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Head and Neck Pathology
Erschienen in: Head and Neck Pathology 1/2020

01.03.2020 | Special Issue: Soft Tissue

Soft Tissue Special Issue: Selected Topics in the Pathology of Adipocytic Tumors

verfasst von: Wonwoo Shon, Steven D. Billings

Erschienen in: Head and Neck Pathology | Ausgabe 1/2020

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Abstract

Our understanding of adipocytic tumors classification and diagnosis continues to evolve. We present a brief review and updated summary of selected adipocytic tumors involving the head and neck region. For the practicing pathologist, knowledge of these established and emerging entities is critical for the correct pathologic diagnosis and treatment of the patient.
Literatur
1.
Enzinger FM, Harvey DA. Spindle cell lipoma. Cancer. 1975;36:781–8.CrossRef
2.
Shmookler BM, Enzinger FM. Pleomorphic lipoma: a benign tumor simulating liposarcoma. A clinicopathologic analysis of 48 cases. Cancer. 1981;47(1):126–33.CrossRefPubMed
3.
Goldblum JR, Folpe AL, Weiss SW, Enzinger FM. Weiss’s soft tissue tumors. Philadelphia: Mosby; 2014. p. 703–32.
4.
Billings SD, Henley JD, Summerlin DJ, et al. Spindle cell lipoma of the oral cavity. Am J Dermatopathol. 2006;28:28–31.CrossRefPubMed
5.
Lau SK, Bishop JA, Thompson LD. Spindle cell lipoma of the tongue: a clinicopathologic study of 8 cases and review of the literature. Head Neck Pathol. 2015;9(2):253–9.CrossRefPubMed
6.
Cheah A, Billings SD, Goldblum JR, et al. Spindle cell/pleomorphic lipomas of the face: an under-recognized diagnosis. Histopathology. 2015;66:430–7.CrossRefPubMed
7.
Fanburg-Smith JC, Devaney KO, Miettinen M, et al. Multiple spindle cell lipomas: a report of 7 familial and 11 nonfamilial cases. Am J Surg Pathol. 1998;22:40–8.CrossRefPubMed
8.
Billings SD, Folpe AL. Diagnostically challenging spindle cell lipomas: a report of 34 “low-fat” and “fat-free” variants. Am J Dermatopathol. 2007;29(5):437–42.CrossRefPubMed
9.
Mandahl N, Hoglund M, Mertens F, et al. Cytogenetic aberrations in 188 benign and borderline adipose tissue tumors. Genes Chromosom Cancer. 1994;9:207–15.CrossRefPubMed
10.
Dal Cin P, Sciot R, Polito P, et al. Lesions of 13q may occur independently of deletion of 16q in spindle cell/pleomorphic lipomas. Histopathology. 2013;31:222–5.
11.
Maggiani F, Debiec-Rychter M, Vanbockrijck M, et al. Celluar angiofibroma: another mesenchymal tumour with 13q14 involvement, suggesting a link with spindle cell lipoma and (extra)-mammary myofibroblatoma. Histopathology. 2007;51:410–2.CrossRefPubMed
12.
Pauwels P, Sciot R, Croiset F, et al. Myofibroblastoma of the breast: genetic link with spindle cell lipoma. J Pathol. 2000;191:282–5.CrossRefPubMed
13.
Agaimy A, Michal M, Giedl J, et al. Superficial acral fibromyxoma: clinicopathological, immunohistochemical, and molecular study of 11 cases highlighting frequent Rb1 loss/deletions. Hum Pathol. 2017;60:192–8.CrossRefPubMed
14.
Chen BJ, Marino-Enriquez A, Fletcher CD, et al. Loss of retinoblastoma protein expression in spindle cell/pleomorphic lipomas and cytogenetically related tumros: an immunohistochemical study with diagnostic implications. Am J Surg Pathol. 2012;36:1119–28.CrossRefPubMed
15.
Gerry D, Fox NF, Spruill LS, et al. Liposarcoma of the head and neck: analysis of 318 cases with comparison to non-head and neck sites. Head Neck. 2014;36:393–400.CrossRefPubMed
16.
Gritli S, Khamassi K, Lachkhem A, et al. Head and neck liposarcomas: a 32 years experience. Auris Nasus Larynx. 2010;37:347–51.CrossRefPubMed
17.
Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F (2013) World Health Organization Classification of Tumours of Soft Tissue and Bone
18.
Waters R, Horvai A, Greipp P, et al. Atypical lipomatous tumour/well-differentiated liposarcoma and de-differentiated liposarcoma in patients aged ≤ 40 years: a study of 116 patients. Histopathology. 2019;75(6):833–42.CrossRefPubMed
19.
Henrick WH, Chu YC, Goldblum JR, et al. Dedifferentiated liposarcoma: a clinicopathological analysis of 155 cases with a proposal for an expanded definition of dedifferentiation. Am J Surg Pathol. 1997;21:271–81.CrossRef
20.
Dickson MA, Tap WD, Keohan ML, et al. Phase II trial of the CDK4 inhibitor PD0332991 in patients with advanced CDK4-amplified well-differentiated or dedifferentiated liposarcoma. J Clin Oncol. 2013;31:2024–8.CrossRefPubMedPubMedCentral
21.
Constantinidou A, Pollack SM, Jones RL. MDM2 inhibition in liposarcoma: a step in the right direction. Lancet Oncol. 2012;13:1070–1.CrossRefPubMed
22.
Agaimy A, Michal M, Hadravsky L, et al. Dedifferentiated liposarcoma composed predominantly of rhabdoid/epithleioid cells: a frequently misdiagnosed highly aggressive variant. Hum Pathol. 2018;77:20–7.CrossRefPubMed
23.
Evans HL, Khurana KK, Kemp BL, et al. Heterologous elements in the dedifferentiated component of dedifferentiated liposarcoma. Am J Surg Pathol. 1994;18:1150–7.CrossRefPubMed
24.
Fanburg-Smith JC, Miettinen M. Liposarcoma with meningothelial-like whorls: a study of 17 cases of a distinctive histological pattern associated with dedifferentiated liposarcoma. Histopathology. 1998;33:141–424.CrossRef
25.
Nascimento AG, Kurtin PJ, Guillou L, et al. Dedifferentiated liposarcoma: a report of nine cases with a peculiar neurallike whorling pattern asscoaited with metaplastic bone formation. Am J Surg Pathol. 1998;22:945–55.CrossRefPubMed
26.
Boland JM, Weiss SW, Oliveira AM, et al. Liposarcomas with mixed well-differentiated and pleomorphic features: a clinicopathologic study of 12 cases. Am J Surg Pathol. 2010;34:837–43.CrossRefPubMed
27.
Marino-Enriquez A, Fletcher CD, Dal Cin P, et al. Dedifferentiated liposarcoma with “homologous” lipoblastic (pleomorphic liposarcoma-like) differentiation: clinicopathologic and moelcular analysis of a series suggesting revised diagnostic criteria. Am J Surg Pathol. 2010;34:1122–31.CrossRefPubMed
28.
Ng W, Messiou C, Smith M, et al. p16 expression in fat necrosis: a potential diagnostic pitfall in the evaluation of differentiated adipocytic neoplasms. Int J Surg Pathol. 2015;23:544–8.CrossRefPubMed
29.
Stojanov IJ, Marino-Enriquez A, Bahri N, et al. Lipomas of the oral cavity: utility of MDM2 and CDK4 in avoiding overdiagnosis as atypical lipomatous tumor. Head Neck Pathol. 2019;13:169–76.CrossRefPubMed
30.
Doyle LA, Tao D, Marino-Enriquez A. STAT6 is amplified in a subset of dedifferentiated liposarcoma. Mod Pathol. 2014;27:1231–7.CrossRefPubMed
31.
Ratan R, Patel SR. Trabectedin and eribulin: where do they fit in the management of soft tissue sarcoma? Curr Treat Options Oncol. 2017;18:34.CrossRefPubMed
32.
Iwasaki H, Ishiguro M, Nishio J, et al. Extensive lipoma-like changes of myxoid liposarcoma: morphologic, immunohistochemical, and molecular cytogenetic analyses. Virchows Arch. 2015;466:453–64.CrossRefPubMedPubMedCentral
33.
Dadone B, Refae S, Lemarie-Delaunay C, et al. Molecular cytogenetics of pediatric adipocytic tumors. Cancer Genet. 2015;208:469–81.CrossRefPubMed
34.
Pedeutour F, Deville A, Steyaert H, et al. Rearrangement of HMGA2 in a case of infantile lipoblastoma without Plag1 alteration. Pediatr Blood Cancer. 2012;58:798–800.CrossRefPubMed
35.
Gardner JM, Dandekar M, Thomas D, et al. Cutaneous and subcutaneous pleomorphic liposarcoma: a clinicopathologic study of 29 cases with evaluation of MDM2 gene amplification in 26. Am J Surg Pathol. 2012;36:1047–51.CrossRefPubMed
36.
Gebhard S, Coindre JM, Michels JJ, et al. Pleomorphic liposarcoma: clinicopathologic, immunohistochemical, and follow-up analysis of 63 cases: a study from the French Federation of Cancer Centers Sarcoma Group. Am J Surg Pathol. 2002;26:601–16.CrossRefPubMed
37.
Hornick JL, Bosenberg MW, Mentzel T, et al. Pleomorphic liposarcoma: clinicopathologic analysis of 57 cases. Am J Surg Pathol. 2004;28:1257–67.CrossRefPubMed
38.
Miettinen M, Enzinger FM. Epithelioid variant of pleomorphic liposarcoma: a study of 12 cases of a distinctive variant of high-grade liposarcoma. Mod Pathol. 1999;12:722–8.PubMed
39.
Barretina J, Taylor BS, Banerji S, et al. Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nat Genet. 2010;42:715–21.CrossRefPubMedPubMedCentral
40.
Cancer Genome Atlas Research Network. Comprehensive and integrated genomic characterization of adult soft tissue sarcomas. Cell. 2017;171(4):950.CrossRef
41.
Evans HL (2015) Subcutaneous minimally atypical lipomatous tumors with variable fat cell size—a study of 13 cases. Mod Pathol 28 (suppl 2_:17A
42.
Evans HL. Anisometric cell lipoma: a predominantly subcutaneous fatty tumor with notable variation in fat cell size but not more than slight nuclear enlargement and atypia. AJSP. 2016;21(4):195–9.
43.
Michal M, Agaimy A, Contreras AL, et al. Dysplastic lipoma: a distinctive atypical lipomatous neoplasm with anisocytosis, focal nuclear atypia, p53 overexpression, and a lack of MDM2 gene amplification by FISH: a report of 66 cases demonstrating occasional multifocality and a rare association with retinoblastoma. Am J Surg Pathol. 2018;42:1530–40.CrossRefPubMed
44.
Marino-Enriquez A, Nascimento AF, Ligon AH, et al. Atypical spindle cell lipomatous tumor: clinicopathologic characterization of 232 cases demonstrating a morphologic spectrum. Am J Surg Pathol. 2017;41:234–44.CrossRefPubMed
45.
Creytens D, Mentzel T, Ferdinande L, et al. “Atypical” pleomorphic lipomatous tumor: a clinicopathologic, immunohistochemical and molecular study of 21 cases, emphasizing its relationship to atypical spindle cell lipomatous tumor and suggesting a morphologic spectrum (atypical spindle cell/pleomorphic lipomatous tumor). Am J Surg Pathol. 2017;41:1443–55.CrossRefPubMed
46.
Bahadir B, Behzatoglu K, Hacihasanoglu E, et al. Atypical spindle cell/pleomorphic lipomatous tumor: a clinicopathologic, immunohistochemical, and molecular study of 20 cases. Pathol Int. 2018;68:550–6.CrossRefPubMed
47.
Italiano A, Chambonniere ML, Attias R, et al. Monosomy 7 and absence of 12q amplification in two cases of spindle cell liposarcoma. Cancer Genet Cytogenet. 2008;184:99–104.CrossRefPubMed
Metadaten
Titel
Soft Tissue Special Issue: Selected Topics in the Pathology of Adipocytic Tumors
verfasst von
Wonwoo Shon
Steven D. Billings
Publikationsdatum
01.03.2020
Verlag
Springer US
Erschienen in
Head and Neck Pathology / Ausgabe 1/2020
Elektronische ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-019-01112-3

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