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Cardiovascular Toxicology

Erschienen in:

20.05.2022

The Cardiotoxic Effect of Roundup® is not Induced by Glyphosate: A Non-specific Blockade of Human Ca_V1.2 Channels

verfasst von: Richard Printemps, Stéphanie Guilbot, Hélène Didier, Renaud Nalin, Bruno Le Grand

Erschienen in: Cardiovascular Toxicology | Ausgabe 7/2022

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Abstract

In Roundup®, the active principle glyphosate is formulated with adjuvants that help it to penetrate the plants’ cell membranes. Several reports and reviews report cardiovascular effects of Roundup®, pointing the presence of arrhythmias as a potential consequence of Roundup® toxicity and death cause. However, it still remains debatable whether these cardiac events are related to glyphosate per se or to the Roundup® adjuvants. The present study aims to compare the pro-arrhythmogenic properties of Roundup® and glyphosate in an animal model and in human cardiomyocytes. In isolated guinea pig heart, the cardiotoxicity of Roundup® (significant effect on heart rate and depressive effect on ventricular contractility) was demonstrated with the highest concentrations (100 µM). In human cardiomyocytes, the cardiotoxicity is confirmed by a marked effect on contractility and a strong effect on cell viability. Finally, this Roundup® depressive effect on heart contractility is due to a concentration-dependent blocking effect on cardiac calcium channel Ca_V1.2 with an IC₅₀ value of 3.76 µM. Surprisingly, no significant effect on each parameter has been shown with glyphosate. Glyphosate was devoid of major effect on cardiac calcium channel with a maximal effect at 100 µM (− 27.2 ± 1.7%, p < 0.01). In conclusion, Roundup® could induce severe cardiac toxicity by a blockade of Ca_V1.2 channel, leading to a worsening of heart contractility and genesis of arrhythmias. This toxicity could not be attributed to glyphosate.

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Titel: The Cardiotoxic Effect of Roundup® is not Induced by Glyphosate: A Non-specific Blockade of Human CaV1.2 Channels
verfasst von: Richard Printemps
Stéphanie Guilbot
Hélène Didier
Renaud Nalin
Bruno Le Grand
Publikationsdatum: 20.05.2022
Verlag: Springer US
Erschienen in: Cardiovascular Toxicology / Ausgabe 7/2022
Print ISSN: 1530-7905
Elektronische ISSN: 1559-0259
DOI: https://doi.org/10.1007/s12012-022-09749-3

Springer Medizin

Abstract

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