Erschienen in:
10.08.2021 | Bild und Fall
Rescued from desperation: adult-onset Still’s disease with life-threatening interstitial lung disease and macrophage activation
Successful treatment by Tocilizumab
verfasst von:
Guangfeng Zhang, Wenxue Liu, Xiao Zhang, Liang Liu
Erschienen in:
Zeitschrift für Rheumatologie
|
Ausgabe 4/2022
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Abstract
This article presents a case of fulminant interstitial lung disease (ILD) with macrophage activation syndrome (MAS) as a rare complication of adult-onset Still’s disease in a 43-year-old male patient. Initial presentation showed severe ILD. Early treatment focused on high-dose corticosteroids; however, disease remission could not be achieved. After an additional inflammatory focus and underlying malignancy were excluded, the triad of pancytopenia, fever, and high ferritin levels indicated MAS; bone marrow biopsy confirmed secondary hemophagocytic histiocytosis. Treatment with tocilizumab induced fast and effective therapeutic success.