Introduction
Methods
Patients
Questionnaire index
Biochemical index analysis
Ultrasound investigation
Statistical analysis
Results
Baseline characteristics
Area | Total joints | Lesions | The percentage of lesions in total joints (%) | Chi-square value | P value | |
---|---|---|---|---|---|---|
Right side | Left side | |||||
Knees | 234 | 22 (18.8%) | 16 (13.7%) | 16.2 | 19.983 | < 0.001 |
Ankles | 234 | 50 (42.7%) | 43 (36.8%) | 39.7 | 11.174 | 0.001 |
MTP 1 | 234 | 56 (47.9%) | 56 (47.9%) | 47.9 | 3.706 | 0.054 |
Lesions examination of joints
Area | Hypodermic edema | Joint effusion | Tenosynovitis | Synovial hyperplasia | Synovitis | Tophi | Double-contour sign | Bone erosion | Tendon sheath effusion | Crystal deposition |
---|---|---|---|---|---|---|---|---|---|---|
Right knee | 0 | 11 | 0 | 0 | 1 | 7 | 16 | 0 | 0 | 0 |
Left knee | 0 | 6 | 0 | 0 | 1 | 4 | 14 | 0 | 0 | 0 |
Right ankle | 18 | 20 | 3 | 2 | 6 | 6 | 23 | 0 | 0 | 0 |
Left ankle | 17 | 22 | 1 | 1 | 4 | 7 | 21 | 0 | 1 | 1 |
Right MTP 1 | 0 | 1 | 0 | 1 | 15 | 36 | 33 | 17 | 0 | 3 |
Left MTP 1 | 1 | 2 | 0 | 0 | 11 | 42 | 31 | 19 | 0 | 1 |
Risk factors analysis of double-contour sign
Parameters | Groups | Without double-contour sign | With double-contour sign | P value |
---|---|---|---|---|
Age* | 37.510 ± 11.709 | 42.640 ± 11.694 | 0.020 | |
BUN (mmol/L) | 5.094 ± 1.461 | 5.368 ± 1.719 | 0.458 | |
CREA (μmol/L) | 75.672 ± 17.683 | 78.345 ± 19.149 | 0.429 | |
UA (μmol/L)* | 443.640 ± 114.603 | 518.120 ± 131.620 | 0.002 | |
TC (mmol/L) | 4.781 ± 1.178 | 4.823 ± 1.450 | 0.646 | |
TG (mmol/L) | 2.049 ± 1.401 | 2.179 ± 1.644 | 0.916 | |
FBG (mmol/L) | 5.217 ± 0.708 | 5.315 ± 1.004 | 0.511 | |
Sex | Female | 3 | 0 | 0.180 |
Male | 50 | 64 | ||
BMI | Normal | 7 | 11 | 0.598 |
Overweight | 22 | 21 | ||
Obesity | 24 | 32 | ||
Duration | ≤ 1 year | 23 | 4 | < 0.001 |
1–5 years | 21 | 35 | ||
≥ 5 years | 9 | 25 | ||
Gout attack in 1 year | 0–2 times | 29 | 13 | < 0.001 |
3–6 times | 20 | 27 | ||
7–12 times | 4 | 24 | ||
Peak blood UA | 421–539 | 19 | 5 | < 0.001 |
≥ 540 | 34 | 59 | ||
UA level | ≤ 421 | 13 | 3 | < 0.001 |
421–539 | 20 | 15 | ||
≥ 540 | 20 | 46 | ||
Frequency of UA or renal function examination | Regularly checked | 13 | 5 | 0.053 |
Occasionally checked | 18 | 26 | ||
Check only when gout attacks | 22 | 31 | ||
Eating habits | Strict diet | 14 | 17 | 0.967 |
Avoid the high purine diet as much as possible, but not strictly controlled | 23 | 29 | ||
No control over diet | 16 | 18 | ||
Medication during the interval | Insist on taking | 15 | 5 | 0.009 |
Without medications | 29 | 41 | ||
Occasional medications | 8 | 17 | ||
Hypertensive | No | 43 | 45 | 0.177 |
Yes | 10 | 19 | ||
CHD | No | 52 | 60 | 0.482 |
Yes | 1 | 4 | ||
Diabetes | No | 51 | 62 | 1.000 |
Yes | 2 | 2 | ||
CKD | No | 49 | 63 | 0.257 |
Yes | 4 | 1 | ||
Other diseases | No | 34 | 38 | 0.597 |
Yes | 19 | 26 | ||
Hyperlipidemia | No | 48 | 61 | 0.519 |
Yes | 5 | 3 | ||
Kidney stones | Yes | 14 | 11 | 0.277 |
No | 29 | 38 | ||
Tophi | Yes | 10 | 16 | 0.086 |
No | 19 | 12 | ||
Ever done a joint US | Done | 9 | 3 | 0.029 |
Never done | 43 | 60 | ||
Whether there is a long-term treatment plan for gout | Yes | 21 | 15 | 0.059 |
No | 32 | 49 | ||
Understand gout | Understand | 13 | 11 | 0.516 |
A little | 27 | 34 | ||
Not understand | 12 | 19 | ||
Knowledge of high purine food | Fully understand | 18 | 14 | 0.334 |
A little | 24 | 34 | ||
Unknown | 10 | 15 |
Variables | P | OR | 95% CI |
---|---|---|---|
Age | 0.067 | 1.051 | 0.997–1.108 |
UA (μmol/L) | 0.011 | 1.006 | 1.001–1.010 |
Duration of gout | 0.062 | 2.322 | 0.958–5.625 |
Gout attacks over the past 1 year | 0.067 | 2.063 | 0.951–4.474 |
The highest UA level | 0.014 | 7.570 | 1.511–37.930 |
Peak blood UA level | 0.937 | 0.962 | 0.366–2.529 |
Drug intervention history in the intermittent period | 0.041 | 2.468 | 1.036–5.876 |
History of US | 0.039 | 8.234 | 1.117–60.710 |
Constants | < 0.001 |
Risk factors analysis of tophi
Parameters | Groups | Without double-contour sign | With double-contour sign | P value |
---|---|---|---|---|
Age* | 36.980 ± 10.940 | 42.640 ± 12.112 | 0.011 | |
BUN (mmol/L) | 5.043 ± 1.380 | 5.383 ± 1.743 | 0.372 | |
CREA (μmol/L) | 77.488 ± 22.947 | 76.888 ± 14.758 | 0.331 | |
UA (μmol/L)* | 478.167 ± 145.745 | 488.704 ± 117.178 | 0.678 | |
TC (mmol/L) | 4.828 ± 1.400 | 4.789 ± 1.296 | 0.618 | |
TG (mmol/L) | 1.991 ± 1.578 | 2.208 ± 1.515 | 0.125 | |
FBG (mmol/L) | 5.225 ± 0.674 | 5.303 ± 1.002 | 0.751 | |
Sex | Female | 1 | 2 | 1.000 |
Male | 47 | 67 | ||
BMI | Normal | 10 | 8 | 0.233 |
Overweight | 19 | 24 | ||
Obesity | 19 | 37 | ||
Duration | ≤ 1 year | 16 | 11 | 0.059 |
1–5 years | 22 | 34 | ||
≥ 5 years | 10 | 24 | ||
Gout attack in 1 year | 0–2 times | 24 | 18 | 0.019 |
3–6 times | 17 | 30 | ||
7–12 times | 7 | 21 | ||
Peak blood UA | 421–539 | 11 | 13 | 0.591 |
≥ 540 | 37 | 56 | ||
UA level | ≤ 421 | 12 | 4 | 0.007 |
421–539 | 15 | 20 | ||
≥ 540 | 21 | 45 | ||
Frequency of UA or renal function examination | Regularly checked | 14 | 4 | 0.002 |
Occasionally checked | 15 | 29 | ||
Check only when gout attacks | 18 | 35 | ||
Eating habits | Strict diet | 16 | 15 | 0.286 |
Avoid the high purine diet as much as possible, but not strictly controlled | 21 | 31 | ||
No control over diet | 11 | 23 | ||
Medication during the interval | Insist on taking | 14 | 6 | 0.010 |
Without medications | 24 | 46 | ||
Occasional medications | 8 | 17 | ||
Hypertensive | No | 35 | 53 | 0.631 |
Yes | 13 | 16 | ||
CHD | No | 48 | 64 | 0.149 |
Yes | 0 | 5 | ||
Diabetes | No | 47 | 66 | 0.884 |
Yes | 1 | 3 | ||
CKD | No | 45 | 67 | 0.677 |
Yes | 3 | 2 | ||
Other diseases | No | 29 | 43 | 0.835 |
Yes | 19 | 26 | ||
Hyperlipidemia | No | 43 | 66 | 0.364 |
Yes | 5 | 3 | ||
Kidney stones | Yes | 12 | 13 | 0.782 |
No | 30 | 37 | ||
Tophi | Yes | 10 | 16 | 0.140 |
No | 18 | 13 | ||
Ever done a joint US | Done | 11 | 1 | < 0.001 |
Never done | 37 | 66 | ||
Whether there is a long-term treatment plan for gout | Yes | 21 | 15 | 0.011 |
No | 27 | 54 | ||
Understand gout | Understand | 14 | 10 | 0.050 |
A little | 26 | 35 | ||
Not understand | 8 | 23 | ||
Knowledge of high purine food | Fully understand | 17 | 15 | 0.083 |
A little | 25 | 33 | ||
Unknown | 6 | 19 |
Variables | P | OR | 95% CI |
---|---|---|---|
Age | 0.008 | 1.070 | 1.018–1.124 |
Gout attacks over the past 1 year | 0.385 | 1.332 | 0.697–2.548 |
Drug intervention history in the intermittent period | 0.422 | 1.367 | 0.638–2.928 |
Joints US history | 0.006 | 26.801 | 2.529–284.051 |
Whether there is a long-term treatment plan | 0.512 | 1.414 | 0.502–3.982 |
Blood UA level | 0.068 | 2.111 | 0.946–4.712 |
Frequency of UA or renal function test | 0.330 | 1.426 | 0.699–2.910 |
Constants | < 0.001 |