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Cardiovascular Toxicology

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01.09.2010 | Original Research

Pomegranate (Punica granatum L.) Juice Supplementation Attenuates Isoproterenol-Induced Cardiac Necrosis in Rats

verfasst von: Ravirajsinh N. Jadeja, Menaka C. Thounaojam, Dipak K. Patel, Ranjitsinh V. Devkar, A. V. Ramachandran

Erschienen in: Cardiovascular Toxicology | Ausgabe 3/2010

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Abstract

The aim of the present study was to evaluate the efficacy of pre-supplementation with pomegranate (Punica granatum L.) juice (PJ) on heart weight, infarct size, plasma marker enzymes of cardiac damage, lipid peroxidation, endogenous enzymatic and non-enzymatic antioxidants, cardiac ATPases and histopathology of isoproterenol (IP)-induced cardiac necrosis (CN) in rats. Rats treated with IP (85 mg/kg, s.c.) for 2 days at an interval of 24 h caused significant (P < 0.05) infarct in myocardium and increase in heart weight, lipid peroxidation (LPO), activity levels of Ca⁺² ATPase and plasma marker enzymes, while there was significant (P < 0.05) decrease in endogenous enzymatic and non-enzymatic antioxidants and Na⁺-K⁺ and Mg⁺²ATPases. Pre-supplementation with PJ for 30 consecutive days and treated with IP on days 29th and 30th showed significantly (P < 0.05) lesser increase in heart weight, infarct size, plasma marker enzymes, lipid peroxidation, Ca⁺² ATPase and a significant protective effect in endogenous enzymatic and non-enzymatic antioxidants, Na⁺-K⁺ and Mg⁺² ATPases compared to IP alone treated group. Present study provides first scientific report on protective effect of supplementation of Pomegranate juice against IP-induced CN in rats.

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Titel: Pomegranate (Punica granatum L.) Juice Supplementation Attenuates Isoproterenol-Induced Cardiac Necrosis in Rats
verfasst von: Ravirajsinh N. Jadeja
Menaka C. Thounaojam
Dipak K. Patel
Ranjitsinh V. Devkar
A. V. Ramachandran
Publikationsdatum: 01.09.2010
Verlag: Humana Press Inc
Erschienen in: Cardiovascular Toxicology / Ausgabe 3/2010
Print ISSN: 1530-7905
Elektronische ISSN: 1559-0259
DOI: https://doi.org/10.1007/s12012-010-9076-9

Springer Medizin

Abstract

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