Risk factors for aneurysm rupture among Kazakhs: findings from a national tertiary hospital

Intracranial saccular aneurysms develop when the wall of the cerebral artery becomes weak to resist hemodynamic pressure [1]. A RIA causes SAH associated with a high rate of mortality, with an in-hospital mortality rate of 18% [2], and permanent disability [3, 4]. SAH is attributed to 85% of IAs ruptures [5]. With such devastating outcomes, it is urgent to identify and prevent IAs from rupturing. However, many IAs remain stable throughout their lifetime, with one lifelong cohort study reporting one-third of rupture cases among the participants with IA [6]. Therefore, identifying markers differentiating stable IAs from those at risk of rupture would be essential to avoid unnecessary surgical interventions as well as avoiding neglect of the patients with SAH risks.

The prevalence of IAs was estimated to be 3.2% in the general population worldwide [7]. The population of Kazakhstan is around 18,700,000 people with around 67.5% of ethnic Kazakhs [8, 9]. About 500,000 people develop IAs, and the annual incidence of IAs is estimated to be 5.4 cases per 100,000 people [10, 11]. However, the true number of IAs in Kazakhstan remains unknown, as available statistics are limited to those who attended diagnostic clinics and hospitals.

Age, sex, arterial hypertension, smoking, history of SAH, aneurysm size, and location are all known risk factors for RIA [12‐14]. The average age of the population with IA varies according to the previous studies [15‐19]. A large multinational study has found that the average age of patients with IA is 50.4 years old [17]. Country-specific findings varied, the average age of IA diagnosis is 53.2 years old in Finland [18], 52 years old in the Netherlands [16], and 60–63 years old in Japan [15, 19]. According to the large cohort study, the IAs occurrence ratio discrepancy between sexes in the adult population was 3:1 female to male [20]. It was found that the size of aneurysms in 90% of cases is less than 10 mm in diameter and anterior cerebral circulation accounts for 90% of IA locations [21]. More than 20–29% of the population with IAs have multiple aneurysms [13, 22]. In addition, ethnic factors [12, 14] and irregular IAs shape [15, 23, 24] play a role in the risk of rupture.

Significant differences in RIA risk factors were found among different study population groups. Specifically, several Japanese [15, 25], Finnish [6, 18] and Australian [26] studies have demonstrated higher risks of RIAs < 7 mm in size than what has been previously reported in several international studies [20, 27]. This study aims to define the risk factors associated with RIA among Kazakhs, as no such work has been done prior.

Seven hundred sixty-two patients with single aneurysm diagnosis data were reviewed (Table 1). Among them, 68% had ruptured aneurysms and approximately 32% had unruptured aneurysms. The mean age of the patients was 48.49 ± 0.44 years with the youngest being 16 years old and the oldest 81 years old. RIA occurred at a significantly higher proportion (79.66%) among the youngest age group of 16–40 years old. Approximately 60% of the participants were women and 40% were men. However, rupture occurred in men more frequently than in women. A quarter of the patients were smokers and almost 84% of smokers had ruptured aneurysms. Just under 30% of the patients had no arterial hypertension, and about 43% had stage 3 hypertension. The proportion of aneurysm rupture was significantly higher (80.66%) among those with stage 3 hypertension. The rest were diagnosed with stage 1 (4.72%) and stage 2 (22.97%) hypertension. The average size of the aneurysms was 9.81 ± 0.29 mm. Unruptured aneurysms were significantly larger than those that did rupture (13.41 ± 0.67 vs 8.15 ± 0.27). The majority of the aneurysms fell into the medium size category (44.09%); however, small-sized aneurysms had the highest proportion of rupture (78.62%). Most of the aneurysms (38.71%) were located on the ICA, but ACA had the highest proportion (87.82%) of ruptured aneurysms.

The correlation between RIAs size and the location of the IAs was found in ACA and ICA (Figure 1). As can be seen from the Figure the distribution of sizes was right-skewed and significantly smaller among RIAs in ACA and ICA. No such correlation was found at MCA and PCA.

Multivariable logistic regression was built to determine factors associated with aneurysm rupture. All variables that showed statistical significance and had a biological basis were considered for the model. Our model included categorical age, sex of the participants, aneurysm size, aneurysm location, arterial hypertension, and smoking as factors influencing the odds of rupture (Table 2). Compared to the youngest age group (16–40 years), other age groups had decreasing odds of rupture with the lowest likelihood (0.07 times) in the oldest age group, when adjusted for other variables. Men had 17% higher odds of rupture, when compared to women and adjusted for other variables. An increase in size decreased the rupture likelihood when compared to the small aneurysms with the smallest odds of 0.22 in giant aneurysms when adjusting to other variables. IA’s location on ACA compared to ICA increased the adjusted odds of rupture 5.43 times. Patients with stage 3 hypertension had a 12.4 times higher likelihood of aneurysm rupture when compared to patients with normal arterial blood pressure and adjusting for other variables. The odds of smokers increased by 86% when compared to non-smokers and adjusted for other variables.

This study aimed to identify risk factors associated with RIA in the Kazakh population. To our knowledge, this is the first study to analyze differentiating factors between those with ruptured and unruptured IAs. The participants of the study were patients who underwent treatment in the NCN located in the capital of Kazakhstan, Nur-Sultan, which admits patients from all over the country.

From the results of the logistical model, such factors as younger age, active smoking status, stage 3 hypertension, location of the aneurysm on ACA, and smaller aneurysm size (< 6 mm) increased the odds of aneurysm rupture. Although studies have shown an association of female sex with reduced risk of aneurysm rupture [30], in the model of this study the factor of sex becomes insignificant when adjusted for other variables. In an unadjusted analysis, men had 1.78 times higher odds of IA rupture, but when adjusted for other variables the odds fell to 1.17. Unadjusted smoking had increased the odds of rupture 3 times, but adjustment for other variables lowered it to 1.86 times, indicating a possible confounding effect. Among our participants, 87.5% of smokers were men.

In line with findings from other studies [30‐32], the youngest age group in our sample had higher odds of RIA. There are several possible explanations for such observation. As was noted [31] in a previous study, this might be due to the slower blood flow rate, as well as due to the calcification of arterial walls among older patients. Meanwhile, Zhang and colleagues [32] found an association between the younger age of the participants and morphological features that are more likely to lead to the rupture, such as the presence of daughter and irregular domes, larger flow angle, and other features. Unfortunately, such factors were not available for analysis in this study.

Hypertension was another factor that had the largest effect on the odds of rupture. Stage 3 hypertension increased the odds of RIA by 12 times when compared to the patients with normal blood pressure. Similar results to a varying degree were found in other studies [33‐35].

Multivariable logistic regression showed that aneurysms located on ACA had 5.43 times increase in odds of rupture compared to ICA. Different studies have found different sites to be more prone to rupture. For example, the ARETA study found an association of ACA/Acom location with RIA [35], while the PHASES study had shown a higher correlation of RIA with PCA and PCoA [12]. In this study sample, the majority (38.71%) of the aneurysms were located on ICA, but only 50.51% of them had ruptured. Meanwhile, among the 29.92% of aneurysms that were located on ACA 87.82% have ruptured. Overall, aneurysms located on ACA accounted for 38.39% of all ruptured IAs in our sample.

Interestingly, smaller aneurysms in this study had a higher likelihood of rupture, while large and giant IAs had a lower probability of rupture. The correlation of rupture with the size of the aneurysm was tested in different locations of the aneurysm, and RIAs on ACA were statistically significantly smaller than unruptured IAs in the same location. Similarly, the same correlation with size was found on ICA. PCA and MCA did not have a significant difference in the sizes of ruptured and unruptured aneurysms. This result confirms findings that suggest anterior communicating artery aneurysms have a higher probability of rupture at a smaller size [36].

There also could be a genetic factor influencing the prevalence of RIA on ACA among our sample. As was found in a previous study, 13 SNPs are associated with the risk of development and rupture of aneurysms in the Kazakh population [37] Other factors, such as morphological features of IAs, were found to be good predictors of IAs rupture [38]. However, no correlation was found between morphological features that predispose to rupture with the size of IA [39]. Therefore, a subset of small aneurysms can be at heightened risk for rupture, which could be the case in our sample.

A study conducted in Finland has shown that 68% of RIA were smaller than 10 mm [18]. The majority of the aneurysms among the population they studied were located on MCA and ACoA. The results differ from those found in a pooled analysis, which indicated location on PCoA as well as aneurysms size ≥ 20 mm as risk factors for North American and European countries [12]. Finland and Japan were the only exceptions. A Japanese study has shown 64.6% of the small IAs (< 6 mm) and 73.9% of medium IAs (≥ 6–15 mm) have ruptured with the majority of the IAs located on ACA [40], which is similar to findings in our study.

Although the PHASES score [12] developed to estimate the risk of RIA suggests minimal risks of rupture for those younger than 70 and with smaller IA (< 10 mm), these recommendations are contrary to the findings of the studies conducted in Japan and Finland. Our study has also confirmed the necessity for a more thorough examination of IAs without the assumption that smaller IA would not rupture. As was noted by Zanaty et al. there is an increasing pool of evidence suggesting a high risk of rupture for smaller aneurysms. The study also emphasized the importance of establishing specific indicators that identify the instability of the small aneurysms at risk of rupture [39]. Population-specific studies are important for establishing more accurate risk factors for the populations, as the findings suggest that increased attention to smaller IAs could decrease SAH incidences among Kazakhs.

This is the first study to examine factors associated with RIA among the Kazakh population. This study has identified younger age, smoking status, stage 3 hypertension, size < 6 mm, and location on ACA as risk factors for RIA among the Kazakhs. Although the larger size of IAs is a major risk factor in many North American and European studies, the Kazakh population coincides with findings from the Finnish and Japanese cohorts, where smaller IAs were at higher risk of rupture. This study confirms the need for a more thorough examination of IA on such aspects as morphology regardless of the size, and the need to pay more sensibility to ethnic differences in risk factors, especially in ethnically diverse countries. Future prospective cohort studies should be conducted to better understand the etymology of IA.