Erschienen in:
04.07.2023 | Research Letter
Urine-to-plasma creatinine ratio and fractional excretion of urea performance in acute-on-chronic kidney disease patients
verfasst von:
Loïc Lievre, Vincent Dupont, Lukshe Kanagaratnam, Laurent Faroux, Alexandre Debrumetz, Philippe Rieu, Alain Wynckel
Erschienen in:
Journal of Nephrology
|
Ausgabe 9/2023
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Excerpt
Acute-on-chronic kidney disease is a common occurrence and is associated with a higher risk of progression to end stage renal disease and death [
1]. Correct identification of the acute kidney injury (AKI) mechanism and prognosis is a key component of the clinical management for these patients. Despite its importance, AKI still represents a day-to-day clinical challenge for nephrologists as the diagnostic performance of the commonly used urinary indices remain uncertain in chronic kidney disease (CKD) patients [
2,
3]. Recently, the consensus report of the Acute Disease Quality Initiative (ADQI) proposed a new objective definition which distinguishes transient AKI (T-AKI) from acute kidney disease (AKD), based on long-term outcomes after an AKI episode [
4]. We aimed to investigate the performance of urine-to-plasma creatinine ratio (U/P Creat) and fractional excretion of urea (FeUrea) to distinguish T-AKI from AKD in acute-on-chronic kidney disease patients. …