Introduction
Patients and methods
Results
Characteristics of the study population
Lean n = 200 (%) | Overweight n = 125 (%) | Obese n = 75 (%) | p value | |
---|---|---|---|---|
Age, years | ||||
Mean (SD) | 48.8 (11.8) | 53.1 (9.9) | 54.5 (10.5) | < .001 |
Tumor size, cm | ||||
< 2 | 92 (46) | 54 (43) | 28 (37) | .428 |
≥ 2 | 108 (54) | 71 (57) | 47 (63) | |
No. of positive nodes | ||||
0 | 132 (66) | 82 (66) | 44 (59) | .677 |
1–3 | 60 (30) | 39 (31) | 26 (35) | |
≥ 4 | 8 (4) | 4 (3) | 5 (6) | |
ER status | ||||
Negative | 14 (7) | 11 (9) | 4 (5) | .666 |
Positive | 186 (93) | 114 (91) | 71 (95) | |
PgR status | ||||
Negative | 62 (31) | 45 (36) | 18 (24) | .218 |
Positive | 138 (69) | 80 (64) | 57 (76) | |
HER2 status | ||||
Negative | 159 (80) | 95 (76) | 66 (88) | .113 |
Positive | 41 (20) | 30 (24) | 9 (12) | |
Histologic grade | ||||
1 | 15 (7) | 7 (6) | 4 (5) | .756 |
2 | 115 (58) | 70 (56) | 40 (54) | |
3 | 65 (33) | 46 (37) | 31 (41) | |
Unknown | 5 (2) | 2 (1) | – | |
Ki-67 | ||||
< 15% | 70 (35) | 38 (30) | 22 (29) | .835 |
≥ 15% | 114 (57) | 78 (63) | 48 (64) | |
Unknown | 16 (8) | 9 (7) | 5 (7) | |
Smoking status | ||||
Never | 110 (55) | 79 (63) | 42 (56) | .190 |
Ever | 90 (45) | 46 (37) | 32 (43) | |
Unknown | – | – | 1 (1) | |
Menopausal status | ||||
Premenopausal | 123 (62) | 58 (47) | 34 (45) | .004 |
Postmenopausal | 77 (38) | 65 (52) | 39 (52) | |
Unknown | – | 2 (1) | 2 (3) |
Relative dose intensity
Univariable | Multivariable | |||||
---|---|---|---|---|---|---|
OR | 95% CI | P value | OR | 95% CI | P value | |
Body mass index | 1.04 | 1.00–1.08 | .051 | 1.02 | 0.98–1.07 | .263 |
Age | 1.04 | 1.02–1.06 | < .001 | 1.04 | 1.02–1.06 | < .001 |
Menopausal status, postmenopausal | 2.00 | 1.32–3.03 | .001 |
Toxicity
Pathological response
Lean n = 128 (%) | Overweight n = 78 (%) | Obese n = 46 (%) | p value | |
---|---|---|---|---|
Age, years | ||||
Mean (SD) | 48.1 (11.6) | 54.0 (10.7) | 53.6 (10.6) | < .001 |
Tumor size, cm | ||||
< 2 | 44 (34) | 19 (24) | 16 (35) | .271 |
≥ 2 | 84 (66) | 59 (76) | 30 (65) | |
No. of positive nodes | ||||
0 | 64 (50) | 38 (49) | 17 (37) | .496 |
1–3 | 56 (44) | 36 (46) | 24 (52) | |
≥ 4 | 8 (6) | 4 (5) | 5 (11) | |
ER status | ||||
Negative | 7 (5) | 6 (8) | 3 (7) | .786 |
Positive | 121 (95) | 72 (92) | 43 (94) | |
PgR status | ||||
Negative | 39 (30) | 32 (41) | 11 (24) | .125 |
Positive | 89 (70) | 46 (59) | 35 (76) | |
HER2 status | ||||
Negative | 101 (79) | 65 (83) | 40 (87) | .453 |
Positive | 27 (21) | 13 (17) | 6 (13) | |
Histologic grade | ||||
1 | 8 (6) | 3 (4) | 2 (4) | .843 |
2 | 74 (58) | 44 (56) | 24 (52) | |
3 | 42 (33) | 29 (37) | 20 (44) | |
Unknown | 4 (3) | 2 (3) | – | |
Ki-67 | ||||
< 15% | 46 (36) | 27 (35) | 10 (22) | .361 |
≥ 15% | 76 (59) | 49 (63) | 33 (72) | |
Unknown | 6 (5) | 2 (2) | 3 (6) | |
Smoking status | ||||
Never | 71 (56) | 50 (64) | 27 (59) | .261 |
Ever | 57 (45) | 28 (36) | 18 (39) | |
Unknown | – | – | 1 (2) | |
Menopausal status | ||||
Premenopausal | 81 (63) | 34 (44) | 26 (57) | .022 |
Postmenopausal | 47 (37) | 44 (56) | 20 (44) | |
Pathological response* | ||||
Complete | 22 (17) | 11 (14) | 6 (13) | .799 |
Near complete | 31 (24) | 13 (17) | 13 (28) | |
Major | 46 (36) | 26 (33) | 17 (37) | |
Minor | 26 (20) | 24 (31) | 10 (22) | |
Unknown | 3 (2) | 4 (5) | – |