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01.11.2007 | Original Article

The use of short-echo-time ¹H MRS for childhood cerebellar tumours prior to histopathological diagnosis

verfasst von: Lisa M. Harris, Nigel Davies, Lesley MacPherson, Katharine Foster, Shaheen Lateef, Kal Natarajan, Spyridon Sgouros, Marie-Anne Brundler, Theodoros N. Arvanitis, Richard G. Grundy, Andrew C. Peet

Erschienen in: Pediatric Radiology | Ausgabe 11/2007

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Abstract

Background

Proton magnetic resonance spectroscopy (MRS) measures concentrations of metabolites in vivo and provides a powerful method for identifying tumours. MRS has not entered routine clinical use partly due to the difficulty of analysing the spectra.

Objective

To create a straightforward method for interpreting short-echo-time MRS of childhood cerebellar tumours.

Materials and methods

Single-voxel MRS (1.5-T Siemens Symphony NUM4, TR/TE 1,500/30 ms) was performed at presentation in 30 children with cerebellar tumours. The MRS results were analysed for comparison with histological diagnosis. Peak heights for N-acetyl aspartate (NAA), creatine (Cr), choline (Cho) and myo-inositol (mIns) were determined and receiver operator characteristic curves used to select ratios that best discriminated between the tumour types. The method was implemented by a group of clinicians and scientists, blinded to the results.

Results

A total of 27 MRS studies met the quality control criteria. NAA/Cr >4.0 distinguished all but one of the astrocytomas from the other tumours. A combination of Cr/Cho <0.75 and mIns/NAA <2.1 separated all the medulloblastomas from the ependymomas.

Conclusion

Peak height ratios from short-echo-time MRS can accurately predict the histopathology of childhood cerebellar tumours.

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Titel: The use of short-echo-time 1H MRS for childhood cerebellar tumours prior to histopathological diagnosis
verfasst von: Lisa M. Harris
Nigel Davies
Lesley MacPherson
Katharine Foster
Shaheen Lateef
Kal Natarajan
Spyridon Sgouros
Marie-Anne Brundler
Theodoros N. Arvanitis
Richard G. Grundy
Andrew C. Peet
Publikationsdatum: 01.11.2007
Verlag: Springer-Verlag
Erschienen in: Pediatric Radiology / Ausgabe 11/2007
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-007-0571-5

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The use of short-echo-time ¹H MRS for childhood cerebellar tumours prior to histopathological diagnosis