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Erschienen in:

01.12.2023 | Review

Quality of life in patients with malignant spinal cord compression: a systematic review

verfasst von: Milena Gojsevic, Saba Shariati, Adrian Wai Chan, Pierluigi Bonomo, Elwyn Zhang, Samantha K. F. Kennedy, Thenugaa Rajeswaran, Dirk Rades, Vassilios Vassiliou, Hany Soliman, Shing-Fung Lee, Henry C. Y. Wong, Agata Rembielak, Eva Oldenburger, Shereen Akkila, Lucas Azevedo, Edward Chow, On behalf of EORTC Quality of Life Group

Erschienen in: Supportive Care in Cancer | Ausgabe 12/2023

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Abstract

Introduction

Malignant spinal cord compression (MSCC) is an oncological emergency that may result in a devastating combination of malignancy and disability. Existing quality of life (QoL) questionnaires commonly used in MSCC literature (EORTC QLQ-C30, BM-22, Brief Pain Inventory, and Spine Oncology Study Group Outcomes) may not capture all the commonly reported symptoms and lack specificity to MSCC. The primary objective of this systematic review is to determine unmet patient needs and underreported QoL issues and compile a comprehensive list of QoL issues. The secondary objective of this review is to compile all existing QoL tools and questionnaires and determine whether any QoL issues are not addressed in the existing tools currently used in the literature.

Methods

A literature search was conducted on Ovid MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials databases between 1946 and February 6, 2023, to compile all QoL issues and existing questionnaires used to assess QoL in patients with MSCC. All study designs were included given that they discussed QoL issues specific to patients with MSCC.

Results

The results of this systematic review identified the most frequently discussed QoL issues in the literature studying MSCC. This included direct symptoms of MSCC such as back pain, paralysis, limb weakness/numbness, and urinary/bowel incontinence. Indirect symptoms coming from radiotherapy treatment such as dysphagia, painful swallowing, mouth pain, dry mouth, diarrhea, fatigue, and nausea/vomiting were also noted. Other symptoms resulting from corticosteroid treatment included difficulty sleeping, blurring of vision, weight gain, and mood disturbance. Patients also experienced psychosocial issues such as anxiety, depression, emotional distress, low self-esteem, concerns about dependence on others, concerns about getting home, and fear about their prognosis and future.

Conclusion

This review highlights the QoL issues specific to patients with MSCC and QoL tools capturing these issues. Relevance of QoL issues identified in this systematic review must be prospectively validated by patients and healthcare professionals with experience in treating MSCC.

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Titel: Quality of life in patients with malignant spinal cord compression: a systematic review
verfasst von: Milena Gojsevic
Saba Shariati
Adrian Wai Chan
Pierluigi Bonomo
Elwyn Zhang
Samantha K. F. Kennedy
Thenugaa Rajeswaran
Dirk Rades
Vassilios Vassiliou
Hany Soliman
Shing-Fung Lee
Henry C. Y. Wong
Agata Rembielak
Eva Oldenburger
Shereen Akkila
Lucas Azevedo
Edward Chow
On behalf of EORTC Quality of Life Group
Publikationsdatum: 01.12.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 12/2023
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-023-08186-4

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Quality of life in patients with malignant spinal cord compression: a systematic review

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