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Inflammation Research
Erschienen in: Inflammation Research 4/2024

18.03.2024 | Review

Tricarboxylic acid cycle metabolites: new players in macrophage

verfasst von: Ying Yang, Bing-Bing Cui, Jian Li, Jiao-Jiao Shan, Jun Xu, Cheng-Yong Zhang, Xiao-Tong Wei, Ri-Ran Zhu, Jing-Yi Wang

Erschienen in: Inflammation Research | Ausgabe 4/2024

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Abstract

Metabolic remodeling is a key feature of macrophage activation and polarization. Recent studies have demonstrated the role of tricarboxylic acid (TCA) cycle metabolites in the innate immune system. In the current review, we summarize recent advances in the metabolic reprogramming of the TCA cycle during macrophage activation and polarization and address the effects of these metabolites in modulating macrophage function. Deciphering the crosstalk between the TCA cycle and the immune response might provide novel potential targets for the intervention of immune reactions and favor the development of new strategies for the treatment of infection, inflammation, and cancer.
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Metadaten
Titel
Tricarboxylic acid cycle metabolites: new players in macrophage
verfasst von
Ying Yang
Bing-Bing Cui
Jian Li
Jiao-Jiao Shan
Jun Xu
Cheng-Yong Zhang
Xiao-Tong Wei
Ri-Ran Zhu
Jing-Yi Wang
Publikationsdatum
18.03.2024
Verlag
Springer International Publishing
Erschienen in
Inflammation Research / Ausgabe 4/2024
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-024-01853-0

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