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Erschienen in: Inflammation Research 7/2023

06.07.2023 | Review

The potential roles of Th17 cells in the pathogenesis of oral lichen planus

verfasst von: Shima Afzali, Elham Mohammadisoleimani, Yaser Mansoori, Poopak Mohaghegh, Maryam Bahmanyar, Behnam Mansoori, Babak Pezeshki, Ghasem Nikfar, Alireza Tavassoli, Abbas Shahi, Ali Moravej

Erschienen in: Inflammation Research | Ausgabe 7/2023

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Abstract

Background

Oral lichen planus (OLP) is a T cell-mediated chronic autoimmune disease, whose pathogenesis and etiology are not entirely understood. OLP is characterized by subepithelial lymphocyte infiltration and elevated intra-epithelial lymphocytes. The majority of lamina propria lymphocytes are CD4+ T cells. CD4+ helper T (Th) cells play a crucial role in activating CD8+ cytotoxic T cells (CTLs) through interactions and cytokine production. Th1 and Th2 cells are well-accepted to be associated with OLP pathogenesis. However, OLP treatment is challenging yet, the more information we have about the pathology of OLP, the easier it will be treated. With the discovery of Th17 cells in recent years and the demonstration of their role in autoimmune disease, many researchers started to investigate the role of Th17 in the pathogenesis of OLP.

Methods

To make up this review, studies covering the role of TH17 in different types of lichen planus were selected from major databases.

Results

As we review in this article, Th17 cells and their signature cytokines play an important role in OLP pathogenesis. As well, utilizing some anti-IL-17 antibodies showed promising results in improving the disease; however, more studies are still needed to better understand and treat OLP.
Literatur
1.
Zurück zum Zitat Cheng YS, Gould A, Kurago Z, Fantasia J, Muller S. Diagnosis of oral lichen planus: a position paper of the American Academy of Oral and Maxillofacial Pathology. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122:332–54.PubMedCrossRef Cheng YS, Gould A, Kurago Z, Fantasia J, Muller S. Diagnosis of oral lichen planus: a position paper of the American Academy of Oral and Maxillofacial Pathology. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122:332–54.PubMedCrossRef
2.
Zurück zum Zitat Parashar P. Oral lichen planus. Otolaryngol Clin North Am. 2011;44(89–107):vi.PubMed Parashar P. Oral lichen planus. Otolaryngol Clin North Am. 2011;44(89–107):vi.PubMed
3.
Zurück zum Zitat Elenbaas A, Enciso R, Al-Eryani K. Oral Lichen Planus: a review of clinical features, etiologies, and treatments. Dentistry Review. 2022;2: 100007.CrossRef Elenbaas A, Enciso R, Al-Eryani K. Oral Lichen Planus: a review of clinical features, etiologies, and treatments. Dentistry Review. 2022;2: 100007.CrossRef
4.
Zurück zum Zitat Chiang CP, Yu-Fong Chang J, Wang YP, Wu YH, Lu SY, Sun A. Oral lichen planus—differential diagnoses, serum autoantibodies, hematinic deficiencies, and management. J Formos Med Assoc. 2018;117:756–65.PubMedCrossRef Chiang CP, Yu-Fong Chang J, Wang YP, Wu YH, Lu SY, Sun A. Oral lichen planus—differential diagnoses, serum autoantibodies, hematinic deficiencies, and management. J Formos Med Assoc. 2018;117:756–65.PubMedCrossRef
5.
Zurück zum Zitat Gupta S, Jawanda MK. Oral Lichen Planus: an update on etiology, pathogenesis, clinical presentation, diagnosis and management. Indian J Dermatol. 2015;60:222–9.PubMedPubMedCentralCrossRef Gupta S, Jawanda MK. Oral Lichen Planus: an update on etiology, pathogenesis, clinical presentation, diagnosis and management. Indian J Dermatol. 2015;60:222–9.PubMedPubMedCentralCrossRef
6.
Zurück zum Zitat Canto AM, Müller H, Freitas RR, Santos PS. Oral lichen planus (OLP): clinical and complementary diagnosis. An Bras Dermatol. 2010;85:669–75.PubMedCrossRef Canto AM, Müller H, Freitas RR, Santos PS. Oral lichen planus (OLP): clinical and complementary diagnosis. An Bras Dermatol. 2010;85:669–75.PubMedCrossRef
7.
Zurück zum Zitat Roopashree MR, Gondhalekar RV, Shashikanth MC, George J, Thippeswamy SH, Shukla A. Pathogenesis of oral lichen planus—a review. J Oral Pathol Med. 2010;39:729–34.PubMedCrossRef Roopashree MR, Gondhalekar RV, Shashikanth MC, George J, Thippeswamy SH, Shukla A. Pathogenesis of oral lichen planus—a review. J Oral Pathol Med. 2010;39:729–34.PubMedCrossRef
8.
Zurück zum Zitat Sugerman PB, Savage NW, Walsh LJ, Zhao ZZ, Zhou XJ, Khan A, Seymour GJ, Bigby M. The pathogenesis of oral lichen planus. Crit Rev Oral Biol Med. 2002;13:350–65.PubMedCrossRef Sugerman PB, Savage NW, Walsh LJ, Zhao ZZ, Zhou XJ, Khan A, Seymour GJ, Bigby M. The pathogenesis of oral lichen planus. Crit Rev Oral Biol Med. 2002;13:350–65.PubMedCrossRef
9.
Zurück zum Zitat Aghamajidi A, Raoufi E, Parsamanesh G, Jalili A, Salehi-Shadkami M, Mehrali M, Mohsenzadegan M. The attentive focus on T cell-mediated autoimmune pathogenesis of psoriasis, lichen planus and vitiligo. Scand J Immunol. 2021;93: e13000.PubMedCrossRef Aghamajidi A, Raoufi E, Parsamanesh G, Jalili A, Salehi-Shadkami M, Mehrali M, Mohsenzadegan M. The attentive focus on T cell-mediated autoimmune pathogenesis of psoriasis, lichen planus and vitiligo. Scand J Immunol. 2021;93: e13000.PubMedCrossRef
10.
Zurück zum Zitat Zhou XJ, Sugerman PB, Savage NW, Walsh LJ. Matrix metalloproteinases and their inhibitors in oral lichen planus. J Cutan Pathol. 2001;28:72–82.PubMedCrossRef Zhou XJ, Sugerman PB, Savage NW, Walsh LJ. Matrix metalloproteinases and their inhibitors in oral lichen planus. J Cutan Pathol. 2001;28:72–82.PubMedCrossRef
11.
Zurück zum Zitat Agha-Hosseini F, Mirzaii-Dizgah I, Mahboobi N, Shirazian S, Harirchi I. Serum and saliva MMP-3 in patients with OLP and oral SCC. J Contemp Dent Pract. 2015;16:107–11.PubMedCrossRef Agha-Hosseini F, Mirzaii-Dizgah I, Mahboobi N, Shirazian S, Harirchi I. Serum and saliva MMP-3 in patients with OLP and oral SCC. J Contemp Dent Pract. 2015;16:107–11.PubMedCrossRef
12.
Zurück zum Zitat Ertugrul AS, Dursun R, Dundar N, Avunduk MC, Hakki SS. MMP-1, MMP-9, and TIMP-1 levels in oral lichen planus patients with gingivitis or periodontitis. Arch Oral Biol. 2013;58:843–52.PubMedCrossRef Ertugrul AS, Dursun R, Dundar N, Avunduk MC, Hakki SS. MMP-1, MMP-9, and TIMP-1 levels in oral lichen planus patients with gingivitis or periodontitis. Arch Oral Biol. 2013;58:843–52.PubMedCrossRef
13.
Zurück zum Zitat Shan J, Li S, Wang C, Liu L, Wang X, Zhu D, Fan Y, Xu J. Expression and biological functions of the CCL5-CCR5 axis in oral lichen planus. Exp Dermatol. 2019;28:816–21.PubMedCrossRef Shan J, Li S, Wang C, Liu L, Wang X, Zhu D, Fan Y, Xu J. Expression and biological functions of the CCL5-CCR5 axis in oral lichen planus. Exp Dermatol. 2019;28:816–21.PubMedCrossRef
14.
Zurück zum Zitat Aravind T, Janardhanan M, Suresh R, Savithri V, Mohan M. Histopathologic evaluation of oral lichen planus and oral lichenoid reaction: a comparative analysis based on basement membrane thickness and the distribution of mast cells. J Oral Maxillofac Pathol. 2021;25:549–50.PubMedCrossRef Aravind T, Janardhanan M, Suresh R, Savithri V, Mohan M. Histopathologic evaluation of oral lichen planus and oral lichenoid reaction: a comparative analysis based on basement membrane thickness and the distribution of mast cells. J Oral Maxillofac Pathol. 2021;25:549–50.PubMedCrossRef
15.
Zurück zum Zitat Pereira T, Aswathy J, Shetty S, Tamgadge A, Tamgadge S, Gotmare S. Quantitative and qualitative analysis of mast cells in oral lichen planus and its effect on basement membrane using special stains. Indian Dermatol Online J. 2019;10:431–6.PubMedPubMedCentralCrossRef Pereira T, Aswathy J, Shetty S, Tamgadge A, Tamgadge S, Gotmare S. Quantitative and qualitative analysis of mast cells in oral lichen planus and its effect on basement membrane using special stains. Indian Dermatol Online J. 2019;10:431–6.PubMedPubMedCentralCrossRef
16.
Zurück zum Zitat Girdhar A, Kamboj M, Narwal A, Devi A, Anand R, Gupta A. Immunohistochemical correlation of mast cells and angiogenesis in oral lichen planus. Arch Oral Biol. 2022;142: 105509.PubMedCrossRef Girdhar A, Kamboj M, Narwal A, Devi A, Anand R, Gupta A. Immunohistochemical correlation of mast cells and angiogenesis in oral lichen planus. Arch Oral Biol. 2022;142: 105509.PubMedCrossRef
17.
Zurück zum Zitat Payeras MR, Cherubini K, Figueiredo MA, Salum FG. Oral lichen planus: focus on etiopathogenesis. Arch Oral Biol. 2013;58:1057–69.PubMedCrossRef Payeras MR, Cherubini K, Figueiredo MA, Salum FG. Oral lichen planus: focus on etiopathogenesis. Arch Oral Biol. 2013;58:1057–69.PubMedCrossRef
18.
Zurück zum Zitat Merry R, Belfield L, McArdle P, McLennan A, Crean S, Foey A. Oral health and pathology: a macrophage account. Br J Oral Maxillofac Surg. 2012;50:2–7.PubMedCrossRef Merry R, Belfield L, McArdle P, McLennan A, Crean S, Foey A. Oral health and pathology: a macrophage account. Br J Oral Maxillofac Surg. 2012;50:2–7.PubMedCrossRef
19.
Zurück zum Zitat Chang JY, Chiang CP, Hsiao CK, Sun A. Significantly higher frequencies of presence of serum autoantibodies in Chinese patients with oral lichen planus. J Oral Pathol Med. 2009;38:48–54.PubMedCrossRef Chang JY, Chiang CP, Hsiao CK, Sun A. Significantly higher frequencies of presence of serum autoantibodies in Chinese patients with oral lichen planus. J Oral Pathol Med. 2009;38:48–54.PubMedCrossRef
20.
Zurück zum Zitat Lukac J, Brozović S, Vucicević-Boras V, Mravak-Stipetić M, Malenica B, Kusić Z. Serum autoantibodies to desmogleins 1 and 3 in patients with oral lichen planus. Croat Med J. 2006;47:53–8.PubMedPubMedCentral Lukac J, Brozović S, Vucicević-Boras V, Mravak-Stipetić M, Malenica B, Kusić Z. Serum autoantibodies to desmogleins 1 and 3 in patients with oral lichen planus. Croat Med J. 2006;47:53–8.PubMedPubMedCentral
21.
Zurück zum Zitat Vahide L, Zahra H, Forugh G, Nazi S. Autoantibodies to desmogleins 1 and 3 in patients with lichen planus. Arch Dermatol Res. 2017;309:579–83.PubMedCrossRef Vahide L, Zahra H, Forugh G, Nazi S. Autoantibodies to desmogleins 1 and 3 in patients with lichen planus. Arch Dermatol Res. 2017;309:579–83.PubMedCrossRef
22.
Zurück zum Zitat Xie S, Ding L, Xiong Z, Zhu S. Implications of Th1 and Th17 cells in pathogenesis of oral lichen planus. J Huazhong Univ Sci Technol Med Sci. 2012;32:451–7.CrossRef Xie S, Ding L, Xiong Z, Zhu S. Implications of Th1 and Th17 cells in pathogenesis of oral lichen planus. J Huazhong Univ Sci Technol Med Sci. 2012;32:451–7.CrossRef
23.
Zurück zum Zitat Kurebayashi Y, Nagai S, Ikejiri A, Koyasu S. Recent advances in understanding the molecular mechanisms of the development and function of Th17 cells. Genes Cells. 2013;18:247–65.PubMedPubMedCentralCrossRef Kurebayashi Y, Nagai S, Ikejiri A, Koyasu S. Recent advances in understanding the molecular mechanisms of the development and function of Th17 cells. Genes Cells. 2013;18:247–65.PubMedPubMedCentralCrossRef
25.
Zurück zum Zitat Kondĕlková K, Vokurková D, Krejsek J, Borská L, Fiala Z, Ctirad A. Regulatory T cells (TREG) and their roles in immune system with respect to immunopathological disorders. Acta Medica (Hradec Kralove). 2010;53:73–7.PubMedCrossRef Kondĕlková K, Vokurková D, Krejsek J, Borská L, Fiala Z, Ctirad A. Regulatory T cells (TREG) and their roles in immune system with respect to immunopathological disorders. Acta Medica (Hradec Kralove). 2010;53:73–7.PubMedCrossRef
27.
Zurück zum Zitat Cerboni S, Gehrmann U, Preite S, Mitra S. Cytokine-regulated Th17 plasticity in human health and diseases. Immunology. 2021;163:3–18.PubMedCrossRef Cerboni S, Gehrmann U, Preite S, Mitra S. Cytokine-regulated Th17 plasticity in human health and diseases. Immunology. 2021;163:3–18.PubMedCrossRef
28.
Zurück zum Zitat Zambrano-Zaragoza JF, Romo-Martínez EJ, Durán-Avelar Mde J, García-Magallanes N, Vibanco-Pérez N. Th17 cells in autoimmune and infectious diseases. Int J Inflam. 2014;2014: 651503.PubMedPubMedCentral Zambrano-Zaragoza JF, Romo-Martínez EJ, Durán-Avelar Mde J, García-Magallanes N, Vibanco-Pérez N. Th17 cells in autoimmune and infectious diseases. Int J Inflam. 2014;2014: 651503.PubMedPubMedCentral
29.
Zurück zum Zitat Yasuda K, Takeuchi Y, Hirota K. The pathogenicity of Th17 cells in autoimmune diseases. Semin Immunopathol. 2019;41:283–97.PubMedCrossRef Yasuda K, Takeuchi Y, Hirota K. The pathogenicity of Th17 cells in autoimmune diseases. Semin Immunopathol. 2019;41:283–97.PubMedCrossRef
30.
Zurück zum Zitat Qin H, Wang L, Feng T, Elson CO, Niyongere SA, Lee SJ, Reynolds SL, Weaver CT, Roarty K, Serra R, et al. TGF-β promotes Th17 cell development through inhibition of SOCS3. J Immunol. 2009;183:97–105.PubMedCrossRef Qin H, Wang L, Feng T, Elson CO, Niyongere SA, Lee SJ, Reynolds SL, Weaver CT, Roarty K, Serra R, et al. TGF-β promotes Th17 cell development through inhibition of SOCS3. J Immunol. 2009;183:97–105.PubMedCrossRef
31.
Zurück zum Zitat Korn T, Bettelli E, Gao W, Awasthi A, Jäger A, Strom TB, Oukka M, Kuchroo VK. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature. 2007;448:484–7.PubMedPubMedCentralCrossRef Korn T, Bettelli E, Gao W, Awasthi A, Jäger A, Strom TB, Oukka M, Kuchroo VK. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature. 2007;448:484–7.PubMedPubMedCentralCrossRef
32.
Zurück zum Zitat Schinocca C, Rizzo C, Fasano S, Grasso G, La Barbera L, Ciccia F, Guggino G. Role of the IL-23/IL-17 pathway in rheumatic diseases: an overview. Front Immunol. 2021;12: 637829.PubMedPubMedCentralCrossRef Schinocca C, Rizzo C, Fasano S, Grasso G, La Barbera L, Ciccia F, Guggino G. Role of the IL-23/IL-17 pathway in rheumatic diseases: an overview. Front Immunol. 2021;12: 637829.PubMedPubMedCentralCrossRef
33.
Zurück zum Zitat Gagliani N, Amezcua Vesely MC, Iseppon A, Brockmann L, Xu H, Palm NW, de Zoete MR, Licona-Limón P, Paiva RS, Ching T, et al. Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation. Nature. 2015;523:221–5.PubMedPubMedCentralCrossRef Gagliani N, Amezcua Vesely MC, Iseppon A, Brockmann L, Xu H, Palm NW, de Zoete MR, Licona-Limón P, Paiva RS, Ching T, et al. Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation. Nature. 2015;523:221–5.PubMedPubMedCentralCrossRef
35.
Zurück zum Zitat Wang H, Bai J, Luo Z, Fu J, Wang H, Sun Z. Overexpression and varied clinical significance of Th9 versus Th17 cells in distinct subtypes of oral lichen planus. Arch Oral Biol. 2017;80:110–6.PubMedCrossRef Wang H, Bai J, Luo Z, Fu J, Wang H, Sun Z. Overexpression and varied clinical significance of Th9 versus Th17 cells in distinct subtypes of oral lichen planus. Arch Oral Biol. 2017;80:110–6.PubMedCrossRef
36.
Zurück zum Zitat Wang H, Guan X, Luo Z, Liu Y, Ren Q, Zhao X. The association and potentially destructive role of Th9/IL-9 is synergistic with Th17 cells by elevating MMP9 production in local lesions of oral lichen planus. J Oral Pathol Med. 2018;47:425–33.PubMedCrossRef Wang H, Guan X, Luo Z, Liu Y, Ren Q, Zhao X. The association and potentially destructive role of Th9/IL-9 is synergistic with Th17 cells by elevating MMP9 production in local lesions of oral lichen planus. J Oral Pathol Med. 2018;47:425–33.PubMedCrossRef
37.
Zurück zum Zitat Gueiros LA, Arão T, Souza T, Vieira CL, Gomez RS, Almeida OP, Lodi G, Leão JC. IL17A polymorphism and elevated IL17A serum levels are associated with oral lichen planus. Oral Dis. 2018;24:377–83.PubMedCrossRef Gueiros LA, Arão T, Souza T, Vieira CL, Gomez RS, Almeida OP, Lodi G, Leão JC. IL17A polymorphism and elevated IL17A serum levels are associated with oral lichen planus. Oral Dis. 2018;24:377–83.PubMedCrossRef
38.
Zurück zum Zitat Lu R, Zeng X, Han Q, Lin M, Long L, Dan H, Zhou G, Chen Q. Overexpression and selectively regulatory roles of IL-23/IL-17 axis in the lesions of oral lichen planus. Mediators Inflamm. 2014;2014: 701094.PubMedPubMedCentralCrossRef Lu R, Zeng X, Han Q, Lin M, Long L, Dan H, Zhou G, Chen Q. Overexpression and selectively regulatory roles of IL-23/IL-17 axis in the lesions of oral lichen planus. Mediators Inflamm. 2014;2014: 701094.PubMedPubMedCentralCrossRef
39.
Zurück zum Zitat Monteiro BV, Pereira Jdos S, Nonaka CF, Godoy GP, da Silveira ÉJ, Miguel MC. Immunoexpression of Th17-related cytokines in oral lichen planus. Appl Immunohistochem Mol Morphol. 2015;23:409–15.PubMedCrossRef Monteiro BV, Pereira Jdos S, Nonaka CF, Godoy GP, da Silveira ÉJ, Miguel MC. Immunoexpression of Th17-related cytokines in oral lichen planus. Appl Immunohistochem Mol Morphol. 2015;23:409–15.PubMedCrossRef
40.
Zurück zum Zitat Wang K, Miao T, Lu W, He J, Cui B, Li J, Li Y, Xiao L. Analysis of oral microbial community and Th17-associated cytokines in saliva of patients with oral lichen planus. Microbiol Immunol. 2015;59:105–13.PubMedCrossRef Wang K, Miao T, Lu W, He J, Cui B, Li J, Li Y, Xiao L. Analysis of oral microbial community and Th17-associated cytokines in saliva of patients with oral lichen planus. Microbiol Immunol. 2015;59:105–13.PubMedCrossRef
41.
Zurück zum Zitat Piccinni MP, Lombardelli L, Logiodice F, Tesi D, Kullolli O, Biagiotti R, Giudizi M, Romagnani S, Maggi E, Ficarra G. Potential pathogenetic role of Th17, Th0, and Th2 cells in erosive and reticular oral lichen planus. Oral Dis. 2014;20:212–8.PubMedCrossRef Piccinni MP, Lombardelli L, Logiodice F, Tesi D, Kullolli O, Biagiotti R, Giudizi M, Romagnani S, Maggi E, Ficarra G. Potential pathogenetic role of Th17, Th0, and Th2 cells in erosive and reticular oral lichen planus. Oral Dis. 2014;20:212–8.PubMedCrossRef
42.
Zurück zum Zitat Melo RA, Silva LAB, Fernades-Costa AN, Monteiro BVB, Silveira EJD, Miguel MCC. Participation of the Th17 response in the pathogenesis of oral lichen planus. J Eur Acad Dermatol Venereol. 2018;32:e264–5.PubMedCrossRef Melo RA, Silva LAB, Fernades-Costa AN, Monteiro BVB, Silveira EJD, Miguel MCC. Participation of the Th17 response in the pathogenesis of oral lichen planus. J Eur Acad Dermatol Venereol. 2018;32:e264–5.PubMedCrossRef
43.
Zurück zum Zitat Shen Z, Gao X, Ma L, Zhou Z, Shen X, Liu W. Expression of Foxp3 and interleukin-17 in lichen planus lesions with emphasis on difference in oral and cutaneous variants. Arch Dermatol Res. 2014;306:441–6.PubMedCrossRef Shen Z, Gao X, Ma L, Zhou Z, Shen X, Liu W. Expression of Foxp3 and interleukin-17 in lichen planus lesions with emphasis on difference in oral and cutaneous variants. Arch Dermatol Res. 2014;306:441–6.PubMedCrossRef
44.
Zurück zum Zitat Weber B, Schlapbach C, Stuck M, Simon HU, Borradori L, Beltraminelli H, Simon D. Distinct interferon-gamma and interleukin-9 expression in cutaneous and oral lichen planus. J Eur Acad Dermatol Venereol. 2017;31:880–6.PubMedCrossRef Weber B, Schlapbach C, Stuck M, Simon HU, Borradori L, Beltraminelli H, Simon D. Distinct interferon-gamma and interleukin-9 expression in cutaneous and oral lichen planus. J Eur Acad Dermatol Venereol. 2017;31:880–6.PubMedCrossRef
45.
Zurück zum Zitat Chen J, Feng J, Chen X, Xu H, Zhou Z, Shen X, Bao Z, Liu W, Shen Z. Immunoexpression of interleukin-22 and interleukin-23 in oral and cutaneous lichen planus lesions: a preliminary study. Mediators Inflamm. 2013;2013: 801974.PubMedPubMedCentralCrossRef Chen J, Feng J, Chen X, Xu H, Zhou Z, Shen X, Bao Z, Liu W, Shen Z. Immunoexpression of interleukin-22 and interleukin-23 in oral and cutaneous lichen planus lesions: a preliminary study. Mediators Inflamm. 2013;2013: 801974.PubMedPubMedCentralCrossRef
46.
Zurück zum Zitat Qian H, Jiao L, Fan Z, Wang L, Liu B, Miao G. Analysis of immunologic function changes in lichen planus after clinical treatment. Med Sci Monit. 2018;24:8716–21.PubMedPubMedCentralCrossRef Qian H, Jiao L, Fan Z, Wang L, Liu B, Miao G. Analysis of immunologic function changes in lichen planus after clinical treatment. Med Sci Monit. 2018;24:8716–21.PubMedPubMedCentralCrossRef
47.
Zurück zum Zitat Wang H, Luo Z, Lei L, Sun Z, Zhou M, Dan H, Zeng X, Chen Q. Interaction between oral lichen planus and chronic periodontitis with Th17-associated cytokines in serum. Inflammation. 2013;36:696–704.PubMedCrossRef Wang H, Luo Z, Lei L, Sun Z, Zhou M, Dan H, Zeng X, Chen Q. Interaction between oral lichen planus and chronic periodontitis with Th17-associated cytokines in serum. Inflammation. 2013;36:696–704.PubMedCrossRef
48.
Zurück zum Zitat Wang H, Han Q, Luo Z, Xu C, Liu J, Dan H, Xu Y, Zeng X, Chen Q. Oral lichen planus may enhance the expression of Th17-associated cytokines in local lesions of chronic periodontitis. Clin Oral Investig. 2014;18:1647–54.PubMedCrossRef Wang H, Han Q, Luo Z, Xu C, Liu J, Dan H, Xu Y, Zeng X, Chen Q. Oral lichen planus may enhance the expression of Th17-associated cytokines in local lesions of chronic periodontitis. Clin Oral Investig. 2014;18:1647–54.PubMedCrossRef
49.
Zurück zum Zitat Vered M, Fürth E, Shalev Y, Dayan D. Inflammatory cells of immunosuppressive phenotypes in oral lichen planus have a proinflammatory pattern of expression and are associated with clinical parameters. Clin Oral Investig. 2013;17:1365–73.PubMedCrossRef Vered M, Fürth E, Shalev Y, Dayan D. Inflammatory cells of immunosuppressive phenotypes in oral lichen planus have a proinflammatory pattern of expression and are associated with clinical parameters. Clin Oral Investig. 2013;17:1365–73.PubMedCrossRef
50.
Zurück zum Zitat Yamauchi M, Moriyama M, Hayashida JN, Maehara T, Ishiguro N, Kubota K, Furukawa S, Ohta M, Sakamoto M, Tanaka A, Nakamura S. Myeloid dendritic cells stimulated by thymic stromal lymphopoietin promote Th2 immune responses and the pathogenesis of oral lichen planus. PLoS One. 2017;12: e0173017.PubMedPubMedCentralCrossRef Yamauchi M, Moriyama M, Hayashida JN, Maehara T, Ishiguro N, Kubota K, Furukawa S, Ohta M, Sakamoto M, Tanaka A, Nakamura S. Myeloid dendritic cells stimulated by thymic stromal lymphopoietin promote Th2 immune responses and the pathogenesis of oral lichen planus. PLoS One. 2017;12: e0173017.PubMedPubMedCentralCrossRef
51.
Zurück zum Zitat Firth FA, Friedlander LT, Parachuru VP, Kardos TB, Seymour GJ, Rich AM. Regulation of immune cells in oral lichen planus. Arch Dermatol Res. 2015;307:333–9.PubMedCrossRef Firth FA, Friedlander LT, Parachuru VP, Kardos TB, Seymour GJ, Rich AM. Regulation of immune cells in oral lichen planus. Arch Dermatol Res. 2015;307:333–9.PubMedCrossRef
52.
Zurück zum Zitat Javvadi LR, Parachuru VP, Milne TJ, Seymour GJ, Rich AM. Regulatory T-cells and IL17A(+) cells infiltrate oral lichen planus lesions. Pathology. 2016;48:564–73.PubMedCrossRef Javvadi LR, Parachuru VP, Milne TJ, Seymour GJ, Rich AM. Regulatory T-cells and IL17A(+) cells infiltrate oral lichen planus lesions. Pathology. 2016;48:564–73.PubMedCrossRef
53.
Zurück zum Zitat Shaker O, Hassan AS. Possible role of interleukin-17 in the pathogenesis of lichen planus. Br J Dermatol. 2012;166:1367–8.PubMedCrossRef Shaker O, Hassan AS. Possible role of interleukin-17 in the pathogenesis of lichen planus. Br J Dermatol. 2012;166:1367–8.PubMedCrossRef
54.
Zurück zum Zitat Shen Z, Zhang C, Zhou Z, Liu W, Shi L, Shen X. Altered expression of interleukin-17A and its targeting microRNAs in oral lichen planus: a pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122:619-624.e611.PubMedCrossRef Shen Z, Zhang C, Zhou Z, Liu W, Shi L, Shen X. Altered expression of interleukin-17A and its targeting microRNAs in oral lichen planus: a pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122:619-624.e611.PubMedCrossRef
55.
Zurück zum Zitat Souza MM, Florezi GP, Nico M, de Paula F, Paula FM, Lourenço SV. Salivary proteomics in lichen planus: a relationship with pathogenesis? Oral Dis. 2018;24:784–92.PubMedCrossRef Souza MM, Florezi GP, Nico M, de Paula F, Paula FM, Lourenço SV. Salivary proteomics in lichen planus: a relationship with pathogenesis? Oral Dis. 2018;24:784–92.PubMedCrossRef
56.
Zurück zum Zitat Schmidt T, Solimani F, Pollmann R, Stein R, Schmidt A, Stulberg I, Kühn K, Eming R, Eubel V, Kind P, et al. T(H)1/T(H)17 cell recognition of desmoglein 3 and bullous pemphigoid antigen 180 in patients with lichen planus. J Allergy Clin Immunol. 2018;142:669-672.e667.PubMedCrossRef Schmidt T, Solimani F, Pollmann R, Stein R, Schmidt A, Stulberg I, Kühn K, Eming R, Eubel V, Kind P, et al. T(H)1/T(H)17 cell recognition of desmoglein 3 and bullous pemphigoid antigen 180 in patients with lichen planus. J Allergy Clin Immunol. 2018;142:669-672.e667.PubMedCrossRef
57.
Zurück zum Zitat Kumaran MS, Bishnoi A, Srivastava N, Tekumalla S, Vinay K, Bhatia A, Parsad D. Significant reduction in the expression of interleukins-17A, 22 and 23A, forkhead box p3 and interferon gamma delineates lichen planus pigmentosus from lichen planus. Arch Dermatol Res. 2019;311:519–27.PubMedCrossRef Kumaran MS, Bishnoi A, Srivastava N, Tekumalla S, Vinay K, Bhatia A, Parsad D. Significant reduction in the expression of interleukins-17A, 22 and 23A, forkhead box p3 and interferon gamma delineates lichen planus pigmentosus from lichen planus. Arch Dermatol Res. 2019;311:519–27.PubMedCrossRef
58.
Zurück zum Zitat Salehi S, Afzali S, Shahi A, Amirzargar AA, Mansoori Y. Potential roles of long noncoding RNAs as therapeutic targets in organ transplantation. Front Immunol. 2022;13: 835746.PubMedPubMedCentralCrossRef Salehi S, Afzali S, Shahi A, Amirzargar AA, Mansoori Y. Potential roles of long noncoding RNAs as therapeutic targets in organ transplantation. Front Immunol. 2022;13: 835746.PubMedPubMedCentralCrossRef
59.
60.
Zurück zum Zitat Dahariya S, Paddibhatla I, Kumar S, Raghuwanshi S, Pallepati A, Gutti RK. Long non-coding RNA: classification, biogenesis and functions in blood cells. Mol Immunol. 2019;112:82–92.PubMedCrossRef Dahariya S, Paddibhatla I, Kumar S, Raghuwanshi S, Pallepati A, Gutti RK. Long non-coding RNA: classification, biogenesis and functions in blood cells. Mol Immunol. 2019;112:82–92.PubMedCrossRef
61.
Zurück zum Zitat Wang J, Zhai X, Guo J, Li Y, Yang Y, Wang L, Yang L, Liu F. Long non-coding RNA DQ786243 modulates the induction and function of CD4(+) Treg cells through Foxp3-miR-146a-NF-κB axis: implications for alleviating oral lichen planus. Int Immunopharmacol. 2019;75: 105761.PubMedCrossRef Wang J, Zhai X, Guo J, Li Y, Yang Y, Wang L, Yang L, Liu F. Long non-coding RNA DQ786243 modulates the induction and function of CD4(+) Treg cells through Foxp3-miR-146a-NF-κB axis: implications for alleviating oral lichen planus. Int Immunopharmacol. 2019;75: 105761.PubMedCrossRef
62.
Zurück zum Zitat Fu ZZ, Chen LQ, Xu YX, Yue J, Ding Q, Xiao WL. Treatment of oral lichen planus by surgical excision and acellular dermal matrix grafting: eleven case reports and review of literature. World J Clin Cases. 2021;9:1446–54.PubMedPubMedCentralCrossRef Fu ZZ, Chen LQ, Xu YX, Yue J, Ding Q, Xiao WL. Treatment of oral lichen planus by surgical excision and acellular dermal matrix grafting: eleven case reports and review of literature. World J Clin Cases. 2021;9:1446–54.PubMedPubMedCentralCrossRef
63.
Zurück zum Zitat Yang K, Oak ASW, Elewski BE. Use of IL-23 inhibitors for the treatment of plaque psoriasis and psoriatic arthritis: a comprehensive review. Am J Clin Dermatol. 2021;22:173–92.PubMedCrossRef Yang K, Oak ASW, Elewski BE. Use of IL-23 inhibitors for the treatment of plaque psoriasis and psoriatic arthritis: a comprehensive review. Am J Clin Dermatol. 2021;22:173–92.PubMedCrossRef
64.
Zurück zum Zitat Solimani F, Pollmann R, Schmidt T, Schmidt A, Zheng X, Savai R, Mühlenbein S, Pickert J, Eubel V, Möbs C, et al. Therapeutic targeting of Th17/Tc17 cells leads to clinical improvement of lichen planus. Front Immunol. 1808;2019:10. Solimani F, Pollmann R, Schmidt T, Schmidt A, Zheng X, Savai R, Mühlenbein S, Pickert J, Eubel V, Möbs C, et al. Therapeutic targeting of Th17/Tc17 cells leads to clinical improvement of lichen planus. Front Immunol. 1808;2019:10.
Metadaten
Titel
The potential roles of Th17 cells in the pathogenesis of oral lichen planus
verfasst von
Shima Afzali
Elham Mohammadisoleimani
Yaser Mansoori
Poopak Mohaghegh
Maryam Bahmanyar
Behnam Mansoori
Babak Pezeshki
Ghasem Nikfar
Alireza Tavassoli
Abbas Shahi
Ali Moravej
Publikationsdatum
06.07.2023
Verlag
Springer International Publishing
Erschienen in
Inflammation Research / Ausgabe 7/2023
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-023-01763-7

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