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01.10.2019 | Review

The role of the intestinal microbiota in uremic solute accumulation: a focus on sulfur compounds

verfasst von: Alessandra F. Perna, Griet Glorieux, Miriam Zacchia, Francesco Trepiccione, Giovanna Capolongo, Carmela Vigorito, Evgeniya Anishchenko, Diego Ingrosso

Erschienen in: Journal of Nephrology | Ausgabe 5/2019

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Abstract

The gut microbiota is considered to be a novel important factor to take into account in the pathogenesis of chronic kidney disease and uremia. Much attention has been paid to specific uremic retention solutes of microbial origin, such as indoxyl sulfate, p-cresyl sulfate, and trimethylamine-N-oxide. However, other novel less well studied compounds, such as hydrogen sulfide and related sulfur metabolites (sulfane sulfur, lanthionine, etc.), should be included in a more comprehensive appraisal of this topic, in light of the potential therapeutic opportunities for the future.

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Titel: The role of the intestinal microbiota in uremic solute accumulation: a focus on sulfur compounds
verfasst von: Alessandra F. Perna
Griet Glorieux
Miriam Zacchia
Francesco Trepiccione
Giovanna Capolongo
Carmela Vigorito
Evgeniya Anishchenko
Diego Ingrosso
Publikationsdatum: 01.10.2019
Verlag: Springer International Publishing
Erschienen in: Journal of Nephrology / Ausgabe 5/2019
Print ISSN: 1121-8428
Elektronische ISSN: 1724-6059
DOI: https://doi.org/10.1007/s40620-019-00589-z

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