nach oben

Inflammation Research

Erschienen in:

01.08.2009 | Review

Shedding light on DARC: the role of the Duffy antigen/receptor for chemokines in inflammation, infection and malignancy

verfasst von: K. Horne, Ian J. Woolley

Erschienen in: Inflammation Research | Ausgabe 8/2009

Einloggen, um Zugang zu erhalten

Excerpt

Duffy antigen (Fy) was first identified in 1950 as a cause of transfusion reactions [1], and 25 years later recognized as receptor allowing the entry of Plasmodium vivax into erythrocytes [2]. It was not until the mid 1990s that a physiological role for this antigen was proposed, when Duffy was found to be a chemokine receptor [3] and was subsequently renamed Duffy antigen receptor for chemokines (DARC). Since then roles for DARC in inflammation, infection and malignancy have begun to emerge. …

Cutbush M, Mollison PL. The Duffy blood group system. Heredity. 1950;4:383–9.PubMedCrossRef

Miller LH, Mason SJ, Dvorak JA, McGinniss MH, Rothman IK. Erythrocyte receptors for (Plasmodium knowlesi) malaria: Duffy blood group determinants. Science. 1975;189:561–3.PubMedCrossRef

Horuk R, Chitnis CE, Darbonne WC, Colby TJ, Rybicki A, Hadley TJ, et al. A receptor for the malarial parasite Plasmodium vivax: the erythrocyte chemokine receptor. Science. 1993;261:1182–4.PubMedCrossRef

Hadley TJ, Peiper SC. From malaria to chemokine receptor: the emerging physiologic role of the Duffy blood group antigen. Blood. 1997;89:3077–91.PubMed

Gardner L, Patterson AM, Ashton BA, Stone MA, Middleton J. The human Duffy antigen binds selected inflammatory but not homeostatic chemokines. Biochem Biophys Res Commun. 2004;321:306–12.PubMedCrossRef

Comerford I, Nibbs RJ. Post-translational control of chemokines: a role for decoy receptors? Immunol Lett. 2005;96:163–74.PubMedCrossRef

Horuk R, Martin A, Hesselgesser J, Hadley T, Lu ZH, Wang ZX, et al. The Duffy antigen receptor for chemokines: structural analysis and expression in the brain. J Leukoc Biol. 1996;59:29–38.PubMed

Middleton J, Americh L, Gayon R, Julien D, Mansat M, Mansat P, et al. A comparative study of endothelial cell markers expressed in chronically inflamed human tissues: MECA-79, Duffy antigen receptor for chemokines, von Willebrand factor, CD31, CD34, CD105 and CD146. J Pathol. 2005;206:260–8.PubMedCrossRef

Lee JS, Frevert CW, Wurfel MM, Peiper SC, Wong VA, Ballman KK, et al. Duffy antigen facilitates movement of chemokine across the endothelium in vitro and promotes neutrophil transmigration in vitro and in vivo. J Immunol. 2003;170:5244–51.PubMed

10.

Pruenster M, Mudde L, Bombosi P, Dimitrova S, Zsak M, Middleton J, et al. The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity. Nat Immunol. 2009;10:101–8.PubMedCrossRef

11.

Dawson TC, Lentsch AB, Wang Z, Cowhig JE, Rot A, Maeda N, et al. Exaggerated response to endotoxin in mice lacking the Duffy antigen/receptor for chemokines (DARC). Blood. 2000;96:1681–4.PubMed

12.

Luo H, Chaudhuri A, Zbrzezna V, He Y, Pogo AO. Deletion of the murine Duffy gene (Dfy) reveals that the Duffy receptor is functionally redundant. Mol Cell Biol. 2000;20:3097–101.PubMedCrossRef

13.

Zarbock A, Schmolke M, Bockhorn SG, Scharte M, Buschmann K, Ley K, et al. The Duffy antigen receptor for chemokines in acute renal failure: a facilitator of renal chemokine presentation. Crit Care Med. 2007;35:2156–63.PubMedCrossRef

14.

Wadhwa M, Seghatchian MJ, Dilger P, Contreras M, Thorpe R. Cytokine accumulation in stored red cell concentrates: effect of buffy-coat removal and leucoreduction. Transfus Sci. 2000;23:7–16.PubMedCrossRef

15.

Jilma B, Akimitsu N, Fukuma N, Sekimizu K, Jilma-Stohlawetz P. Man, mouse and Duffy genotype-phenotype-specific pharmacokinetics of monocyte chemotactic protein-1. Transfus Med. 2004;14:251–2.PubMedCrossRef

16.

Smith E, McGettrick HM, Stone MA, Shaw JS, Middleton J, Nash GB, et al. Duffy antigen receptor for chemokines and CXCL5 are essential for the recruitment of neutrophils in a multicellular model of rheumatoid arthritis synovium. Arthritis Rheum. 2008;58:1968–73.PubMedCrossRef

17.

Akalin E, Neylan JF. The influence of Duffy blood group on renal allograft outcome in African Americans. Transplantation. 2003;75:1496–500.PubMedCrossRef

18.

Mange KC, Prak EL, Kamoun M, Du Y, Goodman N, Danoff T, et al. Duffy antigen receptor and genetic susceptibility of African Americans to acute rejection and delayed function. Kidney Int. 2004;66:1187–92.PubMedCrossRef

19.

He W, Neil S, Kulkarni H, Wright E, Agan BK, Marconi VC, et al. Duffy antigen receptor for chemokines mediates trans-infection of HIV-1 from red blood cells to target cells and affects HIV-AIDS susceptibility. Cell Host Microbe. 2008;4:52–62.PubMedCrossRef

20.

Lachgar A, Jaureguiberry G, Le Buenac H, Bizzini B, Zagury JF, Rappaport J, et al. Binding of HIV-1 to RBCs involves the Duffy antigen receptors for chemokines (DARC). Biomed Pharmacother. 1998;52:436–9.PubMedCrossRef

21.

Woolley IJ, Kalayjian R, Valdez H, Hamza N, Jacobs G, Lederman MM, et al. HIV nephropathy and the Duffy antigen/receptor for chemokines in African Americans. J Nephrol. 2001;14:384–7.PubMed

22.

Velzing-Aarts FV, van der Dijs FP, Muskiet FA, Duits AJ. The association of pre-eclampsia with the Duffy negative phenotype in women of West African descent. Br J Obstet Gynecol. 2002;109:453–5.

23.

Velzing-Aarts FV, Muskiet FA, van der Dijs FP, Duits AJ. High serum interleukin-8 levels in afro-caribbean women with pre-eclampsia. Relations with tumor necrosis factor-alpha, duffy negative phenotype and von Willebrand factor. Am J Reprod Immunol. 2002;48:319–22.PubMedCrossRef

24.

Woolley IJ, Wood EM, Sramkoski RM, Zimmerman PA, Miller JP, Kazura JW. Expression of Duffy antigen receptor for chemokines during reticulocyte maturation: using a CD71 flow cytometric technique to identify reticulocytes. Immunohematology. 2005;21:15–20.PubMed

25.

Miller LH, Mason SJ, Clyde DF, McGinniss MH. The resistance factor to Plasmodium vivax in blacks. The Duffy-blood-group genotype, FyFy. N Engl J Med. 1976;295:302–4.PubMed

26.

Tournamille C, Colin Y, Cartron JP, Le Van Kim C. Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals. Nat Genet. 1995;10:224–8.PubMedCrossRef

27.

Peiper SC, Wang ZX, Neote K, Martin AW, Showell HJ, Conklyn MJ, et al. The Duffy antigen/receptor for chemokines (DARC) is expressed in endothelial cells of Duffy negative individuals who lack the erythrocyte receptor. J Exp Med. 1995;181:1311–7.PubMedCrossRef

28.

Tournamille C, Le Van Kim C, Gane P, Cartron JP, Colin Y. Molecular basis and PCR-DNA typing of the Fya/fyb blood group polymorphism. Hum Genet. 1995;95:407–10.PubMedCrossRef

29.

Michon P, Woolley I, Wood EM, Kastens W, Zimmerman PA, Adams JH. Duffy-null promoter heterozygosity reduces DARC expression and abrogates adhesion of the P. vivax ligand required for blood-stage infection. FEBS Lett. 2001;495:111–4.PubMedCrossRef

30.

Michon P, Fraser T, Adams JH. Naturally acquired and vaccine-elicited antibodies block erythrocyte cytoadherence of the Plasmodium vivax Duffy binding protein. Infect Immun. 2000;68:3164–71.PubMedCrossRef

31.

Grimberg BT, Udomsangpetch R, Xainli J, McHenry A, Panichakul T, Sattabongkot J, et al. Plasmodium vivax invasion of human erythrocytes inhibited by antibodies directed against the Duffy binding protein. PLoS Med. 2007;4:e337.PubMedCrossRef

32.

Beeson JG, Crabb BS. Towards a vaccine against Plasmodium vivax malaria. PLoS Med. 2007;4:e350.PubMedCrossRef

33.

Xu L, Ashkenazi A, Chaudhuri A. Duffy antigen/receptor for chemokines (DARC) attenuates angiogenesis by causing senescence in endothelial cells. Angiogenesis. 2007;10:307–18.PubMedCrossRef

34.

Bandyopadhyay S, Zhan R, Chaudhuri A, Watabe M, Pai SK, Hirota S, et al. Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression. Nat Med. 2006;12:933–8.PubMedCrossRef

35.

Horton LW, Yu Y, Zaja-Milatovic S, Strieter RM, Richmond A. Opposing roles of murine Duffy antigen receptor for chemokine and murine CXC chemokine receptor-2 receptors in murine melanoma tumor growth. Cancer Res. 2007;67:9791–9.PubMedCrossRef

36.

Shen H, Schuster R, Stringer KF, Waltz SE, Lentsch AB. The Duffy antigen/receptor for chemokines (DARC) regulates prostate tumor growth. FASEB J. 2006;20:59–64.PubMedCrossRef

37.

Addison CL, Belperio JA, Burdick MD, Strieter RM. Overexpression of the duffy antigen receptor for chemokines (DARC) by NSCLC tumor cells results in increased tumor necrosis. BMC Cancer. 2004;4:28.PubMedCrossRef

38.

Wang J, Ou ZL, Hou YF, Luo JM, Shen ZZ, Ding J, et al. Enhanced expression of Duffy antigen receptor for chemokines by breast cancer cells attenuates growth and metastasis potential. Oncogene. 2006;25:7201–11.PubMedCrossRef

Titel: Shedding light on DARC: the role of the Duffy antigen/receptor for chemokines in inflammation, infection and malignancy
verfasst von: K. Horne
Ian J. Woolley
Publikationsdatum: 01.08.2009
Verlag: SP Birkhäuser Verlag Basel
Erschienen in: Inflammation Research / Ausgabe 8/2009
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI: https://doi.org/10.1007/s00011-009-0023-9

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Excerpt

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 8/2009

Intra-articular treatment of inflammatory arthritis with microsphere formulations of methotrexate: pharmacokinetics and efficacy determination in antigen-induced arthritic rabbits

Ozone oxidative preconditioning reduces nitrite levels in blood serum in LPS: induced endotoxic shock in mice

Evidence for the contribution of tumour necrosis factor in oedema formation induced by histamine in the hind paw of the rat

Local and systemic chemokine patterns in a human musculoskeletal trauma model

In vivo visualization of nitric oxide and interactions among platelets, leukocytes, and endothelium following hemorrhagic shock and reperfusion

feG-COOH blunts eosinophilic airway inflammation in a feline model of allergic asthma

Leitlinien kompakt für die Innere Medizin

Update Innere Medizin