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Archives of Virology

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03.08.2022 | Brief Report

Rapid emergence of a PB2 D701N substitution during adaptation of an H9N2 avian influenza virus in mice

verfasst von: Fan Yang, Xiaodi Zhang, Fumin Liu, Hangping Yao, Nanping Wu, Haibo Wu

Erschienen in: Archives of Virology | Ausgabe 11/2022

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Abstract

H9N2 avian influenza viruses (AIVs) have been isolated frequently from multiple avian species and, occasionally, from humans. To explore the potential molecular basis of cross-species transmission of H9N2 AIVs, an H9N2 AIV (A/chicken/Zhejiang/221/2016) was serially passaged in mouse lung. The results showed that the mouse-adapted H9N2 virus exhibited higher virulence and replicated more efficiently in mouse lung and liver. Whole-genome sequencing showed an amino acid substitution, D701N, in the PB2 protein, which is likely associated with the increased replicative ability of H9N2 virus in mice. The rapid emergence of adaptive substitutions indicates the necessity of continuous monitoring of H9N2 virus in poultry.

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Titel: Rapid emergence of a PB2 D701N substitution during adaptation of an H9N2 avian influenza virus in mice
verfasst von: Fan Yang
Xiaodi Zhang
Fumin Liu
Hangping Yao
Nanping Wu
Haibo Wu
Publikationsdatum: 03.08.2022
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 11/2022
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-022-05536-1

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Rapid emergence of a PB2 D701N substitution during adaptation of an H9N2 avian influenza virus in mice

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