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Die Highlights vom Kongress des American College of Cardiology 2024

Im April diskutierten die Herz-Kreislauf-Spezialisten aus der ganzen Welt auf dem  Kongress des American College of Cardiology (ACC) u.a. neue Therapieansätze bei akutem Myokardinfarkt, koronarer Herzerkrankung, kardiogenem Schock oder Aortenklappenstenose. In unserem Kongress-Dossier haben wir für Sie Berichte über die „Late-Breaking Trials“ und andere wichtige Studien zusammengestellt. 
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Current Treatment Options in Oncology
Erschienen in: Current Treatment Options in Oncology 4/2024

19.02.2024

A Comprehensive Review of Cancer Drug–Induced Cardiotoxicity in Blood Cancer Patients: Current Perspectives and Therapeutic Strategies

verfasst von: Vincenzo Costanzo, PhD, Yashwant Kumar Ratre, PhD, Emanuela Andretta, PhD, Rakesh Acharya, M.sc Zoology, L. V. K. S. Bhaskar, PhD, Henu Kumar Verma, PhD

Erschienen in: Current Treatment Options in Oncology | Ausgabe 4/2024

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Opinion statement

Cardiotoxicity has emerged as a serious outcome catalyzed by various therapeutic targets in the field of cancer treatment, which includes chemotherapy, radiation, and targeted therapies. The growing significance of cancer drug–induced cardiotoxicity (CDIC) and radiation-induced cardiotoxicity (CRIC) necessitates immediate attention. This article intricately unveils how cancer treatments cause cardiotoxicity, which is exacerbated by patient-specific risks. In particular, drugs like anthracyclines, alkylating agents, and tyrosine kinase inhibitors pose a risk, along with factors such as hypertension and diabetes. Mechanistic insights into oxidative stress and topoisomerase-II-B inhibition are crucial, while cardiac biomarkers show early damage. Timely intervention and prompt treatment, especially with specific agents like dexrazoxane and beta-blockers, are pivotal in the proactive management of CDIC.
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Metadaten
Titel
A Comprehensive Review of Cancer Drug–Induced Cardiotoxicity in Blood Cancer Patients: Current Perspectives and Therapeutic Strategies
verfasst von
Vincenzo Costanzo, PhD
Yashwant Kumar Ratre, PhD
Emanuela Andretta, PhD
Rakesh Acharya, M.sc Zoology
L. V. K. S. Bhaskar, PhD
Henu Kumar Verma, PhD
Publikationsdatum
19.02.2024
Verlag
Springer US
Erschienen in
Current Treatment Options in Oncology / Ausgabe 4/2024
Print ISSN: 1527-2729
Elektronische ISSN: 1534-6277
DOI
https://doi.org/10.1007/s11864-023-01175-z

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