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Archives of Gynecology and Obstetrics

Erschienen in:

05.02.2024 | Gynecologic Endocrinology and Reproductive Medicine

Prioritized single vitrified blastocyst to be warmed between grades 3 or 4 blastocyst on day 5 transfer cycles

verfasst von: Juan Ji, Xiufeng Ling, Qiao Zhou, Lin Zhou, Hui Ji, Xun Wu, Juanqiang Zhang, Shanren Cao

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 4/2024

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Abstract

Purpose

Selecting the optimal blastocyst to implant during cryopreservation and warming is critial for in vitro fertilization success. Therefore, the aim of this study was to explore which blastocyst should be prioritized to be thawed when facing a single vitrified blastocyst on day 5 transfer.

Methods

A retrospective study including 1,976 single vitrified-warmed blastocyst transfer cycles was conducted from January 2016 to December 2020.

Results

We found that grade 4 vitrified blastocyst had a higher clinical pregnancy (60.64% vs. 49.48%, P < 0.001) and live birth rates (50.12% vs 39.59%, P < 0.001) than the grade 3 vitrified blastocyst. However, no statistical difference was found between groups in miscarriage rate, birth weight, or gestational age. Besides, the grade 4 vitrified–thawed blastocyst had significant potential to develop into grade 6 blastocyst after further culturing for 16 h (73.68% vs. 48.60%, P < 0.001). The grade 6 transferred blastocyst was markedly higher in both clinical pregnancy rate (61.88% vs. 51.53%, P < 0.001) and live birth rate (50.91% vs. 40.46%, P < 0.001) compared to grade 5 transferred blastocyst.

Conclusions

Grade 4 vitrified blastocyst is recommended when facing single vitrified blastocyst on day 5 transfer. More importantly, the “embryonic escape hypothesis” was firstly proposed to reveal the findings.

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Titel: Prioritized single vitrified blastocyst to be warmed between grades 3 or 4 blastocyst on day 5 transfer cycles
verfasst von: Juan Ji
Xiufeng Ling
Qiao Zhou
Lin Zhou
Hui Ji
Xun Wu
Juanqiang Zhang
Shanren Cao
Publikationsdatum: 05.02.2024
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 4/2024
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-023-07336-7

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Prioritized single vitrified blastocyst to be warmed between grades 3 or 4 blastocyst on day 5 transfer cycles