nach oben

European Journal of Applied Physiology

Erschienen in:

24.10.2020 | Original Article

Serotonin 1A agonist and cardiopulmonary improvements with whole-body exercise in acute, high-level spinal cord injury: a retrospective analysis

verfasst von: Isabelle Vivodtzev, Glen Picard, Kevin O’Connor, J. Andrew Taylor

Erschienen in: European Journal of Applied Physiology | Ausgabe 2/2021

Einloggen, um Zugang zu erhalten

Abstract

Purpose

High-level spinal cord injury (SCI) can result in spinal and supraspinal respiratory control deficits leading to insufficient ventilatory responses to exercise and training-related adaptations. We hypothesized a serotonin agonist, known to improve respiratory function in animal models, would improve adaptations to whole-body functional electrical stimulation (FES) exercise training in patients with acute high-level SCI.

Methods

We identified 10 patients (< 2 years of injury with SCI from C4 to T3) in our program who had performed 6 months of FES-row training while on Buspirone (29 ± 17 mg/day) between 2012 and 2018. We also identified well-matched individuals who trained for six months but not on Buspirone (n = 11). A peak incremental FES-rowing exercise test and resting pulmonary function test had been performed before and after training.

Results

Those on Buspirone demonstrated greater increases in peak oxygen consumption (VO₂peak: + 0.24 ± 0.23 vs. + 0.10 ± 0.13 L/min, p = 0.08) and peak ventilation (VEpeak: + 6.5 ± 8.1 vs. − 0.7 ± 6.9 L/min, p < 0.05) compared to control. In addition, changes in VO₂peak and VEpeak were correlated across all patients (r = 0.63, p < 0.01), but most strongly in those on Buspirone (r = 0.85, p < 0.01). Furthermore, changes in respiratory function correlated with increased peak tidal volume in the Buspirone group (r > 0.66, p < 0.05).

Conclusion

These results suggest Buspirone improves cardiorespiratory adaptations to FES-exercise training in individuals with acute, high-level SCI. The strong association between increases in ventilatory and aerobic capacities suggests improved respiratory function is a mechanism; however, controlled studies are needed to determine if this preliminary finding is reproducible.

Andaku DK, Mercadante MT, Schwartzman JS (2005) Buspirone in Rett syndrome respiratory dysfunction. Brain Dev 27:437–438. https://doi.org/10.1016/j.braindev.2004.09.011CrossRefPubMed

Argyropoulou P, Patakas D, Koukou A, Vasiliadis P, Georgopoulos D (1993) Buspirone effect on breathlessness and exercise performance in patients with chronic obstructive pulmonary disease. Respiration 60:216–220. https://doi.org/10.1159/000196202CrossRefPubMed

Battikha M, Sa L, Porter A, Taylor JA (2014) Relationship between pulmonary function and exercise capacity in individuals with spinal cord injury. Am J Phys Med Rehabil 93:413–421. https://doi.org/10.1097/PHM.0000000000000046CrossRefPubMed

Bauman WA, Adkins RH, Spungen AM, Waters RL (1999) The effect of residual neurological deficit on oral glucose tolerance in persons with chronic spinal cord injury. Spinal Cord 37:765–771CrossRef

Bezdudnaya T, Marchenko V, Zholudeva LV, Spruance VM, Lane MA (2017) Supraspinal respiratory plasticity following acute cervical spinal cord injury. Exp Neurol 293:181–189. https://doi.org/10.1016/j.expneurol.2017.04.003CrossRefPubMedPubMedCentral

Bjerkefors A, Carpenter MG, Cresswell AG, Thorstensson A (2009) Trunk muscle activation in a person with clinically complete thoracic spinal cord injury. J Rehabil Med 41:390–392. https://doi.org/10.2340/16501977-0336CrossRefPubMed

Canessa ML (1989) The Na-K-Cl cotransport in essential hypertension: cellular functions and genetic environment interactions. Int J Cardiol 25(Suppl 1):S37-45CrossRef

Choi H et al (2005) Respiratory abnormalities resulting from midcervical spinal cord injury and their reversal by serotonin 1A agonists in conscious rats. J Neurosci 25:4550–4559. https://doi.org/10.1523/JNEUROSCI.5135-04.2005CrossRefPubMedPubMedCentral

De Troyer A, Heilporn A (1980) Respiratory mechanics in quadriplegia. The respiratory function of the intercostal muscles. Am Rev Respir Dis 122:591–600. https://doi.org/10.1164/arrd.1980.122.4.591CrossRefPubMed

De Troyer A, Estenne M, Heilporn A (1986) Mechanism of active expiration in tetraplegic subjects. N Engl J Med 314:740–744. https://doi.org/10.1056/NEJM198603203141203CrossRefPubMed

Dempsey JA, Amann M, Romer LM, Miller JD (2008) Respiratory system determinants of peripheral fatigue and endurance performance. Med Sci Sports Exerc 40:457–461. https://doi.org/10.1249/MSS.0b013e31815f8957CrossRefPubMed

El-Khatib MF, Kiwan RA, Jamaleddine GW (2003) Buspirone treatment for apneustic breathing in brain stem infarct. Respir Care 48:956–958PubMed

Gad P, Gerasimenko Y, Zdunowski S, Turner A, Sayenko D, Lu DC, Edgerton VR (2017) Weight bearing over-ground stepping in an exoskeleton with non-invasive spinal cord neuromodulation after motor complete paraplegia. Front Neurosci 11:333. https://doi.org/10.3389/fnins.2017.00333CrossRefPubMedPubMedCentral

Gautier H (1973) Respiratory responses of the anesthetized rabbit to vagotomy and thoracic dorsal rhizotomy. Respir Physiol 17:238–247CrossRef

Ghosh M, Pearse DD (2014) The role of the serotonergic system in locomotor recovery after spinal cord injury. Front Neural Circuits 8:151. https://doi.org/10.3389/fncir.2014.00151CrossRefPubMed

Howland RH (2015) Buspirone: back to the future. J Psychosoc Nurs Ment Health Serv 53:21–24. https://doi.org/10.3928/02793695-20151022-01CrossRefPubMed

Kelley A, Garshick E, Gross ER, Lieberman SL, Tun CG, Brown R (2003) Spirometry testing standards in spinal cord injury. Chest 123:725–730. https://doi.org/10.1378/chest.123.3.725CrossRefPubMedPubMedCentral

McKinley AC, Auchincloss JH Jr, Gilbert R, Nicholas JJ (1969) Pulmonary function, ventilatory control, and respiratory complications in quadriplegic subjects. Am Rev Respir Dis 100:526–532. https://doi.org/10.1164/arrd.1969.100.4.526CrossRefPubMed

Morgan JW, Ferrazzani E, Taylor JA, Vivodtzev I (2018) Augmenting exercise capacity with noninvasive ventilation in high-level spinal cord injury. J Appl Physiol (1985) 124:1294–1296. https://doi.org/10.1152/japplphysiol.01028.2017CrossRef

Moxon KA, Oliviero A, Aguilar J, Foffani G (2014) Cortical reorganization after spinal cord injury: always for good? Neuroscience 283:78–94. https://doi.org/10.1016/j.neuroscience.2014.06.056CrossRefPubMedPubMedCentral

O’Sullivan RJ, Brown IG, Pender MP (2008) Apneusis responding to buspirone in multiple sclerosis. Mult Scler 14:705–707. https://doi.org/10.1177/1352458507085802CrossRefPubMed

Qiu S, Alzhab S, Picard G, Taylor JA (2016) Ventilation limits aerobic capacity after functional electrical stimulation row training in high spinal cord injury. Med Sci Sports Exerc 48:1111–1118. https://doi.org/10.1249/MSS.0000000000000880CrossRefPubMedPubMedCentral

Rochester DF (1993) Respiratory muscles and ventilatory failure: 1993 perspective. Am J Med Sci 305:394–402. https://doi.org/10.1097/00000441-199306000-00008CrossRefPubMed

Ross R et al (2016) Importance of assessing cardiorespiratory fitness in clinical practice: a case for fitness as a clinical vital sign: a scientific statement from the American Heart Association. Circulation 134:e653–e699. https://doi.org/10.1161/CIR.0000000000000461CrossRefPubMed

Schilero GJ, Radulovic M, Wecht JM, Spungen AM, Bauman WA, Lesser M (2014) A center’s experience: pulmonary function in spinal cord injury. Lung 192:339–346. https://doi.org/10.1007/s00408-014-9575-8CrossRefPubMed

Shields RK (2002) Muscular, skeletal, and neural adaptations following spinal cord injury. J Orthop Sports Phys Ther 32:65–74. https://doi.org/10.2519/jospt.2002.32.2.65CrossRefPubMedPubMedCentral

Soden RJ, Walsh J, Middleton JW, Craven ML, Rutkowski SB, Yeo JD (2000) Causes of death after spinal cord injury. Spinal Cord 38:604–610CrossRef

Standardization of Spirometry, 1994 Update. American Thoracic Society (1995). Am J Respir Crit Care Med 152:1107–1136. doi:https://doi.org/10.1164/ajrccm.152.3.7663792

Taylor JA, Picard G, Widrick JJ (2011) Aerobic capacity with hybrid FES rowing in spinal cord injury: comparison with arms-only exercise and preliminary findings with regular training. PM R 3:817–824. https://doi.org/10.1016/j.pmrj.2011.03.020CrossRefPubMed

Teng YD, Bingaman M, Taveira-DaSilva AM, Pace PP, Gillis RA, Wrathall JR (2003) Serotonin 1A receptor agonists reverse respiratory abnormalities in spinal cord-injured rats. J Neurosci 23:4182–4189CrossRef

Thor KB, Nickolaus S, Helke CJ (1993) Autoradiographic localization of 5-hydroxytryptamine1A, 5-hydroxytryptamine1B and 5-hydroxytryptamine1C/2 binding sites in the rat spinal cord. Neuroscience 55:235–252. https://doi.org/10.1016/0306-4522(93)90469-VCrossRefPubMed

Ung RV, Rouleau P, Guertin PA (2012) Functional and physiological effects of treadmill training induced by buspirone, carbidopa, and L-DOPA in clenbuterol-treated paraplegic mice. Neurorehabil Neural Repair 26:385–394. https://doi.org/10.1177/1545968311427042CrossRefPubMed

Vivodtzev I, Picard G, Cepeda FX, Taylor JA (2019) Acute ventilatory support during whole-body hybrid rowing in patients with high-level spinal cord injury: a randomized controlled crossover trial. Chest. https://doi.org/10.1016/j.chest.2019.10.044CrossRefPubMed

Wien MF, Garshick E, Tun CG, Lieberman SL, Kelley A, Brown R (1999) Breathlessness and exercise in spinal cord injury. J Spinal Cord Med 22:297–302CrossRef

Wilken B, Lalley P, Bischoff AM, Christen HJ, Behnke J, Hanefeld F, Richter DW (1997) Treatment of apneustic respiratory disturbance with a serotonin-receptor agonist. J Pediatr 130:89–94. https://doi.org/10.1016/S0022-3476(97)70315-9CrossRefPubMed

Williams PT, Thompson PD (2013) The relationship of walking intensity to total and cause-specific mortality. Results from the National Walkers’ Health Study. PLoS ONE 8:e81098. https://doi.org/10.1371/journal.pone.0081098CrossRefPubMedPubMedCentral

Zimmer MB, Goshgarian HG (2006) Spinal activation of serotonin 1A receptors enhances latent respiratory activity after spinal cord injury. J Spinal Cord Med 29:147–155CrossRef

Zimmer MB, Goshgarian HG (2007) Spinal cord injury in neonates alters respiratory motor output via supraspinal mechanisms. Exp Neurol 206:137–145. https://doi.org/10.1016/j.expneurol.2007.05.003CrossRefPubMed

Titel: Serotonin 1A agonist and cardiopulmonary improvements with whole-body exercise in acute, high-level spinal cord injury: a retrospective analysis
verfasst von: Isabelle Vivodtzev
Glen Picard
Kevin O’Connor
J. Andrew Taylor
Publikationsdatum: 24.10.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Applied Physiology / Ausgabe 2/2021
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-020-04536-w

Neu im Fachgebiet Arbeitsmedizin

Das Geschlechterparadoxon in der gesundheitlich beeinträchtigten Lebenszeit – Ende eines Mythos?

Open Access Hüftgelenksbewegungseinschränkung Leitthema

Beginnend mit den 1920er-Jahren hat sich eine Vorstellung über die Geschlechterdifferenzen in Gesundheit und Mortalität etabliert, die von Lorber und Moore in dem einprägsamen Satz: „Women get sicker, but men die quicker“, zusammengefasst wurde [ 1 …, S. 13]. Tatsächlich erscheinen vor dem Hintergrund der höheren Lebenserwartung der Frauen die Studienergebnisse zu den Geschlechterdifferenzen in der Morbidität überraschend, wonach Frauen im Durchschnitt einen schlechteren Gesundheitszustand aufweisen als Männer [

Gesunde Lebenserwartung: Ein kritischer Blick auf Nutzen und Potenziale des demographischen Gesundheitsindikators

Open Access Leitthema

Die demographische Alterung hat vielfältige gesellschaftliche Konsequenzen, deren Ausmaß wesentlich vom Gesundheitszustand der Bevölkerung abhängt. Um diesen analysieren und bewerten zu können, wurden spezielle Kennziffern entwickelt, die in …

Wie hat sich die Lebenserwartung ohne funktionelle Einschränkungen in Deutschland entwickelt? Eine Analyse mit Daten des Deutschen Alterssurveys (DEAS)

Open Access Hüftgelenksbewegungseinschränkung Leitthema

Deutschland erfährt, wie andere Hocheinkommensstaaten, aufgrund kontinuierlich rückläufiger Mortalität und niedriger Geburtenraten tiefgreifende demografische Veränderungen. Der demografische Wandel führt in Deutschland zu einem zunehmend höheren …

Hitzeschutz im Fokus der hessischen Betreuungs- und Pflegeaufsicht

Open Access Klimawandel Übersichtsartikel

Im Sommer 2023 kündigte das Bundesministerium für Gesundheit (BMG) einen nationalen Hitzeschutzplan an und forderte die Länder auf, zu prüfen, „ob die Warnstufen des [Deutschen Wetterdienstes] DWD mit der Durchführung von Akutmaßnahmen …

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2021

Multidimensional breathlessness assessment during cardiopulmonary exercise testing in healthy adults

Contractile history affects sag and boost properties of unfused tetanic contractions in human quadriceps muscles

The effect of pedalling cadence on respiratory frequency: passive vs. active exercise of different intensities

Baroreflex responses during dry resting and exercise apnoeas in air and pure oxygen

H-reflex and M-wave responses after voluntary and electrically evoked muscle cramping

Intermittent post-exercise sauna bathing improves markers of exercise capacity in hot and temperate conditions in trained middle-distance runners

Neu im Fachgebiet Arbeitsmedizin

Das Geschlechterparadoxon in der gesundheitlich beeinträchtigten Lebenszeit – Ende eines Mythos?

Gesunde Lebenserwartung: Ein kritischer Blick auf Nutzen und Potenziale des demographischen Gesundheitsindikators

Wie hat sich die Lebenserwartung ohne funktionelle Einschränkungen in Deutschland entwickelt? Eine Analyse mit Daten des Deutschen Alterssurveys (DEAS)

Hitzeschutz im Fokus der hessischen Betreuungs- und Pflegeaufsicht