-019-0610-0.CrossRefPubMed

30.

Smith RA, Andrews KS, Brooks D, et al. Cancer screening in the United States, 2019: a review of current American Cancer Society guidelines and current issues in cancer screening. CA Cancer J Clin. 2019;69(3):184–210. https://doi.org/10.3322/caac.21557.CrossRefPubMed

31.

Redondo P, Marquina M, Pretel M, Aguado L, Iglesias ME. Methyl-ALA-induced fluorescence in photodynamic diagnosis of basal cell carcinoma prior to Mohs micrographic surgery. Arch Dermatol. 2008;144(1):115–7. https://doi.org/10.1001/archdermatol.2007.3.CrossRefPubMed

32.

Fernández-Guarino M, Harto A, Pérez-García B, Royuela A, Jaén P. Six years of experience in photodynamic therapy for Basal cell carcinoma: results and fluorescence diagnosis from 191 lesions. J Skin Cancer. 2014;2014:849248. https://doi.org/10.1155/2014/849248.CrossRefPubMedPubMedCentral

33.

Ganly I, Kaye SB. Recurrent squamous-cell carcinoma of the head and neck: overview of current therapy and future prospects. Ann Oncol. 2000;11(1):11–6. https://doi.org/10.1023/a:1008330026617.CrossRefPubMed

34.

Stenquist B, Ericson MB, Strandeberg C, et al. Bispectral fluorescence imaging of aggressive basal cell carcinoma combined with histopathological mapping: a preliminary study indicating a possible adjunct to Mohs micrographic surgery. Br J Dermatol. 2006;154(2):305–9. https://doi.org/10.1111/j.1365-2133.2005.07035.x.CrossRefPubMed

35.

Kamrava SK, Behtaj M, Ghavami Y, et al. Evaluation of diagnostic values of photodynamic diagnosis in identifying the dermal and mucosal squamous cell carcinoma. Photodiagnosis Photodyn Ther. 2012;9(4):293–8. https://doi.org/10.1016/j.pdpdt.2012.03.004.CrossRefPubMed

36.

Jaeger AB, Gramkow A, Hjalgrim H, et al. Bowen disease and risk of subsequent malignant neoplasms: a population-based cohort study of 1147 patients. Arch Dermatol. 1999;135(7):790–3. https://doi.org/10.1001/archderm.135.7.790.CrossRefPubMed

37.

Truchuelo MT, Pérez B, Fernández-Guarino M, et al. Fluorescence diagnosis and photodynamic therapy for Bowen’s disease treatment. J Eur Acad Dermatol Venereol. 2014;28(1):86–93. https://doi.org/10.1111/jdv.12064.CrossRefPubMed

38.

Bayan CY, Khanna T, Rotemberg V, et al. A review of non-invasive imaging in extramammary Paget’s disease. J Eur Acad Dermatol Venereol. 2018;32(11):1862–73. https://doi.org/10.1111/jdv.15072.CrossRefPubMed

39.

Kaku-Ito Y, Ito T, Tsuji G, et al. Evaluation of mapping biopsies for extramammary Paget disease: a retrospective study. J Am Acad Dermatol. 2018;78(6):1171–7. https://doi.org/10.1016/j.jaad.2017.12.040.CrossRefPubMed

40.

Li L, Deng Y, Zhang L, Liao W, Luo R, Huang Z. Treatment of perianal Paget’s disease using photodynamic therapy with assistance of fluorescence examination: case report. Lasers Med Sci. 2009;24(6):981–4. https://doi.org/10.1007/s10103-009-0653-8.CrossRefPubMed

41.

•• Li X, Zhao C, Kou H, Zhu F, Yang Y, Lu Y. PDD-guided tumor excision combined with photodynamic therapy in patients with extramammary Paget’s disease. Photodiagnosis Photodyn Ther. 2022;38:102841. https://doi.org/10.1016/j.pdpdt.2022.102841. This reference is of importance because the study suggested PDD may forecast tumor margins in EMPD to guide surgery, which is an effective protocol using PDD for diagnosis and PDT for multiple therapies, showing potential as a clinical treatment for EMPD.CrossRefPubMed

42.

Redondo P, Marquina M, Pretel M, et al. MAL-induced fluorescence in photodynamic diagnosis of BCC prior to Mohs surgery. Arch Dermatol. 2008;144(1):115–7. https://doi.org/10.1001/archdermatol.2007.3.CrossRefPubMed

43.

Grimbergen MC, van Swol CF, Jonges TG, Boon TA, van Moorselaar RJ. Reduced specificity of 5-ALA induced fluorescence in photodynamic diagnosis of transitional cell carcinoma after previous intravesical therapy. Eur Urol. 2003;44(1):51–6. https://doi.org/10.1016/s0302-2838(03)00210-0.CrossRefPubMed

44.

Ray ER, Chatterton K, Khan MS, et al. Hexylaminolaevulinate fluorescence cystoscopy in patients previously treated with intravesical bacille Calmette-Guérin. BJU Int. 2010;105(6):789–94. https://doi.org/10.1111/j.1464-410X.2009.08839.x.CrossRefPubMed

45.

Fantini F, Greco A, Cesinaro AM, et al. Pathologic changes after photodynamic therapy for Basal cell carcinoma and Bowen disease: a histologic and immunohistochemical investigation. Arch Dermatol. 2008;144(2):186–94. https://doi.org/10.1001/archdermatol.2007.31.CrossRefPubMed

46.

Gupta AK, Versteeg SG, Shear NH. Onychomycosis in the 21st century: an update on diagnosis, epidemiology, and treatment. J Cutan Med Surg. 2017;21(6):525–39. https://doi.org/10.1177/1203475417716362.CrossRefPubMed

47.

Wetzig T, Kendler M, Maschke J, Paasch U, Simon JC. No clinical benefit of preoperative fluorescence diagnosis of basal cell carcinoma localized in the H-zone of the face. Br J Dermatol. 2010;162(6):1370–6. https://doi.org/10.1111/j.1365-2133.2010.09666.x.CrossRefPubMed

Titel: Photodynamic application in diagnostic procedures and treatment of non-melanoma skin cancers
verfasst von: Zhiya Yang, MEng
Dongmei Li, MD
Dongmei Shi, MD
Publikationsdatum: 06.04.2024
Verlag: Springer US
Erschienen in: Current Treatment Options in Oncology / Ausgabe 5/2024
Print ISSN: 1527-2729
Elektronische ISSN: 1534-6277
DOI: https://doi.org/10.1007/s11864-024-01193-5

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Photodynamic application in diagnostic procedures and treatment of non-melanoma skin cancers

Opinion statement

Neu im Fachgebiet Onkologie

Alphablocker schützt vor Miktionsproblemen nach der Biopsie

Antikörper-Wirkstoff-Konjugat hält solide Tumoren in Schach

Mammakarzinom: Senken Statine das krebsbedingte Sterberisiko?

Labor, CT-Anthropometrie zeigen Risiko für Pankreaskrebs

Update Onkologie

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Opinion statement

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2024

Role of Metastasis-Directed Therapy in Genitourinary Cancers

Circulating Tumor DNA in Diffuse Large B-Cell Lymphoma: from Bench to Bedside?

Correction to: Surgical Management and Considerations for Patients with Localized High-Risk Prostate Cancer

Molecular Heterogeneity in Leiomyosarcoma and Implications for Personalised Medicine

Precision Cardio-oncology: Update on Omics-Based Diagnostic Methods

Immunotherapy for Brain Tumors: Where We Have Been, and Where Do We Go From Here?

Neu im Fachgebiet Onkologie

Alphablocker schützt vor Miktionsproblemen nach der Biopsie

Antikörper-Wirkstoff-Konjugat hält solide Tumoren in Schach

Mammakarzinom: Senken Statine das krebsbedingte Sterberisiko?

Labor, CT-Anthropometrie zeigen Risiko für Pankreaskrebs

Update Onkologie