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Inflammation Research

Erschienen in:

15.08.2022 | Review

Review: the role of GSDMD in sepsis

verfasst von: Ruifei Shao, Xiran Lou, Jinfang Xue, Deyuan Ning, Guobing Chen, Lihong Jiang

Erschienen in: Inflammation Research | Ausgabe 10-11/2022

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Abstract

Purpose

Gasdermin D (GSDMD) is a cytoplasmic protein that is encoded by the gasdermin family GSDMD gene and is the ultimate executor of pyroptosis. Pyroptosis is a mode of lysis and inflammation that regulates cell death, ultimately leading to cell swelling and rupture. In sepsis, a dysregulated host response to infection frequently results in hyperinflammatory responses and immunosuppression, eventually leading to multiple organ dysfunction. Pyroptosis regulates innate immune defenses and plays an important role in the process of inflammatory cell death, and the absence of any link in the entire pathway from GSDMD to pyroptosis causes bacterial clearance to be hampered. Under normal conditions, the process of pyroptosis occurs much faster than apoptosis, and the threat to the body is also much greater.

Materials and methods

We conducted a systematic review of relevant reviews and experimental articles using the keywords sepsis, Gasdermin D, and Pyroptosis in the PubMed, Scopus, Google Scholar, and Web of Science databases.

Conclusion

Combined with the pathogenesis of sepsis, it is not difficult to find that pyroptosis plays a key role in bacterial inflammation and sepsis. Therefore, GSDMD inhibitors may be used as targeted drugs to treat sepsis by reducing the occurrence of pyroptosis. This review mainly discusses the key role of GSDMD in sepsis.

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Titel: Review: the role of GSDMD in sepsis
verfasst von: Ruifei Shao
Xiran Lou
Jinfang Xue
Deyuan Ning
Guobing Chen
Lihong Jiang
Publikationsdatum: 15.08.2022
Verlag: Springer International Publishing
Erschienen in: Inflammation Research / Ausgabe 10-11/2022
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI: https://doi.org/10.1007/s00011-022-01624-9

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25.04.2024 | Hypotonie | Nachrichten

Update Innere Medizin

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Springer Medizin

Review: the role of GSDMD in sepsis

Abstract

Purpose

Materials and methods

Conclusion

Leitlinien kompakt für die Innere Medizin

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Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Viel Bewegung in der Parkinsonforschung

Adjuvante Immuntherapie verlängert Leben bei RCC

Update Innere Medizin

Springer Medizin

Abstract

Purpose

Materials and methods

Conclusion

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Viel Bewegung in der Parkinsonforschung

Adjuvante Immuntherapie verlängert Leben bei RCC

Update Innere Medizin