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Erschienen in:

18.01.2021 | Short Communication

Tryptophan depletion predicts lower positive affect in sexual minority men living with HIV who use methamphetamine

verfasst von: Ji-Young Lee, Tiffany R. Glynn, Judith T. Moskowitz, Dietmar Fuchs, Torsten B. Neilands, Samantha E. Dilworth, Daniel J. Feaster, Allan Rodriguez, Adam W. Carrico

Erschienen in: Journal of NeuroVirology | Ausgabe 1/2021

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Abstract

This longitudinal study with 76 sexual minority men living with HIV who use methamphetamine examined whether dysregulation of essential amino acid precursors for neurotransmitters at baseline predicted positive and negative affect at 15 months. After controlling for covariates including baseline positive affect, a higher baseline kynurenine/tryptophan (K/T) ratio independently predicted lower positive affect at 15 months (β = − 18.31; 95% CI = − 35.35, − 1.27; p = 0.036). Future clinical research should examine whether bio-behavioral interventions targeting tryptophan degradation could optimize treatments for people living with co-occurring HIV and stimulant use disorders.

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Titel: Tryptophan depletion predicts lower positive affect in sexual minority men living with HIV who use methamphetamine
verfasst von: Ji-Young Lee
Tiffany R. Glynn
Judith T. Moskowitz
Dietmar Fuchs
Torsten B. Neilands
Samantha E. Dilworth
Daniel J. Feaster
Allan Rodriguez
Adam W. Carrico
Publikationsdatum: 18.01.2021
Verlag: Springer International Publishing
Erschienen in: Journal of NeuroVirology / Ausgabe 1/2021
Print ISSN: 1355-0284
Elektronische ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-020-00937-x

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