Erschienen in:
01.05.2024 | Research Letter
Selinexor targets expression of metabolic genes in Merkel cell carcinoma cells
verfasst von:
Stephen A. Moore, Jennifer R. Landes, Rebecca A. Simonette, Qin He, Hung Q. Doan, Peter L. Rady, Stephen K. Tyring
Erschienen in:
Archives of Dermatological Research
|
Ausgabe 4/2024
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Excerpt
Merkel cell carcinoma (MCC) is a rare yet lethal neuroendocrine, cutaneous cancer [
1]. MCC is very aggressive with a mortality rate ranging from 50% to almost 80% that primarily affects the elderly and immunocompromised [
1]. MCC carcinogenesis is primarily initiated through integration of the Merkel cell polyomavirus (MCPyV) and ultraviolet (UV)-mediated DNA damage caused by exposure to UV from sunlight [
1]. The primary treatment for MCC is immune checkpoint inhibitors; however, many patients are unresponsive to or do not meet criteria for treatment [
2]. …