Erschienen in:
01.03.2010 | Short Communication
Search for novel, high affinity histamine H3 receptor ligands with fluorescent properties
verfasst von:
K. J. Kuder, T. Kottke, H. Stark, X. Ligneau, J.-C. Camelin, R. Seifert, K. Kieć-Kononowicz
Erschienen in:
Inflammation Research
|
Sonderheft 2/2010
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Excerpt
Histamine H
3 receptors are constitutively active G
i-protein coupled receptors, described as presynaptically located auto- and heteroreceptors, that modulate the levels of histamine as well as that of other neurotransmitters such as: acetylcholine, noradrenaline and serotonin. Therefore, blockade of these receptors could be useful in the treatment of different central disorders [
1,
2]. Fluorescent ligands have been in use since the mid-1970s, mainly as histological stains [
3]. Recently, new applications for these ligands have emerged. One of the most important areas in this field are G-protein coupled receptors [
3,
4]. …